MX388696B - Derivados de oxazina como inhibidores de beta secretasa y metodos de uso. - Google Patents

Derivados de oxazina como inhibidores de beta secretasa y metodos de uso.

Info

Publication number
MX388696B
MX388696B MX2019007101A MX2019007101A MX388696B MX 388696 B MX388696 B MX 388696B MX 2019007101 A MX2019007101 A MX 2019007101A MX 2019007101 A MX2019007101 A MX 2019007101A MX 388696 B MX388696 B MX 388696B
Authority
MX
Mexico
Prior art keywords
sup
compounds
beta
bace
methods
Prior art date
Application number
MX2019007101A
Other languages
English (en)
Other versions
MX2019007101A (es
Inventor
Corey Reeves
Jennifer R Allen
Matthew P Bourbeau
Michael J Frohn
Ning Chen
Paul E Harrington
Qingyian Liu
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2019007101A publication Critical patent/MX2019007101A/es
Publication of MX388696B publication Critical patent/MX388696B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente descripción proporciona una clase de compuestos útiles para la modulación de la actividad de la enzima beta-secretasa (BACE). Los compuestos tienen una fórmula general I: (ver fórmula). Donde las variables W, X, Y, R2, R2', R3, R4, R5, R6, Y R7 de la fórmula I se definen en el presente documento. Esta descripción también proporciona composiciones farmacéuticas que comprenden los compuestos y usos de los compuesto y composiciones para el tratamiento de trastornos y/o afecciones relacionadas con la formación y el depósito de placas de amiloide beta (Aß), que resultan de la actividad biológica de BACE. Dichos trastornos mediados por BACE incluyen, por ejemplo, enfermedad de Alzheimer, déficits cognitivos, trastornos cognitivos y otras afecciones del sistema nervioso central.
MX2019007101A 2016-12-15 2017-12-13 Derivados de oxazina como inhibidores de beta secretasa y metodos de uso. MX388696B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662434711P 2016-12-15 2016-12-15
US201762570425P 2017-10-10 2017-10-10
PCT/US2017/066177 WO2018112081A1 (en) 2016-12-15 2017-12-13 Oxazine derivatives as beta-secretase inhibitors and methods of use

Publications (2)

Publication Number Publication Date
MX2019007101A MX2019007101A (es) 2019-12-16
MX388696B true MX388696B (es) 2025-03-20

Family

ID=60888744

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007101A MX388696B (es) 2016-12-15 2017-12-13 Derivados de oxazina como inhibidores de beta secretasa y metodos de uso.

Country Status (8)

Country Link
US (1) US10947223B2 (es)
EP (1) EP3555080B1 (es)
JP (1) JP7177773B2 (es)
AU (1) AU2017376441B2 (es)
CA (1) CA3047286A1 (es)
MA (1) MA52722A (es)
MX (1) MX388696B (es)
WO (1) WO2018112081A1 (es)

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Also Published As

Publication number Publication date
AU2017376441A1 (en) 2019-07-04
US10947223B2 (en) 2021-03-16
US20200207747A1 (en) 2020-07-02
MA52722A (fr) 2021-04-14
EP3555080B1 (en) 2023-09-20
WO2018112081A1 (en) 2018-06-21
MX2019007101A (es) 2019-12-16
JP7177773B2 (ja) 2022-11-24
AU2017376441B2 (en) 2021-10-14
EP3555080A1 (en) 2019-10-23
JP2020503293A (ja) 2020-01-30
CA3047286A1 (en) 2018-06-21

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