TW200505895A - Piperidyl- and piperazinyl-alkylcarbamate derivatives, preparation and therapeutic application thereof - Google Patents

Piperidyl- and piperazinyl-alkylcarbamate derivatives, preparation and therapeutic application thereof

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Publication number
TW200505895A
TW200505895A TW093112818A TW93112818A TW200505895A TW 200505895 A TW200505895 A TW 200505895A TW 093112818 A TW093112818 A TW 093112818A TW 93112818 A TW93112818 A TW 93112818A TW 200505895 A TW200505895 A TW 200505895A
Authority
TW
Taiwan
Prior art keywords
therapeutic application
piperidyl
piperazinyl
preparation
alkylcarbamate
Prior art date
Application number
TW093112818A
Other languages
Chinese (zh)
Other versions
TWI337607B (en
Inventor
Ahmed Abouabdellah
Philippe Burnier
Christian Hoornaert
Jean Jeunesse
Frederic Puech
Original Assignee
Sanofi Synthelabo
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Publication date
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Publication of TW200505895A publication Critical patent/TW200505895A/en
Application granted granted Critical
Publication of TWI337607B publication Critical patent/TWI337607B/en

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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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Abstract

Compound corresponding to the general formula (I): , in which A = N or CR2; R2 = H, F, OH, CN, CF3, C1-g-alkyl or C1-6-alkoxy; n = 2 or 3 and m = 2 when A = N; n = 1, 2 or 3 and m = 1 or 2 when A = CR2 B = covalent bond or C1-8-alkylene; R1 = optionally substituted heteroaryl; R3 = CHR4CONHR5; P4 = H or C1-6-alkyl; R5 = H, C1-6-aikyl, C1-7-cycloalkyl or C3-7-cycloalkyl-C2-6-alkylene; in the form of the base, an acid-addition salt, a hydrate or a solvate. Therapeutic application.
TW093112818A 2003-05-07 2004-05-06 Piperidyl- and piperazinyl-alkylcarbamate derivatives, preparation and therapeutic application thereof TWI337607B (en)

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FR2945531A1 (en) * 2009-05-12 2010-11-19 Sanofi Aventis 7-AZA-SPIRO® 3,5-NONANE-7-CARBOXYLATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
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US20130150346A1 (en) 2010-01-08 2013-06-13 Quest Ventures Ltd. Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
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US20060089344A1 (en) 2006-04-27
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CN1812980A (en) 2006-08-02
CA2521700A1 (en) 2004-11-18
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UA81808C2 (en) 2008-02-11
EP1633735B1 (en) 2011-11-30
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