MX389573B - Composiciones a base de listeria que comprenden un sistema de expresion de minigen peptidico y metodos de uso de estas. - Google Patents

Composiciones a base de listeria que comprenden un sistema de expresion de minigen peptidico y metodos de uso de estas.

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Publication number
MX389573B
MX389573B MX2017011246A MX2017011246A MX389573B MX 389573 B MX389573 B MX 389573B MX 2017011246 A MX2017011246 A MX 2017011246A MX 2017011246 A MX2017011246 A MX 2017011246A MX 389573 B MX389573 B MX 389573B
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Mexico
Prior art keywords
same
methods
listeria
expression system
based compositions
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Application number
MX2017011246A
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English (en)
Other versions
MX2017011246A (es
Inventor
Michael F Princiotta
Robert Petit
Original Assignee
Advaxis Inc
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Publication date
Application filed by Advaxis Inc filed Critical Advaxis Inc
Publication of MX2017011246A publication Critical patent/MX2017011246A/es
Publication of MX389573B publication Critical patent/MX389573B/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20071—Demonstrated in vivo effect

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a composiciones, que incluyen vectores de entrega de Listeria que comprenden constructos minigénicos de expresión, y métodos para usar los mismos para inducir una respuesta inmunitaria contra un tumor que expresa antígenos y para el tratamiento del mismo, y vacunar contra los mismos en sujetos que portan los tumores.
MX2017011246A 2015-03-03 2016-03-03 Composiciones a base de listeria que comprenden un sistema de expresion de minigen peptidico y metodos de uso de estas. MX389573B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562127614P 2015-03-03 2015-03-03
PCT/US2016/020571 WO2016141121A1 (en) 2015-03-03 2016-03-03 Listeria-based compositions comprising a peptide minigene expression system and methods of use thereof

Publications (2)

Publication Number Publication Date
MX2017011246A MX2017011246A (es) 2018-01-12
MX389573B true MX389573B (es) 2025-03-20

Family

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Family Applications (1)

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MX2017011246A MX389573B (es) 2015-03-03 2016-03-03 Composiciones a base de listeria que comprenden un sistema de expresion de minigen peptidico y metodos de uso de estas.

Country Status (14)

Country Link
US (3) US10900044B2 (es)
EP (1) EP3265553A4 (es)
JP (2) JP6921750B2 (es)
KR (1) KR20170120119A (es)
CN (1) CN107406822A (es)
AU (2) AU2016226247B2 (es)
CA (1) CA2978082A1 (es)
HK (1) HK1248758A1 (es)
IL (2) IL290248B2 (es)
MA (1) MA41644A (es)
MX (1) MX389573B (es)
SG (2) SG11201706969YA (es)
TW (2) TWI808415B (es)
WO (1) WO2016141121A1 (es)

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