MX9302906A - Derivados de mercaptoacetilamida novedosos utiles como inhibidores de la encefalinasa. - Google Patents
Derivados de mercaptoacetilamida novedosos utiles como inhibidores de la encefalinasa.Info
- Publication number
- MX9302906A MX9302906A MX9302906A MX9302906A MX9302906A MX 9302906 A MX9302906 A MX 9302906A MX 9302906 A MX9302906 A MX 9302906A MX 9302906 A MX9302906 A MX 9302906A MX 9302906 A MX9302906 A MX 9302906A
- Authority
- MX
- Mexico
- Prior art keywords
- novelly
- derivatives useful
- encephalinase
- inhibitors
- mercaptoacetylamide derivatives
- Prior art date
Links
- GYXHHICIFZSKKZ-UHFFFAOYSA-N 2-sulfanylacetamide Chemical class NC(=O)CS GYXHHICIFZSKKZ-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 102400000748 Beta-endorphin Human genes 0.000 abstract 1
- 101800005049 Beta-endorphin Proteins 0.000 abstract 1
- 102400000967 Bradykinin Human genes 0.000 abstract 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- 108010049140 Endorphins Proteins 0.000 abstract 1
- 102000009025 Endorphins Human genes 0.000 abstract 1
- 108010092674 Enkephalins Proteins 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- URLZCHNOLZSCCA-VABKMULXSA-N Leu-enkephalin Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 URLZCHNOLZSCCA-VABKMULXSA-N 0.000 abstract 1
- 108020001621 Natriuretic Peptide Proteins 0.000 abstract 1
- 102000004571 Natriuretic peptide Human genes 0.000 abstract 1
- WOPZMFQRCBYPJU-NTXHZHDSSA-N beta-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CC=CC=C1 WOPZMFQRCBYPJU-NTXHZHDSSA-N 0.000 abstract 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000002792 enkephalinase inhibitor Substances 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000000692 natriuretic peptide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/886,029 US5238932A (en) | 1992-05-20 | 1992-05-20 | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9302906A true MX9302906A (es) | 1993-11-01 |
Family
ID=25388225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9302906A MX9302906A (es) | 1992-05-20 | 1993-05-19 | Derivados de mercaptoacetilamida novedosos utiles como inhibidores de la encefalinasa. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5238932A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0641343B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP3295848B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR100281608B1 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE243694T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU669716B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2135751C (cg-RX-API-DMAC10.html) |
| DE (1) | DE69333062T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK0641343T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2201058T3 (cg-RX-API-DMAC10.html) |
| FI (1) | FI108136B (cg-RX-API-DMAC10.html) |
| HU (1) | HUT71107A (cg-RX-API-DMAC10.html) |
| IL (1) | IL105727A (cg-RX-API-DMAC10.html) |
| MX (1) | MX9302906A (cg-RX-API-DMAC10.html) |
| NO (1) | NO302366B1 (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ252785A (cg-RX-API-DMAC10.html) |
| PT (1) | PT641343E (cg-RX-API-DMAC10.html) |
| TW (1) | TW269682B (cg-RX-API-DMAC10.html) |
| WO (1) | WO1993023397A1 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA933423B (cg-RX-API-DMAC10.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5308841A (en) * | 1990-12-21 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| EP0534363B1 (en) * | 1991-09-27 | 1997-07-09 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| CA2078759C (en) * | 1991-09-27 | 2003-09-16 | Alan M. Warshawsky | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace |
| US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| JP3460838B2 (ja) * | 1992-02-14 | 2003-10-27 | メレルファーマスーティカルズインコーポレイテッド | エンケファリナーゼ及びａｃｅの阻害剤として有用な，アミノアセチルメルカプトアセチルアミド誘導体類 |
| US5420271A (en) * | 1992-08-24 | 1995-05-30 | Merrell Dow Pharmaceuticals, Inc. | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| CA2146238C (en) * | 1992-10-30 | 2001-03-13 | Gary A. Flynn | Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace |
| CA2140553A1 (en) * | 1993-06-11 | 1994-12-22 | Hitoshi Oinuma | Amino acid derivative |
| AU680512B2 (en) * | 1993-06-11 | 1997-07-31 | Eisai Co. Ltd. | Amino acid derivative |
| EP0746566A1 (en) * | 1994-02-14 | 1996-12-11 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| KR100364947B1 (ko) * | 1994-02-14 | 2003-03-06 | 메렐 파마슈티칼스 인크. | 엔케팔리나제및ace의억제제로서유용한신규의머캅토아세틸아미도1,3,4,5-테트라히드로-벤조[c]아제핀-3-온디술파이드유도체 |
| US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
| DE69524064T2 (de) * | 1994-02-14 | 2002-07-11 | Merrell Pharmaceuticals Inc., Cincinnati | Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren |
| CA2183320C (en) * | 1994-02-14 | 1999-10-26 | Gary A. Flynn | Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
| EP0751774B1 (en) * | 1994-03-24 | 2003-08-13 | Merrell Pharmaceuticals Inc. | Hypocholesterolemic mercaptoacetylamide disulfide derivatives |
| WO1995025532A1 (en) * | 1994-03-24 | 1995-09-28 | Merrell Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives |
