MXPA06007556A - Geles cohesivos de hialuronano y/o hilano entrecruzados, su preparacion y su uso. - Google Patents

Geles cohesivos de hialuronano y/o hilano entrecruzados, su preparacion y su uso.

Info

Publication number
MXPA06007556A
MXPA06007556A MXPA06007556A MXPA06007556A MXPA06007556A MX PA06007556 A MXPA06007556 A MX PA06007556A MX PA06007556 A MXPA06007556 A MX PA06007556A MX PA06007556 A MXPA06007556 A MX PA06007556A MX PA06007556 A MXPA06007556 A MX PA06007556A
Authority
MX
Mexico
Prior art keywords
gel
dvs
solution
polymer
cpi
Prior art date
Application number
MXPA06007556A
Other languages
English (en)
Spanish (es)
Inventor
Valentina Vasilyeva
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MXPA06007556A publication Critical patent/MXPA06007556A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
MXPA06007556A 2003-12-30 2004-12-30 Geles cohesivos de hialuronano y/o hilano entrecruzados, su preparacion y su uso. MXPA06007556A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53342903P 2003-12-30 2003-12-30
PCT/US2004/043811 WO2005066215A1 (en) 2003-12-30 2004-12-30 Cohesive gels form cross-linked hyaluronan and/or hylan, their preparation and use

Publications (1)

Publication Number Publication Date
MXPA06007556A true MXPA06007556A (es) 2006-08-31

Family

ID=34748900

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06007556A MXPA06007556A (es) 2003-12-30 2004-12-30 Geles cohesivos de hialuronano y/o hilano entrecruzados, su preparacion y su uso.

Country Status (10)

