IL256556B - Oxopyridine histories are transmuted - Google Patents

Oxopyridine histories are transmuted

Info

Publication number
IL256556B
IL256556B IL256556A IL25655617A IL256556B IL 256556 B IL256556 B IL 256556B IL 256556 A IL256556 A IL 256556A IL 25655617 A IL25655617 A IL 25655617A IL 256556 B IL256556 B IL 256556B
Authority
IL
Israel
Prior art keywords
oxopyridine derivatives
substituted oxopyridine
substituted
derivatives
oxopyridine
Prior art date
Application number
IL256556A
Other languages
English (en)
Hebrew (he)
Other versions
IL256556A (en
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of IL256556A publication Critical patent/IL256556A/en
Publication of IL256556B publication Critical patent/IL256556B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
IL256556A 2015-07-09 2017-12-25 Oxopyridine histories are transmuted IL256556B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15176099 2015-07-09
EP16157350 2016-02-25
PCT/EP2016/065787 WO2017005725A1 (en) 2015-07-09 2016-07-05 Substituted oxopyridine derivatives

Publications (2)

Publication Number Publication Date
IL256556A IL256556A (en) 2018-02-28
IL256556B true IL256556B (en) 2021-02-28

Family

ID=56345141

Family Applications (1)

Application Number Title Priority Date Filing Date
IL256556A IL256556B (en) 2015-07-09 2017-12-25 Oxopyridine histories are transmuted

Country Status (39)

Country Link
US (4) US10421742B2 (OSRAM)
EP (1) EP3319956B1 (OSRAM)
JP (1) JP6871180B2 (OSRAM)
KR (1) KR102596164B1 (OSRAM)
CN (2) CN108026072B (OSRAM)
AU (1) AU2016289746B2 (OSRAM)
CA (1) CA2990901C (OSRAM)
CL (1) CL2018000039A1 (OSRAM)
CO (1) CO2018000113A2 (OSRAM)
CR (1) CR20180017A (OSRAM)
CU (1) CU24512B1 (OSRAM)
CY (1) CY1123996T1 (OSRAM)
DK (1) DK3319956T3 (OSRAM)
DO (1) DOP2018000004A (OSRAM)
EA (1) EA036208B1 (OSRAM)
EC (1) ECSP18001308A (OSRAM)
ES (1) ES2856554T3 (OSRAM)
GE (1) GEP20197046B (OSRAM)
HR (1) HRP20210459T1 (OSRAM)
HU (1) HUE053552T2 (OSRAM)
IL (1) IL256556B (OSRAM)
JO (1) JO3703B1 (OSRAM)
LT (1) LT3319956T (OSRAM)
MA (1) MA42376B1 (OSRAM)
MX (1) MX377903B (OSRAM)
MY (1) MY196640A (OSRAM)
NI (1) NI201800001A (OSRAM)
PE (1) PE20180538A1 (OSRAM)
PH (1) PH12018500057A1 (OSRAM)
PL (1) PL3319956T3 (OSRAM)
RS (1) RS61584B1 (OSRAM)
SI (1) SI3319956T1 (OSRAM)
SV (1) SV2018005610A (OSRAM)
TN (1) TN2018000011A1 (OSRAM)
TW (1) TWI717367B (OSRAM)
UA (1) UA122341C2 (OSRAM)
UY (1) UY36780A (OSRAM)
WO (1) WO2017005725A1 (OSRAM)
ZA (1) ZA201800826B (OSRAM)

