HRP20210459T1 - Supstituirani derivati oksopiridina - Google Patents

Supstituirani derivati oksopiridina Download PDF

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Publication number
HRP20210459T1
HRP20210459T1 HRP20210459TT HRP20210459T HRP20210459T1 HR P20210459 T1 HRP20210459 T1 HR P20210459T1 HR P20210459T T HRP20210459T T HR P20210459TT HR P20210459 T HRP20210459 T HR P20210459T HR P20210459 T1 HRP20210459 T1 HR P20210459T1
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Croatia
Prior art keywords
formula
solvates
image
compound
compound according
Prior art date
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HRP20210459TT
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English (en)
Croatian (hr)
Inventor
Eloisa JIMENEZ NUNEZ
Jens Ackerstaff
Susanne Röhrig
Alexander Hillisch
Katharina MEIER
Stefan Heitmeier
Adrian Tersteegen
Jan Stampfuss
Pascal ELLERBROCK
Daniel Meibom
Dieter Lang
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Bayer Pharma Aktiengesellschaft
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Publication of HRP20210459T1 publication Critical patent/HRP20210459T1/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
HRP20210459TT 2015-07-09 2016-07-05 Supstituirani derivati oksopiridina HRP20210459T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15176099 2015-07-09
EP16157350 2016-02-25
EP16734672.5A EP3319956B1 (en) 2015-07-09 2016-07-05 Substituted oxopyridine derivatives
PCT/EP2016/065787 WO2017005725A1 (en) 2015-07-09 2016-07-05 Substituted oxopyridine derivatives

Publications (1)

Publication Number Publication Date
HRP20210459T1 true HRP20210459T1 (hr) 2021-05-14

Family

ID=56345141

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20210459TT HRP20210459T1 (hr) 2015-07-09 2016-07-05 Supstituirani derivati oksopiridina

Country Status (39)

Country Link
US (4) US10421742B2 (OSRAM)
EP (1) EP3319956B1 (OSRAM)
JP (1) JP6871180B2 (OSRAM)
KR (1) KR102596164B1 (OSRAM)
CN (2) CN108026072B (OSRAM)
AU (1) AU2016289746B2 (OSRAM)
CA (1) CA2990901C (OSRAM)
CL (1) CL2018000039A1 (OSRAM)
CO (1) CO2018000113A2 (OSRAM)
CR (1) CR20180017A (OSRAM)
CU (1) CU24512B1 (OSRAM)
CY (1) CY1123996T1 (OSRAM)
DK (1) DK3319956T3 (OSRAM)
DO (1) DOP2018000004A (OSRAM)
EA (1) EA036208B1 (OSRAM)
EC (1) ECSP18001308A (OSRAM)
ES (1) ES2856554T3 (OSRAM)
GE (1) GEP20197046B (OSRAM)
HR (1) HRP20210459T1 (OSRAM)
HU (1) HUE053552T2 (OSRAM)
IL (1) IL256556B (OSRAM)
JO (1) JO3703B1 (OSRAM)
LT (1) LT3319956T (OSRAM)
MA (1) MA42376B1 (OSRAM)
MX (1) MX377903B (OSRAM)
MY (1) MY196640A (OSRAM)
NI (1) NI201800001A (OSRAM)
PE (1) PE20180538A1 (OSRAM)
PH (1) PH12018500057A1 (OSRAM)
PL (1) PL3319956T3 (OSRAM)
RS (1) RS61584B1 (OSRAM)
SI (1) SI3319956T1 (OSRAM)
SV (1) SV2018005610A (OSRAM)
TN (1) TN2018000011A1 (OSRAM)
TW (1) TWI717367B (OSRAM)
UA (1) UA122341C2 (OSRAM)
UY (1) UY36780A (OSRAM)
WO (1) WO2017005725A1 (OSRAM)
ZA (1) ZA201800826B (OSRAM)

