DK1298208T3 - Ribozymer der er målrettet mod en HIV-tat-sekvens - Google Patents
Ribozymer der er målrettet mod en HIV-tat-sekvensInfo
- Publication number
- DK1298208T3 DK1298208T3 DK02025406T DK02025406T DK1298208T3 DK 1298208 T3 DK1298208 T3 DK 1298208T3 DK 02025406 T DK02025406 T DK 02025406T DK 02025406 T DK02025406 T DK 02025406T DK 1298208 T3 DK1298208 T3 DK 1298208T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- hiv
- hiv tat
- tat sequence
- ribozymes targeting
- Prior art date
Links
- 102000053642 Catalytic RNA Human genes 0.000 title abstract 2
- 108090000994 Catalytic RNA Proteins 0.000 title abstract 2
- 108091092562 ribozyme Proteins 0.000 title abstract 2
- 108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 238000013518 transcription Methods 0.000 abstract 2
- 230000035897 transcription Effects 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/122—Hairpin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/178,082 US5712384A (en) | 1994-01-05 | 1994-01-05 | Ribozymes targeting retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs |
US08/310,259 US6114167A (en) | 1994-01-05 | 1994-09-21 | Ribozymes targeting the MoMLV PSI packaging sequence and the HIV tat sequence |
EP95905220A EP0753062A4 (en) | 1994-01-05 | 1995-01-05 | RIBOZYMES TARGETING RECOMBINATION PRODUCTS OF EXPRESSION OF RETROVIRAL PACKAGING SEQUENCES AND RECOMBINANT RETROVIRUSES CONTAINING SAID RECOMBINATION PRODUCTS |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1298208T3 true DK1298208T3 (da) | 2006-07-24 |
Family
ID=26873946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02025406T DK1298208T3 (da) | 1994-01-05 | 1995-01-05 | Ribozymer der er målrettet mod en HIV-tat-sekvens |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP1298208B1 (da) |
JP (1) | JP3691849B2 (da) |
CN (1) | CN1267552C (da) |
AT (1) | ATE320487T1 (da) |
AU (1) | AU698730B2 (da) |
CA (1) | CA2180358A1 (da) |
DE (1) | DE69534864T2 (da) |
DK (1) | DK1298208T3 (da) |
ES (1) | ES2260376T3 (da) |
IL (1) | IL112261A (da) |
NO (1) | NO319376B1 (da) |
NZ (1) | NZ278432A (da) |
PT (1) | PT1298208E (da) |
WO (1) | WO1995018854A1 (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020058636A1 (en) * | 1994-09-21 | 2002-05-16 | Geoffrey P. Symonds | Ribozymes targeting the retroviral packaging sequence expression constructs and recombinant retroviruses containing such constructs |
EP0865282A4 (en) * | 1995-08-25 | 2002-01-16 | Univ California | Chimeric antiviral agents that contain REV-binding nucleic acids |
NZ324157A (en) * | 1995-11-28 | 2000-10-27 | Univ Johns Hopkins Med | Conditionally replicating viral vectors and their use in treating HIV |
US5888767A (en) | 1996-11-27 | 1999-03-30 | The Johns Hopkins University School Of Medicine | Method of using a conditionally replicating viral vector to express a gene |
US6776986B1 (en) | 1996-06-06 | 2004-08-17 | Novartis Ag | Inhibition of HIV-1 replication by antisense RNA expression |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
NZ547283A (en) | 1998-03-20 | 2008-06-30 | Commw Scient Ind Res Org | Control of gene expression |
AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
EP1147204A1 (en) | 1999-01-28 | 2001-10-24 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
EP1229134A3 (en) | 2001-01-31 | 2004-01-28 | Nucleonics, Inc | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
