MXPA05009722A - Inhibidores heterociclicos de cinasa: metodos de uso y sintesis. - Google Patents
Inhibidores heterociclicos de cinasa: metodos de uso y sintesis.Info
- Publication number
- MXPA05009722A MXPA05009722A MXPA05009722A MXPA05009722A MXPA05009722A MX PA05009722 A MXPA05009722 A MX PA05009722A MX PA05009722 A MXPA05009722 A MX PA05009722A MX PA05009722 A MXPA05009722 A MX PA05009722A MX PA05009722 A MXPA05009722 A MX PA05009722A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- independently
- heterocyclyl
- heteroaryl
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45345703P | 2003-03-10 | 2003-03-10 | |
US46091003P | 2003-04-07 | 2003-04-07 | |
US46302503P | 2003-04-15 | 2003-04-15 | |
US50271003P | 2003-09-12 | 2003-09-12 | |
PCT/US2004/007286 WO2004080463A1 (en) | 2003-03-10 | 2004-03-10 | Heterocyclic kinase inhibitors: methods of use and synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05009722A true MXPA05009722A (es) | 2006-03-09 |
Family
ID=32996376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05009722A MXPA05009722A (es) | 2003-03-10 | 2004-03-10 | Inhibidores heterociclicos de cinasa: metodos de uso y sintesis. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1601357A4 (de) |
JP (1) | JP2006519846A (de) |
CA (1) | CA2518398A1 (de) |
MX (1) | MXPA05009722A (de) |
WO (1) | WO2004080463A1 (de) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
CA2619706A1 (en) | 2005-08-17 | 2007-02-22 | Schering Corporation | Novel high affinity quinoline-based kinase ligands |
EP2043655A2 (de) | 2006-04-25 | 2009-04-08 | Astex Therapeutics Limited | Purin- und deazapurin-derivate als pharmazeutische verbindungen |
US7511063B2 (en) * | 2006-08-16 | 2009-03-31 | Schering Corporation | High affinity quinoline-based kinase ligands |
ATE509925T1 (de) | 2006-11-17 | 2011-06-15 | Pfizer | Substituierte bicyclocarbonsäureamidverbindungen |
AU2007329064C1 (en) | 2006-12-07 | 2013-01-17 | F. Hoffmann-La Roche Ag | 2-Aminoquinolines as 5-HT(5A) receptor antagonists |
MX2009009793A (es) | 2007-03-14 | 2009-10-16 | Ranbaxy Lab Ltd | Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa. |
PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
CA2687230A1 (en) * | 2007-05-23 | 2008-12-11 | Merck & Co., Inc. | Cyclopropyl pyrrolidine orexin receptor antagonists |
EP2559686A1 (de) * | 2007-08-22 | 2013-02-20 | Allergan, Inc. | Therapeutische Chinolin- und Naphthalinderivate |
WO2009040290A1 (en) * | 2007-09-27 | 2009-04-02 | F. Hoffmann-La Roche Ag | Quinoline derivatives as 5ht5a receptor antagonists |
JP4705695B2 (ja) | 2007-10-11 | 2011-06-22 | アストラゼネカ アクチボラグ | プロテインキナーゼb阻害剤としてのピロロ[2,3−d]ピリミジン誘導体 |
EP2202228B1 (de) | 2007-10-15 | 2014-12-10 | Takeda Pharmaceutical Company Limited | Amidverbindungen und ihre verwendung |
KR20100093552A (ko) | 2007-11-02 | 2010-08-25 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 c-세타로서의 [1h-피라졸로[3,4-b]피리딘-4-일]-페닐 또는 -피리딘-2-일 유도체 |
WO2009095752A1 (en) * | 2008-01-29 | 2009-08-06 | Glenmark Pharmaceuticals, S.A. | Fused pyrazole derivatives as cannabinoid receptor modulators |
CN101959876A (zh) * | 2008-03-05 | 2011-01-26 | 弗·哈夫曼-拉罗切有限公司 | 2-氨基喹啉类化合物 |
CN101939055A (zh) * | 2008-03-07 | 2011-01-05 | 弗·哈夫曼-拉罗切有限公司 | 2-氨基喹啉 |
WO2009109491A1 (en) * | 2008-03-07 | 2009-09-11 | F. Hoffmann-La Roche Ag | 2-aminoquinoline derivatives |
CA2716907A1 (en) | 2008-03-12 | 2009-09-17 | F. Hoffmann-La Roche Ag | 2-aminoquinolines as 5-ht5a receptor antagonists |
