MY196640A - Substituted Oxopyridine Derivatives - Google Patents

Substituted Oxopyridine Derivatives

Info

Publication number
MY196640A
MY196640A MYPI2018700053A MYPI2018700053A MY196640A MY 196640 A MY196640 A MY 196640A MY PI2018700053 A MYPI2018700053 A MY PI2018700053A MY PI2018700053 A MYPI2018700053 A MY PI2018700053A MY 196640 A MY196640 A MY 196640A
Authority
MY
Malaysia
Prior art keywords
oxopyridine derivatives
substituted oxopyridine
disorders
substituted
derivatives
Prior art date
Application number
MYPI2018700053A
Other languages
English (en)
Inventor
Lang Dieter
Tersteegen Adrian
Jens Ackerstaff
Heitmeier Stefan
Jimenez Nunez Eloisa
Rohrig Susanne
Hillisch Alexander
Meier Katharina
Stampfu? Jan
Ellerbrock Pascal
Meibom Daniel
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MY196640A publication Critical patent/MY196640A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
MYPI2018700053A 2015-07-09 2016-07-05 Substituted Oxopyridine Derivatives MY196640A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15176099 2015-07-09
EP16157350 2016-02-25
PCT/EP2016/065787 WO2017005725A1 (en) 2015-07-09 2016-07-05 Substituted oxopyridine derivatives

Publications (1)

Publication Number Publication Date
MY196640A true MY196640A (en) 2023-04-25

Family

ID=56345141

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2018700053A MY196640A (en) 2015-07-09 2016-07-05 Substituted Oxopyridine Derivatives

Country Status (39)

Country Link
US (4) US10421742B2 (OSRAM)
EP (1) EP3319956B1 (OSRAM)
JP (1) JP6871180B2 (OSRAM)
KR (1) KR102596164B1 (OSRAM)
CN (2) CN113292539B (OSRAM)
AU (1) AU2016289746B2 (OSRAM)
CA (1) CA2990901C (OSRAM)
CL (1) CL2018000039A1 (OSRAM)
CO (1) CO2018000113A2 (OSRAM)
CR (1) CR20180017A (OSRAM)
CU (1) CU24512B1 (OSRAM)
CY (1) CY1123996T1 (OSRAM)
DK (1) DK3319956T3 (OSRAM)
DO (1) DOP2018000004A (OSRAM)
EA (1) EA036208B1 (OSRAM)
EC (1) ECSP18001308A (OSRAM)
ES (1) ES2856554T3 (OSRAM)
GE (1) GEP20197046B (OSRAM)
HR (1) HRP20210459T1 (OSRAM)
HU (1) HUE053552T2 (OSRAM)
IL (1) IL256556B (OSRAM)
JO (1) JO3703B1 (OSRAM)
LT (1) LT3319956T (OSRAM)
MA (1) MA42376B1 (OSRAM)
MX (1) MX377903B (OSRAM)
MY (1) MY196640A (OSRAM)
NI (1) NI201800001A (OSRAM)
PE (1) PE20180538A1 (OSRAM)
PH (1) PH12018500057A1 (OSRAM)
PL (1) PL3319956T3 (OSRAM)
RS (1) RS61584B1 (OSRAM)
SI (1) SI3319956T1 (OSRAM)
SV (1) SV2018005610A (OSRAM)
TN (1) TN2018000011A1 (OSRAM)
TW (1) TWI717367B (OSRAM)
UA (1) UA122341C2 (OSRAM)
UY (1) UY36780A (OSRAM)
WO (1) WO2017005725A1 (OSRAM)
ZA (1) ZA201800826B (OSRAM)

