KR890008078A - 치환 알킬 아민 유도체 - Google Patents

치환 알킬 아민 유도체 Download PDF

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KR890008078A
KR890008078A KR1019880015645A KR880015645A KR890008078A KR 890008078 A KR890008078 A KR 890008078A KR 1019880015645 A KR1019880015645 A KR 1019880015645A KR 880015645 A KR880015645 A KR 880015645A KR 890008078 A KR890008078 A KR 890008078A
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South Korea
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group
substituted
formula
compound
atom
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KR1019880015645A
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히로시 다께자와
마사히로 하야시
요시가즈 이와사와
마사아끼 호소이
요시아끼 이이다
요시미 즈찌야
마사히로 호리에
도시오 가메이
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도오야마 노리유끼
반유세이야꾸 가부시끼가이샤
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Publication of KR890008078A publication Critical patent/KR890008078A/ko

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
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    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

치환 알킬 아민 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (19)

  1. 일반식(I)의 치환 알킬아민 유도체 및 그의 무독성 염
    [식중에서, A는 메틴기, 질소원자, 산소원자, 또는 황원자를 나타내고 : Q는, 질소, 산소, 및 황원자로 구성된 군으로부터 선택된 1개 또는 2개의 헤테로원자를 포함할 수 있는 기를 나타내고 인접한 탄소원자 및 A와 함께 5원 또는 6원 방향족 고리(방향족 고리는 할로겐원자, 하드록실기, 저급 알킬기 및 저급 알콕시기로 구성된 군에서 선택된 1개의 치환체 또는 2개의 동일하거나 상이한 치환체를 포함할 수 있다)를 형성하고 : X 및 Y는 동일하거나 상이하고 각각은 산소원자, 황원자, 카르보닐기, 일반식 -CHRа- 의 기 (여기서, Ra는 수소원자 또는 저급 알킬기를 나타낸다)또는 일반식 -NRb- 의 기(여기서 Rb는 수소원자 또는 저급 알킬기를 나타낸다)를 나타내거나, X 및 Y는 함께 비닐렌 또는 에티닐렌기를 나타내고 : R¹은 치환될 수 있는 저급 일케닐기, 치환될 수 있는 시클로알케닐기, 치환될 수 있는 저급 알키닐기, 치환될 수 있는 저급 알키닐기, 치환될 수 있는 라릴기 또는 치환될 수 있는 헤테로 시클기를 나타내고 : R²는 수소원자 또는 저급 알킬기를 나타내고; R³은 수소원자, 저급 알킬기, 저급 알케닐기, 저급 알키닐기 또는 시클로알킬기를 나타내고 : R4및 R5는 동일하거나 상이하며 각각은 수소원자 또는 할레겐원자를 나타내며 : R6은 치환될 수 있는 비고리 탄화수소기 (이는 이중결합 및 삼중 결합으로부터 선택된 1 또는 2개의 불포화 결합을 포함할 수 있다)치환될 수 있는 시클로알케닐기 또는 치환될 수 있는 페닐기를 나타내고, 단 X 및 Y중 어느 하나가 산소 또는 황원자, 또는 -NRb- 기(Rb는 상기 정의한 바와 같다)를 나타낼때는, 다른 하나는 카르보닐기 또는 -CHRa-기 (Ra는 상기 정의한 바와 같다)를 나타낸다]
