MX395730B - Uso de lavados alcalinos durante la cromatografia para remover impurezas. - Google Patents
Uso de lavados alcalinos durante la cromatografia para remover impurezas.Info
- Publication number
- MX395730B MX395730B MX2017011121A MX2017011121A MX395730B MX 395730 B MX395730 B MX 395730B MX 2017011121 A MX2017011121 A MX 2017011121A MX 2017011121 A MX2017011121 A MX 2017011121A MX 395730 B MX395730 B MX 395730B
- Authority
- MX
- Mexico
- Prior art keywords
- remove impurities
- protein
- interest
- during chromatography
- chromatography matrix
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562132974P | 2015-03-13 | 2015-03-13 | |
| PCT/US2016/021984 WO2016149088A1 (en) | 2015-03-13 | 2016-03-11 | Use of alkaline washes during chromatography to remove impurities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017011121A MX2017011121A (es) | 2017-11-28 |
| MX395730B true MX395730B (es) | 2025-03-25 |
Family
ID=55699796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017011121A MX395730B (es) | 2015-03-13 | 2016-03-11 | Uso de lavados alcalinos durante la cromatografia para remover impurezas. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10695693B2 (enExample) |
| EP (2) | EP4194071A1 (enExample) |
| JP (1) | JP6807859B2 (enExample) |
| KR (1) | KR102490956B1 (enExample) |
| CN (1) | CN107636005B (enExample) |
| AU (2) | AU2016233557B2 (enExample) |
| BR (1) | BR112017018365A2 (enExample) |
| CA (1) | CA2978095C (enExample) |
| EA (1) | EA035635B1 (enExample) |
| IL (1) | IL254372B (enExample) |
| MX (1) | MX395730B (enExample) |
| SG (2) | SG10201908027QA (enExample) |
| WO (1) | WO2016149088A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10738078B2 (en) * | 2014-11-03 | 2020-08-11 | Bristol-Myers Squibb Company | Use of caprylic acid precipitation for protein purification |
| BR112017018365A2 (pt) | 2015-03-13 | 2018-04-10 | Bristol-Myers Squibb Company | uso de lavagens alcalinas durante cromatografia para remoção de impurezas |
| CA3233933A1 (en) | 2017-01-30 | 2018-08-02 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for reducing bioburden in chromatography |
| WO2019246153A1 (en) * | 2018-06-19 | 2019-12-26 | Bristol-Myers Squibb Company | Methods of purifying proteins using chromatography |
| SG11202101369XA (en) * | 2018-08-17 | 2021-03-30 | Regeneron Pharma | Method and chromatography system for determining amount and purity of a multimeric protein |
| KR102270048B1 (ko) * | 2020-07-10 | 2021-06-28 | 주식회사 녹십자 | 바리셀라 조스터 바이러스 표면 단백질 항원의 생산 방법 |
| CA3116717A1 (en) * | 2018-10-31 | 2020-05-07 | Regeneron Pharmaceuticals, Inc. | Method and system of identifying and quantifying a protein |
| US20210380638A1 (en) * | 2018-12-21 | 2021-12-09 | WuXi Biologics Ireland Limited | A method for improving aggregate removal by Protein A chromatography |
| SG11202106370WA (en) | 2019-01-16 | 2021-07-29 | Regeneron Pharma | Method and system of identifying and quantifying antibody fragmentation |
| CN109870428A (zh) * | 2019-01-21 | 2019-06-11 | 江苏华泰疫苗工程技术研究有限公司 | 一种基于表面等离子共振技术的抗体定量检测方法 |
| GB201904741D0 (en) * | 2019-04-04 | 2019-05-22 | Glaxosmithkline Ip Dev Ltd | Novel process |
| KR20260058863A (ko) * | 2019-09-24 | 2026-04-29 | 리제너론 파아마슈티컬스, 인크. | 크로마토그래피의 사용 및 재생을 위한 시스템 및 방법 |
| CN114599971A (zh) * | 2019-10-14 | 2022-06-07 | 皮尔斯生物科技有限公司 | 肽纯化配制物和方法 |
| JP7817945B2 (ja) * | 2020-03-27 | 2026-02-19 | ハエマロジックス・リミテッド | 組成物および方法 |
| PE20231507A1 (es) * | 2020-10-02 | 2023-09-26 | Lilly Co Eli | Metodos para reducir el contenido de proteinas de la celula huesped en procesos de purificacion de anticuerpos y composiciones de anticuerpos que tienen un contenido reducido de proteinas de la celula huesped |
| TW202600582A (zh) * | 2024-02-20 | 2026-01-01 | 美商艾克塞里克斯公司 | 用於蛋白質純化之方法 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| JPS63276494A (ja) * | 1987-02-26 | 1988-11-14 | ダナーファーバー・キャンサー・インスチチュート・インコーポレーテッド | Ｌｆａ−３の精製法 |
| US5190859A (en) * | 1987-02-26 | 1993-03-02 | Dana-Farber Cancer Institute, Inc. | Purification of LFA-3 |
| CA1323567C (en) * | 1987-10-05 | 1993-10-26 | Gene R. Nathans | Method for purification of antibodies |
| US5476996A (en) | 1988-06-14 | 1995-12-19 | Lidak Pharmaceuticals | Human immune system in non-human animal |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) * | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) * | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| JPH07503132A (ja) | 1991-12-17 | 1995-04-06 | ジェンファーム インターナショナル，インコーポレイティド | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
