BRPI0406221A - Bases altamente puras de monoésteres de 3,3-difenilpropilamina - Google Patents

Bases altamente puras de monoésteres de 3,3-difenilpropilamina

Info

Publication number
BRPI0406221A
BRPI0406221A BR0406221-3A BRPI0406221A BRPI0406221A BR PI0406221 A BRPI0406221 A BR PI0406221A BR PI0406221 A BRPI0406221 A BR PI0406221A BR PI0406221 A BRPI0406221 A BR PI0406221A
Authority
BR
Brazil
Prior art keywords
highly pure
general formula
compound
preparation
configuration
Prior art date
Application number
BR0406221-3A
Other languages
English (en)
Inventor
Armin Breitenbach
Claus Meese
Hans-Michael Wolff
Roland Drews
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of BRPI0406221A publication Critical patent/BRPI0406221A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

"BASES ALTAMENTE PURAS DE MONOéSTERES DE 3,3-DIFENILPROPILAMINA". A presente invenção refere-se a um composto da fórmula geral (1), na qual A representa deutério ou hidrogênio, R representa um grupo, que é selecionado de C~ 1-6~ alquila, C~ 3-10~ cicloalquila ou fenila, que pode ser substituída em cada caso por C1-3 alcóxi, flúor, cloro, bromo, iodo, nitro, amino, hidróxi, oxo, mercapto ou deutério e em que o átomo de carbono marcado com ' * ' (estrela) pode apresentar-se na configuração (R), na configuração (S) ou como mistura das mesmas, caracterizado pelo fato de que o dito composto se apresenta como base livre com um grau de pureza superior a 97% em peso. Além disso, a invenção refere-se a um processo para a preparação de compostos altamente puros da fórmula geral (I), bem como à aplicação dos compostos altamente puros para a preparação de medicamentos.
BR0406221-3A 2003-04-08 2004-04-03 Bases altamente puras de monoésteres de 3,3-difenilpropilamina BRPI0406221A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10315917A DE10315917A1 (de) 2003-04-08 2003-04-08 Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
PCT/EP2004/003567 WO2004089872A1 (de) 2003-04-08 2004-04-03 Hochreine basen von 3,3-diphenylpropylaminmonoestern

Publications (1)

Publication Number Publication Date
BRPI0406221A true BRPI0406221A (pt) 2005-08-09

Family

ID=33154113

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0406221-3A BRPI0406221A (pt) 2003-04-08 2004-04-03 Bases altamente puras de monoésteres de 3,3-difenilpropilamina

Country Status (17)

Country Link
US (2) US20060014832A1 (pt)
EP (1) EP1613584B1 (pt)
JP (2) JP4651035B2 (pt)
KR (1) KR100912451B1 (pt)
CN (1) CN100475775C (pt)
AU (1) AU2004228163B2 (pt)
BR (1) BRPI0406221A (pt)
CA (1) CA2505848A1 (pt)
DE (2) DE10315917A1 (pt)
ES (1) ES2297409T3 (pt)
HK (1) HK1087399A1 (pt)
MX (1) MXPA05003562A (pt)
NO (1) NO20055078L (pt)
RU (1) RU2394019C2 (pt)
UA (1) UA81803C2 (pt)
WO (1) WO2004089872A1 (pt)
ZA (1) ZA200502679B (pt)

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DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
EP1902708A1 (de) 2006-09-25 2008-03-26 Losan Pharma GmbH Wirkstoff enthaltende stabilisierte feste Arzneimittelformen und Verfahren zu ihrer Herstellung
JP5254799B2 (ja) * 2006-09-26 2013-08-07 株式会社カネカ 遊離アミンの製造方法
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IT1392082B1 (it) * 2008-12-10 2012-02-09 Chemi Spa Nuove forme solide della fesoterodina fumarato
KR20160129915A (ko) * 2008-12-18 2016-11-09 노파르티스 아게 1-［4-［1-(4-시클로헥실-3-트리플루오로메틸-벤질옥시이미노)-에틸］-2-에틸-벤질］-아제티딘-3-카르복실산의 헤미푸마레이트 염
KR20120053027A (ko) 2009-09-03 2012-05-24 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 페소테로딘 푸마레이트 및 페소테로딘 염기의 결정형
EP2316432A1 (de) * 2009-10-30 2011-05-04 ratiopharm GmbH Zusammensetzung enthaltend Fesoterodin und Ballaststoffe
TWI520732B (zh) * 2011-01-18 2016-02-11 輝瑞有限公司 固體分子分散液
KR102122626B1 (ko) 2013-03-15 2020-06-12 헌터더글라스인코포레이티드 롤러 지지된 건축물 덮개를 위한 위치 잠금장치
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Also Published As

Publication number Publication date
JP4651035B2 (ja) 2011-03-16
US20060014832A1 (en) 2006-01-19
EP1613584A1 (de) 2006-01-11
US7989654B2 (en) 2011-08-02
RU2005134170A (ru) 2006-07-27
MXPA05003562A (es) 2005-06-03
CA2505848A1 (en) 2004-10-21
DE502004005560D1 (de) 2008-01-03
ZA200502679B (en) 2006-04-26
RU2394019C2 (ru) 2010-07-10
AU2004228163A1 (en) 2004-10-21
JP2006522758A (ja) 2006-10-05
US20090012159A1 (en) 2009-01-08
DE10315917A1 (de) 2004-11-18
KR100912451B1 (ko) 2009-08-14
KR20060006012A (ko) 2006-01-18
JP2010215643A (ja) 2010-09-30
UA81803C2 (en) 2008-02-11
NO20055078L (no) 2005-10-31
WO2004089872A1 (de) 2004-10-21
ES2297409T3 (es) 2008-05-01
AU2004228163B2 (en) 2007-06-07
EP1613584B1 (de) 2007-11-21
CN1802345A (zh) 2006-07-12
HK1087399A1 (en) 2006-10-13
CN100475775C (zh) 2009-04-08

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