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ES2722423T3 (es) * 2014-09-24 2019-08-12 Bayer Pharma AG Derivados de oxopiridina sustituidos
CA2979937A1 (en) * 2015-03-19 2016-09-22 Bayer Pharma Aktiengesellschaft Oxo-pyridine-derivatives as factor xia inhibitors for the treatment of thrombosis
JO3703B1 (ar) * 2015-07-09 2021-01-31 Bayer Pharma AG مشتقات أوكسوبيريدين مستبدلة
CN113912586B (zh) 2016-08-31 2023-04-07 江苏恒瑞医药股份有限公司 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用
EP3765452B1 (en) * 2018-03-15 2022-04-13 Bayer Aktiengesellschaft Preparative process of two 4-{[(2s)-2-{4-[5-chloro-2-(1h-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2h)-yl}butanoyl]amino}-2-fluorobenzamide derivatives
SG11202008352YA (en) 2018-04-10 2020-09-29 Bayer Pharma AG A substituted oxopyridine derivative
CN112004810B (zh) 2018-07-02 2022-04-08 江苏恒瑞医药股份有限公司 一种氧代吡啶酰胺类衍生物的晶型及制备方法
AR115870A1 (es) 2018-07-31 2021-03-10 Sumitomo Chemical Co MÉTODO PARA CONTROLAR EL HONGO DE LA ROYA DE LA SOJA QUE TIENE RESISTENCIA AL INHIBIDOR DE SITIO Qₒ
CA3123324A1 (en) 2018-12-17 2020-06-25 Bayer Aktiengesellschaft Substituted oxopyridine derivatives for the treatment and/or prophylaxis of thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications
CA3124296A1 (en) 2018-12-21 2020-06-25 Bayer Aktiengesellschaft Substituted oxopyridine derivatives
CN113474348A (zh) 2018-12-21 2021-10-01 拜耳公司 取代的氧代吡啶衍生物
WO2021057818A1 (zh) * 2019-09-27 2021-04-01 深圳信立泰药业股份有限公司 FXIa抑制剂及其制备方法和医药用途
JP7700218B2 (ja) 2020-09-17 2025-06-30 浙江海正薬業股▲ふん▼有限公司 ピペラジン誘導体、その製造方法、およびその使用
CN114621140B (zh) * 2020-12-10 2023-08-11 中国科学院上海药物研究所 芳基二氟乙酰胺化合物及其制备方法和用途
EP4304714A1 (en) * 2021-03-09 2024-01-17 Bayer Aktiengesellschaft Crystalline forms of (4s)-2 4-chloro-4-ethyl-7 3-fluoro-3 5-methoxy-3 2,5-dioxo-1 4-(trifluoromethyl)-3 2h-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-5 dibenzenaheptaphane-7 4-carboxamide
EP4304561A1 (en) 2021-03-09 2024-01-17 Bayer Aktiengesellschaft Pharmaceutical dosage forms comprising (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5- dioxo-14-(trifluoromethyl)-32h-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)- dibenzenaheptaphane-74-carboxamide
WO2022189280A1 (en) 2021-03-09 2022-09-15 Bayer Aktiengesellschaft Solvates of (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5-dioxo-14-(trifluoro-methyl)-32 h-6- aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
US11919881B2 (en) 2021-03-18 2024-03-05 Janssen Pharmaceutica Nv Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11814364B2 (en) 2021-03-18 2023-11-14 Janssen Pharmaceutica Nv Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11845748B2 (en) 2021-03-18 2023-12-19 Janssen Pharmaceutica Nv Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
CN113666826B (zh) * 2021-07-30 2024-03-26 五邑大学 一种芳基或杂芳基甲氧基化反应的方法
CN116199672A (zh) * 2021-11-30 2023-06-02 成都泰和伟业生物科技有限公司 一种嘧啶酰胺类衍生物及其制备方法和用途
WO2023174399A1 (zh) * 2022-03-18 2023-09-21 苏州晶云药物科技股份有限公司 取代的氧代吡啶类衍生物的晶型及其制备方法
CN116262740A (zh) * 2022-11-18 2023-06-16 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN116262735B (zh) * 2022-11-18 2025-05-13 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN116262734B (zh) * 2022-11-18 2025-05-13 成都施贝康生物医药科技有限公司 氧代吡啶类化合物及其制备方法和用途
CN116082303B (zh) 2022-12-21 2025-02-25 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其中间体和应用
CN116262736B (zh) * 2022-12-26 2025-05-13 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
WO2024200335A1 (en) 2023-03-31 2024-10-03 Bayer Aktiengesellschaft Pharmaceutical dosage forms comprising (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5- dioxo-14-(trifluoromethyl)-32 h-6-aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
CN116621742B (zh) * 2023-06-09 2025-05-06 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116751136B (zh) * 2023-06-21 2025-08-29 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116621728B (zh) * 2023-06-09 2025-07-29 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116535392B (zh) * 2023-06-26 2023-09-05 成都施贝康生物医药科技有限公司 一种氧代吡啶类化合物的制备方法及中间体和应用
WO2024251276A1 (zh) 2023-06-09 2024-12-12 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体和应用
CN116730861A (zh) * 2023-06-21 2023-09-12 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116874387B (zh) * 2023-06-21 2025-08-26 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN117164564B (zh) * 2023-09-07 2025-07-08 成都施贝康生物医药科技有限公司 氧代哒嗪类化合物及其制备方法和用途
CN117164565B (zh) * 2023-09-07 2025-05-27 成都施贝康生物医药科技有限公司 一种氧代嘧啶类化合物及其制备方法和用途
CN117164562B (zh) * 2023-09-07 2025-06-13 成都施贝康生物医药科技有限公司 一种氧代哒嗪类化合物及其制备方法和用途
CN117164566B (zh) * 2023-09-07 2025-06-06 成都施贝康生物医药科技有限公司 一种氧代哒嗪类化合物及其制备方法和用途
CN117164561A (zh) * 2023-09-07 2023-12-05 成都施贝康生物医药科技有限公司 一种氧代嘧啶类化合物及其制备方法和用途
CN117164563B (zh) * 2023-09-07 2025-06-10 成都施贝康生物医药科技有限公司 氧代嘧啶类化合物及其制备方法和用途
CN117186073B (zh) * 2023-09-08 2025-06-06 成都施贝康生物医药科技有限公司 氧代嘧啶类化合物及其制备方法和用途
CN118894814B (zh) * 2024-07-15 2025-09-12 上海康鹏科技股份有限公司 1-(2-溴-4-氯苯基)-4-(三氟甲基)-1h-1,2,3-三唑的制备方法