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JO3703B1 (ar) * 2015-07-09 2021-01-31 Bayer Pharma AG مشتقات أوكسوبيريدين مستبدلة
CN113912586B (zh) 2016-08-31 2023-04-07 江苏恒瑞医药股份有限公司 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用
EP3765452B1 (en) * 2018-03-15 2022-04-13 Bayer Aktiengesellschaft Preparative process of two 4-{[(2s)-2-{4-[5-chloro-2-(1h-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2h)-yl}butanoyl]amino}-2-fluorobenzamide derivatives
SG11202008352YA (en) 2018-04-10 2020-09-29 Bayer Pharma AG A substituted oxopyridine derivative
CN112004810B (zh) 2018-07-02 2022-04-08 江苏恒瑞医药股份有限公司 一种氧代吡啶酰胺类衍生物的晶型及制备方法
AR115870A1 (es) 2018-07-31 2021-03-10 Sumitomo Chemical Co MÉTODO PARA CONTROLAR EL HONGO DE LA ROYA DE LA SOJA QUE TIENE RESISTENCIA AL INHIBIDOR DE SITIO Qₒ
CA3123324A1 (en) 2018-12-17 2020-06-25 Bayer Aktiengesellschaft Substituted oxopyridine derivatives for the treatment and/or prophylaxis of thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications
CA3124296A1 (en) 2018-12-21 2020-06-25 Bayer Aktiengesellschaft Substituted oxopyridine derivatives
CN113474348A (zh) 2018-12-21 2021-10-01 拜耳公司 取代的氧代吡啶衍生物
WO2021057818A1 (zh) * 2019-09-27 2021-04-01 深圳信立泰药业股份有限公司 FXIa抑制剂及其制备方法和医药用途
JP7700218B2 (ja) 2020-09-17 2025-06-30 浙江海正薬業股▲ふん▼有限公司 ピペラジン誘導体、その製造方法、およびその使用
CN114621140B (zh) * 2020-12-10 2023-08-11 中国科学院上海药物研究所 芳基二氟乙酰胺化合物及其制备方法和用途
EP4304714A1 (en) * 2021-03-09 2024-01-17 Bayer Aktiengesellschaft Crystalline forms of (4s)-2 4-chloro-4-ethyl-7 3-fluoro-3 5-methoxy-3 2,5-dioxo-1 4-(trifluoromethyl)-3 2h-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-5 dibenzenaheptaphane-7 4-carboxamide
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US11814364B2 (en) 2021-03-18 2023-11-14 Janssen Pharmaceutica Nv Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11845748B2 (en) 2021-03-18 2023-12-19 Janssen Pharmaceutica Nv Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
CN113666826B (zh) * 2021-07-30 2024-03-26 五邑大学 一种芳基或杂芳基甲氧基化反应的方法
CN116199672A (zh) * 2021-11-30 2023-06-02 成都泰和伟业生物科技有限公司 一种嘧啶酰胺类衍生物及其制备方法和用途
WO2023174399A1 (zh) * 2022-03-18 2023-09-21 苏州晶云药物科技股份有限公司 取代的氧代吡啶类衍生物的晶型及其制备方法
CN116262740A (zh) * 2022-11-18 2023-06-16 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN116262735B (zh) * 2022-11-18 2025-05-13 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN116262734B (zh) * 2022-11-18 2025-05-13 成都施贝康生物医药科技有限公司 氧代吡啶类化合物及其制备方法和用途
CN116082303B (zh) 2022-12-21 2025-02-25 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其中间体和应用
CN116262736B (zh) * 2022-12-26 2025-05-13 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
WO2024200335A1 (en) 2023-03-31 2024-10-03 Bayer Aktiengesellschaft Pharmaceutical dosage forms comprising (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5- dioxo-14-(trifluoromethyl)-32 h-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
