WO1994021675A3 - T cell epitopes of ryegrass pollen allergen - Google Patents

T cell epitopes of ryegrass pollen allergen Download PDF

Info

Publication number
WO1994021675A3
WO1994021675A3 PCT/US1994/002537 US9402537W WO9421675A3 WO 1994021675 A3 WO1994021675 A3 WO 1994021675A3 US 9402537 W US9402537 W US 9402537W WO 9421675 A3 WO9421675 A3 WO 9421675A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
lol
allergen
cell epitopes
diagnostic
Prior art date
Application number
PCT/US1994/002537
Other languages
French (fr)
Other versions
WO1994021675A2 (en
Inventor
Irwin J Griffith
Mei-Chang Kuo
Mohammad Luqman
Stephen Palmer Powers
Original Assignee
Immulogic Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immulogic Pharma Corp filed Critical Immulogic Pharma Corp
Priority to AU65175/94A priority Critical patent/AU684501B2/en
Priority to EP94912761A priority patent/EP0688338A1/en
Priority to NZ263913A priority patent/NZ263913A/en
Priority to JP6521096A priority patent/JPH08509966A/en
Publication of WO1994021675A2 publication Critical patent/WO1994021675A2/en
Publication of WO1994021675A3 publication Critical patent/WO1994021675A3/en
Priority to NO953571A priority patent/NO953571L/en
Priority to FI954269A priority patent/FI954269A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides isolated peptides of Lol p I, a major protein allergen of the species Lolium perenne. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen of Lol p I. The invention also provides modified peptides having similar or enhanced therapeutic or diagnostic properties as the corresponding, naturally-occurring allergen or portion thereof, but having additional properties, e.g., reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment and diagnosis of sensitivity to Lol p I or an allergen immunologically related to Lol p I in an individual (such as Dac g I, Poa p I, or Phl p I) also are provided. Compositions for therapeutic, diagnostic or reagent uses comprising one or more peptides of the invention are also provided.
PCT/US1994/002537 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen WO1994021675A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU65175/94A AU684501B2 (en) 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen
EP94912761A EP0688338A1 (en) 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen
NZ263913A NZ263913A (en) 1993-03-12 1994-03-09 Lol pi protein allergen from ryegrass and related peptides coding sequences, vectors, protein production and use
JP6521096A JPH08509966A (en) 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen
NO953571A NO953571L (en) 1993-03-12 1995-09-11 T-cell epitopes of common raigress pollen allergen
FI954269A FI954269A (en) 1993-03-12 1995-09-12 T-cell epitopes of ryegrass pollen antigen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3100193A 1993-03-12 1993-03-12
US08/031,001 1993-03-12

Publications (2)

Publication Number Publication Date
WO1994021675A2 WO1994021675A2 (en) 1994-09-29
WO1994021675A3 true WO1994021675A3 (en) 1994-11-10

Family

ID=21857138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/002537 WO1994021675A2 (en) 1993-03-12 1994-03-09 T cell epitopes of ryegrass pollen allergen

Country Status (10)

Country Link
EP (1) EP0688338A1 (en)
JP (1) JPH08509966A (en)
AU (1) AU684501B2 (en)
CA (1) CA2157596A1 (en)
FI (1) FI954269A (en)
IL (1) IL108940A0 (en)
NO (1) NO953571L (en)
NZ (1) NZ263913A (en)
WO (1) WO1994021675A2 (en)
ZA (1) ZA941708B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652485B2 (en) 2007-08-15 2014-02-18 Circassia Limited Peptide for vaccine

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858689A (en) * 1993-07-22 1999-01-12 Ludwig Institute For Cancer Research Isolated peptides derived from the gage tumor rejection antigen precursor and uses thereof
SE9402089D0 (en) * 1994-06-14 1994-06-14 Rudolf Valenta Recombinant allergen, fragments thereof, corresponding recombinant DNA molecules, vectors and hosts containing the DNA molecules, diagnostic and therapeutic uses of said allergens and fragments
US6759234B1 (en) 1994-09-02 2004-07-06 Immulogic Pharmaceutical Corporation Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response
JPH10505356A (en) * 1994-09-02 1998-05-26 イミユロジク・フアーマシユーチカル・コーポレーシヨン Compositions and methods for administration to humans, peptides capable of down-regulating an antigen-specific immune response
JP4340329B2 (en) 1996-03-21 2009-10-07 サーカッシア リミテッド Latent peptides and methods for identifying them
US5817463A (en) * 1996-06-28 1998-10-06 Abbott Laboratories Nucleic acid primers and probes for detecting Mycoplasma pneumoniae
US7879977B2 (en) 1998-01-31 2011-02-01 University Of Arkansas Methods and reagents for decreasing clinical reaction to allergy
ATE430199T1 (en) 1998-01-31 2009-05-15 Univ Arkansas METHODS AND REAGENTS FOR REDUCING THE CLINICAL RESPONSE TO ALLERGY
AU2001219510B2 (en) 2000-04-06 2007-06-14 Allertein Therapeutics, Llc Microbial delivery system
US8246945B2 (en) 2000-04-06 2012-08-21 University Of Arkansas Methods and reagents for decreasing clinical reaction to allergy
FR2809415B1 (en) * 2000-05-29 2004-10-08 Tabacs & Allumettes Ind CLONING AND SEQUENCING OF DAC G1 ALLERGEN FROM DACTILYS GLOMERATA POLLEN, ITS PREPARATION AND ITS USE
AUPR779201A0 (en) * 2001-09-20 2001-10-11 University Of Melbourne, The Immunotherapeutic and immunoprophylactic reagents
AU2003213861B2 (en) * 2002-04-02 2010-04-29 Circassia Limited Immunotherapeutic and immunoprophylactic reagents
AUPS148202A0 (en) * 2002-04-02 2002-05-09 Monash University Immunotherapeutic and immunoprophylactic reagents
GB0710529D0 (en) 2007-06-01 2007-07-11 Circassia Ltd Vaccine
PL2393830T3 (en) 2009-02-05 2015-07-31 Circassia Ltd Grass peptides for vaccine
EP2249162A1 (en) * 2009-04-30 2010-11-10 Stallergenes Sa Method for grass species identification
WO2017004561A1 (en) 2015-07-01 2017-01-05 Alk-Abelló A/S Peptide combinations and uses thereof for treating grass allergy
WO2019038668A1 (en) 2017-08-21 2019-02-28 Glycom A/S Synthetic composition for reducing allergy symptoms

