BR0312445A - Sistemas multiunitários para disponibilização de fármaco de liberação modificada - Google Patents

Sistemas multiunitários para disponibilização de fármaco de liberação modificada

Info

Publication number
BR0312445A
BR0312445A BR0312445-2A BR0312445A BR0312445A BR 0312445 A BR0312445 A BR 0312445A BR 0312445 A BR0312445 A BR 0312445A BR 0312445 A BR0312445 A BR 0312445A
Authority
BR
Brazil
Prior art keywords
systems
unit
outermost surface
release drug
delivery
Prior art date
Application number
BR0312445-2A
Other languages
English (en)
Inventor
Patrick Kumar
Girish Kumar Jain
Ashok Rampal
Ravikumar Nithiyanandam
Sankar Ramakrishnan
Rajeev Singh Raghuvanshi
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of BR0312445A publication Critical patent/BR0312445A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

"SISTEMAS MULTIUNITáRIOS PARA DISPONIBILIZAçãO DE FáRMACO DE LIBERAçãO MODIFICADA". A invenção se refere a novos sistemas multiunitários de liberação modificada, e a métodos para preparar esses sistemas, os quais podem ser facilmente compressos na forma de comprimidos ou enchidos em cápsulas ou saches sem afetar as desejadas características de liberação dos ingredientes ativos farmacêuticos incorporados a esses sistemas. O comprimido multiunitário inclui unidades múltiplas. Cada unidade inclui pelo menos um núcleo tendo uma superfície mais externa, uma primeira camada de revestimento envolvendo pelo menos uma parte da superfície mais externa do núcleo e tendo uma superfície mais externa, um ou mais polímeros de controle de taxa, e um ou mais ingredientes ativos farmacêuticos. A camada de revestimento inclui um ou ambos de um ou mais ingredientes ativos farmacêuticos e o um ou mais polímeros de controle de taxa. O comprimido pode, ainda, incluir uma camada mais externa da unidade, a qual inclui um material que possui uma ou ambas as propriedades de ser elástico e compressível. O material pode ser um material ceroso, tais como polietileno glicóis (PEGs).
BR0312445-2A 2002-06-07 2003-06-09 Sistemas multiunitários para disponibilização de fármaco de liberação modificada BR0312445A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN617DE2002 2002-06-07
IN1157DE2002 2002-11-15
IN234DE2003 2003-03-06
PCT/IB2003/002186 WO2003103637A2 (en) 2002-01-10 2003-06-09 Modified release, multiple unit drug delivery systems

Publications (1)

Publication Number Publication Date
BR0312445A true BR0312445A (pt) 2005-05-10

Family

ID=29740489

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312445-2A BR0312445A (pt) 2002-06-07 2003-06-09 Sistemas multiunitários para disponibilização de fármaco de liberação modificada

Country Status (5)

Country Link
US (1) US20060257482A1 (pt)
CN (1) CN1674877A (pt)
AU (1) AU2003236947A1 (pt)
BR (1) BR0312445A (pt)
WO (1) WO2003103637A2 (pt)

Families Citing this family (40)