Country Link
US (1) US20050142152A1 (cg-RX-API-DMAC10.html)
EP (1) EP1701981B1 (cg-RX-API-DMAC10.html)
JP (2) JP5016926B2 (cg-RX-API-DMAC10.html)
CN (1) CN100537606C (cg-RX-API-DMAC10.html)
AU (1) AU2004312532B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0418309B8 (cg-RX-API-DMAC10.html)
CA (1) CA2550718C (cg-RX-API-DMAC10.html)
IL (1) IL176465A (cg-RX-API-DMAC10.html)
MX (1) MXPA06007556A (cg-RX-API-DMAC10.html)
WO (1) WO2005066215A1 (cg-RX-API-DMAC10.html)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7338433B2 (en) 2002-08-13 2008-03-04 Allergan, Inc. Remotely adjustable gastric banding method
US7811298B2 (en) 2002-08-28 2010-10-12 Allergan, Inc. Fatigue-resistant gastric banding device
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
CN1909844B (zh) 2004-01-23 2011-02-16 阿勒根公司 可松脱式固定的一体式可调胃带
EP2145610A1 (en) 2004-03-08 2010-01-20 Allergan Medical S.A. Closure system for tubular organs
EP1732635B1 (en) 2004-03-18 2011-07-27 Allergan, Inc. Apparatus for volume adjustment of intragastric balloons
EP1817347B1 (en) * 2004-11-24 2017-05-17 Albumedix A/S Method of cross-linking hyaluronic acid with divinylsulfone
CN103860582A (zh) * 2004-12-30 2014-06-18 建新公司 用于关节内粘弹性补充的方案
US8251888B2 (en) 2005-04-13 2012-08-28 Mitchell Steven Roslin Artificial gastric valve
US20070067045A1 (en) * 2005-09-19 2007-03-22 Ar2 Partners, Inc. Systems and methods for skin wrinkle removal
US8043206B2 (en) 2006-01-04 2011-10-25 Allergan, Inc. Self-regulating gastric band with pressure data processing
US7798954B2 (en) 2006-01-04 2010-09-21 Allergan, Inc. Hydraulic gastric band with collapsible reservoir
EP1994062B1 (en) * 2006-03-02 2009-07-15 Novozymes Biopolymer A/S Aryl/alkyl vinyl sulfone hyaluronic acid derivatives
FR2909560B1 (fr) 2006-12-06 2012-12-28 Fabre Pierre Dermo Cosmetique Gel d'acide hyaluronique pour injection intradermique
CA2687990A1 (en) * 2007-05-23 2008-12-04 Allergan, Inc. Cross-linked collagen and uses thereof
US8658148B2 (en) 2007-06-22 2014-02-25 Genzyme Corporation Chemically modified dendrimers
US8318695B2 (en) * 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
PT2818184T (pt) 2007-11-16 2019-01-28 Aclaris Therapeutics Inc Composições e métodos para o tratamento de púrpura
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
AU2015252122A1 (en) * 2008-08-04 2015-11-26 Allergan Industrie Sas Hyaluronic acid-based gels including anesthetic agents
US8357795B2 (en) * 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
CA2735173C (en) 2008-09-02 2017-01-10 Tautona Group Lp Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
EP2341953B1 (en) * 2008-09-04 2018-11-21 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
US20100305397A1 (en) * 2008-10-06 2010-12-02 Allergan Medical Sarl Hydraulic-mechanical gastric band
WO2010042493A1 (en) 2008-10-06 2010-04-15 Allergan, Inc. Mechanical gastric band with cushions
US20100185049A1 (en) 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
FR2938187B1 (fr) * 2008-11-07 2012-08-17 Anteis Sa Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur
US8390326B2 (en) * 2009-05-05 2013-03-05 William Marsh Rice University Method for fabrication of a semiconductor element and structure thereof
FR2945293B1 (fr) 2009-05-11 2011-06-17 Teoxane Procede de preparation d'un gel reticule.
BR112012002117A2 (pt) 2009-07-30 2019-09-24 Carbylan Biosurgery Inc composições poliméricas modificadas de ácido hialurônico e métodos relacionados.
US8273725B2 (en) * 2009-09-10 2012-09-25 Genzyme Corporation Stable hyaluronan/steroid formulation
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
US8758221B2 (en) 2010-02-24 2014-06-24 Apollo Endosurgery, Inc. Source reservoir with potential energy for remotely adjustable gastric banding system
US8840541B2 (en) * 2010-02-25 2014-09-23 Apollo Endosurgery, Inc. Pressure sensing gastric banding system
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
US8586562B2 (en) 2010-03-12 2013-11-19 Allergan Industrie, Sas Fluid compositions for improving skin conditions
EP4062950A1 (en) 2010-03-22 2022-09-28 Allergan, Inc. Syringe comprising dermal filler for soft tissue augmentation
US9028394B2 (en) 2010-04-29 2015-05-12 Apollo Endosurgery, Inc. Self-adjusting mechanical gastric band
US9044298B2 (en) 2010-04-29 2015-06-02 Apollo Endosurgery, Inc. Self-adjusting gastric band
US20110270024A1 (en) 2010-04-29 2011-11-03 Allergan, Inc. Self-adjusting gastric band having various compliant components
US20110270025A1 (en) 2010-04-30 2011-11-03 Allergan, Inc. Remotely powered remotely adjustable gastric band system
EP2575909B1 (en) * 2010-06-03 2020-01-15 Technology Innovation Momentum Fund (Israel) Limited Partnership Malleable hydrogel hybrids made of self-assembled peptides and biocompatible polymers and uses thereof
US8517915B2 (en) 2010-06-10 2013-08-27 Allergan, Inc. Remotely adjustable gastric banding system
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US20120059216A1 (en) 2010-09-07 2012-03-08 Allergan, Inc. Remotely adjustable gastric banding system
PT2637710T (pt) 2010-11-08 2017-07-12 Allergan Ind Sas Formulações à base de ácido hialurónico
US8961393B2 (en) 2010-11-15 2015-02-24 Apollo Endosurgery, Inc. Gastric band devices and drive systems
RU2624239C2 (ru) 2011-06-03 2017-07-03 Аллерган, Инк. Составы кожного наполнителя, включая антиоксиданты
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
RU2613887C2 (ru) 2011-08-10 2017-03-21 Гликорес 2000 С.Р.Л. Устойчивый к расщеплению сшитый низкомолекулярный гиалуронат
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
CN104105474B (zh) * 2011-09-14 2018-04-06 阿勒根公司 用于细纹治疗的真皮填充剂组合物
CN102558600A (zh) * 2011-12-01 2012-07-11 上海白衣缘生物工程有限公司 交联透明质酸海绵及其制备方法
US8876694B2 (en) 2011-12-07 2014-11-04 Apollo Endosurgery, Inc. Tube connector with a guiding tip
US8961394B2 (en) 2011-12-20 2015-02-24 Apollo Endosurgery, Inc. Self-sealing fluid joint for use with a gastric band
IN2014DN10147A (cg-RX-API-DMAC10.html) 2012-06-15 2015-08-21 Merz Pharma Gmbh & Co Kgaa
US9579388B2 (en) 2012-11-29 2017-02-28 Rene Gauthier System and method for alleviating the appearance of scars and/or scar tissue
US9421198B2 (en) 2013-07-30 2016-08-23 Teoxane Composition comprising hyaluronic acid and mepivacaine
US20170080120A1 (en) * 2014-05-16 2017-03-23 Ulstrast, Inc. Phase-shifting formulations
WO2016051219A1 (en) 2014-09-30 2016-04-07 Allergan Industrie, Sas Stable hydrogel compositions including additives
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
RU2715234C2 (ru) 2015-02-13 2020-02-26 Аллерган Эндюстри, Сас Имплантаты для моделирования, увеличения или коррекции частей лица, например подбородка
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
WO2017119198A1 (ja) * 2016-01-05 2017-07-13 デンカ株式会社 半月板変性治療用組成物
AR110299A1 (es) 2016-12-02 2019-03-13 Sanofi Sa Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico
CN108250457A (zh) * 2017-05-08 2018-07-06 上海利康瑞生物工程有限公司 一种剪切粘度可控的双相交联透明质酸钠凝胶及其制备方法和制剂
US20190240335A1 (en) * 2018-02-07 2019-08-08 Promedon S.A. Biocompatible Hydrogel Compositions
WO2020030629A1 (en) * 2018-08-07 2020-02-13 Merz Pharma Gmbh & Co. Kgaa Method for dynamic filtration of a cross-linked hydrogel
WO2022051060A1 (en) * 2020-09-01 2022-03-10 Orthogenrx, Inc. Crosslinking of non-animal-derived hyaluronic acid with divinyl sulfone
JP2025502169A (ja) 2022-01-11 2025-01-24 ワイコ・エセペア 革新的充填剤としての新規なヒアルロン酸誘導体
IT202400006892A1 (it) 2024-03-27 2025-09-27 Gpq S R L Riempitivi tissutali polisaccaridici reticolati con resveratrolo

