MX9805282A - Uso de compuestos que tienen actividad especifica o selectiva del receptor raralfa. - Google Patents
Uso de compuestos que tienen actividad especifica o selectiva del receptor raralfa.Info
- Publication number
- MX9805282A MX9805282A MX9805282A MX9805282A MX9805282A MX 9805282 A MX9805282 A MX 9805282A MX 9805282 A MX9805282 A MX 9805282A MX 9805282 A MX9805282 A MX 9805282A MX 9805282 A MX9805282 A MX 9805282A
- Authority
- MX
- Mexico
- Prior art keywords
- rar
- alpha
- treatment
- compounds
- methods
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 206010000871 Acute monocytic leukaemia Diseases 0.000 abstract 1
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- -1 Retinoid compounds Chemical class 0.000 abstract 1
- 206010040880 Skin irritation Diseases 0.000 abstract 1
- 206010043275 Teratogenicity Diseases 0.000 abstract 1
- 208000019065 cervical carcinoma Diseases 0.000 abstract 1
- 201000003911 head and neck carcinoma Diseases 0.000 abstract 1
- 201000000050 myeloid neoplasm Diseases 0.000 abstract 1
- 231100000475 skin irritation Toxicity 0.000 abstract 1
- 230000036556 skin irritation Effects 0.000 abstract 1
- 231100000211 teratogenicity Toxicity 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N25/00—Investigating or analyzing materials by the use of thermal means
- G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
- G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
- G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample
- G01N25/4866—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample by using a differential method
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Combustion & Propulsion (AREA)
- Obesity (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Los compuestos retinoides que actuan específicamente o selectivamente sobre los subtipos del receptor RARalfa de preferencia que sobre los subtipos de receptores RAR beta y RARr, poseen propiedades farmacéuticas deseables asociadas con los retinoides, y son particularmente adecuados para el tratamiento de tumores, tales como leucemia monocítica aguda, carcinoma cervical, mieloma, carcinomas del ovario y carcinomas de la cabeza y del cuello, sin tener uno o más efectos colaterales indeseables de los retinoides, tales como la induccion de la pérdida del peso. la toxicidad mucocutánea, la irritacion de la piel y la teratogenicidad.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/580,553 US5965606A (en) | 1995-12-29 | 1995-12-29 | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9805282A true MX9805282A (es) | 1998-10-31 |
Family
ID=24321568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9805282A MX9805282A (es) | 1995-12-29 | 1998-06-29 | Uso de compuestos que tienen actividad especifica o selectiva del receptor raralfa. |
Country Status (16)
Country | Link |
---|---|
US (4) | US5965606A (es) |
EP (1) | EP0869782A2 (es) |
JP (1) | JP2000502707A (es) |
KR (1) | KR19990076814A (es) |
CN (1) | CN1211180A (es) |
AU (1) | AU710483B2 (es) |
BR (1) | BR9612318A (es) |
CA (1) | CA2241758A1 (es) |
CZ (1) | CZ206998A3 (es) |
HU (1) | HUP0001643A3 (es) |
IL (1) | IL125121A0 (es) |
MX (1) | MX9805282A (es) |
NZ (1) | NZ326155A (es) |
PL (1) | PL327627A1 (es) |
RU (1) | RU2191009C2 (es) |