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Also Published As

Publication number Publication date
UA122341C2 (uk) 2020-10-26
PH12018500057A1 (en) 2018-07-09
ZA201800826B (en) 2021-08-25
KR102596164B1 (ko) 2023-11-01
CN113292539A (zh) 2021-08-24
TWI717367B (zh) 2021-02-01
PE20180538A1 (es) 2018-03-20
CY1123996T1 (el) 2022-07-22
GEP20197046B (en) 2019-12-10
UY36780A (es) 2017-01-31
MA42376B1 (fr) 2021-04-30
EP3319956B1 (en) 2021-01-06
MX2018000076A (es) 2018-02-26
US11180471B2 (en) 2021-11-23
CN108026072A (zh) 2018-05-11
US20250282748A1 (en) 2025-09-11
MY196640A (en) 2023-04-25
ECSP18001308A (es) 2018-03-31
SV2018005610A (es) 2018-04-27
CL2018000039A1 (es) 2018-07-13
SI3319956T1 (sl) 2021-02-26
PL3319956T3 (pl) 2021-07-05
TN2018000011A1 (en) 2019-07-08
CN108026072B (zh) 2021-08-17
US20180194745A1 (en) 2018-07-12
ES2856554T3 (es) 2021-09-27
MA42376A (fr) 2018-05-16
CU20180001A7 (es) 2018-06-05
JO3703B1 (ar) 2021-01-31
HK1255045A1 (zh) 2019-08-02
RS61584B1 (sr) 2021-04-29
CU24512B1 (es) 2021-05-12
CA2990901A1 (en) 2017-01-12
NZ739109A (en) 2024-09-27
CN113292539B (zh) 2023-12-22
CO2018000113A2 (es) 2018-06-12
MX377903B (es) 2025-03-10
CR20180017A (es) 2018-03-07
NI201800001A (es) 2018-10-19
US20230024752A1 (en) 2023-01-26
LT3319956T (lt) 2021-02-10
HUE053552T2 (hu) 2021-07-28
BR112018000209A2 (pt) 2018-09-04
US20190367478A1 (en) 2019-12-05
US10421742B2 (en) 2019-09-24
DOP2018000004A (es) 2018-01-31
IL256556A (en) 2018-02-28
TW201706261A (zh) 2017-02-16
DK3319956T3 (da) 2021-03-29
JP2018519323A (ja) 2018-07-19
AU2016289746A1 (en) 2018-01-25
KR20180026761A (ko) 2018-03-13
AU2016289746B2 (en) 2020-08-20
EA201890111A1 (ru) 2018-06-29
EP3319956A1 (en) 2018-05-16
JP6871180B2 (ja) 2021-05-12
EA036208B1 (ru) 2020-10-14
WO2017005725A1 (en) 2017-01-12
CA2990901C (en) 2024-11-12
HRP20210459T1 (hr) 2021-05-14

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