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009260A1 (en) * 1988-03-23 1989-10-05 The University Of Melbourne Ryegrass pollen allergen
WO1992003550A1 (en) * 1990-08-17 1992-03-05 The University Of Melbourne Ryegrass pollen allergen
WO1993004174A1 (en) * 1991-08-16 1993-03-04 The University Of Melbourne Ryegrass pollen allergen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009260A1 (en) * 1988-03-23 1989-10-05 The University Of Melbourne Ryegrass pollen allergen
WO1992003550A1 (en) * 1990-08-17 1992-03-05 The University Of Melbourne Ryegrass pollen allergen
WO1993004174A1 (en) * 1991-08-16 1993-03-04 The University Of Melbourne Ryegrass pollen allergen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8652485B2 (en) 2007-08-15 2014-02-18 Circassia Limited Peptide for vaccine

Also Published As

Publication number Publication date
JPH08509966A (en) 1996-10-22
FI954269A0 (en) 1995-09-12
EP0688338A1 (en) 1995-12-27
FI954269A (en) 1995-09-12
NO953571L (en) 1995-11-10
AU6517594A (en) 1994-10-11
WO1994021675A2 (en) 1994-09-29
IL108940A0 (en) 1994-06-24
NO953571D0 (en) 1995-09-11
CA2157596A1 (en) 1994-09-29
ZA941708B (en) 1994-10-05
AU684501B2 (en) 1997-12-18
NZ263913A (en) 1997-10-24

Similar Documents

Publication Publication Date Title
WO1994021675A3 (en) T cell epitopes of ryegrass pollen allergen
IL103452A0 (en) T cell epitopes of the major allergens from dermatophagoides(house dust mite)
WO2000034317A3 (en) Method for reducing immunogenicity of proteins
WO1998039446A3 (en) 70 human secreted proteins
WO1998039448A3 (en) 186 human secreted proteins
WO1998040483A3 (en) 28 human secreted proteins
WO1998031800A3 (en) Human proteins
EP1053245A4 (en) 45 human secreted proteins
WO1998045712A3 (en) 20 human secreted proteins
WO1995006728A3 (en) T cell epitopes of ryegrass pollen allergen
WO2000017222A8 (en) 31 human secreted proteins
WO1993021321A3 (en) T CELL EPITOPES OF THE MAJOR ALLERGENS FROM $i(AMBROSIA ARTEMISIIFOLIA)
WO2000052136A3 (en) Human glycosylation enzymes
EP0656012A4 (en) T cell epitopes of ryegrass pollen allergen.
EP1042342A4 (en) 53 human secreted proteins
WO2001062891A3 (en) 207 human secreted proteins
EP1443055A3 (en) Interleukins-21 and 22
WO2000058339A3 (en) 50 human secreted proteins
WO2000043495A3 (en) 33 human secreted proteins
CA2160121A1 (en) T cell epitopes of the major allergens from dermatophagoides (house dust mite)
EP1428833A3 (en) 207 human secreted proteins
CA2121497A1 (en) T cell epitopes of the major allergens from dermatophagoides (house dust mite)
EP1557425A3 (en) 123 human secreted proteins
EP1394252A3 (en) 70 human secreted proteins
EP1538161A3 (en) 32 human secreted proteins

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU BB BG BR BY CA CN CZ FI HU JP KP KR KZ LK LV MG MN MW NO NZ PL RO RU SD SK UA UZ VN

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 263913

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2157596

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 954269

Country of ref document: FI

WWE Wipo information: entry into national phase

Ref document number: 1994912761

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1994912761

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1994912761

Country of ref document: EP