MXPA04000268A - Metodos para la modificacion genetica de celulas hemotopoyeticas progenitoras y usos de las celulas modificadas. - Google Patents
Metodos para la modificacion genetica de celulas hemotopoyeticas progenitoras y usos de las celulas modificadas.Info
- Publication number
- MXPA04000268A MXPA04000268A MXPA04000268A MXPA04000268A MXPA04000268A MX PA04000268 A MXPA04000268 A MX PA04000268A MX PA04000268 A MXPA04000268 A MX PA04000268A MX PA04000268 A MXPA04000268 A MX PA04000268A MX PA04000268 A MXPA04000268 A MX PA04000268A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- hematopoietic cells
- hematopoietic
- gene
- subject
- Prior art date
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- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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| US34348401P | 2001-12-21 | 2001-12-21 | |
| US38606302P | 2002-06-04 | 2002-06-04 | |
| PCT/US2002/021907 WO2003006691A1 (en) | 2001-07-10 | 2002-07-10 | Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells |
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| US20020058636A1 (en) * | 1994-09-21 | 2002-05-16 | Geoffrey P. Symonds | Ribozymes targeting the retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs |
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| KR20040084885A (ko) * | 2001-07-10 | 2004-10-06 | 존슨 앤드 존슨 리서치 피티와이 리미티드 | 형질도입된 조혈 선조 세포의 제조 방법 |
| ES2358187T3 (es) * | 2001-07-10 | 2011-05-06 | JOHNSON & JOHNSON RESEARCH PTY LIMITED | Procedimientos para la modificación genética de las células progenitoras hematopoyéticas y utilizaciones de las células modificadas. |
| KR101015913B1 (ko) | 2001-07-10 | 2011-02-23 | 존슨 앤드 존슨 리서치 피티와이 리미티드 | 조혈모세포의 유전적 변이 치료 방법 및 변이 세포의 용도 |
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| AU2002326906C1 (en) | 2001-09-13 | 2009-01-29 | California Institute Of Technology | Method for expression of small antiviral RNA molecules within a cell |
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| DE10224750A1 (de) | 2002-06-04 | 2003-12-24 | Fresenius Medical Care De Gmbh | Vorrichtung zur Behandlung einer medizinischen Flüssigkeit |
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| EP1613742A2 (en) * | 2003-04-08 | 2006-01-11 | YEDA RESEARCH AND DEVELOPMENT Co. LTD. | Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same |
| GB0410130D0 (en) * | 2004-05-06 | 2004-06-09 | Molmed Spa | Cell preparation |
| US7935074B2 (en) * | 2005-02-28 | 2011-05-03 | Fresenius Medical Care Holdings, Inc. | Cassette system for peritoneal dialysis machine |
| US8197231B2 (en) | 2005-07-13 | 2012-06-12 | Purity Solutions Llc | Diaphragm pump and related methods |
| ATE525460T1 (de) * | 2005-07-20 | 2011-10-15 | Seoul Nat Univ Ind Foundation | Verfahren zur kultivierung und vermehrung hämatopoetischer stammzellen und vorläuferzellen unter verwendung menschlicher endometriumzellen |
| EP2489728A1 (en) * | 2006-06-15 | 2012-08-22 | Neostem, Inc | Processing procedure for peripheral blood stem cells |
| JP2011160661A (ja) * | 2008-06-02 | 2011-08-25 | Kyowa Hakko Kirin Co Ltd | 血球細胞の初期化法 |
| US8112365B2 (en) * | 2008-12-19 | 2012-02-07 | Foster Scott C | System and method for online employment recruiting and evaluation |
| US20100210989A1 (en) | 2008-12-23 | 2010-08-19 | Janet Lesley Macpherson | Processing blood |
| US8192401B2 (en) | 2009-03-20 | 2012-06-05 | Fresenius Medical Care Holdings, Inc. | Medical fluid pump systems and related components and methods |
| CN102438631A (zh) * | 2009-04-09 | 2012-05-02 | 史坦赛特股份有限公司 | 抗hiv干细胞及其用途 |
| CA2767668C (en) | 2009-07-15 | 2017-03-07 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US8720913B2 (en) | 2009-08-11 | 2014-05-13 | Fresenius Medical Care Holdings, Inc. | Portable peritoneal dialysis carts and related systems |
| EP2647697B1 (en) | 2010-12-01 | 2016-08-24 | Nissan Chemical Industries, Ltd. | Method for producing hematopoietic stem cells using pyrazole compound |
| DE102010053973A1 (de) | 2010-12-09 | 2012-06-14 | Fresenius Medical Care Deutschland Gmbh | Medizinisches Gerät mit einer Heizung |
| WO2012087798A2 (en) | 2010-12-20 | 2012-06-28 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US9624915B2 (en) | 2011-03-09 | 2017-04-18 | Fresenius Medical Care Holdings, Inc. | Medical fluid delivery sets and related systems and methods |
| JP6062920B2 (ja) | 2011-04-21 | 2017-01-18 | フレセニウス メディカル ケア ホールディングス インコーポレーテッド | 医療流体ポンピング・システムならびに関係するデバイスおよび方法 |
| US9186449B2 (en) | 2011-11-01 | 2015-11-17 | Fresenius Medical Care Holdings, Inc. | Dialysis machine support assemblies and related systems and methods |