  2. 제 1 항에 있어서, R¹이 치환될 수 있는 아릴기 또는 헤테로시클기를 나타내고 : X가 메틸렌기를 나타내며 Y가 산소원자 또는 이미노기를 나타내거나, X 및 Y가 에틸렌기 또는 (E)-비닐렌기를 나타내고 : 식-의 방향족 고리가 벤젠, 푸란, 티오펜, 옥사졸, 이소록사졸, 티아졸, 피리딘 또는 피리미딘 고리를 나타내며 : R²가 수소원자를 나타내고, : R³가 1 내지 5탄소원자를 갖는 알킬기, 3 내지 5탄소원자를 갖는 알케닐기, 3 내지5탄소원자를 갖는 탄소 원자를 갖는 알키닐기, 또는 3 내지 5 탄소원자를 갖는 시클로알킬기를 나타내며: R⁴ 및 R5가 각각 수소원자이고 이들이 결합된 두 개의 탄소원자에 의해 형성된 이중결합이 트랜스-형 (E-형)이며: R6가 식 -CH=CH-Rc인 기 또는 식 -C=Cc인 기 (여기서 Rc, 는 1 내지 4탄소 원자를 갖는 하나의 알콕시기에 의해 치완될 수 있는 3 내지 6탄소원자를 갖는 알킬기 또는 알케닐기, 또는 1 내지 4탄소원자를 갖는 1 또는 2일킬기에 의해 치환될 수 있는 3 내지 6탄소원자를 갖는 시클로알킬기를 나타낸다)인 치환 알킬아민 유도체 및 그의 무독성 염
  3. 제 2 항에 있어서, R¹이 할로겐원자 및 시아노기, 포르밀기, 히드록시메틸기, 저급 알킬기, 저급알케닐기, 저급 알키닐기, 저급 알콕시기, 저급 알케닐옥시기, 페닐기, 푸릴기, 티에닐기, 오사졸릴기, 티아조릴기, 이소옥사졸릴기, 이소티아졸릴기, 피롤릴기, 이미다족릭기, 푸라자닐기, 피리딜기, 피라지닐기, 파라미디닐기, 피리다지닐기, 1,3,5-트리아지닐기, 1,3,4-옥사디아졸릭기, 및 1,3,4-티아디아졸릴기로 구성되는 군에서 선택된 하나의 치환체, 또는 두 개의 동일하거나 상이한 치환체를 가질수 있는 아릴기 또는 방향족 헤테로시클기인 치환 알킬 아민 유도체 및 그의 무독성 염
  4. 제 3 항에 있어서, 방향족 헤테로시클기가 질소, 산소 및 황원자로 구성되는 군에서 선택된 1 내지 3헤테로 원자를 함유하는 5-내지 12-원의 방향족 헤테로 시클기인 치환 알킬 아민 유도체 및 그의 무독성 염
  5. 제 2 항에 있어서, R¹이 할로겐 원자 및 히드록실기, 시아노기, 포르밀기, 히드록시메틸기, C₁~C₃알킬기, C3~C5알케닐기, C3~C5알키닐기, C₁~C₃ 알콕시기, C3~C5알케닐옥시기, 페닐기, 푸릴기, 티에닐기, 옥사졸릴기, 티아졸릴기, 이소옥사졸릴기, 피롤릴기, 및 이미다졸릴기로 구성되는 군에서 선택된 하나의 치환체 또는 두 개의 동일하거나 상이한 치환체를 가질 수 있는 페닐기, 나프틸기, 푸릴기, 티에닐기, 피리딜기 옥사졸릴기, 티아졸릴기, 이소옥사졸릴기, 이소티아졸릴기, 피라지릴기, 피라마디닐기, 파라다지닐기, 1,3,5-트리아지닐기, 벤조푸라닐기, 벤조티에닐기, 벤조옥사졸릴기, 벤조티아졸릴기, 또는 벤조푸라지릴기인 치환 알킬아민 유도체 및 그의 무독성 염
  6. 제 2 항에 있어서 R¹이 2-메틸페닐기, 2-플루오로페닐기, 3-시이노페닐기, 3-(2-푸릴)페닐기, 3-(2-티에닐)페닐기, 3-(5-옥사졸릴)페닐기, 3-(1-피롤릴)페닐기, 3-(1-이미다졸릴)페닐기 또는 3-(5-티아졸릴)페닐기인 치환 알킬아민 유도체 및 그의 무독성 염
  7. 제 1 항에 있어서 R³가 1 내지 3탄소원자를 갖는 알킬기, 일릴기, 프로파길기 또는 시클로프로필기를 나타내며: R6가 일반식의 기(식중, Rd는 수소원자, 1 내지 4틴소원자를 갖는 알킬기, 또는 1 내지 4 탄소원자를 갖는 알콕시기를 나타내고, Re및 Rf는 동일하거나 상이하며 각각 메틸기 또는 에틸기를 나타내거나, 함께 시클로 프로필기를 나타낼 수 있다)인 치환 알킬 아민 유도체 및 그의 무독성 염
  8. 제 7 항에 있어서, R³가 메틸기, 에틸기 또는 프로필기를 타나내는 치환 알킬아민 유도체 및 그의 무독성 염
