DE602004016727D1 - Sphingolipiden zur verbesserung der darmflorazusammensetzung - Google Patents
Sphingolipiden zur verbesserung der darmflorazusammensetzungInfo
- Publication number
- DE602004016727D1 DE602004016727D1 DE602004016727T DE602004016727T DE602004016727D1 DE 602004016727 D1 DE602004016727 D1 DE 602004016727D1 DE 602004016727 T DE602004016727 T DE 602004016727T DE 602004016727 T DE602004016727 T DE 602004016727T DE 602004016727 D1 DE602004016727 D1 DE 602004016727D1
- Authority
- DE
- Germany
- Prior art keywords
- improving
- sphingolipids
- darm
- composition
- flora composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003408 sphingolipids Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 230000000968 intestinal effect Effects 0.000 abstract 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 abstract 1
- OKTWQKXBJUBAKS-WQADZSDSSA-N 2-[[(e,2r,3s)-2-amino-3-hydroxyoctadec-4-enoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC\C=C\[C@H](O)[C@H](N)COP(O)(=O)OCC[N+](C)(C)C OKTWQKXBJUBAKS-WQADZSDSSA-N 0.000 abstract 1
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 abstract 1
- OTKJDMGTUTTYMP-UHFFFAOYSA-N dihydrosphingosine Natural products CCCCCCCCCCCCCCCC(O)C(N)CO OTKJDMGTUTTYMP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 abstract 1
- 229940033329 phytosphingosine Drugs 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- OTKJDMGTUTTYMP-ZWKOTPCHSA-N sphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO OTKJDMGTUTTYMP-ZWKOTPCHSA-N 0.000 abstract 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Saccharide Compounds (AREA)
- Confectionery (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1022443A NL1022443C2 (nl) | 2003-01-20 | 2003-01-20 | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
PCT/NL2004/000046 WO2004064819A1 (en) | 2003-01-20 | 2004-01-20 | Sphingolipids for improvement of the composition of the intestinal flora |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004016727D1 true DE602004016727D1 (de) | 2008-11-06 |
Family
ID=32768715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004016727T Expired - Lifetime DE602004016727D1 (de) | 2003-01-20 | 2004-01-20 | Sphingolipiden zur verbesserung der darmflorazusammensetzung |
Country Status (7)
Country | Link |
---|---|
US (1) | US8703172B2 (de) |
EP (1) | EP1585509B1 (de) |
JP (1) | JP2006516278A (de) |
AT (1) | ATE409030T1 (de) |
DE (1) | DE602004016727D1 (de) |
NL (1) | NL1022443C2 (de) |
WO (1) | WO2004064819A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITRM20010688A1 (it) | 2001-11-21 | 2003-05-21 | Univ Roma | Composti immunoregolatori. |
NL1022443C2 (nl) | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
EP1585508B1 (de) | 2003-01-20 | 2009-04-01 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Die verwendung von sphingolipiden zur senkung der cholesterin- und triglyzeridspiegel im plasma. |
US20050196461A1 (en) * | 2004-01-14 | 2005-09-08 | Udell Ronald G. | Ceramide formulations suitable for oral administration |
JP2005281257A (ja) * | 2004-03-30 | 2005-10-13 | Snow Brand Milk Prod Co Ltd | 美肌剤 |
AU2005310341A1 (en) * | 2004-11-30 | 2006-06-08 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae |
US8025552B2 (en) * | 2004-12-30 | 2011-09-27 | The United States Of America As Represented By The Secretary Of Agriculture | Artificial diets for honey bees |
GB0513431D0 (en) * | 2005-06-30 | 2005-08-10 | Kherion Technology Ltd | Prophylactic compositions and uses |
WO2009082214A1 (en) * | 2007-12-21 | 2009-07-02 | N.V. Nutricia | Use of non-digestible carbohydrates for improving intestinal microbiota |
US20090162482A1 (en) * | 2007-12-21 | 2009-06-25 | S.A.F.E. Research & Development, Llc | Nutritional Compositions for Bees |
JP6675752B2 (ja) * | 2016-02-23 | 2020-04-01 | 国立大学法人佐賀大学 | 腸内Blautia coccoides増殖刺激剤 |
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US3622666A (en) * | 1968-03-04 | 1971-11-23 | Stanley Drug Products Inc | Methods for treating bacterial infections with phrenosin |
FR2492259A1 (fr) | 1980-10-21 | 1982-04-23 | Idinvex Sa | Formulation d'heparine |
JPS61152632A (ja) | 1984-12-26 | 1986-07-11 | Dai Ichi Seiyaku Co Ltd | 抗動脈硬化剤 |
JPS6344842A (ja) | 1986-08-12 | 1988-02-25 | Kao Corp | 油中水中油型乳化油脂組成物 |
IT1235162B (it) | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisosfingolipidi |
US5190876A (en) * | 1988-12-27 | 1993-03-02 | Emory University | Method of modifying cellular differentiation and function and compositions therefor |
AU653363B2 (en) | 1990-08-13 | 1994-09-29 | Duke University | Methods for inducing cell differentiation using ceramides |
US5543390A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
US5232837A (en) * | 1991-08-05 | 1993-08-03 | Emory University | Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination |
US5374616A (en) * | 1991-10-18 | 1994-12-20 | Georgetown University | Compositions containing sphingosylphosphorylcholine and the use thereof as a cellular growth factor |
