JP5179697B2 - 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用 - Google Patents

造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用 Download PDF

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JP5179697B2
JP5179697B2 JP2003512448A JP2003512448A JP5179697B2 JP 5179697 B2 JP5179697 B2 JP 5179697B2 JP 2003512448 A JP2003512448 A JP 2003512448A JP 2003512448 A JP2003512448 A JP 2003512448A JP 5179697 B2 JP5179697 B2 JP 5179697B2
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JP2005528319A5 (enExample
JP2005528319A (ja
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シモンズ、ジョッフェリー・ピー
アマド、ラファエル
スン、ルン−クァン
マクファーソン、ジャネット
ファンニング、グレッグ
ガーラッチ、ウェイン
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/111Antisense spanning the whole gene, or a large part of it
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/12Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121Hammerhead
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2003512448A 2001-07-10 2002-07-10 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用 Expired - Fee Related JP5179697B2 (ja)

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US30428301P 2001-07-10 2001-07-10
US30412701P 2001-07-10 2001-07-10
US60/304,283 2001-07-10
US60/304,127 2001-07-10
US34348401P 2001-12-21 2001-12-21
US60/343,484 2001-12-21
US38606302P 2002-06-04 2002-06-04
US60/386,063 2002-06-04
PCT/US2002/021907 WO2003006691A1 (en) 2001-07-10 2002-07-10 Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells

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JP2009211662A Division JP2010077125A (ja) 2001-07-10 2009-09-14 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用

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JP2005528319A JP2005528319A (ja) 2005-09-22
JP2005528319A5 JP2005528319A5 (enExample) 2012-09-27
JP5179697B2 true JP5179697B2 (ja) 2013-04-10

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JP2009211662A Pending JP2010077125A (ja) 2001-07-10 2009-09-14 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用

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CN (2) CN1553963A (enExample)
AT (1) ATE490322T1 (enExample)
AU (1) AU2002316640C1 (enExample)
BR (1) BR0211079A (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010077125A (ja) 2001-07-10 2010-04-08 Johnson & Johnson Research Pty Ltd 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用

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JP2010077125A (ja) 2001-07-10 2010-04-08 Johnson & Johnson Research Pty Ltd 造血前駆細胞を遺伝的に改変する方法及び改変された細胞の使用

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WO2003006691A1 (en) 2003-01-23
EP1414996A4 (en) 2007-03-28
CN101926824A (zh) 2010-12-29
ATE490322T1 (de) 2010-12-15
US20080044394A1 (en) 2008-02-21
NZ530624A (en) 2009-02-28
JP2005528319A (ja) 2005-09-22
EP2322618A1 (en) 2011-05-18
US7776595B2 (en) 2010-08-17
IL159637A (en) 2013-07-31
AU2002316640C1 (en) 2009-01-29
HK1065074A1 (en) 2005-02-08
JP2010077125A (ja) 2010-04-08
BR0211079A (pt) 2005-08-30
AU2002316640B2 (en) 2008-06-12
US7345025B2 (en) 2008-03-18
IL159637A0 (en) 2004-06-01
EP1414996A1 (en) 2004-05-06
CN1553963A (zh) 2004-12-08
DK1414996T3 (da) 2011-03-21
MXPA04000268A (es) 2005-03-07
CA2453531A1 (en) 2003-01-23
KR20040032852A (ko) 2004-04-17
DE60238486D1 (de) 2011-01-13
EP1414996B1 (en) 2010-12-01
US20040072771A1 (en) 2004-04-15
KR101015913B1 (ko) 2011-02-23

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