NL1017500C1 - Werkwijze voor de bereiding van Citalopram. - Google Patents

Werkwijze voor de bereiding van Citalopram. Download PDF

Info

Publication number
NL1017500C1
NL1017500C1 NL1017500A NL1017500A NL1017500C1 NL 1017500 C1 NL1017500 C1 NL 1017500C1 NL 1017500 A NL1017500 A NL 1017500A NL 1017500 A NL1017500 A NL 1017500A NL 1017500 C1 NL1017500 C1 NL 1017500C1
Authority
NL
Netherlands
Prior art keywords
compound
formula
cyano group
group
acid
Prior art date
Application number
NL1017500A
Other languages
English (en)
Dutch (nl)
Inventor
Hans Petersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of NL1017500C1 publication Critical patent/NL1017500C1/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NL1017500A 2000-03-13 2001-03-05 Werkwijze voor de bereiding van Citalopram. NL1017500C1 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000404 2000-03-13
DK200000404 2000-03-13

Publications (1)

Publication Number Publication Date
NL1017500C1 true NL1017500C1 (nl) 2001-04-26

Family

ID=8159323

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1017500A NL1017500C1 (nl) 2000-03-13 2001-03-05 Werkwijze voor de bereiding van Citalopram.

Country Status (31)

Country Link
US (1) US6717000B2 (it)
EP (1) EP1265880B1 (it)
JP (1) JP2003527384A (it)
KR (1) KR20020080471A (it)
CN (1) CN1423644A (it)
AR (1) AR029893A1 (it)
AT (1) ATE282031T1 (it)
AU (1) AU3920301A (it)
BE (1) BE1011598A6 (it)
BG (1) BG107048A (it)
BR (1) BR0109267A (it)
CA (1) CA2402386A1 (it)
CZ (1) CZ20023383A3 (it)
DE (1) DE60107061D1 (it)
EA (1) EA200200971A1 (it)
FR (1) FR2806085B1 (it)
HR (1) HRP20020741A2 (it)
HU (1) HUP0300180A2 (it)
IE (1) IES20010206A2 (it)
IL (1) IL151489A0 (it)
IS (1) IS6528A (it)
IT (1) ITMI20010487A1 (it)
MX (1) MXPA02008872A (it)
NL (1) NL1017500C1 (it)
NO (1) NO20024214L (it)
NZ (1) NZ521202A (it)
PL (1) PL360108A1 (it)
SK (1) SK14592002A3 (it)
TR (1) TR200202167T2 (it)
WO (1) WO2001068628A1 (it)
ZA (1) ZA200206898B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CA2402553A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
CN1429219A (zh) 2000-03-13 2003-07-09 H·隆德贝克有限公司 制备西酞普兰的方法
ATE257832T1 (de) 2000-03-14 2004-01-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (it) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DK1015416T3 (da) 1997-07-08 2001-11-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EA002770B1 (ru) 1997-11-11 2002-08-29 Х.Лундбекк А/С Способ получения циталопрама
KR100411505B1 (ko) 1998-10-20 2003-12-18 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
CA2356188C (en) 1998-12-23 2006-05-23 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2229774T3 (es) 1999-10-25 2005-04-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
SI1246812T1 (en) 1999-12-28 2004-08-31 H. Lundbeck A/S Method for the preparation of citalopram
HUP0203840A3 (en) 1999-12-30 2005-02-28 Lundbeck & Co As H Method for the preparation of citalopram
IL150561A0 (en) 2000-01-14 2003-02-12 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CA2402553A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
GB2357762B (en) 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
CN1429219A (zh) 2000-03-13 2003-07-09 H·隆德贝克有限公司 制备西酞普兰的方法
ATE257832T1 (de) 2000-03-14 2004-01-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
TR200202168T2 (tr) 2000-03-16 2002-12-23 H. Lundbeck A/S 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
AU2001272368A1 (en) 2000-07-06 2002-01-21 H. Lundbeck, A/S Method for the preparation of citalopram
FI20011621A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
EA003581B1 (ru) 2000-12-22 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
EA003459B1 (ru) 2000-12-28 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама

Also Published As

Publication number Publication date
US20030069304A1 (en) 2003-04-10
NO20024214L (no) 2002-10-31
BG107048A (en) 2003-05-30
SK14592002A3 (sk) 2003-03-04
FR2806085B1 (fr) 2005-02-25
EP1265880B1 (en) 2004-11-10
TR200202167T2 (tr) 2002-12-23
WO2001068628A1 (en) 2001-09-20
IS6528A (is) 2002-08-27
ATE282031T1 (de) 2004-11-15
IES20010206A2 (en) 2002-03-06
HUP0300180A2 (en) 2003-05-28
US6717000B2 (en) 2004-04-06
CN1423644A (zh) 2003-06-11
NZ521202A (en) 2004-11-26
IL151489A0 (en) 2003-04-10
PL360108A1 (en) 2004-09-06
AU3920301A (en) 2001-09-24
EP1265880A1 (en) 2002-12-18
DE60107061D1 (de) 2004-12-16
BE1011598A6 (fr) 2001-07-03
JP2003527384A (ja) 2003-09-16
MXPA02008872A (es) 2003-02-10
ZA200206898B (en) 2004-04-20
AR029893A1 (es) 2003-07-23
ITMI20010487A1 (it) 2002-09-08
CZ20023383A3 (cs) 2003-01-15
KR20020080471A (ko) 2002-10-23
CA2402386A1 (en) 2001-09-20
FR2806085A1 (fr) 2001-09-14
HRP20020741A2 (en) 2003-12-31
NO20024214D0 (no) 2002-09-04
BR0109267A (pt) 2002-12-17
EA200200971A1 (ru) 2003-02-27

Similar Documents

Publication Publication Date Title
NO312031B1 (no) Krystallin base av citalopram
SK14812002A3 (sk) Spôsob prípravy 5-kyano-1-(4-fluórfenyl)-1,3-dihydrobenzofuránov a antidepresívny farmaceutický prostriedok
NL1017500C1 (nl) Werkwijze voor de bereiding van Citalopram.
NL1017417C1 (nl) Werkwijze voor de bereiding van Citalopram.
CZ20023384A3 (cs) Způsob výroby citalopramu a meziprodukt
US6864379B2 (en) Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
US6806376B2 (en) Method for the preparation of citalopram
JP3365764B2 (ja) シタロプラムの製造方法

Legal Events

Date Code Title Description
VD1 Lapsed due to non-payment of the annual fee

Effective date: 20051001