| US9610392B2 (en) | 2012-06-08 | 2017-04-04 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US9500188B2 (en) | 2012-06-11 | 2016-11-22 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| CN120718856A (zh) * | 2012-09-07 | 2025-09-30 | 再生元制药公司 | 经遗传修饰的非人动物及其使用方法 |
| ES2748662T3 (es) * | 2012-11-05 | 2020-03-17 | Institute For Res In Biomedicine Irb | Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos |
| CN105102612B (zh) * | 2012-12-06 | 2020-11-17 | 恩立夫克治疗有限责任公司 | 治疗性凋亡细胞制剂、其制备方法以及其用途 |
| US9561323B2 (en) | 2013-03-14 | 2017-02-07 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassette leak detection methods and devices |
| US10117985B2 (en) | 2013-08-21 | 2018-11-06 | Fresenius Medical Care Holdings, Inc. | Determining a volume of medical fluid pumped into or out of a medical fluid cassette |
| CN103471896A (zh) * | 2013-09-09 | 2013-12-25 | 上海兰卫临床检验有限公司 | 革兰染色液质控品制备方法 |
| WO2018201065A1 (en) * | 2017-04-27 | 2018-11-01 | Fred Hutchinson Cancer Research Center | Therapeutic formulations containing cd34+ stem cells derived from negative selection |
| MX2020004811A (es) * | 2017-11-15 | 2020-10-07 | Weird Science Llc | Métodos y composiciones de reconstrucción no mieloablativa de médula ósea. |
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| EP0321201B2 (en) | 1987-12-15 | 2004-11-24 | Gene Shears Pty Limited | Ribozymes |
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| US5866701A (en) | 1988-09-20 | 1999-02-02 | The Board Of Regents For Northern Illinois University Of Dekalb | HIV targeted hairpin ribozymes |
| US4978514A (en) | 1989-09-12 | 1990-12-18 | Fuel Tech, Inc. | Combined catalytic/non-catalytic process for nitrogen oxides reduction |
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| US20020058636A1 (en) | 1994-09-21 | 2002-05-16 | Geoffrey P. Symonds | Ribozymes targeting the retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs |
| EP0821740A1 (en) | 1995-04-20 | 1998-02-04 | Chiron Corporation | High efficiency ex vivo transduction of hematopoietic stem cells by recombinant retroviral preparations |
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| US6060317A (en) | 1998-08-11 | 2000-05-09 | The United States Of America As Represented By The Department Of Health And Human Services | Method of transducing mammalian cells, and products related thereto |
| AU2036700A (en) * | 1998-12-04 | 2000-06-26 | City Of Hope | A method of genetically modifying very primitive quiescent human hematopoietic stem cells |
| AU5403100A (en) * | 1999-06-08 | 2000-12-28 | Novartis Ag | Enforced expression of bcl-xl |
| JP2004509120A (ja) | 2000-09-13 | 2004-03-25 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼ阻害剤およびそれらの用途 |
| WO2002059300A2 (en) | 2000-12-28 | 2002-08-01 | J & J Research Pty Ltd | Double-stranded rna-mediated gene suppression |
| KR101015913B1 (ko) | 2001-07-10 | 2011-02-23 | 존슨 앤드 존슨 리서치 피티와이 리미티드 | 조혈모세포의 유전적 변이 치료 방법 및 변이 세포의 용도 |
| ES2358187T3 (es) | 2001-07-10 | 2011-05-06 | JOHNSON & JOHNSON RESEARCH PTY LIMITED | Procedimientos para la modificación genética de las células progenitoras hematopoyéticas y utilizaciones de las células modificadas. |
| KR20040084885A (ko) | 2001-07-10 | 2004-10-06 | 존슨 앤드 존슨 리서치 피티와이 리미티드 | 형질도입된 조혈 선조 세포의 제조 방법 |
| KR100646702B1 (ko) * | 2001-08-16 | 2006-11-17 | 에스케이씨 주식회사 | 홀 및/또는 그루브로 형성된 화학적 기계적 연마패드 |
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| Publication number | Publication date |
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| WO2003006691A1 (en) | 2003-01-23 |
| IL159637A (en) | 2013-07-31 |
| KR20040032852A (ko) | 2004-04-17 |
| JP2010077125A (ja) | 2010-04-08 |
| BR0211079A (pt) | 2005-08-30 |
| CA2453531A1 (en) | 2003-01-23 |
| US7345025B2 (en) | 2008-03-18 |
| EP1414996A1 (en) | 2004-05-06 |
| EP2322618A1 (en) | 2011-05-18 |
| AU2002316640C1 (en) | 2009-01-29 |
| JP2005528319A (ja) | 2005-09-22 |
| CN1553963A (zh) | 2004-12-08 |
| IL159637A0 (en) | 2004-06-01 |
| US7776595B2 (en) | 2010-08-17 |
| NZ530624A (en) | 2009-02-28 |
| CN101926824A (zh) | 2010-12-29 |
| JP5179697B2 (ja) | 2013-04-10 |
| US20080044394A1 (en) | 2008-02-21 |
| DE60238486D1 (de) | 2011-01-13 |
| KR101015913B1 (ko) | 2011-02-23 |
| US20040072771A1 (en) | 2004-04-15 |
| EP1414996A4 (en) | 2007-03-28 |
| AU2002316640B2 (en) | 2008-06-12 |
| EP1414996B1 (en) | 2010-12-01 |
| HK1065074A1 (en) | 2005-02-08 |
| DK1414996T3 (da) | 2011-03-21 |
| ATE490322T1 (de) | 2010-12-15 |
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