WO (1) | WO1997024116A2 (es) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5977125A (en) | 1994-10-31 | 1999-11-02 | Eisai Co., Ltd. | Mono-or polyenic carboxylic acid derivatives |
JP3964478B2 (ja) | 1995-06-30 | 2007-08-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬 |
US5965606A (en) * | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
US20070213290A1 (en) * | 1996-10-17 | 2007-09-13 | Kingsman Alan J | Neurite regeneration |
US20040266715A1 (en) * | 1999-03-31 | 2004-12-30 | Wong Liang Fong | Neurite regeneration |
GB9907461D0 (en) * | 1999-03-31 | 1999-05-26 | King S College London | Neurite regeneration |
CA2307613A1 (en) | 1997-10-22 | 1999-04-29 | Eisai Co., Ltd. | Retinoic acid agonist as a prophylactic and therapeutic agent for nephritis |
US6083973A (en) * | 1998-03-09 | 2000-07-04 | Syntex (U.S.A.) Inc. | Methods for inhibiting mucin secretion using RAR α selective antagonists |
FR2776511B1 (fr) * | 1998-03-31 | 2001-05-11 | Galderma Rech Dermatologique | Utilisation dans ou pour la preparation d'une composition d'au moins un inhibiteur de l'activite de l'acide retinoique |
US6197798B1 (en) | 1998-07-21 | 2001-03-06 | Novartis Ag | Amino-benzocycloalkane derivatives |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
ES2240420T3 (es) | 2000-01-18 | 2005-10-16 | Novartis Ag | Carboxamidas utiles como inhibidores de la proteina de transferencia de trigliceridos microsomicos y de la secrecion de apolipoproteina b. |
AU2001244354A1 (en) * | 2000-03-30 | 2001-10-15 | Oxford Biomedica (Uk) Limited | Retinoic acid receptor beta-2, its antagonists, and gene therapy vectors for thetreatment of neurological disorders |
TWI281911B (en) | 2000-04-04 | 2007-06-01 | Allergan Inc | Treatment of tumors with RARalpha selective retinoid compounds in combination with other anti-tumor agents |
US6369261B1 (en) | 2000-08-29 | 2002-04-09 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
CA2420869A1 (en) * | 2000-08-29 | 2002-03-07 | Allergan, Inc. | Compounds having activity as inhibitors of cytochrome p450rai |
US6380256B1 (en) * | 2000-08-29 | 2002-04-30 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
US6313107B1 (en) * | 2000-08-29 | 2001-11-06 | Allergan Sales, Inc. | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI |
US6387951B1 (en) | 2000-08-29 | 2002-05-14 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
US6369225B1 (en) | 2000-08-29 | 2002-04-09 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
US6252090B1 (en) | 2000-08-29 | 2001-06-26 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
PL208665B1 (pl) * | 2000-10-02 | 2011-05-31 | Hoffmann La Roche | Związki retinoidowe, ich zastosowanie, środek farmaceutyczny i sposób wytwarzania związków retinoidowych |
EP1935869A1 (en) * | 2000-10-02 | 2008-06-25 | F. Hoffmann-La Roche Ag | Retinoids for the treatment of emphysema |
JP2002131257A (ja) * | 2000-10-26 | 2002-05-09 | Nisshinbo Ind Inc | 熱伝導率測定方法、測定装置及び断熱材の製造方法 |
US6843595B2 (en) * | 2001-01-26 | 2005-01-18 | Waters Investment Limited | Differential scanning calorimeter accounting for heat leakage |
AU2002333655A1 (en) * | 2001-09-25 | 2003-04-07 | Smithkline Beecham Corporation | Bicyclic heterocycles as rxr ligands |
US6740676B2 (en) | 2002-03-19 | 2004-05-25 | Allergan, Inc. | 4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome p450rai inhibitory activity |
DE10227182B4 (de) * | 2002-06-18 | 2013-01-31 | Mettler-Toledo Ag | Probenhalter für die Differenz-Thermoanalyse |
