MX9401234A - Alquilamida sustituida con un heterociclo como inhibidores de la acat. - Google Patents
Alquilamida sustituida con un heterociclo como inhibidores de la acat.Info
- Publication number
- MX9401234A MX9401234A MX9401234A MX9401234A MX9401234A MX 9401234 A MX9401234 A MX 9401234A MX 9401234 A MX9401234 A MX 9401234A MX 9401234 A MX9401234 A MX 9401234A MX 9401234 A MX9401234 A MX 9401234A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- phenyl
- oxadiazole
- substituted
- acat
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención describe compuestos farmacéuticamente útiles que tienen actividad inhibidora de la ACAT de la fórmula, en la que n es 0, 1 ó 2 para X diferente de tetrazol y n 2 luego R2 R3 H; R1 es fenilo, fenilo sustituido, naftilo, naftilo sustituido, un grupo heteroaromático o un grupo hidrocarburo, que tiene de uno a 18 átomos de carbono; R2 y R3 son hidrógeno, halo, hidroxi, alquilo, alquenilo, cicloalquilo, fenilo, fenilo sustituido, un grupo heteroalilo o forman un grupo espiroalquilo; X es un anillo de 5 miembros heteromonocíclico que contiene de uno a cuatro heteroátomos, los heteroátomos son nitrógeno, oxígeno o azufre y sus combinaciones; y R4 es un grupo hidrocarburo que tiene de uno a 20 átomos de carbono, así como también los métodos para su fabricación.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/019,411 US5366987A (en) | 1991-08-22 | 1993-02-18 | Isoxazolyl-substituted alkyl amide ACAT inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9401234A true MX9401234A (es) | 1994-08-31 |
Family
ID=21793060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9401234A MX9401234A (es) | 1993-02-18 | 1994-02-17 | Alquilamida sustituida con un heterociclo como inhibidores de la acat. |
Country Status (12)
Country | Link |
---|---|
US (4) | US5366987A (es) |
EP (2) | EP0684945B1 (es) |
JP (1) | JP3568204B2 (es) |
AT (2) | ATE221053T1 (es) |
AU (1) | AU679726B2 (es) |
CA (1) | CA2155104C (es) |
DE (2) | DE69431042T2 (es) |
DK (1) | DK0684945T3 (es) |
ES (1) | ES2179069T3 (es) |
MX (1) | MX9401234A (es) |
PT (1) | PT684945E (es) |
WO (1) | WO1994019330A1 (es) |
Families Citing this family (59)
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US5360811A (en) * | 1990-03-13 | 1994-11-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents |
US5420339A (en) * | 1993-11-22 | 1995-05-30 | Warner-Lambert Company | Alpha-aryl or heteroaryl-substituted amide ester ACAT inhibitors |
US5547967A (en) * | 1993-12-08 | 1996-08-20 | Kali-Chemie Pharma Gmbh | (Phenylalkylaminoalkyloxy)-heteroaryl-compounds, processes and intermediates for their production and pharmaceutical compositions containing them |
US5461049A (en) * | 1994-05-27 | 1995-10-24 | Warner-Lambert Company | Amide tetrazole ACAT inhibitors |
US5491170A (en) * | 1994-12-19 | 1996-02-13 | Warner-Lambert Company | β-carboxy sulfonamide ACAT inhibitors |
US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
US5861398A (en) * | 1996-08-26 | 1999-01-19 | Alanex Corporation | Benzoperimidine-carboxylic acids and derivatives thereof |
BR9912296A (pt) * | 1998-07-21 | 2001-04-17 | Warner Lambert Co | Co-adminiostração de inibidores acat e mmp para o tratamento de lesões ateroscleróticas |
AU1455500A (en) * | 1998-10-29 | 2000-05-22 | Trega Biosciences, Inc. | Oxadiazole, thiadiazole and triazole derivatives and combinatorial libraries thereof |
US20040072903A1 (en) * | 2001-05-08 | 2004-04-15 | Auerbach Bruce Jeffrey | Carboxyalkylether-acat inhibitors combinations |
CA2547518A1 (en) * | 2003-12-12 | 2005-06-30 | Wyeth | Quinolines useful in treating cardiovascular disease |
EP1709029A2 (en) * | 2004-01-30 | 2006-10-11 | Euro-Celtique S.A. | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds |
AP2204A (en) * | 2004-05-06 | 2011-02-07 | Warner Lambert Co | 4-phenylamino-quinazolin-6-yl-amides. |
ES2421233T3 (es) * | 2008-10-03 | 2013-08-29 | Scinopharm Taiwan Ltd. | Síntesis de Decitabina |
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FR2946342B1 (fr) | 2009-06-05 | 2011-06-24 | Galderma Res & Dev | Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
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CN105732580B (zh) | 2012-04-27 | 2018-12-07 | 陶氏益农公司 | 杀虫组合物和与其相关的方法 |
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JP2016535008A (ja) | 2013-10-17 | 2016-11-10 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除化合物の調製法 |