JPH05320048A (ja) * | 1992-05-19 | 1993-12-03 | Shiseido Co Ltd | 抗酸化剤 |
US6190894B1 (en) * | 1993-03-19 | 2001-02-20 | The Regents Of The University Of California | Method and compositions for disrupting the epithelial barrier function |
US5478860A (en) * | 1993-06-04 | 1995-12-26 | Inex Pharmaceuticals Corp. | Stable microemulsions for hydrophobic compound delivery |
US5830853A (en) * | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
US6773719B2 (en) | 1994-03-04 | 2004-08-10 | Esperion Luv Development, Inc. | Liposomal compositions, and methods of using liposomal compositions to treat dislipidemias |
US20020182250A1 (en) * | 1995-09-06 | 2002-12-05 | Goro Hori | Lipid metabolism improving agent |
DE69607854T2 (de) | 1995-09-29 | 2000-08-17 | Georgetown University Washingt | Sphingosylphosphorylcholin als wirkstoff zur wundheilung |
DE19602108A1 (de) * | 1996-01-22 | 1997-07-24 | Beiersdorf Ag | Gegen Bakterien, Parasiten, Protozoen, Mycota und Viren wirksame Substanzen |
AU2195297A (en) * | 1996-02-20 | 1997-09-02 | Sloan-Kettering Institute For Cancer Research | Combinations of pkc inhibitors and therapeutic agents for treating cancers |
CN101928213B (zh) * | 1996-03-28 | 2012-12-05 | Dsmip资产有限公司 | 粒状微生物生物质的制备及其有价值的化合物的分离方法 |
ES2318236T3 (es) | 1997-04-10 | 2009-05-01 | Kyowa Hakko Kirin Co., Ltd. | Agentes activadores de celulas nkt que contienen alfa-glucosilceramidas. |
US6800661B1 (en) * | 1997-04-15 | 2004-10-05 | Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
KR100541271B1 (ko) * | 1997-05-02 | 2006-04-21 | 코스모페름 베.파우 | 국소적 사용을 위한 항균조성물 |
US5989803A (en) * | 1997-09-05 | 1999-11-23 | The Trustees Of Columbia University In The City Of New York | Method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase |
JP4091250B2 (ja) * | 1997-09-11 | 2008-05-28 | タカラバイオ株式会社 | スフィンゴシン類誘導体及び医薬組成物 |
DE69943314D1 (de) * | 1998-02-12 | 2011-05-12 | Kapil N Bhalla | Sphingolipid-derivate und verfahren zu deren verwendung |
JP3581010B2 (ja) | 1998-03-18 | 2004-10-27 | 雪印乳業株式会社 | 脂質の消化吸収機能改善剤 |
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AU776785B2 (en) | 1999-02-24 | 2004-09-23 | Johns Hopkins University, The | Compositions and methods for modulating serum cholesterol |
JP3544493B2 (ja) | 1999-06-10 | 2004-07-21 | 雪印乳業株式会社 | 乳幼児用栄養組成物 |
KR100341793B1 (ko) | 1999-07-02 | 2002-06-24 | 권 영 근 | 스핑고신 1-포스페이트를 유효성분으로 포함하는 혈관신생 촉진제 |
WO2001003739A1 (fr) * | 1999-07-12 | 2001-01-18 | Ono Pharmaceutical Co., Ltd. | Inhibiteurs de fibrose contenant comme ingredient actif l'agoniste du recepteur de sphingosine-1-phosphate ou la sphingosine-1-phosphate |
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FR2820037B1 (fr) * | 2001-01-29 | 2005-12-09 | Dermaconcept Jmc | Composition dermatologique a usage veterinaire comprenant une base sphingoide |
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WO2003011873A2 (en) | 2001-07-27 | 2003-02-13 | Neptune Technologies & Bioressources Inc. | Natural marine source phospholipids comprising flavonoids, polyunsaturated fatty acids and their applications |
EP1291340B1 (de) | 2001-09-05 | 2006-03-15 | Charmzone Co., Ltd | Phytosphingosinderivate mit Antitumorwirkung |
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EP1585508B1 (de) | 2003-01-20 | 2009-04-01 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Die verwendung von sphingolipiden zur senkung der cholesterin- und triglyzeridspiegel im plasma. |
NL1022443C2 (nl) | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
GB0301395D0 (en) | 2003-01-21 | 2003-02-19 | Univ Aston | Inflammatory disorder treatment |
US20040171522A1 (en) | 2003-02-27 | 2004-09-02 | Yaron Ilan | Regulation of immune responses by manipulation of intermediary metabolite levels |
US9717754B2 (en) * | 2003-02-27 | 2017-08-01 | Enzo Therapeutics, Inc. | Glucocerebroside treatment of disease |
JP5107573B2 (ja) | 2003-04-25 | 2012-12-26 | ザ ペン ステイト リサーチ ファウンデーション | 増殖抑制性脂質由来生物活性化合物の全身送達方法およびシステム |
-
2003
- 2003-01-20 NL NL1022443A patent/NL1022443C2/nl not_active IP Right Cessation
-
2004
- 2004-01-20 AT AT04703547T patent/ATE409030T1/de not_active IP Right Cessation
- 2004-01-20 EP EP04703547A patent/EP1585509B1/de not_active Revoked
- 2004-01-20 JP JP2006500733A patent/JP2006516278A/ja active Pending
- 2004-01-20 US US10/542,838 patent/US8703172B2/en not_active Expired - Fee Related
- 2004-01-20 WO PCT/NL2004/000046 patent/WO2004064819A1/en active Application Filing
- 2004-01-20 DE DE602004016727T patent/DE602004016727D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE409030T1 (de) | 2008-10-15 |
JP2006516278A (ja) | 2006-06-29 |
US8703172B2 (en) | 2014-04-22 |
NL1022443C2 (nl) | 2004-07-22 |
EP1585509B1 (de) | 2008-09-24 |
EP1585509A1 (de) | 2005-10-19 |
US20060134182A1 (en) | 2006-06-22 |
WO2004064819A1 (en) | 2004-08-05 |
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Legal Events
Date | Code | Title | Description |
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8363 | Opposition against the patent |