MX9803891A - Derivados de pirazol, metodo para preparar los mismos y composiciones farmaceuticas que contienen esos derivados. - Google Patents

Derivados de pirazol, metodo para preparar los mismos y composiciones farmaceuticas que contienen esos derivados.

Info

Publication number
MX9803891A
MX9803891A MX9803891A MX9803891A MX9803891A MX 9803891 A MX9803891 A MX 9803891A MX 9803891 A MX9803891 A MX 9803891A MX 9803891 A MX9803891 A MX 9803891A MX 9803891 A MX9803891 A MX 9803891A
Authority
MX
Mexico
Prior art keywords
alkyl
derivatives
pharmaceutical compositions
compositions containing
alkoxy
Prior art date
Application number
MX9803891A
Other languages
English (en)
Inventor
Francis Barth
Christian Congy
Serge Martinez
Murielle Rinaldi
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX9803891A publication Critical patent/MX9803891A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

En la presente invencion se describen compuestos de formula (I), en donde R1 es fluor, hidroxi alcoxi (de 1 a 5 átomos de carbono), alquiltio de 1 a 5átomos de carbono, hidroxi (alcoxi de 1 a 5 átomos de carbono), un grupo -NR10R11, ciano, alquilsulfonilo de 1 a 5 átomos de carbono o alquilsulfinilo de 1 a 5átomos de carbono ; R2 y R3 son cada uno alquilo de 1 a 4 átomos de carbono o, tomados junto con el átomo de nitrogeno, al cual están unidos, forman radicales heterocíclicos, saturados o insaturados de 5 a 10 miembros, sustituidos una o más veces por alquilo de 1 a 3 átomos de carbono o alcoxi de 1 a 3 átomos de carbono; cada una de las R4, R5, R6, R7, R8 y R9 son independientemente hidrogeno, halogeno o trifluorometilo, y cuando R1 es fluor, R4, R5, R6, R7, R8 y R9 pueden ser fluorometilo; con la condicion de que al menos uno de los substituyentes R4 o R7 sean diferentes del hidrogeno; cada uno de R10 y R11 son independientemente, hidrogeno, alquilo de 1 a 5 átomos de carbono, o R10 y R11 tomados conjuntamente con el átomo de nitrogeno al cual están unidos, forman un radical heterocíclico seleccionado de pirrolidin-1-ilo, piperidin-1-ilo, morfolin-4-ilo o piperazin-1-ilo, substituidos opcionalmente por alquilo de 1 a 4 átomos de carbono; un método para preparar los mismos, y composiciones esos compuestos. Estos compuestos tienen alta afinidad por los receptores canabinoides centrales.
MX9803891A 1995-11-23 1998-05-15 Derivados de pirazol, metodo para preparar los mismos y composiciones farmaceuticas que contienen esos derivados. MX9803891A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9513956A FR2741621B1 (fr) 1995-11-23 1995-11-23 Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant

Publications (1)

Publication Number Publication Date
MX9803891A true MX9803891A (es) 1998-09-30

Family

ID=9484869

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9803891A MX9803891A (es) 1995-11-23 1998-05-15 Derivados de pirazol, metodo para preparar los mismos y composiciones farmaceuticas que contienen esos derivados.

Country Status (16)

Country Link
US (1) US6028084A (es)
EP (1) EP0876350B1 (es)
JP (1) JP2000500479A (es)
AT (1) ATE203015T1 (es)
AU (1) AU7698596A (es)
BR (1) BR9611618A (es)
CA (1) CA2238430C (es)
DE (1) DE69613860T2 (es)
DK (1) DK0876350T3 (es)
ES (1) ES2161382T3 (es)
FR (1) FR2741621B1 (es)
GR (1) GR3036830T3 (es)
MX (1) MX9803891A (es)
NO (1) NO310508B1 (es)
PT (1) PT876350E (es)
WO (1) WO1997019063A1 (es)

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PT876350E (pt) 2001-12-28
FR2741621A1 (fr) 1997-05-30
EP0876350A1 (fr) 1998-11-11
CA2238430A1 (en) 1997-05-29
DE69613860D1 (de) 2001-08-16
CA2238430C (en) 2006-05-09
ATE203015T1 (de) 2001-07-15
GR3036830T3 (en) 2002-01-31
ES2161382T3 (es) 2001-12-01
AU7698596A (en) 1997-06-11
JP2000500479A (ja) 2000-01-18
NO310508B1 (no) 2001-07-16
WO1997019063A1 (fr) 1997-05-29
DE69613860T2 (de) 2002-04-04
DK0876350T3 (da) 2001-11-05
NO982330D0 (no) 1998-05-22
EP0876350B1 (fr) 2001-07-11
FR2741621B1 (fr) 1998-02-13
US6028084A (en) 2000-02-22
BR9611618A (pt) 1999-03-30

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