  9. (a)일반식(II)의 치환아민 유도체 또는 그의 적당하게 보호된 유도체를 일반식(III)의 화합물 또는 그의 적당하게 보호된 유도체와 반응시킨후, 필요하면, 보호기를제거하거나, (b)일반식(IV)의 화합물 또는 그의 적당하게 보호된 유도체를 일반식(V)의 치환아민 또는 그의 적당하게 보호된 유도체와 반응시킨후, 필요하면 보호기를 제거하고, 필요하면, 수득된 화합물을 무독성 염으로 전환시킴을 특징으로 하는 제 1 항에서 청구한 일반식(I)의 치환 알킬 아민 유도체 및 그의 무독성 염의 제조방법
    (식중, A,Q,X,Y,R1,R2,R3,R4,R5및 R6는 제 1 항에서 정의한 바와 동일하고 Z는 이탈기이다)
  10. 일반식(Ia) 의 치환 알킬아민 유도체 또는 그의 적당하게 보호된 화합물을 일반식(Ⅵ)의 화합물과 반응시키고, 필요하면 보호기를 제거하고, 필요하면 수득된 화합물을 무독성 염으로 전환시킴을 특징으로 하는 일반식(Ib) 의 치환 알킬아민 유도체 및 그의 무독성 염의 제조방법
    식중[A,Q,X,Y,R1,R2,R4,R5및 R6는 제 1 항에서 정의한 바와 동일하고, R3 ′는 저급 알킬기, 저급 알케닐기, 저급 알키닐기 또는 시클로알킬기를 나타내고, Z는 이탈기를 나타낸다]
  11. 일반식 (Ⅶ)의 화합물 또는 그의 적당하게 보호된 유도체를 일반식(Ⅷ)의 치환 아민 유도체 또는 그의 적당하게 보호된 화합물과 반응시키고, 필요하면 보호기를 제거하고, 필요하면 수득된 화합물을 무독성 염으로 전환시킴을 특징으로 하는 일반식(Ic) 의 치환 알킬 아민 유도체 또는 그의 무독성 염의 제조방법
    식중 [A,Q,R1,R2,R4,R5및 R6는 제 1 항에서 정의한 바와 동일하고, Xa는 카르보닐기 또는 식-CHRa- 의 기 (여기서, Ra는 수소원자 또는 저급 알킬기를 나타낸다)이고 Ya는 산소원자 또는 황원자 또는 식-NR5′의 기)여기서 Rb는 수소원자 또는 저급 알킬기를 나타낸다)이고, Z는 이탈기를 나타낸다]
  12. 일반식 (IX)의 화합물 또는 그의 적당하게 보호된 유도체를 일반식(X)의 치환 아민 유도체 또는 그의 적당하게 보호된 화합물과 반응시키고, 필요하면 보호기를 제거한 다음 필요하면, 수득된 화합물을 무독성 염으로 전환시킴을 특징으로 하는 일반식(Id) 의 치환 알킬 아민 유도체 또는 그의 무독성 염의 제조방법
    식중[ A,Q,R1,R2,R4,R5및 R6는 제 1 항에서 정의한 바와 동일하고, Xb는 산소원자 또는 황원자 또는 식 -NRb- 의 기)여기서 Rb는 수소원자 또는 저급 알킬기를 나타낸다)를 나타내고, Yb는 카르보닐기 또는 식 -CHRa- 의기 (여기서 Ra는 수소원자 또는 저급 알킬기를 나타낸다)를 나타내고, Z는 이탈기를 나타낸다.
  13. 제 1 항에 따른 일반식(I)의 화합물 또느 약제학적으로 허용 가능한 그의 염을 함유하는 의약
  14. 일반식 (I)의 화합물 또는 약제학적으로 허용 가능한 그의 염을 함유하는 과콜레스테롤혈중, 과지방혈증, 또는 동맥경화증의 치료제
  15. 제 1 항에 따른 일반식 (I)의 화합물 또는 약제학적으로 허용 가능한 그의 염의 유효량 및 약제학적으로 허용 가능한 담체 또는 희석제를 함유항는 약제학적 제제
  16. 치료를 필요로 하는 개인에게 제 1 항에 따른 화합물의 치료 유효량을 투여하여, 개인의 과콜레스테롤혈증, 과지방혈증, 또는 동맥경화증을 치료하는 방법
  17. 질병의 억제 또는 예방을 위한 제 1 항의 일반식 (I)의 화합물 또는 약제학적으로 허용 가능한 그의 염의 용도
  18. 과콜레스테롤혈증, 과지방혈증, 또는 동맥경화증을 억제 또는 예방하기 위한 제 1 항의 일반식(I)화합물 또는 약제학적으로 허용 가능한 그의 염의 용도
  19. 제 1 항의 일반식(I) 화합물 또는 약제학적으로 허용 가능한 그의 염을 함유하는 스쿠알렌옥시다제 저해제.
KR1019880015645A 1987-11-27 1988-11-26 치환 알킬 아민 유도체 KR890008078A (ko)