GB0812969D0 (en) | 2008-07-15 | 2008-08-20 | Sentinel Oncology Ltd | Pharmaceutical compounds |
PT2401267E (pt) | 2009-02-27 | 2014-04-10 | Ambit Biosciences Corp | Derivados de quinazolina moduladores de quinase jak e sua utilização em métodos |
CN102414180A (zh) * | 2009-03-02 | 2012-04-11 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的8-取代的喹啉及相关的类似物 |
KR101973348B1 (ko) * | 2009-06-12 | 2019-04-26 | 아비박스 | 조기 노화, 구체적으로 조로증을 치료하는데 유용한 화합물 |
US10253020B2 (en) | 2009-06-12 | 2019-04-09 | Abivax | Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging |
ES2575154T3 (es) | 2009-12-17 | 2016-06-24 | Merck Sharp & Dohme Corp. | Moduladores alostéricos positivos del receptor M1 de quinolina amida |
CA2786245A1 (en) | 2010-01-29 | 2011-08-04 | Boehringer Ingelheim International Gmbh | Substituted naphthyridines and their use as syk kinase inhibitors |
WO2011159554A1 (en) * | 2010-06-15 | 2011-12-22 | Merck Sharp & Dohme Corp. | Tetrahydroquinoline amide m1 receptor positive allosteric modulators |
US8470852B2 (en) * | 2010-08-27 | 2013-06-25 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators |
KR20130102060A (ko) | 2010-09-01 | 2013-09-16 | 암비트 바이오사이언시즈 코포레이션 | 퀴나졸린 화합물 및 이의 사용 방법 |
EP2489663A1 (de) | 2011-02-16 | 2012-08-22 | Almirall, S.A. | Verbindungen als Syk-Kinasehemmer |
US9051305B2 (en) | 2011-03-08 | 2015-06-09 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
PL2694056T3 (pl) | 2011-04-01 | 2020-03-31 | Astrazeneca Ab | Leczenie terapeutyczne |
US9120785B2 (en) | 2011-05-10 | 2015-09-01 | Merck Sharp & Dohme Corp. | Pyridyl aminopyridines as Syk inhibitors |
RU2013154412A (ru) | 2011-05-10 | 2015-06-20 | Мерк Шарп И Доум Корп. | Аминопиримидины в качестве ингибиторов syc |
US9145391B2 (en) | 2011-05-10 | 2015-09-29 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as Syk inhibitors |
MX336224B (es) | 2011-07-26 | 2016-01-12 | Boehringer Ingelheim Int | Quinolinas sustituidas y su uso como medicamentos. |
US9216173B2 (en) | 2011-10-05 | 2015-12-22 | Merck Sharp & Dohme Corp. | 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors |
US8987456B2 (en) | 2011-10-05 | 2015-03-24 | Merck Sharp & Dohme Corp. | 3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors |
EP2763974B1 (de) | 2011-10-05 | 2016-09-14 | Merck Sharp & Dohme Corp. | Phenylcarboxamidhaltige milztyrosinkinase (syk) hemmer |
EP2785349B2 (de) | 2011-11-30 | 2022-11-09 | Astrazeneca AB | Kombinationsbehandlung von krebs |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
EP2863913B1 (de) | 2012-06-20 | 2018-09-12 | Merck Sharp & Dohme Corp. | Imidazolylanaloga als syk-hemmer |
US9242984B2 (en) | 2012-06-20 | 2016-01-26 | Merck Sharp & Dohme Corp. | Pyrazolyl derivatives as Syk inhibitors |
US20150150869A1 (en) | 2012-06-20 | 2015-06-04 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
US9416111B2 (en) | 2012-06-22 | 2016-08-16 | Merck Sharp & Dohme Corp. | Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors |
WO2013192098A1 (en) | 2012-06-22 | 2013-12-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
US9353066B2 (en) | 2012-08-20 | 2016-05-31 | Merck Sharp & Dohme Corp. | Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors |
WO2014048065A1 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Triazolyl derivatives as syk inhibitors |
EP2922544B1 (de) | 2012-11-21 | 2018-08-01 | Eutropics Pharmaceuticals, Inc. | Verfahren und zusammensetzungen zur behandlung von erkrankungen mit beteiligung von proteinen der bcl-2-familie mithilfe von chinolinderivaten |
