CN100537606C - 源自交联的透明质酸和/或hylan的粘性凝胶、其制备和用途 - Google Patents

源自交联的透明质酸和/或hylan的粘性凝胶、其制备和用途 Download PDF

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Publication number
CN100537606C
CN100537606C CNB2004800391832A CN200480039183A CN100537606C CN 100537606 C CN100537606 C CN 100537606C CN B2004800391832 A CNB2004800391832 A CN B2004800391832A CN 200480039183 A CN200480039183 A CN 200480039183A CN 100537606 C CN100537606 C CN 100537606C
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China
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gel
solution
dvs
polymer
ipc
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Expired - Lifetime
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English (en)
Chinese (zh)
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CN1902232A (zh
Inventor
A·K·莱希纳
P·A·科诺维克
V·瓦西里耶夫
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Genzyme Corp
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Genzyme Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
CNB2004800391832A 2003-12-30 2004-12-30 源自交联的透明质酸和/或hylan的粘性凝胶、其制备和用途 Expired - Lifetime CN100537606C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53342903P 2003-12-30 2003-12-30
US60/533,429 2003-12-30

Publications (2)

Publication Number Publication Date
CN1902232A CN1902232A (zh) 2007-01-24
CN100537606C true CN100537606C (zh) 2009-09-09

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CNB2004800391832A Expired - Lifetime CN100537606C (zh) 2003-12-30 2004-12-30 源自交联的透明质酸和/或hylan的粘性凝胶、其制备和用途

Country Status (10)

Country Link
US (1) US20050142152A1 (cg-RX-API-DMAC10.html)
EP (1) EP1701981B1 (cg-RX-API-DMAC10.html)
JP (2) JP5016926B2 (cg-RX-API-DMAC10.html)
CN (1) CN100537606C (cg-RX-API-DMAC10.html)
AU (1) AU2004312532B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0418309B8 (cg-RX-API-DMAC10.html)
CA (1) CA2550718C (cg-RX-API-DMAC10.html)
IL (1) IL176465A (cg-RX-API-DMAC10.html)
MX (1) MXPA06007556A (cg-RX-API-DMAC10.html)
WO (1) WO2005066215A1 (cg-RX-API-DMAC10.html)

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Publication number Publication date
WO2005066215A1 (en) 2005-07-21
CN1902232A (zh) 2007-01-24
CA2550718C (en) 2013-11-05
EP1701981B1 (en) 2017-06-07
BRPI0418309A (pt) 2007-05-02
BRPI0418309B8 (pt) 2021-05-25
JP2007519779A (ja) 2007-07-19
CA2550718A1 (en) 2005-07-21
BRPI0418309B1 (pt) 2016-08-02
IL176465A0 (en) 2006-10-05
JP5016926B2 (ja) 2012-09-05
AU2004312532A1 (en) 2005-07-21
IL176465A (en) 2013-07-31
US20050142152A1 (en) 2005-06-30
JP2012025955A (ja) 2012-02-09
EP1701981A1 (en) 2006-09-20
AU2004312532B2 (en) 2010-05-20
JP5680501B2 (ja) 2015-03-04
MXPA06007556A (es) 2006-08-31

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Granted publication date: 20090909