| DE69533002T2 (de) * | 1994-12-21 | 2005-05-04 | Aventis Pharmaceuticals Inc. | Verfahren zur Herstellung von Zwischenprodukten von Inhibitoren Von Enkephalinase und Angiotensin konvertierendem Enzym und Zwischenprodukte davon |
| US5641880A (en) * | 1994-12-21 | 1997-06-24 | Hoechst Marion Roussel, Inc. | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
| US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
| US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
| US6635632B1 (en) * | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| IT1298268B1 (it) * | 1998-02-18 | 1999-12-20 | Zambon Spa | Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico |
| US6774125B2 (en) * | 1998-06-22 | 2004-08-10 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
| US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6569851B1 (en) * | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| WO2000041686A1 (en) * | 1999-01-12 | 2000-07-20 | Seymour Ehrenpreis | Treatment of hypertension with compounds that inhibit the destruction of enkephalins or endorphins |
| AU2001281464A1 (en) * | 2000-03-13 | 2001-09-24 | Monsanto Technology Llc | Recombinant proteins containing repeating units |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
| US20050192265A1 (en) * | 2003-03-20 | 2005-09-01 | Thompson Richard C. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
| CN116535304B (zh) * | 2023-03-31 | 2024-07-19 | 中国科学院成都生物研究所 | 毛兰素类似物及其合成方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
| GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
| NZ204130A (en) * | 1982-05-12 | 1986-03-14 | Hoffmann La Roche | Bicyclic heterocyclic compounds and pharmaceutical compositions |
| US4584294A (en) * | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
| JPH0678531B2 (ja) * | 1986-06-11 | 1994-10-05 | 株式会社日立製作所 | 石炭ガス化方法及び装置 |
| CA1337654C (en) * | 1986-06-13 | 1995-11-28 | Gary A. Flynn | Fused tricyclic lactams as antihypertensive agents |
| ZA874106B (en) * | 1986-06-13 | 1987-12-08 | Merrell Dow Pharmaceuticals Inc. | Novel antihypertensive agent |
| US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
| US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
| GB8926512D0 (en) * | 1989-11-23 | 1990-01-10 | Pfizer Ltd | Therapeutic agents |
| WO1991009840A1 (en) * | 1989-12-22 | 1991-07-11 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
| CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
-
1992
- 1992-05-20 US US07/886,029 patent/US5238932A/en not_active Expired - Fee Related
-
1993
- 1993-04-06 WO PCT/US1993/003150 patent/WO1993023397A1/en not_active Ceased
- 1993-04-06 JP JP52021093A patent/JP3295848B2/ja not_active Expired - Fee Related
- 1993-04-06 DE DE69333062T patent/DE69333062T2/de not_active Expired - Fee Related
- 1993-04-06 KR KR1019940704127A patent/KR100281608B1/ko not_active Expired - Fee Related
- 1993-04-06 DK DK93912116T patent/DK0641343T3/da active
- 1993-04-06 AU AU42779/93A patent/AU669716B2/en not_active Ceased
- 1993-04-06 PT PT93912116T patent/PT641343E/pt unknown
- 1993-04-06 EP EP93912116A patent/EP0641343B1/en not_active Expired - Lifetime
- 1993-04-06 ES ES93912116T patent/ES2201058T3/es not_active Expired - Lifetime
- 1993-04-06 AT AT93912116T patent/ATE243694T1/de not_active IP Right Cessation
- 1993-04-06 HU HU9403323A patent/HUT71107A/hu unknown
- 1993-04-06 NZ NZ252785A patent/NZ252785A/en not_active IP Right Cessation
- 1993-04-06 CA CA002135751A patent/CA2135751C/en not_active Expired - Fee Related
- 1993-05-17 ZA ZA933423A patent/ZA933423B/xx unknown
- 1993-05-18 IL IL10572793A patent/IL105727A/xx not_active IP Right Cessation
- 1993-05-18 TW TW082103913A patent/TW269682B/zh active
- 1993-05-19 MX MX9302906A patent/MX9302906A/es not_active IP Right Cessation
-
1994
- 1994-11-18 NO NO944430A patent/NO302366B1/no unknown
- 1994-11-18 FI FI945434A patent/FI108136B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0641343A1 (en) | 1995-03-08 |
| NO944430L (no) | 1995-01-17 |
| IL105727A (en) | 2000-11-21 |
| ATE243694T1 (de) | 2003-07-15 |
| FI945434A0 (fi) | 1994-11-18 |
| TW269682B (cg-RX-API-DMAC10.html) | 1996-02-01 |
| AU4277993A (en) | 1993-12-13 |
| FI945434L (fi) | 1994-11-18 |
| NO302366B1 (no) | 1998-02-23 |
| ZA933423B (en) | 1993-12-08 |
| IL105727A0 (en) | 1993-09-22 |
| NZ252785A (en) | 1995-11-27 |
| FI108136B (fi) | 2001-11-30 |
| EP0641343B1 (en) | 2003-06-25 |
| HUT71107A (en) | 1995-11-28 |
| JP3295848B2 (ja) | 2002-06-24 |
| US5238932A (en) | 1993-08-24 |
| DE69333062D1 (de) | 2003-07-31 |
| DK0641343T3 (da) | 2003-10-13 |
| CA2135751A1 (en) | 1993-11-25 |
| ES2201058T3 (es) | 2004-03-16 |
| KR950701632A (ko) | 1995-04-28 |
| NO944430D0 (no) | 1994-11-18 |
| AU669716B2 (en) | 1996-06-20 |
| DE69333062T2 (de) | 2004-05-06 |
| HU9403323D0 (en) | 1995-02-28 |
| PT641343E (pt) | 2003-10-31 |
| WO1993023397A1 (en) | 1993-11-25 |
| JPH07506827A (ja) | 1995-07-27 |
| CA2135751C (en) | 1999-09-21 |
| KR100281608B1 (ko) | 2001-02-15 |
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