MXPA05003119A - Nuevas imidazopirazinas como inhibidores de cinasas dependientes de ciclinas. - Google Patents
Nuevas imidazopirazinas como inhibidores de cinasas dependientes de ciclinas.Info
- Publication number
- MXPA05003119A MXPA05003119A MXPA05003119A MXPA05003119A MXPA05003119A MX PA05003119 A MXPA05003119 A MX PA05003119A MX PA05003119 A MXPA05003119 A MX PA05003119A MX PA05003119 A MXPA05003119 A MX PA05003119A MX PA05003119 A MXPA05003119 A MX PA05003119A
- Authority
- MX
- Mexico
- Prior art keywords
- nr5r6
- alkyl
- group
- heteroaryl
- compound according
- Prior art date
Links
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 title 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title 1
- 150000005235 imidazopyrazines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 26
- 102000003903 Cyclin-dependent kinases Human genes 0.000 claims abstract 7
- 108090000266 Cyclin-dependent kinases Proteins 0.000 claims abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 5
- 201000010099 disease Diseases 0.000 claims abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 4
- 108091007914 CDKs Proteins 0.000 claims abstract 3
- 125000000217 alkyl group Chemical group 0.000 claims 20
- -1 CF3 heteroaryl Chemical group 0.000 claims 17
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- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 7
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 6
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41290602P | 2002-09-23 | 2002-09-23 | |
| PCT/US2003/029456 WO2004026310A1 (en) | 2002-09-23 | 2003-09-19 | Novel imidazopyrazines as cyclin dependent kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05003119A true MXPA05003119A (es) | 2005-06-22 |
Family
ID=32030939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05003119A MXPA05003119A (es) | 2002-09-23 | 2003-09-19 | Nuevas imidazopirazinas como inhibidores de cinasas dependientes de ciclinas. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7186740B2 (https=) |
| EP (1) | EP1542693A1 (https=) |
| JP (1) | JP2006503838A (https=) |
| KR (1) | KR20060010709A (https=) |
| CN (1) | CN1694706A (https=) |
| AR (1) | AR041346A1 (https=) |
| AU (1) | AU2003275031B2 (https=) |
| CA (1) | CA2499874A1 (https=) |
| MX (1) | MXPA05003119A (https=) |
| NZ (1) | NZ538686A (https=) |
| TW (1) | TW200412967A (https=) |
| WO (1) | WO2004026310A1 (https=) |
| ZA (1) | ZA200502380B (https=) |
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| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| EP2186811A1 (en) | 2002-08-23 | 2010-05-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
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| US20060183746A1 (en) * | 2003-06-04 | 2006-08-17 | Currie Kevin S | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
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| US8227473B2 (en) * | 2008-08-01 | 2012-07-24 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use |
| CA2730148C (en) | 2008-08-01 | 2018-04-03 | Lixte Biotechnology, Inc. | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| PE20120121A1 (es) | 2008-12-08 | 2012-02-20 | Gilead Connecticut Inc | Derivados de imidazopirazina como inhibidores de syk |
| PL2716157T3 (pl) | 2008-12-08 | 2017-06-30 | Gilead Connecticut, Inc. | Imidazopirazynowe inhibitory Syk |
| EP2473041B1 (en) | 2009-09-04 | 2018-03-07 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
| KR101774035B1 (ko) | 2009-10-30 | 2017-09-01 | 얀센 파마슈티카 엔.브이. | 이미다조［１，２―ｂ］피리다진 유도체 및 ＰＤＥ１０ 저해제로서의 그의 용도 |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| AU2011226689B2 (en) | 2010-03-11 | 2016-09-01 | Kronos Bio, Inc. | Imidazopyridines Syk inhibitors |
| CA2821817A1 (en) * | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | Substituted 6-imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| CA2821819A1 (en) * | 2010-12-17 | 2012-06-21 | Marcus Koppitz | 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| WO2013000924A1 (en) | 2011-06-27 | 2013-01-03 | Janssen Pharmaceutica Nv | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES |
| WO2014001314A1 (en) | 2012-06-26 | 2014-01-03 | Janssen Pharmaceutica Nv | Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
| AU2013289284B2 (en) | 2012-07-09 | 2017-03-30 | Janssen Pharmaceutica Nv | Inhibitors of phosphodiesterase 10 enzyme |