US6620963B1 (en) | 2002-09-19 | 2003-09-16 | Allergan, Inc. | TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-PHENYL AND TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-HETEROARYL AND RELATED COMPOUNDS HAVING RARα RECEPTOR SELECTIVE BIOLOGICAL ACTIVITY |
ATE371862T1 (de) * | 2003-10-28 | 2007-09-15 | Mettler Toledo Ag | Thermoanalytischer sensor und verfahren zu dessen herstellung |
US7077563B2 (en) * | 2003-11-19 | 2006-07-18 | General Electric Company | Deposition sensor based on differential heat flux measurement |
BRPI0416933A (pt) | 2003-11-25 | 2007-01-16 | Novo Nordisk As | composto, composição farmacêutica, método para tratar uma doença, uso de um composto, e, métodos para aumentar a respiração mitocondrial em um paciente, e para reduzir a quantidade de espécies de oxigênio reativas em um paciente |
KR20070007818A (ko) * | 2004-03-10 | 2007-01-16 | 재단법인 이쯔우 연구소 | 기억 고정 촉진제 |
EP1717566A1 (de) * | 2005-04-25 | 2006-11-02 | Mettler-Toledo AG | Thermoanalytischer Sensor |
US20070060620A1 (en) * | 2005-09-09 | 2007-03-15 | John Sefton | Use of RAR retinoid agonists to increase sperm count and sperm mobility in males |
PT1937244T (pt) | 2005-09-30 | 2018-11-07 | Io Therapeutics Llc | Tratamento do cancro com agonistas específicos de rxr |
GB0605683D0 (en) * | 2006-03-21 | 2006-05-03 | Servomex Group Ltd | Thermal conductivity sensor |
US20080273572A1 (en) * | 2006-06-02 | 2008-11-06 | James Madison University | Thermal detector for chemical or biological agents |
JP4849961B2 (ja) * | 2006-06-05 | 2012-01-11 | エスアイアイ・ナノテクノロジー株式会社 | 熱分析装置 |
US7470057B2 (en) * | 2006-08-24 | 2008-12-30 | Waters Investments Limited | Differential scanning calorimeter sensor and method |
JP2008089474A (ja) * | 2006-10-03 | 2008-04-17 | Rigaku Corp | 熱分析装置のセンサユニットおよびその製造方法 |
FR2925163B1 (fr) * | 2007-12-12 | 2010-02-26 | Centre Nat Rech Scient | Procede et appareil d'analyse thermique |
DE602008005427D1 (de) * | 2008-06-13 | 2011-04-21 | Mettler Toledo Ag | Wärmeanalyseinstrument mit dynamischer Leistungskompensation |
EP2214005B1 (en) * | 2009-02-03 | 2019-09-18 | Mettler-Toledo GmbH | Thermo-Analytical Instrument |
US8517600B2 (en) * | 2009-10-27 | 2013-08-27 | General Electric Company | Deposition sensor based on differential heat transfer resistance |
JP5642525B2 (ja) * | 2010-02-02 | 2014-12-17 | 株式会社日立ハイテクサイエンス | 示差走査熱量計 |
KR101853882B1 (ko) * | 2011-01-10 | 2018-05-02 | 삼성전자주식회사 | 생체물질 검사장치 및 그 제어방법 |
WO2012125749A2 (en) * | 2011-03-14 | 2012-09-20 | Io Therapeutics, Inc. | INFLAMMATION AND AUTOIMMUNE DISORDER TREATMENT USING RARα SELECTIVE AGONISTS |
BR112013033309B1 (pt) | 2011-06-24 | 2022-07-05 | Gri Bio, Inc | Uso de tazaroteno e método in vitro para inibição de ativação de células nkt tipo i |
WO2013019653A1 (en) * | 2011-07-29 | 2013-02-07 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
MX352727B (es) | 2011-12-13 | 2017-12-06 | Dartmouth College | Tratamiento de trastorno autoinmune al usar agonistas de rxr. |
US10653650B2 (en) | 2011-12-13 | 2020-05-19 | Io Therapeutics, Inc. | Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists |
US11116738B2 (en) | 2012-06-07 | 2021-09-14 | Children's Hospital Los Angeles | Methods for treating neutropenia using retinoid agonists |