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ES2722423T3 (es) * 2014-09-24 2019-08-12 Bayer Pharma AG Derivados de oxopiridina sustituidos
US20190119213A1 (en) * 2015-03-19 2019-04-25 Bayer Pharma Aktiengesellschaft Oxo-pyridine-derivatives as factor xia inhibitors for the treatment of thrombosis
JO3703B1 (ar) * 2015-07-09 2021-01-31 Bayer Pharma AG مشتقات أوكسوبيريدين مستبدلة
HUE057289T2 (hu) 2016-08-31 2022-05-28 Jiangsu Hengrui Medicine Co Oxopikolinamid-származék, annak elõállítási módszere és gyógyszerészeti felhasználása
HRP20220565T1 (hr) * 2018-03-15 2022-06-10 Bayer Aktiengesellschaft Postupak pripreme dva derivata 4-{[(2s)-2-{4-[5-klor-2-(1h-1,2,3-triazol-1-il)fenil]-5-metoksi-2-oksopiridin-1(2h)-il}butanoil]amino}-2-fluorbenzamida
ES2922533T3 (es) 2018-04-10 2022-09-16 Bayer Pharma AG Un derivado de oxopiridina sustituido
EP3822264A4 (en) 2018-07-02 2021-11-10 Jiangsu Hengrui Medicine Co., Ltd. CRYSTALLINE FORMS OF AN OXYPYRIDINE AMIDE DERIVATIVE AND THEIR PREPARATION PROCESS
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KR20210105939A (ko) * 2018-12-17 2021-08-27 바이엘 악티엔게젤샤프트 혈전성 또는 혈전색전성 장애 및/또는 혈전성 또는 혈전색전성 합병증의 치료 및/또는 예방을 위한 치환된 옥소피리딘 유도체
AR117435A1 (es) 2018-12-21 2021-08-04 Bayer Ag Derivados de oxopiridina sustituidos
EP3898634A1 (en) 2018-12-21 2021-10-27 Bayer Aktiengesellschaft Substituted oxopyridine derivatives
JP7450024B2 (ja) * 2019-09-27 2024-03-14 シェンヅェン サルブリス ファーマシューティカルズ カンパニー リミテッド FXIa阻害剤及びその調製方法と医薬用途
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CN114621140B (zh) * 2020-12-10 2023-08-11 中国科学院上海药物研究所 芳基二氟乙酰胺化合物及其制备方法和用途
CA3212645A1 (en) 2021-03-09 2022-09-15 Bayer Aktiengesellschaft Crystalline forms of (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5-dioxo-14-(trifluoromethyl)-32h-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
PE20250018A1 (es) * 2021-03-09 2025-01-07 Bayer Ag Formas de dosificacion farmaceuticas que comprenden (4s)-24-cloro-4-etil-73-fluoro-35- metoxi-32 ,5-dioxo-14-(trifluorometil)-32h-6-aza-3(4,1)-piridina-1(1)-[1,2,3]triazola- 2(1,2),7(1)-dibencenaheptafano-74-carboxamida
WO2022189280A1 (en) 2021-03-09 2022-09-15 Bayer Aktiengesellschaft Solvates of (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5-dioxo-14-(trifluoro-methyl)-32 h-6- aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
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US11845748B2 (en) 2021-03-18 2023-12-19 Janssen Pharmaceutica Nv Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11814364B2 (en) 2021-03-18 2023-11-14 Janssen Pharmaceutica Nv Pyridine N-oxide derivatives useful as factor XIa inhibitors
CN113666826B (zh) * 2021-07-30 2024-03-26 五邑大学 一种芳基或杂芳基甲氧基化反应的方法
CN116199672A (zh) * 2021-11-30 2023-06-02 成都泰和伟业生物科技有限公司 一种嘧啶酰胺类衍生物及其制备方法和用途
WO2023174399A1 (zh) * 2022-03-18 2023-09-21 苏州晶云药物科技股份有限公司 取代的氧代吡啶类衍生物的晶型及其制备方法
CN116262735B (zh) * 2022-11-18 2025-05-13 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN116262734B (zh) * 2022-11-18 2025-05-13 成都施贝康生物医药科技有限公司 氧代吡啶类化合物及其制备方法和用途
CN116262740A (zh) * 2022-11-18 2023-06-16 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN116082303B (zh) * 2022-12-21 2025-02-25 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其中间体和应用