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4586865A (en) * 1982-12-09 1986-05-06 Hansen John C Rotatable discharge conveyor for a belly-dump trailer
SE442820B (sv) * 1984-06-08 1986-02-03 Pharmacia Ab Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
EP0224987B1 (en) * 1985-11-29 1992-04-15 Biomatrix, Inc. Drug delivery systems based on hyaluronan, derivatives thereof and their salts and method of producing same
US4795741A (en) * 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof
AU619760B2 (en) * 1987-12-10 1992-02-06 Genzyme Biosurgery Corporation Hylan preparation and method of recovery thereof from animal tissues
SE8900422D0 (sv) * 1989-02-08 1989-02-08 Pharmacia Ab Tvaerbundna hyaluronatgeler samt foerfarande foer framstaellning av dessa
US5143724A (en) * 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5246698A (en) * 1990-07-09 1993-09-21 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
JP4551563B2 (ja) * 1998-11-10 2010-09-29 電気化学工業株式会社 ヒアルロン酸ゲルの製造方法及び医用材料
US6521223B1 (en) * 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
AU4935701A (en) * 2000-03-24 2001-10-08 Genentech Inc Use of insulin for the treatment of cartilagenous disorders

Also Published As

Publication number Publication date
WO2005066215A1 (en) 2005-07-21
CN1902232A (zh) 2007-01-24
CA2550718C (en) 2013-11-05
EP1701981B1 (en) 2017-06-07
BRPI0418309A (pt) 2007-05-02
BRPI0418309B8 (pt) 2021-05-25
JP2007519779A (ja) 2007-07-19
CA2550718A1 (en) 2005-07-21
BRPI0418309B1 (pt) 2016-08-02
IL176465A0 (en) 2006-10-05
JP5016926B2 (ja) 2012-09-05
AU2004312532A1 (en) 2005-07-21
IL176465A (en) 2013-07-31
US20050142152A1 (en) 2005-06-30
JP2012025955A (ja) 2012-02-09
EP1701981A1 (en) 2006-09-20
AU2004312532B2 (en) 2010-05-20
JP5680501B2 (ja) 2015-03-04
CN100537606C (zh) 2009-09-09

Similar Documents

Publication Publication Date Title
CA2550718C (en) Cohesive gels from cross-linked hyaluronan and/or hylan, their preparation and use
US8524213B2 (en) Polymeric materials, their preparation and use
CA2810590C (en) Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof
EP0648122B1 (en) PREVENTING TISSUE ADHESION USING $i(IN SITU) MODIFICATION OF ALGINATE
RU2230752C2 (ru) Поперечносшитые гиалуроновые кислоты и их применение в медицине
EP1753787B1 (en) Method of covalently linking hyaluronan and chitosan
US20140309315A1 (en) Carboxymethylcellulose Polyethylene Glycol Compositions for Medical Uses
JP2004507586A (ja) 過カルボン酸エステル化された多糖類、及びそれらの作製方法
EP1263793A1 (en) Single phase gels for the prevention of adhesions
RU2750000C1 (ru) Способ получения модифицированного гиалуронана и его применение в медицине, в том числе при эндопротезировании

Legal Events

Date Code Title Description
FG Grant or registration