MY202025A - Rnai agents and compositions for inhibiting expression of apolipoprotein c-iii (apoc3) - Google Patents

Rnai agents and compositions for inhibiting expression of apolipoprotein c-iii (apoc3)

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Publication number
MY202025A
MY202025A MYPI2020001153A MYPI2020001153A MY202025A MY 202025 A MY202025 A MY 202025A MY PI2020001153 A MYPI2020001153 A MY PI2020001153A MY PI2020001153 A MYPI2020001153 A MY PI2020001153A MY 202025 A MY202025 A MY 202025A
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MY
Malaysia
Prior art keywords
apoc3
rnai agents
iii
compositions
apolipoprotein
Prior art date
Application number
MYPI2020001153A
Other languages
English (en)
Inventor
Tao Pei
Zhen Li
Rui Zhu
So Wong
Steven Kanner
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of MY202025A publication Critical patent/MY202025A/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

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  • Plant Pathology (AREA)
  • Microbiology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
MYPI2020001153A 2017-09-11 2018-09-10 Rnai agents and compositions for inhibiting expression of apolipoprotein c-iii (apoc3) MY202025A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762556818P 2017-09-11 2017-09-11
US201862643927P 2018-03-16 2018-03-16
US201862720434P 2018-08-21 2018-08-21
PCT/US2018/050248 WO2019051402A1 (en) 2017-09-11 2018-09-10 RNA INTERFERENCE AGENTS AND COMPOSITIONS FOR INHIBITING THE EXPRESSION OF APOLIPOPROTEIN C-III (APOC3)

Publications (1)

Publication Number Publication Date
MY202025A true MY202025A (en) 2024-03-29

Family

ID=65630632

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2020001153A MY202025A (en) 2017-09-11 2018-09-10 Rnai agents and compositions for inhibiting expression of apolipoprotein c-iii (apoc3)

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US (5) US10597657B2 (enExample)
EP (1) EP3681516A4 (enExample)
JP (4) JP7438103B2 (enExample)
KR (2) KR20240161202A (enExample)
CN (2) CN118879696A (enExample)
AU (2) AU2018329190B2 (enExample)
BR (1) BR112020002413A2 (enExample)
CA (1) CA3074303A1 (enExample)
CL (2) CL2020000593A1 (enExample)
CO (1) CO2020002586A2 (enExample)
CR (1) CR20200108A (enExample)
EC (1) ECSP20017905A (enExample)
IL (2) IL273172B2 (enExample)
JO (1) JOP20200054A1 (enExample)
MX (2) MX2020002648A (enExample)
MY (1) MY202025A (enExample)
PE (1) PE20201283A1 (enExample)
PH (1) PH12020500332A1 (enExample)
SG (1) SG11201912178VA (enExample)
TN (1) TN2020000039A1 (enExample)
TW (2) TWI811238B (enExample)
UA (1) UA130735C2 (enExample)
UY (1) UY37871A (enExample)
WO (1) WO2019051402A1 (enExample)
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CN120344664A (zh) * 2023-10-27 2025-07-18 北京安龙生物医药有限公司 靶向脂蛋白a的寡核苷酸及其用途
WO2025125576A2 (en) * 2023-12-15 2025-06-19 E-Therapeutics Plc Inhibitors of expression and/or function
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