MXPA05011941A - Derivados de piperidinil- y piperazinil-alquilcarbamatos, su preparacion y su aplicacion terapeutica. - Google Patents

Derivados de piperidinil- y piperazinil-alquilcarbamatos, su preparacion y su aplicacion terapeutica.

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Publication number
MXPA05011941A
MXPA05011941A MXPA05011941A MXPA05011941A MXPA05011941A MX PA05011941 A MXPA05011941 A MX PA05011941A MX PA05011941 A MXPA05011941 A MX PA05011941A MX PA05011941 A MXPA05011941 A MX PA05011941A MX PA05011941 A MXPA05011941 A MX PA05011941A
Authority
MX
Mexico
Prior art keywords
therapeutics
application
piperazinyl
piperidinyl
derivatives
Prior art date
Application number
MXPA05011941A
Other languages
English (en)
Inventor
Frederic Puech
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MXPA05011941A publication Critical patent/MXPA05011941A/es

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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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Abstract

Compuesto que responde a la formula general (I); en la cual A = N o CR2; R2 = H, F, OH, CN, CF3, alquilo-C1-6, alcoxi-C1-6; n = 2 o 3 y m = 2 cuando A = N; n = 1, 2 o 3 y m = 1 o 2 cuando A = CR2; B = enlace covalente o alquileno-C1-8; R1 = heteroarilo eventualmente substituido; R3 = CHR4CONHR5; R4 = H o alquilo-C1-6; R5 = H, alquilo-C1-6, cicloalquilo-C3-7, cicloalquilo-C3-7-alquileno-C-1-6; en estado de base, de sal de adicion con un acido, de hidrato o de solvato. Aplicacion terapeutica.
MXPA05011941A 2003-05-07 2004-05-06 Derivados de piperidinil- y piperazinil-alquilcarbamatos, su preparacion y su aplicacion terapeutica. MXPA05011941A (es)

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FR0305540A FR2854633B1 (fr) 2003-05-07 2003-05-07 Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
PCT/FR2004/001102 WO2004099176A1 (fr) 2003-05-07 2004-05-06 Derives de piperidinyl- et piperazinyl-alkylcarbamates, leurs procedes de preparation et leur application en therapeutique

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FR2866886B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique
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EP1903037A1 (de) * 2006-09-07 2008-03-26 Bayer Schering Pharma Aktiengesellschaft 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioharnstoffe als Modulatoren des EP2-Rezeptors
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US20090099240A1 (en) * 2006-10-02 2009-04-16 N.V. Organon Methods for treating energy metabolism disorders by inhibiting fatty acid amide hydrolase activity
CA2674359A1 (en) * 2006-11-20 2008-05-29 N.V. Organon Metabolically-stabilized inhibitors of fatty acid amide hydrolase
TWI434842B (zh) * 2008-07-14 2014-04-21 Astellas Pharma Inc Azole compounds
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FR2938537B1 (fr) * 2008-11-14 2012-10-26 Sanofi Aventis Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
FR2941696B1 (fr) 2009-02-05 2011-04-15 Sanofi Aventis Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
WO2010124082A1 (en) * 2009-04-22 2010-10-28 Janssen Pharmaceutica Nv Azetidinyl diamides as monoacylglycerol lipase inhibitors
FR2945531A1 (fr) * 2009-05-12 2010-11-19 Sanofi Aventis Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
WO2011029633A1 (en) * 2009-09-14 2011-03-17 Recordati Ireland Limited Heterocyclic mglu5 antagonists
US20130150346A1 (en) 2010-01-08 2013-06-13 Quest Ventures Ltd. Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
US20130224151A1 (en) 2010-03-31 2013-08-29 United States Of America Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
GB201017345D0 (en) 2010-10-14 2010-11-24 Proximagen Ltd Receptor antagonists
KR101653473B1 (ko) * 2012-01-06 2016-09-01 어바이드 테라퓨틱스, 인크. 카르바메이트 화합물 및 그의 제조 및 이용 방법
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EP3022179B1 (en) * 2013-07-18 2017-11-15 Fondazione Istituto Italiano Di Tecnologia Phenyl carbamates and their use as inhibitors of the fatty acid amide hydrolase (faah) enzyme and modulators of the d3 dopamine receptor (d3dr)
DE102013016573A1 (de) 2013-10-04 2015-04-09 Matthias Lehr 1-Tetrazolylpropan-2-one als Inhibitoren von cytosolischer Phospholipase A2 und Fatty Acid Amide Hydrolase, insbesondere geeignet zur topischen Anwendung
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MEP22308A (en) 2010-06-10
TW200505895A (en) 2005-02-16
NO20055204D0 (no) 2005-11-04
CN1812980B (zh) 2011-04-06
AU2004236006A1 (en) 2004-11-18
JP2006525293A (ja) 2006-11-09
NO20055204L (no) 2006-02-07
US20070142350A1 (en) 2007-06-21
HK1093508A1 (en) 2007-03-02
EA200501477A1 (ru) 2006-04-28
AR044178A1 (es) 2005-08-24
CN1812980A (zh) 2006-08-02
TNSN05253A1 (en) 2007-07-10
FR2854633B1 (fr) 2005-06-24
US7214798B2 (en) 2007-05-08
NZ542941A (en) 2010-02-26
EA009468B1 (ru) 2007-12-28
CN101712660A (zh) 2010-05-26
MA27791A1 (fr) 2006-03-01
ZA200508158B (en) 2007-01-31
KR20060009900A (ko) 2006-02-01
WO2004099176A1 (fr) 2004-11-18
JP2011063620A (ja) 2011-03-31
US20060089344A1 (en) 2006-04-27
IS8070A (is) 2005-10-13
UA81808C2 (en) 2008-02-11
AU2004236006B2 (en) 2010-03-11
JP4669836B2 (ja) 2011-04-13
ATE535518T1 (de) 2011-12-15
BRPI0410123A (pt) 2006-05-09
TWI337607B (en) 2011-02-21
US8034818B2 (en) 2011-10-11
RS20050805A (en) 2007-11-15
FR2854633A1 (fr) 2004-11-12
EP1633735B1 (fr) 2011-11-30
CA2521700A1 (en) 2004-11-18
EP1633735A1 (fr) 2006-03-15
IL171694A (en) 2011-05-31
US20120004207A1 (en) 2012-01-05

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