| ATE139900T1 (de) | 1992-11-13 | 1996-07-15 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
| ATE370961T1 (de) * | 1998-05-06 | 2007-09-15 | Genentech Inc | Reinigung von antikörpern durch ionenaustauschchromatographie |
| NZ517202A (en) | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
| DE60131456T2 (de) | 2000-11-30 | 2008-07-10 | Medarex, Inc., Milpitas | Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern |
| EP1472275B1 (en) | 2002-02-05 | 2008-12-17 | Genentech, Inc. | Protein purification |
| US7763706B1 (en) * | 2003-07-17 | 2010-07-27 | Campina B.V. | Arginine/lysine-enriched peptides |
| BRPI0415887B1 (pt) * | 2003-10-27 | 2021-01-26 | Wyeth | métodos para a remoção de agregados de elevado peso molecular utilizando cromatografia de hidroxiapatita |
| EP1874825B1 (en) * | 2005-04-26 | 2010-03-24 | Sandoz AG | Affinity ligands |
| US8263750B2 (en) * | 2006-03-16 | 2012-09-11 | Amgen Inc. | Method for purifying a protein using protein-A affinity chromatography using an intermediate wash step |
| JP2010501623A (ja) * | 2006-08-28 | 2010-01-21 | アレス トレーディング ソシエテ アノニム | Ｆｃ含有タンパク質の精製法 |
| TW200821026A (en) | 2006-09-08 | 2008-05-16 | Wyeth Corp | Arginine wash in protein purification using affinity chromatography |
| HUE024877T2 (en) * | 2007-10-30 | 2016-02-29 | Genentech Inc | Antibody purification by cation exchange chromatography |
| CA2932207A1 (en) * | 2008-10-20 | 2010-12-09 | Abbvie Inc. | Isolation and purification of antibodies using protein a affinity chromatography |
| BR112012014937B1 (pt) | 2009-12-18 | 2021-01-19 | Novartis Ag | método de produção de um anticorpo, fragmento de anticorpo ou proteína de fusão fc purificada usando uma matriz de cromatografia de afinidade |
| JP2012001462A (ja) * | 2010-06-15 | 2012-01-05 | Kaneka Corp | 抗体精製用カラム |
| KR101953405B1 (ko) | 2011-06-01 | 2019-02-28 | 노파르티스 아게 | 친화성 크로마토그래피를 위한 세척 용액 및 방법 |
| TWI596107B (zh) * | 2013-06-25 | 2017-08-21 | 卡地拉保健有限公司 | 單株抗體之新穎純化方法 |
| WO2016031932A1 (ja) | 2014-08-27 | 2016-03-03 | 田辺三菱製薬株式会社 | アルカリ洗浄によるＦｃ領域を有するタンパク質の製造方法 |
| BR112017018365A2 (pt) | 2015-03-13 | 2018-04-10 | Bristol-Myers Squibb Company | uso de lavagens alcalinas durante cromatografia para remoção de impurezas |
-
2016
- 2016-03-11 BR BR112017018365A patent/BR112017018365A2/pt not_active Application Discontinuation
- 2016-03-11 SG SG10201908027Q patent/SG10201908027QA/en unknown
- 2016-03-11 KR KR1020177028511A patent/KR102490956B1/ko active Active
- 2016-03-11 SG SG11201707330RA patent/SG11201707330RA/en unknown
- 2016-03-11 MX MX2017011121A patent/MX395730B/es unknown
- 2016-03-11 US US15/558,033 patent/US10695693B2/en active Active
- 2016-03-11 WO PCT/US2016/021984 patent/WO2016149088A1/en not_active Ceased
- 2016-03-11 CA CA2978095A patent/CA2978095C/en active Active
- 2016-03-11 EA EA201792012A patent/EA035635B1/ru not_active IP Right Cessation
- 2016-03-11 CN CN201680015033.0A patent/CN107636005B/zh active Active
- 2016-03-11 JP JP2017548109A patent/JP6807859B2/ja active Active
- 2016-03-11 AU AU2016233557A patent/AU2016233557B2/en active Active
- 2016-03-11 EP EP22206303.4A patent/EP4194071A1/en active Pending
- 2016-03-11 EP EP16715383.2A patent/EP3268100A1/en not_active Withdrawn
-
2017
- 2017-09-07 IL IL254372A patent/IL254372B/en unknown
-
2020
- 2020-05-22 US US16/881,102 patent/US12157073B2/en active Active
-
2021
- 2021-08-26 AU AU2021221870A patent/AU2021221870A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL254372A0 (en) | 2017-11-30 |
| CN107636005A (zh) | 2018-01-26 |
| MX2017011121A (es) | 2017-11-28 |
| KR102490956B1 (ko) | 2023-01-19 |
| CN107636005B (zh) | 2021-07-16 |
| SG11201707330RA (en) | 2017-10-30 |
| US12157073B2 (en) | 2024-12-03 |
| US10695693B2 (en) | 2020-06-30 |
| CA2978095C (en) | 2022-02-15 |
| KR20170125948A (ko) | 2017-11-15 |
| IL254372B (en) | 2022-05-01 |
| AU2016233557B2 (en) | 2021-06-24 |
| SG10201908027QA (en) | 2019-10-30 |
| EP4194071A1 (en) | 2023-06-14 |
| EA201792012A1 (ru) | 2018-01-31 |
| EP3268100A1 (en) | 2018-01-17 |
| BR112017018365A2 (pt) | 2018-04-10 |
| AU2016233557A1 (en) | 2017-11-02 |
| US20200282332A1 (en) | 2020-09-10 |
| JP2018510867A (ja) | 2018-04-19 |
| WO2016149088A1 (en) | 2016-09-22 |
| AU2021221870A1 (en) | 2021-09-23 |
| US20180078876A1 (en) | 2018-03-22 |
| JP6807859B2 (ja) | 2021-01-06 |
| CA2978095A1 (en) | 2016-09-22 |
| EA035635B1 (ru) | 2020-07-17 |
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