| EP2983661B1 (en) | 2013-04-09 | 2024-05-29 | Lixte Biotechnology, Inc. | Formulations of oxabicycloheptanes and oxabicycloheptenes |
| KR101810798B1 (ko) | 2013-07-30 | 2017-12-19 | 질레드 코네티컷 인코포레이티드 | Ｓｙｋ 억제제의 다형체 |
| PE20160605A1 (es) | 2013-07-30 | 2016-07-20 | Gilead Connecticut Inc | Formulaciones de inhibidores de la syk |
| KR20160090903A (ko) | 2013-12-04 | 2016-08-01 | 길리애드 사이언시즈, 인코포레이티드 | 암을 치료하는 방법 |
| TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
| US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
| SG11201610551TA (en) | 2014-07-14 | 2017-01-27 | Gilead Sciences Inc | Combinations for treating cancers |
| MX2018006250A (es) | 2015-11-18 | 2018-09-05 | Genzyme Corp | Biomarcador de enfermedad poliquistica renal y usos del mismo. |
| MX2019006694A (es) | 2016-12-08 | 2019-08-21 | Lixte Biotechnology Inc | Oxabicicloheptanos para la modulacion de la respuesta inmunitaria. |
| EP3672974A1 (en) | 2017-08-25 | 2020-07-01 | Gilead Sciences, Inc. | Polymorphs of syk inhibitors |
| US11339168B2 (en) | 2019-02-22 | 2022-05-24 | Kronos Bio, Inc. | Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors |
| US20230348475A1 (en) * | 2020-09-17 | 2023-11-02 | The Translational Genomics Research Institute | Imidazopyridazine and imidazopyrazine compounds as inhibitors of cdk7 |
| CN114042065B (zh) * | 2021-11-26 | 2024-03-15 | 长沙拜特生物科技研究所有限公司 | 一种复方甲苯咪唑透皮溶液剂及其制备方法 |
| WO2025199359A1 (en) * | 2024-03-21 | 2025-09-25 | The Translational Genomics Research Institute | Methods of modulating cdk7 and flt3 using fused bicyclic compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4797764A (en) * | 1986-01-27 | 1989-01-10 | Minnesota Mining And Manufacturing Company | Recording disk with low total indicated runout |
| FR2607813B1 (fr) | 1986-12-05 | 1989-03-31 | Montpellier I Universite | Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique |
| PT778277E (pt) | 1995-12-08 | 2003-11-28 | Pfizer | Derivados heterociclicos substituidos como antagonistas do crf |
| WO2002006286A2 (en) | 2000-07-14 | 2002-01-24 | Bristol-Myers Squibb Pharma Company | IMIDAZO[1,2-a]PYRAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS |
| CA2417254A1 (en) | 2000-07-26 | 2002-02-07 | Bristol Myers Squibb Company | N-¢5-¢¢¢5-alkyl-2-oxazolyl!methyl!thio!-2-thiazolyl! carboxamide inhibitors of cyclin dependent kinases |
| US20040102455A1 (en) * | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
| KR20050008691A (ko) | 2002-04-19 | 2005-01-21 | 셀룰러 지노믹스 아이엔씨 | 이미다조[1,2-ａ]피라진-8-일 아민, 그의 제조방법 및사용방법 |
| NZ538685A (en) * | 2002-09-23 | 2008-02-29 | Schering Corp | Imidazopyrazines as cyclin dependent kinase inhibitors |
-
2003
- 2003-09-19 NZ NZ538686A patent/NZ538686A/en unknown
- 2003-09-19 US US10/666,424 patent/US7186740B2/en not_active Expired - Fee Related
- 2003-09-19 JP JP2004538213A patent/JP2006503838A/ja active Pending
- 2003-09-19 MX MXPA05003119A patent/MXPA05003119A/es active IP Right Grant
- 2003-09-19 CA CA002499874A patent/CA2499874A1/en not_active Abandoned
- 2003-09-19 WO PCT/US2003/029456 patent/WO2004026310A1/en not_active Ceased
- 2003-09-19 CN CNA038251027A patent/CN1694706A/zh active Pending
- 2003-09-19 KR KR1020057004674A patent/KR20060010709A/ko not_active Ceased
- 2003-09-19 AU AU2003275031A patent/AU2003275031B2/en not_active Ceased
- 2003-09-19 TW TW092125931A patent/TW200412967A/zh unknown
- 2003-09-19 EP EP03759300A patent/EP1542693A1/en not_active Withdrawn
- 2003-09-22 AR ARP030103440A patent/AR041346A1/es unknown
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2005
- 2005-03-22 ZA ZA200502380A patent/ZA200502380B/en unknown
-
2007
- 2007-03-01 US US11/680,929 patent/US20070155751A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1694706A (zh) | 2005-11-09 |
| US7186740B2 (en) | 2007-03-06 |
| US20070155751A1 (en) | 2007-07-05 |
| KR20060010709A (ko) | 2006-02-02 |
| ZA200502380B (en) | 2005-09-27 |
| AU2003275031B2 (en) | 2006-08-17 |
| AR041346A1 (es) | 2005-05-11 |
| JP2006503838A (ja) | 2006-02-02 |
| WO2004026310A8 (en) | 2005-06-30 |
| WO2004026310A1 (en) | 2004-04-01 |
| TW200412967A (en) | 2004-08-01 |
| NZ538686A (en) | 2008-01-31 |
| AU2003275031A1 (en) | 2004-04-08 |
| CA2499874A1 (en) | 2004-04-01 |
| US20040072835A1 (en) | 2004-04-15 |
| EP1542693A1 (en) | 2005-06-22 |
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