CN116262736B (zh) * 2022-12-26 2025-05-13 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN120936342A (zh) 2023-03-31 2025-11-11 拜耳公司 包含(4s)-24-氯-4-乙基-73-氟-35-甲氧基-32,5-二氧代-14-(三氟甲基)-32h-6-氮杂-3(4,1)-吡啶-1(1)-[1,2,3]三唑-2(1,2),7(1)-二苯杂七蕃-74-甲酰胺的药物剂型
WO2024251276A1 (zh) 2023-06-09 2024-12-12 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体和应用
CN116751136B (zh) * 2023-06-21 2025-08-29 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116535392B (zh) * 2023-06-26 2023-09-05 成都施贝康生物医药科技有限公司 一种氧代吡啶类化合物的制备方法及中间体和应用
CN116621742B (zh) * 2023-06-09 2025-05-06 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116621728B (zh) * 2023-06-09 2025-07-29 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116874387B (zh) * 2023-06-21 2025-08-26 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116730861A (zh) * 2023-06-21 2023-09-12 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN117164565B (zh) * 2023-09-07 2025-05-27 成都施贝康生物医药科技有限公司 一种氧代嘧啶类化合物及其制备方法和用途
CN117164566B (zh) * 2023-09-07 2025-06-06 成都施贝康生物医药科技有限公司 一种氧代哒嗪类化合物及其制备方法和用途
CN117164562B (zh) * 2023-09-07 2025-06-13 成都施贝康生物医药科技有限公司 一种氧代哒嗪类化合物及其制备方法和用途
CN117164563B (zh) * 2023-09-07 2025-06-10 成都施贝康生物医药科技有限公司 氧代嘧啶类化合物及其制备方法和用途
CN117164564B (zh) * 2023-09-07 2025-07-08 成都施贝康生物医药科技有限公司 氧代哒嗪类化合物及其制备方法和用途
CN117164561A (zh) * 2023-09-07 2023-12-05 成都施贝康生物医药科技有限公司 一种氧代嘧啶类化合物及其制备方法和用途
CN117186073B (zh) * 2023-09-08 2025-06-06 成都施贝康生物医药科技有限公司 氧代嘧啶类化合物及其制备方法和用途
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JO3703B1 (ar) 2021-01-31
EA036208B1 (ru) 2020-10-14
CR20180017A (es) 2018-03-07
KR20180026761A (ko) 2018-03-13
CN113292539B (zh) 2023-12-22
CU20180001A7 (es) 2018-06-05
CN108026072A (zh) 2018-05-11
AU2016289746A1 (en) 2018-01-25
UA122341C2 (uk) 2020-10-26
DK3319956T3 (da) 2021-03-29
US10421742B2 (en) 2019-09-24
PH12018500057A1 (en) 2018-07-09
ES2856554T3 (es) 2021-09-27
CA2990901A1 (en) 2017-01-12
CO2018000113A2 (es) 2018-06-12
UY36780A (es) 2017-01-31
US20190367478A1 (en) 2019-12-05
AU2016289746B2 (en) 2020-08-20
DOP2018000004A (es) 2018-01-31
HRP20210459T1 (hr) 2021-05-14
GEP20197046B (en) 2019-12-10
MA42376A (fr) 2018-05-16
IL256556B (en) 2021-02-28
EP3319956B1 (en) 2021-01-06
ECSP18001308A (es) 2018-03-31
LT3319956T (lt) 2021-02-10
US20250282748A1 (en) 2025-09-11
IL256556A (en) 2018-02-28
CY1123996T1 (el) 2022-07-22
TWI717367B (zh) 2021-02-01
WO2017005725A1 (en) 2017-01-12
MA42376B1 (fr) 2021-04-30
CA2990901C (en) 2024-11-12
BR112018000209A2 (pt) 2018-09-04
PL3319956T3 (pl) 2021-07-05
EA201890111A1 (ru) 2018-06-29
CU24512B1 (es) 2021-05-12
HUE053552T2 (hu) 2021-07-28
NI201800001A (es) 2018-10-19
JP6871180B2 (ja) 2021-05-12
ZA201800826B (en) 2021-08-25
CN113292539A (zh) 2021-08-24
TW201706261A (zh) 2017-02-16
PE20180538A1 (es) 2018-03-20
NZ739109A (en) 2024-09-27
US11180471B2 (en) 2021-11-23
HK1255045A1 (zh) 2019-08-02
JP2018519323A (ja) 2018-07-19
CN108026072B (zh) 2021-08-17
CL2018000039A1 (es) 2018-07-13
SI3319956T1 (sl) 2021-02-26
TN2018000011A1 (en) 2019-07-08
EP3319956A1 (en) 2018-05-16
RS61584B1 (sr) 2021-04-29
SV2018005610A (es) 2018-04-27
US20230024752A1 (en) 2023-01-26
KR102596164B1 (ko) 2023-11-01
MX2018000076A (es) 2018-02-26
US20180194745A1 (en) 2018-07-12
MX377903B (es) 2025-03-10

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