MX2020004811A - Métodos y composiciones de reconstrucción no mieloablativa de médula ósea. - Google Patents

Métodos y composiciones de reconstrucción no mieloablativa de médula ósea.

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Publication number
MX2020004811A
MX2020004811A MX2020004811A MX2020004811A MX2020004811A MX 2020004811 A MX2020004811 A MX 2020004811A MX 2020004811 A MX2020004811 A MX 2020004811A MX 2020004811 A MX2020004811 A MX 2020004811A MX 2020004811 A MX2020004811 A MX 2020004811A
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MX
Mexico
Prior art keywords
methods
bone marrow
compositions
marrow reconstitution
myeloablative
Prior art date
Application number
MX2020004811A
Other languages
English (en)
Inventor
Serhat Gumrukcu
Original Assignee
Weird Science Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weird Science Llc filed Critical Weird Science Llc
Publication of MX2020004811A publication Critical patent/MX2020004811A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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Abstract

La descripción hace referencia, en términos generales, a métodos y composiciones para realizar trasplantes de médula ósea usando un agente quimioterapéutico no mieloablativo y células resistentes a agentes quimioterapéuticos. Usando los métodos y las composiciones que se describen en la presente, es posible reconstituir la médula ósea de un paciente y el paciente evita los efectos secundarios adversos, incluidos la mieloablación y/o una alteración del sistema inmunológico.
MX2020004811A 2017-11-15 2018-11-15 Métodos y composiciones de reconstrucción no mieloablativa de médula ósea. MX2020004811A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762586813P 2017-11-15 2017-11-15
PCT/US2018/061211 WO2019099619A1 (en) 2017-11-15 2018-11-15 Methods and compositions for non-myeloablative bone marrow reconstitution

Publications (1)

Publication Number Publication Date
MX2020004811A true MX2020004811A (es) 2020-10-07

Family

ID=66539907

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004811A MX2020004811A (es) 2017-11-15 2018-11-15 Métodos y composiciones de reconstrucción no mieloablativa de médula ósea.

Country Status (12)

Country Link
US (1) US20190269734A1 (es)
EP (1) EP3710013A4 (es)
JP (1) JP2021503015A (es)
KR (1) KR20200089289A (es)
CN (1) CN111417407A (es)
AU (1) AU2018367546A1 (es)
BR (1) BR112020009377A2 (es)
CA (1) CA3082404A1 (es)
IL (1) IL274632A (es)
MX (1) MX2020004811A (es)
SG (1) SG11202004145QA (es)
WO (1) WO2019099619A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
CA2935960C (en) 2014-01-08 2023-01-10 Bart Lipkens Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
EP4096649A4 (en) * 2020-01-31 2024-04-17 G Tech Bio Llc COMPOSITIONS AND METHODS FOR PROVIDING CHEMOPROTECTIVE EFFECTS
US20220241326A1 (en) * 2021-02-01 2022-08-04 Serhat Gumrukcu Compositions and methods for providing chemoprotective effects

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL109168A0 (en) * 1993-04-01 1994-06-24 Univ Columbia A retroviral vector capable of transducing the aldehyde dehydrogenase-1 gene and making cells resistant to the chemotherapeutic agent cyclophosphamide and its derivatives and analogs
DE60238486D1 (de) * 2001-07-10 2011-01-13 Johnson & Johnson Res Pty Ltd Verfahren zur genetischen modifikation hämatopoetischer vorläuferzellen und verwendungen der modifizierten zellen
US7737124B2 (en) * 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
US20100129329A1 (en) * 2006-11-08 2010-05-27 Aldagen, Inc. METHODS FOR USING ALDHbr CELLS TO SUPPLEMENT STEM CELL TRANSPLANTATION
WO2009094456A2 (en) * 2008-01-22 2009-07-30 Johns Hopkins University Use of high-dose, post-transplantation oxazaphosphorine drugs for reduction of transplant rejection
WO2011008348A2 (en) * 2009-07-15 2011-01-20 Calimmune Inc. Dual vector for inhibition of human immunodeficiency virus
WO2013093919A2 (en) * 2011-12-22 2013-06-27 Yeda Research And Development Co. Ltd. A combination therapy for a stable and long term engraftment using specific protocols for t/b cell depletion
AU2013204327B2 (en) * 2012-04-20 2016-09-01 Aviagen Cell transfection method
WO2014165825A2 (en) * 2013-04-04 2014-10-09 President And Fellows Of Harvard College Therapeutic uses of genome editing with crispr/cas systems

Also Published As

Publication number Publication date
KR20200089289A (ko) 2020-07-24
WO2019099619A1 (en) 2019-05-23
IL274632A (en) 2020-06-30
CA3082404A1 (en) 2019-05-23
US20190269734A1 (en) 2019-09-05
EP3710013A1 (en) 2020-09-23
CN111417407A (zh) 2020-07-14
EP3710013A4 (en) 2021-06-16
JP2021503015A (ja) 2021-02-04
SG11202004145QA (en) 2020-06-29
BR112020009377A2 (pt) 2020-11-24
AU2018367546A1 (en) 2020-05-28

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