DE60238486D1 (de) | 2001-07-10 | 2011-01-13 | Johnson & Johnson Res Pty Ltd | Verfahren zur genetischen modifikation hämatopoetischer vorläuferzellen und verwendungen der modifizierten zellen |
US7994144B2 (en) | 2001-07-10 | 2011-08-09 | Johnson & Johnson Research Pty, Limited | Process for the preparation of a composition of genetically modified hematopoietic progenitor cells |
CN102841007A (zh) * | 2012-09-05 | 2012-12-26 | 福建省农业科学院畜牧兽医研究所 | 一种便于鸭精子计数的精液稀释液及其使用方法 |
CN113549641B (zh) * | 2021-06-29 | 2023-12-22 | 复旦大学 | 一种核酶介导的多顺反子载体及其构建方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225337A (en) * | 1989-09-25 | 1993-07-06 | Innovir Laboratories, Inc. | Ribozyme compositions and methods for use |
JPH06506599A (ja) * | 1991-04-05 | 1994-07-28 | エディソン アニマル バイオテクノロジー センター,オハイオ ユニバーシティー | パッケージング配列に相補的なアンチセンス核酸によるレトロウイルスの抑制 |
CA2154363A1 (en) * | 1993-01-22 | 1994-08-04 | Bruce A. Sullenger | Localization of therapeutic agents |
IL108719A0 (en) * | 1993-02-25 | 1994-08-26 | Ortho Pharma Corp | Expression constructs containing hiv inhibitory antisense and other nucleotide sequences, retroviralvectors and recombinant retroviruses containing them |
WO1995004818A1 (en) * | 1993-08-06 | 1995-02-16 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting human immunodeficiency virus replication |
-
1995
- 1995-01-05 AU AU13912/95A patent/AU698730B2/en not_active Ceased
- 1995-01-05 AT AT02025406T patent/ATE320487T1/de not_active IP Right Cessation
- 1995-01-05 WO PCT/IB1995/000050 patent/WO1995018854A1/en not_active Application Discontinuation
- 1995-01-05 DE DE69534864T patent/DE69534864T2/de not_active Expired - Lifetime
- 1995-01-05 DK DK02025406T patent/DK1298208T3/da active
- 1995-01-05 JP JP51840395A patent/JP3691849B2/ja not_active Expired - Fee Related
- 1995-01-05 EP EP02025406A patent/EP1298208B1/en not_active Expired - Lifetime
- 1995-01-05 IL IL11226195A patent/IL112261A/xx not_active IP Right Cessation
- 1995-01-05 EP EP95905220A patent/EP0753062A4/en not_active Withdrawn
- 1995-01-05 PT PT02025406T patent/PT1298208E/pt unknown
- 1995-01-05 CN CNB951919318A patent/CN1267552C/zh not_active Expired - Fee Related
- 1995-01-05 ES ES02025406T patent/ES2260376T3/es not_active Expired - Lifetime
- 1995-01-05 NZ NZ278432A patent/NZ278432A/en not_active IP Right Cessation
- 1995-01-05 CA CA002180358A patent/CA2180358A1/en not_active Abandoned
-
1996
- 1996-07-04 NO NO19962826A patent/NO319376B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1298208B1 (en) | 2006-03-15 |
IL112261A0 (en) | 1995-03-30 |
CN1145638A (zh) | 1997-03-19 |
NO962826D0 (no) | 1996-07-04 |
EP0753062A1 (en) | 1997-01-15 |
WO1995018854A1 (en) | 1995-07-13 |
CN1267552C (zh) | 2006-08-02 |
NO962826L (no) | 1996-08-27 |
PT1298208E (pt) | 2006-10-31 |
AU1391295A (en) | 1995-08-01 |
JPH09508004A (ja) | 1997-08-19 |
IL112261A (en) | 2005-08-31 |
ES2260376T3 (es) | 2006-11-01 |
NZ278432A (en) | 1998-06-26 |
DE69534864T2 (de) | 2007-02-22 |
DE69534864D1 (de) | 2006-05-11 |
AU698730B2 (en) | 1998-11-05 |
EP1298208A3 (en) | 2004-01-07 |
EP0753062A4 (en) | 1999-10-20 |
JP3691849B2 (ja) | 2005-09-07 |
ATE320487T1 (de) | 2006-04-15 |
CA2180358A1 (en) | 1995-07-13 |
NO319376B1 (no) | 2005-07-25 |
EP1298208A2 (en) | 2003-04-02 |
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