MX391332B - Sintesis de derivados de fosfato - Google Patents

Sintesis de derivados de fosfato

Info

Publication number
MX391332B
MX391332B MX2019014907A MX2019014907A MX391332B MX 391332 B MX391332 B MX 391332B MX 2019014907 A MX2019014907 A MX 2019014907A MX 2019014907 A MX2019014907 A MX 2019014907A MX 391332 B MX391332 B MX 391332B
Authority
MX
Mexico
Prior art keywords
protides
synthesis
diastereomerically pure
substantially diastereomerically
pure phosphate
Prior art date
Application number
MX2019014907A
Other languages
English (en)
Spanish (es)
Other versions
MX2019014907A (es
Inventor
Gordon Kennovin
Hugh Griffith
Mani Bushan Kotala
Venkata Lakshmi Narasimha Rao Dammalapati
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuCana plc filed Critical NuCana plc
Publication of MX2019014907A publication Critical patent/MX2019014907A/es
Publication of MX391332B publication Critical patent/MX391332B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MX2019014907A 2017-06-14 2018-06-14 Sintesis de derivados de fosfato MX391332B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1709471.5A GB201709471D0 (en) 2017-06-14 2017-06-14 Diastereoselective synthesis of hosphate derivatives
PCT/GB2018/051638 WO2018229493A2 (en) 2017-06-14 2018-06-14 Synthesis of phosphate derivatives

Publications (2)

Publication Number Publication Date
MX2019014907A MX2019014907A (es) 2020-02-13
MX391332B true MX391332B (es) 2025-03-21

Family

ID=59358400

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2019014914A MX390901B (es) 2017-06-14 2018-06-14 Síntesis de 3'-desoxiadenosina-5'-0-[fenil(benciloxi-l-alaninil)]fosfato (nuc-7738).
MX2019014907A MX391332B (es) 2017-06-14 2018-06-14 Sintesis de derivados de fosfato
MX2022003822A MX2022003822A (es) 2017-06-14 2019-12-10 Sintesis de derivados de fosfato.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019014914A MX390901B (es) 2017-06-14 2018-06-14 Síntesis de 3'-desoxiadenosina-5'-0-[fenil(benciloxi-l-alaninil)]fosfato (nuc-7738).

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022003822A MX2022003822A (es) 2017-06-14 2019-12-10 Sintesis de derivados de fosfato.

Country Status (18)

Country Link
US (4) US11414452B2 (OSRAM)
EP (2) EP3638684A2 (OSRAM)
JP (4) JP7279991B2 (OSRAM)
KR (2) KR102695300B1 (OSRAM)
CN (3) CN110753697B (OSRAM)
AU (3) AU2018284131B2 (OSRAM)
BR (1) BR112019026747A2 (OSRAM)
CA (2) CA3064177A1 (OSRAM)
CL (1) CL2019003632A1 (OSRAM)
EA (1) EA201992873A1 (OSRAM)
GB (1) GB201709471D0 (OSRAM)
IL (3) IL312228B2 (OSRAM)
MA (1) MA49379A (OSRAM)
MX (3) MX390901B (OSRAM)
PH (1) PH12019502825A1 (OSRAM)
SA (1) SA519410795B1 (OSRAM)
SG (1) SG11201911543UA (OSRAM)
WO (2) WO2018229493A2 (OSRAM)

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LT3119794T (lt) 2014-06-25 2018-02-12 NuCana plc Kompozicija, apimanti gemcitabino provaistą
MX394059B (es) 2014-11-28 2025-03-24 NuCana plc Nuevos derivados de ester fosforamidato 3'-desoxiadenosina de 2' y/o 5' aminoacido como compuestos anti-cancer
PT3386998T (pt) 2015-12-11 2021-11-30 NuCana plc Síntese diastereosseletiva de derivados fosfato e do pró-fármaco gemcitabina nuc-10311
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GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
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GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
CN112409421A (zh) * 2020-12-01 2021-02-26 上海兆维科技发展有限公司 一种3’-磷酸酯核苷的制备方法
CN119546313A (zh) 2022-05-12 2025-02-28 努卡那有限公司 使用nuc-7738的癌症治疗
EP4630433A1 (en) 2022-12-07 2025-10-15 NuCana plc Synthesis of nucleoside derivative nuc-3373

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Also Published As

Publication number Publication date
KR20200016864A (ko) 2020-02-17
CL2019003632A1 (es) 2020-08-14
CA3065682A1 (en) 2018-12-20
MA49379A (fr) 2020-04-22
EA201992873A1 (ru) 2020-05-19
US20220402962A1 (en) 2022-12-22
AU2018284131B2 (en) 2022-04-07
JP2023095954A (ja) 2023-07-06
GB201709471D0 (en) 2017-07-26
CA3064177A1 (en) 2018-12-20
AU2022204691B2 (en) 2023-11-23
BR112019026747A2 (pt) 2020-06-30
WO2018229493A2 (en) 2018-12-20
PH12019502825A1 (en) 2020-10-26
IL302559B1 (en) 2024-05-01
MX2022003822A (es) 2022-05-25
CN110753697B (zh) 2023-10-13
IL271159B1 (en) 2023-06-01
AU2022204691A1 (en) 2022-08-04
AU2024200428A1 (en) 2024-02-08
US11414452B2 (en) 2022-08-16
IL302559A (en) 2023-07-01
IL302559B2 (en) 2024-09-01
MX2019014914A (es) 2020-02-13
JP2024138523A (ja) 2024-10-08
JP2020523381A (ja) 2020-08-06
JP7525687B2 (ja) 2024-07-30
IL271159A (en) 2020-01-30
IL312228B1 (en) 2025-02-01
KR20240127483A (ko) 2024-08-22
MX390901B (es) 2025-03-21
US20200181190A1 (en) 2020-06-11
WO2018229495A1 (en) 2018-12-20
IL312228B2 (en) 2025-06-01
CN110753697A (zh) 2020-02-04
JP7279991B2 (ja) 2023-05-23
SA519410795B1 (ar) 2023-11-19
JP7248209B2 (ja) 2023-03-29
CN110785425B (zh) 2023-11-21
IL271159B2 (en) 2023-10-01
AU2024200428B2 (en) 2025-10-16
SG11201911543UA (en) 2020-01-30
US20200181186A1 (en) 2020-06-11
EP3638685A1 (en) 2020-04-22
US11897913B2 (en) 2024-02-13
CN110785425A (zh) 2020-02-11
KR102695300B1 (ko) 2024-08-16
US20250171487A1 (en) 2025-05-29
CN117486959A (zh) 2024-02-02
AU2018284131A1 (en) 2020-01-16
MX2019014907A (es) 2020-02-13
EP3638684A2 (en) 2020-04-22
US12054511B2 (en) 2024-08-06
WO2018229493A3 (en) 2019-02-07
IL312228A (en) 2024-06-01
JP2020523378A (ja) 2020-08-06

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