AU2017376445B2 - Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use - Google Patents

Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use Download PDF

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Publication number
AU2017376445B2
AU2017376445B2 AU2017376445A AU2017376445A AU2017376445B2 AU 2017376445 B2 AU2017376445 B2 AU 2017376445B2 AU 2017376445 A AU2017376445 A AU 2017376445A AU 2017376445 A AU2017376445 A AU 2017376445A AU 2017376445 B2 AU2017376445 B2 AU 2017376445B2
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fluoro
thiazin
fluorophenyl
fluorovinyl
amino
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AU2017376445A1 (en
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Jennifer R. Allen
Matthew P. Bourbeau
Ning Chen
Qingyian Liu
Liping H. Pettus
Aaron C. Siegmund
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Amgen Inc
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AU2017376445A 2016-12-15 2017-12-13 Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use Active AU2017376445B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662434719P 2016-12-15 2016-12-15
US62/434,719 2016-12-15
US201762570429P 2017-10-10 2017-10-10
US62/570,429 2017-10-10
PCT/US2017/066180 WO2018112084A1 (en) 2016-12-15 2017-12-13 Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use

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AU2017376445A1 AU2017376445A1 (en) 2019-07-04
AU2017376445B2 true AU2017376445B2 (en) 2021-09-30

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US (1) US11548903B2 (enExample)
EP (1) EP3555106B1 (enExample)
JP (1) JP7148518B2 (enExample)
AU (1) AU2017376445B2 (enExample)
CA (1) CA3047285A1 (enExample)
ES (1) ES2910367T3 (enExample)
MA (1) MA54101A (enExample)
MX (1) MX394391B (enExample)
WO (1) WO2018112084A1 (enExample)

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US11021493B2 (en) 2016-12-15 2021-06-01 Amgen Inc. 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
EP3555106B1 (en) 2016-12-15 2022-03-09 Amgen Inc. Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
US10947223B2 (en) 2016-12-15 2021-03-16 Amgen Inc. Substituted oxazines as beta-secretase inhibitors

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Also Published As

Publication number Publication date
EP3555106A1 (en) 2019-10-23
EP3555106B1 (en) 2022-03-09
JP7148518B2 (ja) 2022-10-05
MX2019007100A (es) 2019-12-16
US20200199153A1 (en) 2020-06-25
WO2018112084A1 (en) 2018-06-21
MA54101A (fr) 2021-10-27
ES2910367T3 (es) 2022-05-12
JP2020503294A (ja) 2020-01-30
AU2017376445A1 (en) 2019-07-04
CA3047285A1 (en) 2018-06-21
MX394391B (es) 2025-03-24
US11548903B2 (en) 2023-01-10

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