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Publication number Priority date Publication date Assignee Title
EP0957073A1 (en) 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
GB0203296D0 (en) 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
CA2507685A1 (en) * 2002-11-28 2004-06-10 Themis Laboratories Private Limited Process for manufacturing sustained release microbeads containing venlafaxine hci
AU2003288608A1 (en) * 2002-12-20 2004-07-14 Ranbaxy Laboratories Limited Controlled release, multiple unit drug delivery systems
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
EP1651192A1 (en) * 2003-08-06 2006-05-03 Nirmal Mulye Pharmaceutical composition containing water soluble drug
FR2861990B1 (fr) * 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
WO2005074895A1 (en) * 2004-02-04 2005-08-18 Alembic Limited Extended release coated microtablets of venlafaxine hydrochloride
DE102004036641A1 (de) * 2004-07-28 2006-03-23 Krka Tovarna Zdravil, D.D. Verzögert freisetzende pharmazeutische Zusammensetzung, die Venlafaxin enthält
US8778395B2 (en) * 2005-08-11 2014-07-15 Andrx Labs, Llc Diltiazem controlled release formulation and method of manufacture
US8158146B2 (en) 2005-09-28 2012-04-17 Teva Pharmaceutical Industries Ltd. Stable combinations of amlodipine besylate and benazepril hydrochloride
KR100831771B1 (ko) * 2005-10-27 2008-05-27 주식회사종근당 서방출과 ｐＨ 의존성 속방출을 나타내는 약제학적 조성물
WO2007132344A2 (en) * 2006-05-09 2007-11-22 Aurobindo Pharma Limited Controlled release compositions of an antidepressant agent
WO2008023869A1 (en) * 2006-08-24 2008-02-28 Hanall Pharmaceutical Co., Ltd. Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
CA2661613C (en) * 2006-08-25 2016-01-26 Boehringer Ingelheim International Gmbh Controlled release system and method for manufacturing the same
EP1923053A1 (en) 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
KR100812538B1 (ko) * 2006-10-23 2008-03-11 한올제약주식회사 약물 제어방출형 메트포르민-글리메피리드 복합제제
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
EP1970056A1 (en) * 2007-03-15 2008-09-17 Polichem S.A. Time-specific delayed/pulsatile release dosage forms
CA2699227C (en) 2007-09-21 2014-12-02 Evonik Roehm Gmbh Ph-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol
EP2044932A1 (en) * 2007-10-04 2009-04-08 Laboratorios del Dr. Esteve S.A. Mechanical protective layer for solid dosage forms
EP2044929A1 (en) * 2007-10-04 2009-04-08 Laboratorios del Dr. Esteve S.A. Oral fast distintegrating tablets
US9011904B2 (en) 2009-07-06 2015-04-21 Aptapharma, Inc. Self-breaking tablets
CN102188386B (zh) * 2010-03-02 2013-09-04 海南葫芦娃制药有限公司 尼美舒利缓释微丸及其制备方法
GB201003734D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Delayed prolonged drug delivery
GB201003766D0 (en) * 2010-03-05 2010-04-21 Univ Strathclyde Pulsatile drug release
GB201003731D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Immediate/delayed drug delivery
JP5860480B2 (ja) 2011-01-11 2016-02-16 キャプシュゲル・ベルジウム・エヌ・ヴィ プルランを含む新しい硬カプセル
KR101378973B1 (ko) * 2012-04-13 2014-03-28 한미약품 주식회사 구형에 가까운 형태의 다중 투여 단위 정제를 포함하는 경질 캡슐 복합 제형 및 이의 제조방법
EA201590776A1 (ru) * 2012-12-19 2015-11-30 Ратиофарм Гмбх Пеллеты с пленочным покрытием
CN107412178A (zh) * 2016-12-14 2017-12-01 北京满格医药科技有限公司 一种盐酸帕罗西汀缓释片及制备方法
US11576870B2 (en) 2017-04-14 2023-02-14 Capsugel Belgium Nv Pullulan capsules
CN110678555B (zh) 2017-04-14 2023-10-13 比利时胶囊公司 制作普鲁兰的方法
CN107875450A (zh) * 2017-11-17 2018-04-06 河北点云生物科技有限公司 一种3d打印人工骨制造干燥型制剂的方法
WO2020255097A1 (en) * 2019-06-21 2020-12-24 Amruth Gowda Doddaveerappa Method of producing multiunit tablet formulations
CN110403912A (zh) * 2019-09-04 2019-11-05 西安科力康医药科技有限公司 缓控释包衣粉
CN112978739B (zh) * 2021-03-16 2021-11-26 复旦大学 一种均一对称或非对称性纳米粒子、大尺寸及改性纳米粒子的合成方法
CN114831956B (zh) * 2022-05-25 2024-03-22 山东新华制药股份有限公司 一种含有伏格列波糖的泡腾片及其制备方法

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* Cited by examiner, † Cited by third party
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DK62184D0 (da) * 1984-02-10 1984-02-10 Benzon As Alfred Diffusionsovertrukket polydepotpraeparat
SE9402422D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New beads for controlled release and a pharmaceutical preparation containing the same
US6274171B1 (en) * 1996-03-25 2001-08-14 American Home Products Corporation Extended release formulation of venlafaxine hydrochloride
AU9062998A (en) * 1997-09-11 1999-03-29 Nycomed Danmark A/S Modified release multiple-units compositions of non-steroid anti-inflammatory drug substances (nsaids)
IL146462A (en) * 2001-11-13 2015-02-26 Lycored Bio Ltd Prolonged-release preparations containing as an active compound and analapaxin hydrochloride

Also Published As

Publication number Publication date
WO2003103637A3 (en) 2004-05-13
AU2003236947A1 (en) 2003-12-22
US20060257482A1 (en) 2006-11-16
CN1674877A (zh) 2005-09-28
WO2003103637A2 (en) 2003-12-18

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]