MXPA05003562A - Bases de alta pureza de monoesteres de 3,3-difenilpropilamina. - Google Patents

Bases de alta pureza de monoesteres de 3,3-difenilpropilamina.

Info

Publication number
MXPA05003562A
MXPA05003562A MXPA05003562A MXPA05003562A MXPA05003562A MX PA05003562 A MXPA05003562 A MX PA05003562A MX PA05003562 A MXPA05003562 A MX PA05003562A MX PA05003562 A MXPA05003562 A MX PA05003562A MX PA05003562 A MXPA05003562 A MX PA05003562A
Authority
MX
Mexico
Prior art keywords
highly pure
pure bases
general formula
production
configuration
Prior art date
Application number
MXPA05003562A
Other languages
English (en)
Inventor
Drews Roland
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of MXPA05003562A publication Critical patent/MXPA05003562A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invencion se refiere a un compuesto de la formula general (I): ver formula (I), en la que A representa deuterio o hidrogeno; R representa un grupo seleccionado de alquilo de 1 a 6 atomos de carbono, cicloalquilo de 3 a 10 atomos de carbono o fenilo; que pueden estar sustituidos con alcoxi de 1 a 3 atomos de carbono, fluor, cloro, bromo, yodo, nitro, amino, hidroxilo, oxo, mercapto o deuterio. El atomo de carbono marcado con asterisco (*) puede estar presente en una configuracion (R), en una configuracion (S) o como una mezcla de ellas. La invencion se caracteriza porque los compuestos mencionados arriba son bases libres con un grado de pureza de mas de 97 por ciento en peso. La invencion se refiere tambien a un metodo para producir compuestos de alta pureza de la formula general (I), y a su uso en la produccion de medicamentos.
MXPA05003562A 2003-04-08 2004-04-03 Bases de alta pureza de monoesteres de 3,3-difenilpropilamina. MXPA05003562A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10315917A DE10315917A1 (de) 2003-04-08 2003-04-08 Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
PCT/EP2004/003567 WO2004089872A1 (de) 2003-04-08 2004-04-03 Hochreine basen von 3,3-diphenylpropylaminmonoestern

Publications (1)

Publication Number Publication Date
MXPA05003562A true MXPA05003562A (es) 2005-06-03

Family

ID=33154113

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05003562A MXPA05003562A (es) 2003-04-08 2004-04-03 Bases de alta pureza de monoesteres de 3,3-difenilpropilamina.

Country Status (17)

Country Link
US (2) US20060014832A1 (es)
EP (1) EP1613584B1 (es)
JP (2) JP4651035B2 (es)
KR (1) KR100912451B1 (es)
CN (1) CN100475775C (es)
AU (1) AU2004228163B2 (es)
BR (1) BRPI0406221A (es)
CA (1) CA2505848A1 (es)
DE (2) DE10315917A1 (es)
ES (1) ES2297409T3 (es)
HK (1) HK1087399A1 (es)
MX (1) MXPA05003562A (es)
NO (1) NO20055078L (es)
RU (1) RU2394019C2 (es)
UA (1) UA81803C2 (es)
WO (1) WO2004089872A1 (es)
ZA (1) ZA200502679B (es)

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DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
EP1902708A1 (de) * 2006-09-25 2008-03-26 Losan Pharma GmbH Wirkstoff enthaltende stabilisierte feste Arzneimittelformen und Verfahren zu ihrer Herstellung
JP5254799B2 (ja) * 2006-09-26 2013-08-07 株式会社カネカ 遊離アミンの製造方法
WO2008144602A1 (en) * 2007-05-18 2008-11-27 Auspex Pharmaceuticals, Inc. Deuterated zamifenacin derivatives
US20090005431A1 (en) * 2007-06-30 2009-01-01 Auspex Pharmaceuticals, Inc. Substituted pyrrolidines
US8374102B2 (en) * 2007-10-02 2013-02-12 Tellabs Communications Canada, Ltd. Intelligent collection and management of flow statistics
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IT1392082B1 (it) * 2008-12-10 2012-02-09 Chemi Spa Nuove forme solide della fesoterodina fumarato
MX2011006609A (es) * 2008-12-18 2011-06-30 Novartis Ag Sal de hemi-fumarato del acido 1-[4-[1-(4-ciclohexil-3-trifluoro-m etil-benciloxi-imino)-etil]-2-etil-bencil]-azetidin-3-carboxilico .
WO2011029005A1 (en) 2009-09-03 2011-03-10 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Crystalline forms of fesoterodine fumarate and fesoterodine base
EP2316432A1 (de) * 2009-10-30 2011-05-04 ratiopharm GmbH Zusammensetzung enthaltend Fesoterodin und Ballaststoffe
TWI590821B (zh) * 2011-01-18 2017-07-11 輝瑞有限公司 固體分子分散液
CN109113555B (zh) 2013-03-15 2020-06-09 亨特道格拉斯公司 用于辊支撑的建筑覆盖件的位置锁定
CA2931944C (en) 2013-11-29 2019-05-07 KIM, No Eul Plastic hot water boiler

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Also Published As

Publication number Publication date
ES2297409T3 (es) 2008-05-01
JP4651035B2 (ja) 2011-03-16
CA2505848A1 (en) 2004-10-21
ZA200502679B (en) 2006-04-26
HK1087399A1 (en) 2006-10-13
JP2010215643A (ja) 2010-09-30
DE502004005560D1 (de) 2008-01-03
US7989654B2 (en) 2011-08-02
EP1613584A1 (de) 2006-01-11
NO20055078L (no) 2005-10-31
US20090012159A1 (en) 2009-01-08
US20060014832A1 (en) 2006-01-19
BRPI0406221A (pt) 2005-08-09
CN1802345A (zh) 2006-07-12
KR20060006012A (ko) 2006-01-18
EP1613584B1 (de) 2007-11-21
KR100912451B1 (ko) 2009-08-14
RU2005134170A (ru) 2006-07-27
UA81803C2 (en) 2008-02-11
CN100475775C (zh) 2009-04-08
AU2004228163A1 (en) 2004-10-21
RU2394019C2 (ru) 2010-07-10
AU2004228163B2 (en) 2007-06-07
WO2004089872A1 (de) 2004-10-21
DE10315917A1 (de) 2004-11-18
JP2006522758A (ja) 2006-10-05

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