US10286039B2 (en) | 2014-02-18 | 2019-05-14 | Children's Hospital Los Angeles | Compositions and methods for treating neutropenia |
EP2921833B1 (de) * | 2014-03-18 | 2016-12-28 | Mettler-Toledo GmbH | Thermoanalytischer Sensor und Verfahren zu dessen Herstellung |
US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
JP2017537984A (ja) | 2014-12-09 | 2017-12-21 | ジーアールアイ バイオ, インコーポレイテッド | 炎症性病態の予防および治療 |
WO2016144976A1 (en) * | 2015-03-09 | 2016-09-15 | Kings College London | Combination therapy with rar alpha agonists for enhancing th1 response |
MX2017012470A (es) | 2015-03-31 | 2018-03-23 | Syros Pharmaceuticals Inc | Metodos para estratificacion de pacientes para tratamiento con agonistas del receptor alfa de acido retinoico. |
US10688122B2 (en) | 2015-09-28 | 2020-06-23 | Azura Ophthalmics Ltd. | Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion |
US10092535B2 (en) | 2015-10-31 | 2018-10-09 | Io Therapeutics, Inc. | Treatment of nervous system disorders using combinations of RXR agonists and thyroid hormones |
WO2017091762A1 (en) * | 2015-11-25 | 2017-06-01 | Io Therapeutics, Inc. | Use of cyp26-resistant rar alpha selective agonists in the treatment of cancer |
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1996
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- 1996-12-16 RU RU98114840/14A patent/RU2191009C2/ru not_active IP Right Cessation
- 1996-12-16 HU HU0001643A patent/HUP0001643A3/hu unknown
- 1996-12-16 CN CN96180109A patent/CN1211180A/zh active Pending
- 1996-12-16 NZ NZ326155A patent/NZ326155A/xx unknown
- 1996-12-16 AU AU13450/97A patent/AU710483B2/en not_active Ceased
- 1996-12-16 BR BR9612318-4A patent/BR9612318A/pt not_active IP Right Cessation
- 1996-12-16 WO PCT/US1996/020511 patent/WO1997024116A2/en not_active Application Discontinuation
- 1996-12-16 KR KR1019980704939A patent/KR19990076814A/ko not_active Application Discontinuation
- 1996-12-16 EP EP96944978A patent/EP0869782A2/en not_active Withdrawn
- 1996-12-16 PL PL96327627A patent/PL327627A1/xx unknown
- 1996-12-16 CZ CZ982069A patent/CZ206998A3/cs unknown
- 1996-12-16 JP JP09524502A patent/JP2000502707A/ja not_active Ceased
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1998
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1999
- 1999-07-09 US US09/350,310 patent/US6534544B1/en not_active Expired - Fee Related
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2001
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- 2001-11-30 US US09/998,356 patent/US6508585B2/en not_active Expired - Fee Related
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KR19990076814A (ko) | 1999-10-15 |
WO1997024116A2 (en) | 1997-07-10 |
CA2241758A1 (en) | 1997-07-10 |
AU710483B2 (en) | 1999-09-23 |
JP2000502707A (ja) | 2000-03-07 |
CZ206998A3 (cs) | 1999-04-14 |
RU2191009C2 (ru) | 2002-10-20 |
HUP0001643A2 (hu) | 2001-05-28 |
AU1345097A (en) | 1997-07-28 |
BR9612318A (pt) | 1999-12-28 |
PL327627A1 (en) | 1998-12-21 |
CN1211180A (zh) | 1999-03-17 |
US5965606A (en) | 1999-10-12 |
US6610744B2 (en) | 2003-08-26 |
US20020085615A1 (en) | 2002-07-04 |
HUP0001643A3 (en) | 2003-01-28 |
US6508585B2 (en) | 2003-01-21 |
NZ326155A (en) | 2000-08-25 |
IL125121A0 (en) | 1999-01-26 |
US20020077360A1 (en) | 2002-06-20 |
WO1997024116A3 (en) | 1997-11-13 |
EP0869782A2 (en) | 1998-10-14 |
US6534544B1 (en) | 2003-03-18 |
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