EP2757161A1 (de) | 2013-01-17 | 2014-07-23 | Splicos | miRNA-124 als ein Biomarker für virale Infektion |
WO2015017788A1 (en) | 2013-08-01 | 2015-02-05 | Eutropics Pharmaceuticals, Inc. | Method for predicting cancer sensitivity |
AU2014342269B2 (en) | 2013-10-30 | 2020-02-27 | Eutropics Pharmaceuticals, Inc. | Methods for determining chemosensitivity and chemotoxicity |
EP3083559B1 (de) | 2013-12-20 | 2021-03-10 | Merck Sharp & Dohme Corp. | Thiazolsubstituierte aminoheteroaryle als milztyrosinkinasehemmer |
US9783531B2 (en) | 2013-12-20 | 2017-10-10 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
EP3083560B1 (de) | 2013-12-20 | 2021-10-27 | Merck Sharp & Dohme Corp. | Thiazolsubstituierte aminoheteroaryle als milztyrosinkinasehemmer |
EP3116506B1 (de) | 2014-03-13 | 2019-04-17 | Merck Sharp & Dohme Corp. | 2-pyrazincarboxamide als milz-tyrosinkinase-inhibitoren |
EP2974729A1 (de) | 2014-07-17 | 2016-01-20 | Abivax | Chinolinderivate zur Verwendung bei der Behandlung von Entzündungskrankheiten |
KR102548547B1 (ko) * | 2014-10-31 | 2023-06-27 | 제노사이언스 파마 | 신규한 항암제로서의 치환 2,4 디아미노-퀴놀린 |
DK3452465T3 (da) | 2016-05-04 | 2021-02-08 | Genoscience Pharma | Substituerede 2,4-diaminoquinolinderivater til anvendelse til behandling af proliferative sygdomme |
CA3065114A1 (en) * | 2017-06-14 | 2018-12-20 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Syk inhibitor and use method therefor |
EP3658560A4 (de) * | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | Somatostatinmodulatoren und verwendungen davon |
EP3620164A1 (de) * | 2018-09-05 | 2020-03-11 | Genoscience Pharma SAS | Substituiertes 2,4-diamino-chinolin als neues medikament erkrankungen im zusammenhang mit fibrose, autophagie und cathepsinen b (ctsb), l (ctsl) und d (ctsd) |
WO2020119785A1 (zh) | 2018-12-14 | 2020-06-18 | 正大天晴药业集团股份有限公司 | 一种Syk抑制剂的盐及其结晶型 |
EP3669873A1 (de) | 2018-12-20 | 2020-06-24 | Abivax | Chinolinderivate zur verwendung bei der behandlung von entzündlichen krankheiten |
US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
CR20230057A (es) | 2020-07-02 | 2023-08-15 | Incyte Corp | Compuestos tríciclicos de urea como inhibidores de jak2 v617f |
US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
CA3211748A1 (en) | 2021-02-25 | 2022-09-01 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
WO2023099589A1 (en) * | 2021-12-01 | 2023-06-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Irap inhibitors for use in the treatment of inflammatory diseases |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2472066A (en) * | 1949-06-07 | Z-arylamino-x-halogenoqtjinolines | ||
DE537104C (de) * | 1926-05-04 | 1933-03-17 | Chem Ind Basel | Verfahren zur Darstellung von substituierten Chinolincarbonsaeureamiden |
DE858698C (de) * | 1951-02-09 | 1952-12-08 | Basf Ag | Verfahren zur Herstellung von Pyridin- und Chinolinderivaten |
GB811957A (en) * | 1956-03-01 | 1959-04-15 | Geigy Ag J R | Improvements relating to 2-hydroxy-4-arylamino-quinolines |
FR6103M (de) * | 1967-02-22 | 1968-06-10 | ||
US3755332A (en) * | 1971-07-01 | 1973-08-28 | Ciba Geigy Corp | Substituted 4 indazolaminoquinolines |
FR2538388B1 (fr) * | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
JPH05310702A (ja) * | 1992-05-06 | 1993-11-22 | Kyowa Hakko Kogyo Co Ltd | 抗炎症剤、免疫調整剤およびキノリン−2,4−ジカルボン酸ジアミド誘導体 |
GB9622363D0 (en) * | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