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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3732889A (en) * 1988-11-11 1990-05-28 Banyu Pharmaceutical Co., Ltd. Substituted allylamine derivatives, process for their preparation and their use
FR2655043B1 (fr) * 1989-11-24 1992-02-07 Adir Nouveaux derives du thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5202471A (en) * 1990-02-06 1993-04-13 Allergan, Inc. Alkyl, alkoxy and thioalkoxy substituted diphenyl acetylenes having retinoid like activity
AU634871B2 (en) * 1990-03-20 1993-03-04 Banyu Pharmaceutical Co., Ltd. Substituted amine derivatives having anti-hyperlipemia activity
US5135935A (en) * 1991-05-17 1992-08-04 Merck & Co., Inc. Squalene synthetase inhibitors
EP0526936A3 (en) 1991-08-02 1993-05-05 Merck & Co. Inc. Cholesterol-lowering agents
DE4216941A1 (de) * 1992-05-22 1993-11-25 Basf Ag Para-substituierte Benzylamine und diese enthaltende therapeutische Mittel
CA2114641A1 (en) * 1992-06-01 1993-12-09 Yoshimi Tsuchiya Substituted heterocyclic derivative having squalene epoxidase inhibition action and its use
US5405873A (en) * 1992-09-10 1995-04-11 Banyu Pharmaceutical Co., Ltd. Substituted acetamide derivatives
WO1994018191A1 (en) * 1993-02-05 1994-08-18 Yamanouchi Pharmaceutical Co., Ltd. Novel amine derivative
US5861496A (en) * 1996-11-07 1999-01-19 Incyte Pharmaceuticals, Inc. Human squalene epoxidase
US6706751B2 (en) 2000-12-21 2004-03-16 Hoffman-La Roche Inc. Dihydroindole and tetrahydroquinoline derivatives
GB0103046D0 (en) * 2001-02-07 2001-03-21 Novartis Ag Organic Compounds
AU2015308350B2 (en) 2014-08-29 2020-03-05 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
CN109952292A (zh) 2016-10-14 2019-06-28 Tes制药有限责任公司 α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂
AR117122A1 (es) 2018-11-20 2021-07-14 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024587B1 (en) 1979-08-22 1984-11-14 Sandoz Ag Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
DE3040912A1 (de) * 1980-10-30 1982-06-09 Bayer Ag, 5090 Leverkusen 4-benzyloxy-(alpha)-trichlormethyl-benzylamine, ein verfahren zu ihrer herstellung, sie enthaltende schaedlingsbekaempfungsmittel, ihre herstellung und verwendung
JPS5798262A (en) * 1980-12-10 1982-06-18 Yoshitomi Pharmaceut Ind Ltd Pyridine derivative
CH648030A5 (de) 1980-12-15 1985-02-28 Sandoz Ag Benzopyran-allylaminderivate, verfahren zu ihrer herstellung und ihre verwendung.
FR2526423B1 (fr) 1982-05-07 1987-07-10 Sandoz Sa Nouvelles amines insaturees, leur preparation et leur utilisation comme medicaments
US4609732A (en) * 1986-01-03 1986-09-02 Fmc Corporation 2-(alpha-perhaloalkylbenzyloxy)pyridyl insecticide intermediates
JPS62201850A (ja) 1986-01-29 1987-09-05 サンド・アクチエンゲゼルシヤフト アミン誘導体類とその製造方法、および用途
NL8700083A (nl) * 1986-01-29 1987-08-17 Sandoz Ag Tegen schimmels werkende aminen, werkwijzen voor de bereiding daarvan en hun toepassing.
US4751245A (en) 1986-06-25 1988-06-14 E. R. Squibb & Sons, Inc. Antifungal derivatives of N-(6,6-dimethyl-2-hepten-4-ynyl)-1-naphthalenemethanamine and method of using same
JPH0451986A (ja) 1990-06-19 1992-02-20 Nec Home Electron Ltd コンピュータ・システム

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EP0318860A2 (en) 1989-06-07
ATE90666T1 (de) 1993-07-15
DK657988D0 (da) 1988-11-25
IL88473A0 (en) 1989-06-30
AU2594488A (en) 1989-06-29
CA1319689C (en) 1993-06-29
DE3881842D1 (de) 1993-07-22
AU619782B2 (en) 1992-02-06
DK657988A (da) 1989-05-28
PT89089B (pt) 1993-03-31
EP0318860A3 (en) 1990-08-29
PT89089A (pt) 1988-12-01
CN1037141A (zh) 1989-11-15
IL88473A (en) 1993-02-21
DE3881842T2 (de) 1993-11-04
EP0318860B1 (en) 1993-06-16
NZ227042A (en) 1991-05-28

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