MX2020004811A - Métodos y composiciones de reconstrucción no mieloablativa de médula ósea. - Google Patents

Métodos y composiciones de reconstrucción no mieloablativa de médula ósea.

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Publication number
MX2020004811A
MX2020004811A MX2020004811A MX2020004811A MX2020004811A MX 2020004811 A MX2020004811 A MX 2020004811A MX 2020004811 A MX2020004811 A MX 2020004811A MX 2020004811 A MX2020004811 A MX 2020004811A MX 2020004811 A MX2020004811 A MX 2020004811A
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Mexico
Prior art keywords
methods
bone marrow
compositions
marrow reconstitution
myeloablative
Prior art date
Application number
MX2020004811A
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English (en)
Inventor
Serhat Gumrukcu
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Weird Science Llc
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Filing date
Publication date
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Publication of MX2020004811A publication Critical patent/MX2020004811A/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
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  • Cell Biology (AREA)
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Abstract

La descripción hace referencia, en términos generales, a métodos y composiciones para realizar trasplantes de médula ósea usando un agente quimioterapéutico no mieloablativo y células resistentes a agentes quimioterapéuticos. Usando los métodos y las composiciones que se describen en la presente, es posible reconstituir la médula ósea de un paciente y el paciente evita los efectos secundarios adversos, incluidos la mieloablación y/o una alteración del sistema inmunológico.
MX2020004811A 2017-11-15 2018-11-15 Métodos y composiciones de reconstrucción no mieloablativa de médula ósea. MX2020004811A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762586813P 2017-11-15 2017-11-15
PCT/US2018/061211 WO2019099619A1 (en) 2017-11-15 2018-11-15 Methods and compositions for non-myeloablative bone marrow reconstitution

Publications (1)

Publication Number Publication Date
MX2020004811A true MX2020004811A (es) 2020-10-07

Family

ID=66539907

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020004811A MX2020004811A (es) 2017-11-15 2018-11-15 Métodos y composiciones de reconstrucción no mieloablativa de médula ósea.
MX2025004115A MX2025004115A (es) 2017-11-15 2020-07-13 Celulas madre de medula osea modificadas para usarse en la reconstitucion de medula osea no mieloablativa.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2025004115A MX2025004115A (es) 2017-11-15 2020-07-13 Celulas madre de medula osea modificadas para usarse en la reconstitucion de medula osea no mieloablativa.

Country Status (13)

Country Link
US (2) US12194062B2 (es)
EP (2) EP3710013B1 (es)
JP (2) JP7568507B2 (es)
KR (1) KR20200089289A (es)
CN (1) CN111417407A (es)
AU (2) AU2018367546B2 (es)
BR (1) BR112020009377A2 (es)
CA (1) CA3082404A1 (es)
ES (1) ES3039609T3 (es)
IL (1) IL274632B2 (es)
MX (2) MX2020004811A (es)
SG (1) SG11202004145QA (es)
WO (1) WO2019099619A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
WO2021155351A1 (en) * 2020-01-31 2021-08-05 Gumrukcu Serhat Compositions and methods for providing chemoprotective effects
US12390491B2 (en) * 2020-01-31 2025-08-19 Gtech Bio Llc Compositions and methods for providing chemoprotective effects

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL109168A0 (en) 1993-04-01 1994-06-24 Univ Columbia A retroviral vector capable of transducing the aldehyde dehydrogenase-1 gene and making cells resistant to the chemotherapeutic agent cyclophosphamide and its derivatives and analogs
DK1414996T3 (da) * 2001-07-10 2011-03-21 Johnson & Johnson Res Pty Ltd Fremgangsmåder til genetisk modifikation af hæmatopoetiske progenitorceller og anvendelser af modificerede celler
US7737124B2 (en) * 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
US20030099621A1 (en) * 2001-11-29 2003-05-29 Robert Chow Stem cell screening and transplantation therapy for HIV infection
WO2008067126A2 (en) * 2006-11-08 2008-06-05 Aldagen, Inc. Methods for using aldhbr cells to supplement stem cell transplantation
WO2009094456A2 (en) * 2008-01-22 2009-07-30 Johns Hopkins University Use of high-dose, post-transplantation oxazaphosphorine drugs for reduction of transplant rejection
US20120201794A1 (en) 2009-07-15 2012-08-09 Calimmune Inc. Dual vector for inhibition of human immunodeficiency virus
US8837250B2 (en) 2010-07-20 2014-09-16 Taiwan Semiconductor Manufacturing Co., Ltd. Method and apparatus for word line decoder layout
MX2014007648A (es) * 2011-12-22 2015-03-19 Yeda Res & Dev Una terapia de combinacion para un injerto estable y a largo plazo usando protocolos especificos para agotamiento de celulas t/b.
AU2013204327B2 (en) * 2012-04-20 2016-09-01 Aviagen Cell transfection method
JP2016522679A (ja) * 2013-04-04 2016-08-04 プレジデント アンド フェローズ オブ ハーバード カレッジ ＣＲＩＳＰＲ／Ｃａｓ系を用いたゲノム編集の治療的使用

Also Published As

Publication number Publication date
US20190269734A1 (en) 2019-09-05
JP2025000910A (ja) 2025-01-07
IL274632B2 (en) 2024-12-01
JP7787265B2 (ja) 2025-12-16
AU2018367546B2 (en) 2024-07-18
AU2018367546A1 (en) 2020-05-28
IL274632A (en) 2020-06-30
JP2021503015A (ja) 2021-02-04
EP3710013B1 (en) 2025-07-30
WO2019099619A1 (en) 2019-05-23
EP3710013A4 (en) 2021-06-16
EP3710013A1 (en) 2020-09-23
CA3082404A1 (en) 2019-05-23
MX2025004115A (es) 2025-05-02
IL274632B1 (en) 2024-08-01
SG11202004145QA (en) 2020-06-29
ES3039609T3 (en) 2025-10-23
CN111417407A (zh) 2020-07-14
KR20200089289A (ko) 2020-07-24
US20250228898A1 (en) 2025-07-17
EP3710013C0 (en) 2025-07-30
BR112020009377A2 (pt) 2020-11-24
JP7568507B2 (ja) 2024-10-16
EP4674969A2 (en) 2026-01-07
AU2024216450A1 (en) 2024-09-26
US12194062B2 (en) 2025-01-14

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