CN116621742B (zh) * 2023-06-09 2025-05-06 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116751136B (zh) * 2023-06-21 2025-08-29 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116621728B (zh) * 2023-06-09 2025-07-29 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116535392B (zh) * 2023-06-26 2023-09-05 成都施贝康生物医药科技有限公司 一种氧代吡啶类化合物的制备方法及中间体和应用
WO2024251276A1 (zh) 2023-06-09 2024-12-12 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体和应用
CN116730861A (zh) * 2023-06-21 2023-09-12 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116874387B (zh) * 2023-06-21 2025-08-26 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN117164564B (zh) * 2023-09-07 2025-07-08 成都施贝康生物医药科技有限公司 氧代哒嗪类化合物及其制备方法和用途
CN117164565B (zh) * 2023-09-07 2025-05-27 成都施贝康生物医药科技有限公司 一种氧代嘧啶类化合物及其制备方法和用途
CN117164562B (zh) * 2023-09-07 2025-06-13 成都施贝康生物医药科技有限公司 一种氧代哒嗪类化合物及其制备方法和用途
CN117164566B (zh) * 2023-09-07 2025-06-06 成都施贝康生物医药科技有限公司 一种氧代哒嗪类化合物及其制备方法和用途
CN117164561A (zh) * 2023-09-07 2023-12-05 成都施贝康生物医药科技有限公司 一种氧代嘧啶类化合物及其制备方法和用途
CN117164563B (zh) * 2023-09-07 2025-06-10 成都施贝康生物医药科技有限公司 氧代嘧啶类化合物及其制备方法和用途
CN117186073B (zh) * 2023-09-08 2025-06-06 成都施贝康生物医药科技有限公司 氧代嘧啶类化合物及其制备方法和用途
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UA122341C2 (uk) 2020-10-26
PH12018500057A1 (en) 2018-07-09
ZA201800826B (en) 2021-08-25
KR102596164B1 (ko) 2023-11-01
CN113292539A (zh) 2021-08-24
TWI717367B (zh) 2021-02-01
PE20180538A1 (es) 2018-03-20
CY1123996T1 (el) 2022-07-22
GEP20197046B (en) 2019-12-10
UY36780A (es) 2017-01-31
MA42376B1 (fr) 2021-04-30
EP3319956B1 (en) 2021-01-06
MX2018000076A (es) 2018-02-26
US11180471B2 (en) 2021-11-23
CN108026072A (zh) 2018-05-11
US20250282748A1 (en) 2025-09-11
MY196640A (en) 2023-04-25
ECSP18001308A (es) 2018-03-31
SV2018005610A (es) 2018-04-27
CL2018000039A1 (es) 2018-07-13
SI3319956T1 (sl) 2021-02-26
PL3319956T3 (pl) 2021-07-05
TN2018000011A1 (en) 2019-07-08
CN108026072B (zh) 2021-08-17
US20180194745A1 (en) 2018-07-12
ES2856554T3 (es) 2021-09-27
MA42376A (fr) 2018-05-16
CU20180001A7 (es) 2018-06-05
JO3703B1 (ar) 2021-01-31
HK1255045A1 (zh) 2019-08-02
RS61584B1 (sr) 2021-04-29
CU24512B1 (es) 2021-05-12
CA2990901A1 (en) 2017-01-12
NZ739109A (en) 2024-09-27
CN113292539B (zh) 2023-12-22
CO2018000113A2 (es) 2018-06-12
MX377903B (es) 2025-03-10
CR20180017A (es) 2018-03-07
NI201800001A (es) 2018-10-19
US20230024752A1 (en) 2023-01-26
LT3319956T (lt) 2021-02-10
HUE053552T2 (hu) 2021-07-28
BR112018000209A2 (pt) 2018-09-04
US20190367478A1 (en) 2019-12-05
US10421742B2 (en) 2019-09-24
DOP2018000004A (es) 2018-01-31
IL256556A (en) 2018-02-28
TW201706261A (zh) 2017-02-16
DK3319956T3 (da) 2021-03-29
IL256556B (en) 2021-02-28
JP2018519323A (ja) 2018-07-19
AU2016289746A1 (en) 2018-01-25
KR20180026761A (ko) 2018-03-13
AU2016289746B2 (en) 2020-08-20
EA201890111A1 (ru) 2018-06-29
EP3319956A1 (en) 2018-05-16
JP6871180B2 (ja) 2021-05-12
EA036208B1 (ru) 2020-10-14
WO2017005725A1 (en) 2017-01-12
CA2990901C (en) 2024-11-12

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