MX9205985A - Epitopes de las celulas t de los alergenos principales del genero dermatophagoides y composiciones farmaceuticas que los contienen. - Google Patents

Epitopes de las celulas t de los alergenos principales del genero dermatophagoides y composiciones farmaceuticas que los contienen.

Info

Publication number
MX9205985A
MX9205985A MX9205985A MX9205985A MX9205985A MX 9205985 A MX9205985 A MX 9205985A MX 9205985 A MX9205985 A MX 9205985A MX 9205985 A MX9205985 A MX 9205985A MX 9205985 A MX9205985 A MX 9205985A
Authority
MX
Mexico
Prior art keywords
peptides
der
genus
epitopes
allergens
Prior art date
Application number
MX9205985A
Other languages
English (en)
Inventor
Richard D Garman
Julia L Greenstein
Mei-Chang Kuo
Bruce L Rogers
Original Assignee
Immulogig Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immulogig Pharmaceutical Corp filed Critical Immulogig Pharmaceutical Corp
Publication of MX9205985A publication Critical patent/MX9205985A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Insects & Arthropods (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Housing For Livestock And Birds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención proporciona péptidos aislados de alergenos de la proteína principal del género Dermatophagoides. Los péptidos dentro del alcance de la invención, comprenden por lo menos un epítopes de células T, o de preferencia por lo menos dos epítopes de las células T de un alergeno proteíco seleccionado de los alergenos Der p I, Der p II, Der f I, o Der f II. La invención también se relaciona con péptidos modificados que tienen propiedades similares o aumentadas que el alergeno o porción del mismo correspondiente, que se presenta en forma natural, pero que tiene efectos laterales reducidos. La invención proporciona además secuencias de ácidos nucleicos que codifican para los péptidos de la invención.
MX9205985A 1991-10-16 1992-10-16 Epitopes de las celulas t de los alergenos principales del genero dermatophagoides y composiciones farmaceuticas que los contienen. MX9205985A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77785991A 1991-10-16 1991-10-16
US88139692A 1992-05-08 1992-05-08

Publications (1)

Publication Number Publication Date
MX9205985A true MX9205985A (es) 1993-08-01

Family

ID=27119374

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9205985A MX9205985A (es) 1991-10-16 1992-10-16 Epitopes de las celulas t de los alergenos principales del genero dermatophagoides y composiciones farmaceuticas que los contienen.

Country Status (15)

