MX394391B - Derivados de tiazina y oxazina biciclicos como inhibidores de beta-secretasa y metodos de uso. - Google Patents

Derivados de tiazina y oxazina biciclicos como inhibidores de beta-secretasa y metodos de uso.

Info

Publication number
MX394391B
MX394391B MX2019007100A MX2019007100A MX394391B MX 394391 B MX394391 B MX 394391B MX 2019007100 A MX2019007100 A MX 2019007100A MX 2019007100 A MX2019007100 A MX 2019007100A MX 394391 B MX394391 B MX 394391B
Authority
MX
Mexico
Prior art keywords
sup
compounds
beta
bace
thiazine
Prior art date
Application number
MX2019007100A
Other languages
English (en)
Spanish (es)
Other versions
MX2019007100A (es
Inventor
Aaron C Siegmund
Jennifer R Allen
Liping H Pettus
Matthew P Bourbeau
Ning Chen
Qingyian Liu
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2019007100A publication Critical patent/MX2019007100A/es
Publication of MX394391B publication Critical patent/MX394391B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
MX2019007100A 2016-12-15 2017-12-13 Derivados de tiazina y oxazina biciclicos como inhibidores de beta-secretasa y metodos de uso. MX394391B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662434719P 2016-12-15 2016-12-15
US201762570429P 2017-10-10 2017-10-10
PCT/US2017/066180 WO2018112084A1 (en) 2016-12-15 2017-12-13 Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use

Publications (2)

Publication Number Publication Date
MX2019007100A MX2019007100A (es) 2019-12-16
MX394391B true MX394391B (es) 2025-03-24

Family

ID=60888746

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007100A MX394391B (es) 2016-12-15 2017-12-13 Derivados de tiazina y oxazina biciclicos como inhibidores de beta-secretasa y metodos de uso.

Country Status (9)

Country Link
US (1) US11548903B2 (enExample)
EP (1) EP3555106B1 (enExample)
JP (1) JP7148518B2 (enExample)
AU (1) AU2017376445B2 (enExample)
CA (1) CA3047285A1 (enExample)
ES (1) ES2910367T3 (enExample)
MA (1) MA54101A (enExample)
MX (1) MX394391B (enExample)
WO (1) WO2018112084A1 (enExample)

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US11021493B2 (en) 2016-12-15 2021-06-01 Amgen Inc. 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
EP3555106B1 (en) 2016-12-15 2022-03-09 Amgen Inc. Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
US10947223B2 (en) 2016-12-15 2021-03-16 Amgen Inc. Substituted oxazines as beta-secretase inhibitors

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Also Published As

Publication number Publication date
EP3555106A1 (en) 2019-10-23
EP3555106B1 (en) 2022-03-09
JP7148518B2 (ja) 2022-10-05
AU2017376445B2 (en) 2021-09-30
MX2019007100A (es) 2019-12-16
US20200199153A1 (en) 2020-06-25
WO2018112084A1 (en) 2018-06-21
MA54101A (fr) 2021-10-27
ES2910367T3 (es) 2022-05-12
JP2020503294A (ja) 2020-01-30
AU2017376445A1 (en) 2019-07-04
CA3047285A1 (en) 2018-06-21
US11548903B2 (en) 2023-01-10

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