CN105636444B (zh) | 2013-10-17 | 2018-04-27 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
US9108946B2 (en) | 2013-10-17 | 2015-08-18 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
MX2016004942A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Procesos para la preparacion de compuestos plaguicidas. |
JP6487426B2 (ja) | 2013-10-17 | 2019-03-20 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除化合物の調製法 |
JP2016536296A (ja) | 2013-10-17 | 2016-11-24 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除性化合物の製造方法 |
CN105658062A (zh) | 2013-10-22 | 2016-06-08 | 美国陶氏益农公司 | 协同杀虫组合物和相关方法 |
JP2016534086A (ja) | 2013-10-22 | 2016-11-04 | ダウ アグロサイエンシィズ エルエルシー | 相乗的有害生物防除組成物および関連する方法 |
AR098095A1 (es) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | Composiciones plaguicidas y los métodos relacionados |
RU2016119368A (ru) | 2013-10-22 | 2017-11-28 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Синергетические пестицидные композиции и связанные с ними способы |
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AU2014340443B2 (en) | 2013-10-22 | 2017-06-08 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
US9295260B2 (en) | 2013-10-22 | 2016-03-29 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
AR098094A1 (es) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | Composiciones plaguicidas sinérgicas y métodos relacionados |
CN106488908A (zh) | 2014-07-31 | 2017-03-08 | 美国陶氏益农公司 | 制备3‑(3‑氯‑1h‑吡唑‑1‑基)吡啶的方法 |
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JPH0580466A (ja) * | 1990-03-12 | 1993-04-02 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
US5073565A (en) * | 1990-04-27 | 1991-12-17 | Warner-Lambert Company | Tetrazole ureas and thioureas and their use as acat inhibitors |
LU87821A1 (fr) * | 1990-10-12 | 1992-05-25 | Cird Galderma | Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique |
GB9025509D0 (en) * | 1990-11-23 | 1991-01-09 | Fujisawa Pharmaceutical Co | New amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
DE4040619A1 (de) * | 1990-12-19 | 1992-06-25 | Boehringer Mannheim Gmbh | Neue aliphatische amide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
DK0600950T3 (da) * | 1991-08-22 | 1997-04-21 | Warner Lambert Co | Tetrazolamider som inhibitorer af ACAT |
-
1993
- 1993-02-18 US US08/019,411 patent/US5366987A/en not_active Expired - Fee Related
-
1994
- 1994-02-08 EP EP94908008A patent/EP0684945B1/en not_active Expired - Lifetime
- 1994-02-08 ES ES94908008T patent/ES2179069T3/es not_active Expired - Lifetime
- 1994-02-08 CA CA002155104A patent/CA2155104C/en not_active Expired - Fee Related
- 1994-02-08 EP EP02001573A patent/EP1203767B1/en not_active Expired - Lifetime
- 1994-02-08 WO PCT/US1994/001420 patent/WO1994019330A1/en active IP Right Grant
- 1994-02-08 JP JP51902094A patent/JP3568204B2/ja not_active Expired - Fee Related
- 1994-02-08 AU AU61358/94A patent/AU679726B2/en not_active Ceased
- 1994-02-08 AT AT94908008T patent/ATE221053T1/de not_active IP Right Cessation
- 1994-02-08 DE DE69431042T patent/DE69431042T2/de not_active Expired - Fee Related
- 1994-02-08 DK DK94908008T patent/DK0684945T3/da active
- 1994-02-08 AT AT02001573T patent/ATE315032T1/de not_active IP Right Cessation
- 1994-02-08 DE DE69434599T patent/DE69434599D1/de not_active Expired - Lifetime
- 1994-02-08 PT PT94908008T patent/PT684945E/pt unknown
- 1994-02-17 MX MX9401234A patent/MX9401234A/es not_active IP Right Cessation
- 1994-07-12 US US08/274,088 patent/US5441975A/en not_active Expired - Fee Related
-
1995
- 1995-05-03 US US08/433,776 patent/US5646170A/en not_active Expired - Fee Related
-
1997
- 1997-01-21 US US08/786,062 patent/US5693657A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP3568204B2 (ja) | 2004-09-22 |
CA2155104C (en) | 2005-11-08 |
EP1203767B1 (en) | 2006-01-04 |
EP0684945B1 (en) | 2002-07-24 |
ATE221053T1 (de) | 2002-08-15 |
CA2155104A1 (en) | 1994-09-01 |
ES2179069T3 (es) | 2003-01-16 |
DE69434599D1 (de) | 2006-03-30 |
US5366987A (en) | 1994-11-22 |
JPH08507060A (ja) | 1996-07-30 |
WO1994019330A1 (en) | 1994-09-01 |
ATE315032T1 (de) | 2006-02-15 |
EP0684945A1 (en) | 1995-12-06 |
US5441975A (en) | 1995-08-15 |
DE69431042D1 (de) | 2002-08-29 |
AU6135894A (en) | 1994-09-14 |
PT684945E (pt) | 2002-12-31 |
DE69431042T2 (de) | 2003-02-13 |
DK0684945T3 (da) | 2002-11-18 |
US5693657A (en) | 1997-12-02 |
EP1203767A1 (en) | 2002-05-08 |
US5646170A (en) | 1997-07-08 |
AU679726B2 (en) | 1997-07-10 |
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