Country Link
EP (1) EP0623168B1 (es)
JP (2) JPH07502890A (es)
KR (1) KR100260342B1 (es)
AT (1) ATE444360T1 (es)
AU (1) AU676668B2 (es)
DE (1) DE69233772D1 (es)
ES (1) ES2334179T3 (es)
FI (1) FI110385B (es)
HU (1) HU220462B1 (es)
IL (1) IL103452A (es)
MX (1) MX9205985A (es)
NO (1) NO314586B1 (es)
NZ (1) NZ244772A (es)
PT (1) PT100979B (es)
WO (1) WO1993008279A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5433948A (en) * 1990-02-13 1995-07-18 Thomas; Wayne R. Cloning and sequencing of allergens of dermatophagoides (house dust mite)
WO1994024281A1 (en) * 1993-04-14 1994-10-27 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
WO1994004572A1 (en) * 1992-08-14 1994-03-03 Torii & Co., Ltd. Allergenic peptide
AU674584B2 (en) * 1993-06-02 1997-01-02 Tvw Telethon Institute For Child Health Research Cryptic peptides for use in inducing immunologic tolerance
EP0714662A4 (en) * 1993-07-16 1997-11-12 Meiji Milk Prod Co Ltd ANTIALLERGY AGENT
KR100733887B1 (ko) * 1993-12-08 2007-12-20 헤스카 코포레이션 DerpⅢ단백질알레르겐을암호화하는분리된핵산
US6180771B1 (en) 1993-12-08 2001-01-30 Immulogic Pharmaceutical Corp. Nucleic acids encoding a house dust mite allergen, Der p III, and uses therefor
JP3520089B2 (ja) * 1993-12-22 2004-04-19 アサヒビール株式会社 新規な組換えＤｅｒｌアレルゲン物質、そのプロ体及びこれらの産生方法
JPH07215996A (ja) * 1994-01-31 1995-08-15 Torii Yakuhin Kk ダニアレルゲンのｂ細胞エピトープ
WO1995028424A1 (en) * 1994-04-14 1995-10-26 Immulogic Pharmaceutical Corporation Pharmaceutical peptide formulations for treatment of dust mite allergy
SE9403526D0 (sv) 1994-10-14 1994-10-14 Astra Ab New Peptides
SE9501067D0 (sv) 1995-03-24 1995-03-24 Astra Ab New peptides
GB2326642B (en) 1996-03-21 2001-02-07 Imperial College Cryptic peptides and method for their identification
EP0958834B1 (en) 1996-11-13 2007-07-04 Meiji Dairies Corporation Use of peptide-based immunotherapeutic agent
AR020102A1 (es) * 1998-07-30 2002-04-10 Ucb Sa Compuesto para la prevencion y/o tratamiento de la alergia; composicion farmaceutica, composicion cosmetica, composicion en forma de bebida, alimento y/oalimento para animales domesticos que lo comprende y uso de dicho compuesto o dicha composicion farmaceutica para la fabricacion de un alimento
GB0006437D0 (en) 2000-03-17 2000-05-10 Leuven Res & Dev Vzw Compounds for the modulation of allergen sensitivity by antigens sharing T cell epitopes with allergens
FR2809413B1 (fr) * 2000-05-29 2004-10-22 Tabacs & Allumettes Ind Production d'allergenes recombinants dans des cellules vegetales
GB0108752D0 (en) * 2001-04-06 2001-05-30 Isis Innovation Peptide epitopes and uses thereof
EP2476437B1 (en) 2006-08-11 2018-11-28 Life Sciences Research Partners VZW Immunogenic peptides and their use in immune disorders
GB0710529D0 (en) 2007-06-01 2007-07-11 Circassia Ltd Vaccine
SI2083856T1 (sl) 2007-08-15 2011-02-28 Circassia Ltd Peptidi za desenzibilizacijo proti alergijam
WO2009101205A2 (en) 2008-02-14 2009-08-20 Life Sciences Research Partners Vzw Immunogenic control of tumours and tumour cells
EP2623124A1 (en) 2008-02-14 2013-08-07 Life Sciences Research Partners VZW Elimination of immune responses to viral vectors
US20120009678A1 (en) 2008-02-14 2012-01-12 Jean-Marie Saint-Remy Immunotherapy targeting intracellular pathogens
EP2245059B1 (en) 2008-02-14 2017-09-20 Life Sciences Research Partners VZW Cd4+ t-cells with cytolytic properties
WO2010018384A1 (en) * 2008-08-15 2010-02-18 Circassia Limited T-cell antigen peptide from allergen for stimulation of il-10 production
GB0821806D0 (en) 2008-11-28 2009-01-07 Circassia Ltd Compositions with reduced dimer formation
DK2643345T5 (da) 2010-11-25 2021-05-17 Imnate Sarl Immunogene peptider til anvendelse til forebyggelse og/eller behandling af infektionssygdomme, autoimmune sygdomme, immunresponser på allofaktorer, allergisygdomme, tumorer, transplantatafstødning og immunresponser på virusvektorer anvendt til genterapi eller genvaccination
GB201201511D0 (en) 2012-01-30 2012-03-14 Univ Leuven Kath Modified epitopes for boosting CD4+ T-cell responses
GB201309469D0 (en) 2013-05-28 2013-07-10 Imcyse Sa Detection of CD4+ T lymphocytes
CA2914037A1 (en) * 2013-06-06 2014-12-11 Anergis S.A. Contiguous overlapping peptides for treatment of house dust mites allergy
US10729791B2 (en) 2015-05-18 2020-08-04 Imcyse Sa Animal models for evaluating pharmaceutical compounds
ES2874077T3 (es) 2015-09-25 2021-11-04 Imcyse Sa Métodos y compuestos mejorados para eliminar respuestas inmunitarias a agentes terapéuticos
KR20180134935A (ko) 2016-04-19 2018-12-19 임시스 에스에이 신규 면역원성 CD1d 결합 펩티드
EP3541420A2 (en) * 2016-11-16 2019-09-25 Immunomic Therapeutics, Inc. Nucleic acids for treatment of allergies
KR102010436B1 (ko) * 2018-02-28 2019-08-13 을지대학교 산학협력단 신규 알러지 반응 검사용 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234569A (en) * 1978-10-04 1980-11-18 The Johns Hopkins University Production of aldehyde-treated allergen-containing substances
AU624077B2 (en) * 1987-06-17 1992-06-04 Institute For Child Health Research Cloning of mite allergens
FR2650181B1 (fr) * 1989-07-27 1993-12-03 Laboratoire Stallergenes Procede pour combiner un melange de substances heterogenes a des liposomes
JP3251012B2 (ja) * 1989-11-03 2002-01-28 イミユロジク・フアーマシユーチカル・コーポレーシヨン 室内塵から単離したヒトｔ細胞反応性猫蛋白質（ｔｒｆｐ）及びその利用
JP2596466B2 (ja) * 1990-03-03 1997-04-02 アサヒビール株式会社 ダニの主要アレルゲンの還伝情報を有するｄｎａおよび該アレルゲンの製造方法
KR100274321B1 (ko) * 1990-09-11 2000-12-15 스미드 이. 그레이엄 데르마토파고이디즈(집 먼지 진드기)의 알레르기 항원의 클로닝 및 서열결정

Also Published As

Publication number Publication date
PT100979A (pt) 1994-01-31
NO314586B1 (no) 2003-04-14
AU2865492A (en) 1993-05-21
NZ244772A (en) 1995-09-26
HUT71211A (en) 1995-11-28
PT100979B (pt) 1999-08-31
ATE444360T1 (de) 2009-10-15
EP0623168A1 (en) 1994-11-09
WO1993008279A1 (en) 1993-04-29
HU220462B1 (hu) 2002-02-28
NO941371D0 (no) 1994-04-15
JPH07502890A (ja) 1995-03-30
HU9401108D0 (en) 1994-08-29
IL103452A0 (en) 1993-03-15
DE69233772D1 (de) 2009-11-12
FI941757A (fi) 1994-06-16
JP2009005709A (ja) 2009-01-15
IL103452A (en) 2004-07-25
FI110385B (fi) 2003-01-15
ES2334179T3 (es) 2010-03-05
NO941371L (no) 1994-06-15
EP0623168B1 (en) 2009-09-30
KR940702936A (ko) 1994-09-17
FI941757A0 (fi) 1994-04-15
KR100260342B1 (ko) 2000-07-01
AU676668B2 (en) 1997-03-20

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