MY163870A - Isoxazolines as therapeutic agents - Google Patents
Isoxazolines as therapeutic agentsInfo
- Publication number
- MY163870A MY163870A MYPI2013702036A MYPI2013702036A MY163870A MY 163870 A MY163870 A MY 163870A MY PI2013702036 A MYPI2013702036 A MY PI2013702036A MY PI2013702036 A MYPI2013702036 A MY PI2013702036A MY 163870 A MY163870 A MY 163870A
- Authority
- MY
- Malaysia
- Prior art keywords
- isoxazolines
- therapeutic agents
- solvates
- stereoisomers
- hydrates
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 150000002547 isoxazolines Chemical class 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| IN1272DE2011 | 2011-04-30 |
Publications (1)
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| MY163870A true MY163870A (en) | 2017-10-31 |
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| MYPI2013702036A MY163870A (en) | 2011-04-30 | 2012-04-30 | Isoxazolines as therapeutic agents |
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| US9593126B2 (en) * | 2012-11-21 | 2017-03-14 | Zoetis Services Llc | Synthesis of spirocyclic isoxazoline derivatives |
| KR20160049008A (ko) * | 2013-09-05 | 2016-05-04 | 애브비 인코포레이티드 | 이속사졸 화합물을 합성하기 위한 부분입체선택적 방법 |
| WO2017012970A2 (en) * | 2015-07-17 | 2017-01-26 | Syngenta Participations Ag | Pesticidally active pyrazole derivatives |
| EP3145168A1 (en) | 2015-09-17 | 2017-03-22 | Thomson Licensing | An apparatus and a method for generating data representing a pixel beam |
| BR112020003217A2 (pt) * | 2017-08-14 | 2020-10-06 | Boehringer Ingelheim Animal Health USA Inc. | compostos pesticidas e parasiticidas de pirazolisoxazolina |
| EP3847169A1 (en) * | 2018-09-04 | 2021-07-14 | F. Hoffmann-La Roche AG | Benzothiazole compounds for the treatment of autoimmune diseases |
| US20230348450A1 (en) * | 2020-09-14 | 2023-11-02 | Genzyme Corporation | Carboxylic acid-containing compounds as modulators of bis-phosphoglycerate mutase for the treatment of sickle cell disease |
| US20250186408A1 (en) | 2021-05-03 | 2025-06-12 | Katholieke Universiteit Leuven | Treatment of pharmacoresistant epilepsy |
| CA3229566A1 (en) * | 2021-08-17 | 2023-02-23 | Kanaph Therapeutics Inc. | Sos1 inhibitor and use thereof |
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| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| CO5170501A1 (es) | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
| ECSP003448A (es) | 2000-04-27 | 2000-05-25 | Azoles sustituidos | |
| MXPA05001592A (es) | 2002-08-09 | 2005-05-05 | Astrazeneca Ab | Oxadiazoles como moduladores de receptor-5 de glutamato metabotropico. |
| US20040067985A1 (en) * | 2002-10-04 | 2004-04-08 | Fortuna Haviv | Method of inhibiting angiogenesis |
| US7166609B2 (en) * | 2002-11-02 | 2007-01-23 | Sanofi-Aventis Deutschland Gmbh | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases |
| KR101050680B1 (ko) | 2002-11-02 | 2011-07-21 | 사노피-아벤티스 도이칠란트 게엠베하 | 콜라게네이즈의 선택적인 억제를 위한 신규한피리미딘-4,6-디카복스아미드 |
| US7125870B2 (en) * | 2002-11-06 | 2006-10-24 | Bristol-Myers Squibb Company | Isoxazoline derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme |
| US20050004111A1 (en) * | 2003-01-03 | 2005-01-06 | Aventis Pharma Deutschland Gmbh | Selective MMP-13 inhibitors |
| EP1694655A2 (en) | 2003-11-26 | 2006-08-30 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
| JP4932495B2 (ja) | 2004-01-23 | 2012-05-16 | アムゲン インコーポレイテッド | 化合物及び使用方法 |
| CN101768129B (zh) * | 2004-03-05 | 2012-05-23 | 日产化学工业株式会社 | 异*唑啉取代苯甲酰胺化合物的制备中间体 |
| DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| PL1848435T3 (pl) * | 2005-01-25 | 2016-08-31 | Synta Pharmaceuticals Corp | Związki przeciwko zapaleniom i zastosowania związane z odpornością |
| CN102659774A (zh) | 2005-08-15 | 2012-09-12 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3拮抗剂的哌啶和哌嗪衍生物 |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| JP2009519937A (ja) * | 2005-12-14 | 2009-05-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 無脊椎有害生物防除用イソオキサゾリン |
| CN101330828A (zh) * | 2005-12-14 | 2008-12-24 | 杜邦公司 | 用于防治无脊椎害虫的异噁唑啉 |
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| AU2006332694A1 (en) * | 2005-12-30 | 2007-07-12 | Alantos Pharmaceuticals, Holding, Inc. | Substituted bis-amide metalloprotease inhibitors |
| TWI412322B (zh) * | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| MX2008013307A (es) | 2006-04-20 | 2008-10-27 | Du Pont | Pirazolinas para controlar plagas de invertebrados. |
| TWI618544B (zh) | 2006-12-26 | 2018-03-21 | 藍瑟斯醫學影像公司 | 使心臟神經分布顯像之配位體 |
| WO2008154528A2 (en) * | 2007-06-13 | 2008-12-18 | E. I. Du Pont De Nemours And Company | Isoxazoline insecticides |
| US20090035381A1 (en) | 2007-08-01 | 2009-02-05 | Stankus John J | Electrospraying method for fabrication of particles and coatings and treatment methods thereof |
