CA3047285A1 - Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use - Google Patents

Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use Download PDF

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Publication number
CA3047285A1
CA3047285A1 CA3047285A CA3047285A CA3047285A1 CA 3047285 A1 CA3047285 A1 CA 3047285A1 CA 3047285 A CA3047285 A CA 3047285A CA 3047285 A CA3047285 A CA 3047285A CA 3047285 A1 CA3047285 A1 CA 3047285A1
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CA
Canada
Prior art keywords
fluoro
tautomer
compound
thiazin
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3047285A
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English (en)
French (fr)
Inventor
Jennifer R. Allen
Matthew P. Bourbeau
Ning Chen
Qingyian Liu
Liping H. Pettus
Aaron C. Siegmund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA3047285A1 publication Critical patent/CA3047285A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CA3047285A 2016-12-15 2017-12-13 Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use Pending CA3047285A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662434719P 2016-12-15 2016-12-15
US62/434,719 2016-12-15
US201762570429P 2017-10-10 2017-10-10
US62/570,429 2017-10-10
PCT/US2017/066180 WO2018112084A1 (en) 2016-12-15 2017-12-13 Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use

Publications (1)

Publication Number Publication Date
CA3047285A1 true CA3047285A1 (en) 2018-06-21

Family

ID=60888746

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3047285A Pending CA3047285A1 (en) 2016-12-15 2017-12-13 Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use

Country Status (9)

Country Link
US (1) US11548903B2 (enExample)
EP (1) EP3555106B1 (enExample)
JP (1) JP7148518B2 (enExample)
AU (1) AU2017376445B2 (enExample)
CA (1) CA3047285A1 (enExample)
ES (1) ES2910367T3 (enExample)
MA (1) MA54101A (enExample)
MX (1) MX394391B (enExample)
WO (1) WO2018112084A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2011071135A1 (ja) † 2009-12-11 2013-04-22 塩野義製薬株式会社 オキサジン誘導体
EP3555084B1 (en) 2016-12-15 2022-03-16 Amgen Inc. Thiazine derivatives as beta-secretase inhibitors and methods of use
EP3555085B1 (en) 2016-12-15 2020-12-02 Amgen Inc. Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
CA3047286A1 (en) * 2016-12-15 2018-06-21 Amgen Inc. Oxazine derivatives as beta-secretase inhibitors and methods of use
EP3555106B1 (en) 2016-12-15 2022-03-09 Amgen Inc. Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
MX387729B (es) 2016-12-15 2025-03-18 Amgen Inc Derivados de dióxido de 1,4-tiazina y dióxido 1,2,4-tiadiazina como inhibidores de beta-secretasa y métodos de uso.

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Also Published As

Publication number Publication date
ES2910367T3 (es) 2022-05-12
WO2018112084A1 (en) 2018-06-21
AU2017376445A1 (en) 2019-07-04
EP3555106A1 (en) 2019-10-23
MX394391B (es) 2025-03-24
JP7148518B2 (ja) 2022-10-05
EP3555106B1 (en) 2022-03-09
US11548903B2 (en) 2023-01-10
MA54101A (fr) 2021-10-27
US20200199153A1 (en) 2020-06-25
AU2017376445B2 (en) 2021-09-30
JP2020503294A (ja) 2020-01-30
MX2019007100A (es) 2019-12-16

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