MX388752B - Composiciones novedosas, usos y métodos para hacerlas. - Google Patents

Composiciones novedosas, usos y métodos para hacerlas.

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Publication number
MX388752B
MX388752B MX2016014555A MX2016014555A MX388752B MX 388752 B MX388752 B MX 388752B MX 2016014555 A MX2016014555 A MX 2016014555A MX 2016014555 A MX2016014555 A MX 2016014555A MX 388752 B MX388752 B MX 388752B
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MX
Mexico
Prior art keywords
methods
making
novel compositions
present
compounds
Prior art date
Application number
MX2016014555A
Other languages
English (en)
Other versions
MX2016014555A (es
Inventor
Mustapha Haddach
Original Assignee
Pimera Inc
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54393079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX388752(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pimera Inc filed Critical Pimera Inc
Publication of MX2016014555A publication Critical patent/MX2016014555A/es
Publication of MX388752B publication Critical patent/MX388752B/es

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Generalmente, la presente invención proporciona compuestos de quinolona novedosos y composición farmacéutica de los mismos que pueden inhibir la proliferación celular y/o inducir la apoptosis celular. La presente invención también proporciona métodos para preparar tales compuestos y composiciones, y métodos para fabricar y usar el mismo.
MX2016014555A 2014-05-09 2015-05-09 Composiciones novedosas, usos y métodos para hacerlas. MX388752B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461991282P 2014-05-09 2014-05-09
US201462050202P 2014-09-15 2014-09-15
US201462054054P 2014-09-23 2014-09-23
US201562128208P 2015-03-04 2015-03-04
PCT/US2015/030046 WO2015172123A1 (en) 2014-05-09 2015-05-09 Novel compositions, uses and methods for making them

Publications (2)

Publication Number Publication Date
MX2016014555A MX2016014555A (es) 2017-05-30
MX388752B true MX388752B (es) 2025-03-20

Family

ID=54393079

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016014555A MX388752B (es) 2014-05-09 2015-05-09 Composiciones novedosas, usos y métodos para hacerlas.

Country Status (33)

Country Link
US (1) US9512123B2 (es)
EP (2) EP3219716B1 (es)
JP (2) JP6188179B2 (es)
KR (3) KR102044648B1 (es)
CN (2) CN106995443B (es)
AU (3) AU2015255738C1 (es)
BR (1) BR112016026150B1 (es)
CA (2) CA2948173C (es)
CL (2) CL2016002798A1 (es)
CY (1) CY1120935T1 (es)
DK (1) DK3140305T3 (es)
EA (1) EA034235B1 (es)
EC (3) ECSP16088687A (es)
ES (1) ES2679628T3 (es)
HR (1) HRP20181105T1 (es)
HU (1) HUE039733T2 (es)
IL (2) IL248638B (es)
LT (1) LT3140305T (es)
MX (1) MX388752B (es)
NI (1) NI201600168A (es)
NZ (1) NZ725917A (es)
PE (2) PE20170678A1 (es)
PH (2) PH12016502213B1 (es)
PL (1) PL3140305T3 (es)
PT (1) PT3140305T (es)
RS (1) RS57493B1 (es)
SG (2) SG11201609171XA (es)
SI (1) SI3140305T1 (es)
SM (1) SMT201800418T1 (es)
TR (1) TR201809990T4 (es)
UA (1) UA117182C2 (es)
WO (1) WO2015172123A1 (es)
ZA (1) ZA201607573B (es)

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US11472791B2 (en) 2019-03-05 2022-10-18 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
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AU2017202145B2 (en) 2019-02-21
IL264454A (en) 2019-02-28
US20160326176A1 (en) 2016-11-10
KR20160144509A (ko) 2016-12-16
ECSP16088687A (es) 2017-01-31
EA201692269A1 (ru) 2017-04-28
ECSP18049420A (es) 2018-07-31
WO2015172123A1 (en) 2015-11-12
EP3140305A1 (en) 2017-03-15
TR201809990T4 (en) 2018-08-27
PH12016502213B1 (en) 2018-09-12
SG10201703658SA (en) 2017-06-29
CN106459068B (zh) 2019-01-22
AU2015255738C1 (en) 2017-09-28
ZA201607573B (en) 2018-08-30
PH12017500660A1 (en) 2019-03-04
UA117182C2 (uk) 2018-06-25
CN106995443A (zh) 2017-08-01
CN106995443B (zh) 2022-01-11
JP6188179B2 (ja) 2017-08-30
KR20170042821A (ko) 2017-04-19
SMT201800418T1 (it) 2018-09-13
PE20170131A1 (es) 2017-03-19
ECSP17031525A (es) 2017-06-30
AU2017202145A1 (en) 2017-04-20
JP2017514889A (ja) 2017-06-08
NI201600168A (es) 2017-01-26
SG11201609171XA (en) 2016-12-29
EP3140305B1 (en) 2018-04-18
SI3140305T1 (sl) 2018-09-28
HUE039733T2 (hu) 2019-01-28
CL2016002798A1 (es) 2017-03-10
JP2017101038A (ja) 2017-06-08
KR101890505B1 (ko) 2018-09-28
LT3140305T (lt) 2018-09-10
EA034235B1 (ru) 2020-01-20
CY1120935T1 (el) 2019-12-11
PT3140305T (pt) 2018-07-24
CN106459068A (zh) 2017-02-22
PE20170678A1 (es) 2017-06-03
BR112016026150B1 (pt) 2019-11-05
RS57493B1 (sr) 2018-10-31
CA2948173C (en) 2018-06-19
ES2679628T3 (es) 2018-08-29
KR102044648B1 (ko) 2019-11-13
US9512123B2 (en) 2016-12-06
EP3219716B1 (en) 2024-12-25
KR20180118806A (ko) 2018-10-31
CL2017000372A1 (es) 2017-09-08
IL248638B (en) 2019-02-28
CA2974960A1 (en) 2015-11-12
EP3140305A4 (en) 2017-03-15
MX2016014555A (es) 2017-05-30
AU2015255738A1 (en) 2016-11-24
NZ725917A (en) 2017-07-28
AU2015255738B2 (en) 2017-04-27
HRP20181105T1 (hr) 2018-09-21
AU2017203955A1 (en) 2017-07-06
CA2948173A1 (en) 2015-11-12
PL3140305T3 (pl) 2018-10-31
PH12016502213A1 (en) 2017-01-16
DK3140305T3 (en) 2018-07-30
EP3219716A1 (en) 2017-09-20

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