| EP2185537A1 (en) | 2007-08-02 | 2010-05-19 | Pfizer Inc. | Pyrimidine and pyridine derivatives and their pharmaceutical use and compositions |
| EP2186804B1 (en) * | 2007-08-10 | 2015-06-17 | Nippon Soda Co., Ltd. | Nitrogen-containing heterocyclic compound and pest control agent |
| WO2009036328A2 (en) | 2007-09-12 | 2009-03-19 | University Of Washington | Methods for blow molding solid-state cellular thermoplastic articles |
| AU2008319309B2 (en) | 2007-10-31 | 2012-09-06 | Merck Sharp & Dohme Llc | P2X3 receptor antagonists for treatment of pain |
| TWI411395B (zh) | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
| JP2009286773A (ja) | 2008-03-14 | 2009-12-10 | Bayer Cropscience Ag | 殺虫性縮環式アリール類 |
| CL2009001059A1 (es) | 2008-05-01 | 2010-11-12 | Boehringer Ingelheim Int | Compuestos derivados de 1,3-oxazin-2-ona-3,6 sustituidos, inhibidores de la actividad de la 11-beta-hidroxiesteroide deshidrogenasa i; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades tales como diabetes mellitus, entre otras. |
| JP5748659B2 (ja) | 2008-06-10 | 2015-07-15 | アッヴィ・インコーポレイテッド | 新規な三環式化合物 |
| WO2010010187A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| EP2331536B1 (en) * | 2008-08-22 | 2013-08-21 | Syngenta Participations AG | Insecticidal compounds |
| WO2010045191A2 (en) | 2008-10-13 | 2010-04-22 | Vuelogic, Llc | Methods and systems for customer performance scoring |
| US8338367B2 (en) | 2008-10-15 | 2012-12-25 | Boehringer Ingelheim International Gmbh | Fused heteroaryl diamide compounds useful as MMP-13 inhibitors |
| ES2534199T3 (es) * | 2008-10-31 | 2015-04-20 | Merck Sharp & Dohme Corp. | Antagonistas del receptor P2X3 para el tratamiento del dolor |
| HUE015568T4 (en) * | 2008-12-19 | 2017-10-30 | Elanco Tiergesundheit Ag | Isoxazoline derivatives and their use as pesticides |
| WO2010084067A2 (en) * | 2009-01-22 | 2010-07-29 | Syngenta Participations Ag | Insecticidal compounds |
| EP2414353A1 (en) * | 2009-04-01 | 2012-02-08 | Basf Se | Isoxazoline compounds for combating invertebrate pests |
| US20120022058A1 (en) | 2009-04-10 | 2012-01-26 | Pfizer Inc. | 4,5-dihydro-1h-pyrazole compounds and their pharmaceutical uses |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| FR2948939B1 (fr) | 2009-08-05 | 2013-03-22 | Pf Medicament | Derives de 2h pyridazin-3-ones, leur preparation et leur application en therapeutique humaine |
| TWI487486B (zh) * | 2009-12-01 | 2015-06-11 | Syngenta Participations Ag | 以異唑啉衍生物為主之殺蟲化合物 |
| GB2481118A (en) | 2010-06-09 | 2011-12-14 | Syngenta Participations Ag | Pesticidal mixtures comprising enantiomerically enriched isoxazoline derivatives |
| KR20130089232A (ko) | 2010-06-15 | 2013-08-09 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 안트라닐산 디아미드 유도체 |
| DK178277B1 (da) | 2010-06-18 | 2015-10-26 | Novartis Tiergesundheit Ag | Diaryloxazolinforbindelser til bekæmpelse af fiskelus |
| JP2014505089A (ja) * | 2011-02-10 | 2014-02-27 | ノバルティス アーゲー | 無脊椎有害動物を防除するためのイソオキサゾリン誘導体 |
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- 2012-04-30 TW TW101115419A patent/TW201247657A/zh unknown
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2013
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2015
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- 2015-10-26 AU AU2015246181A patent/AU2015246181A1/en not_active Abandoned
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2016
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Also Published As
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| DOP2013000251A (es) | 2014-02-28 |
| EP2704712A4 (en) | 2014-10-15 |
| CA2834237A1 (en) | 2012-11-08 |
| JP6101250B2 (ja) | 2017-03-22 |
| JP2014513122A (ja) | 2014-05-29 |
| MX2013012686A (es) | 2013-12-02 |
| ECSP13013026A (es) | 2014-01-31 |
| AU2012250979A1 (en) | 2013-04-18 |
| AR086113A1 (es) | 2013-11-20 |
| GT201300267A (es) | 2014-12-12 |
| CN103764145A (zh) | 2014-04-30 |
| US20150297596A1 (en) | 2015-10-22 |
| KR20140041512A (ko) | 2014-04-04 |
| WO2012151158A1 (en) | 2012-11-08 |
| PE20141190A1 (es) | 2014-10-12 |
| RU2013152961A (ru) | 2015-06-10 |
| EP2704712A1 (en) | 2014-03-12 |
| AU2015246181A1 (en) | 2015-11-12 |
| AU2012250979B2 (en) | 2015-07-30 |
| IL229081A0 (en) | 2013-12-31 |
| UY34043A (es) | 2012-10-31 |
| MX355996B (es) | 2018-05-08 |
| PH12013502218A1 (en) | 2019-06-03 |
| TW201247657A (en) | 2012-12-01 |
| US20130023526A1 (en) | 2013-01-24 |
| CO6801765A2 (es) | 2013-11-29 |
| CL2013003125A1 (es) | 2014-04-25 |
| US9029409B2 (en) | 2015-05-12 |
| SG194696A1 (en) | 2013-12-30 |
| CR20130597A (es) | 2014-02-24 |
| PH12016500838A1 (en) | 2016-09-26 |
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