EP0975345A1 (de) * | 1997-11-26 | 2000-02-02 | Cerebrus Pharmaceuticals Limited | (-)-mefloquine zur blockierung der purinrezeptoren und zur behandlung von bewegung- oder neurodegenerativen erkrankungen |
AU3386700A (en) * | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
WO2000076982A1 (en) * | 1999-06-16 | 2000-12-21 | University Of Iowa Research Foundation | Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases |
US6593324B2 (en) * | 2000-03-01 | 2003-07-15 | Orion Corporation | Dervatives of quinoline as alpha-2 antagonists |
MXPA03001344A (es) * | 2000-08-16 | 2004-04-05 | Neurogen Corp | Derivados de piridina 2,4-substituidos. |
US6900226B2 (en) * | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
ATE387428T1 (de) * | 2001-05-21 | 2008-03-15 | Hoffmann La Roche | Chinolinderivate als liganden für den neuropeptid-y-rezeptor |
GB0118479D0 (en) * | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
SE0102858D0 (sv) * | 2001-08-27 | 2001-08-27 | Astrazeneca Ab | N-type calcium channel antagonists for the treatment of pain |
GB0206215D0 (en) * | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
CN1678586A (zh) * | 2002-06-27 | 2005-10-05 | 舍林股份公司 | 取代的喹啉ccr5受体拮抗剂 |
EP1631810A4 (de) * | 2003-03-10 | 2008-11-05 | Schering Corp | Ligandenanalyse |
-
2004
- 2004-03-10 EP EP04719237A patent/EP1601357A4/de not_active Withdrawn
- 2004-03-10 MX MXPA05009722A patent/MXPA05009722A/es not_active Application Discontinuation
- 2004-03-10 JP JP2006507031A patent/JP2006519846A/ja active Pending
- 2004-03-10 CA CA002518398A patent/CA2518398A1/en not_active Abandoned
- 2004-03-10 WO PCT/US2004/007286 patent/WO2004080463A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JP2006519846A (ja) | 2006-08-31 |
EP1601357A4 (de) | 2007-10-03 |
WO2004080463A1 (en) | 2004-09-23 |
EP1601357A1 (de) | 2005-12-07 |
CA2518398A1 (en) | 2004-09-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MXPA05009722A (es) | Inhibidores heterociclicos de cinasa: metodos de uso y sintesis. | |
JP2006519846A5 (de) | ||
US8242271B2 (en) | Heterocyclic compounds and uses thereof | |
JP4173738B2 (ja) | Erk2の複素環式インヒビターおよびその使用 | |
EP1592686B1 (de) | Gyraseinhibitoren und deren verwendungen | |
JP6054406B2 (ja) | Fgfrキナーゼ阻害を介した抗癌ベンゾピラジン | |
US20090042928A1 (en) | Modulators of muscarinic receptors | |
JP2012525390A (ja) | 置換イミダゾ[1,2−a]ピリジン誘導体、医薬組成物、及びβ−セクレターゼ阻害剤としての使用方法 | |
BG65106B1 (bg) | Заместени 2-арил-3-(хетероарил)-имидазо[1,2-а]пиримидини, лекарствени средства, които ги съдържат, използването им и метод за тяхното получаване | |
JP2005509592A (ja) | プロテインキナーゼインヒビターとしての5−(2−アミノピリミジン−4−イル)ベンズイソキサゾール | |
BG63769B1 (bg) | 1,2,4-тризаместени имидазоли, полезни като цитокини | |
MXPA03002294A (es) | Compuestos de pirazol utiles como inhibidores de proteina cinasa. | |
JP2004532234A (ja) | トリアゾール由来キナーゼインヒビターおよびその使用 | |
JP2008507534A (ja) | フラノピリジン誘導体および使用方法 | |
BG99879A (bg) | Инхибитори на нiv реверсивна транскриптаза | |
JP2013533318A (ja) | ヘテロアリールおよびその使用 | |
JP6629884B2 (ja) | 哺乳動物のチロシンキナーゼror1活性の阻害剤として有用な2−フェニル−3h−イミダゾ[4,5−b]ピリジン誘導体 | |
JP2010529129A (ja) | キナーゼ阻害剤化合物 | |
JP2013522364A (ja) | 置換イミダゾ[1,2−b]ピリダジン誘導体、医薬組成物、及びβ−セクレターゼ阻害剤としての使用の方法 | |
JP2018502141A (ja) | キナゾリン及びキノリン化合物、ならびにその使用 | |
US20050222186A1 (en) | Substituted diaminopyrimidines | |
US20080119515A1 (en) | Heterocyclic Kinase Inhibitors: Methods of Use and Synthesis | |
CN111909133B (zh) | 作为布鲁诺酪氨酸激酶抑制剂的取代的1-氨基-1h-咪唑-5-甲酰胺 | |
TW202246243A (zh) | 胺基嘧啶化合物及其使用方法 | |
KR20170030550A (ko) | 퀴녹살린 화합물, 그것의 제조 방법 및 용도 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |