MX388752B - Composiciones novedosas, usos y métodos para hacerlas. - Google Patents

Composiciones novedosas, usos y métodos para hacerlas.

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Publication number
MX388752B
MX388752B MX2016014555A MX2016014555A MX388752B MX 388752 B MX388752 B MX 388752B MX 2016014555 A MX2016014555 A MX 2016014555A MX 2016014555 A MX2016014555 A MX 2016014555A MX 388752 B MX388752 B MX 388752B
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MX
Mexico
Prior art keywords
methods
making
novel compositions
present
compounds
Prior art date
Application number
MX2016014555A
Other languages
English (en)
Other versions
MX2016014555A (es
Inventor
Mustapha Haddach
Original Assignee
Pimera Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54393079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX388752(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pimera Inc filed Critical Pimera Inc
Publication of MX2016014555A publication Critical patent/MX2016014555A/es
Publication of MX388752B publication Critical patent/MX388752B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Generalmente, la presente invención proporciona compuestos de quinolona novedosos y composición farmacéutica de los mismos que pueden inhibir la proliferación celular y/o inducir la apoptosis celular. La presente invención también proporciona métodos para preparar tales compuestos y composiciones, y métodos para fabricar y usar el mismo.
MX2016014555A 2014-05-09 2015-05-09 Composiciones novedosas, usos y métodos para hacerlas. MX388752B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461991282P 2014-05-09 2014-05-09
US201462050202P 2014-09-15 2014-09-15
US201462054054P 2014-09-23 2014-09-23
US201562128208P 2015-03-04 2015-03-04
PCT/US2015/030046 WO2015172123A1 (en) 2014-05-09 2015-05-09 Novel compositions, uses and methods for making them

Publications (2)

Publication Number Publication Date
MX2016014555A MX2016014555A (es) 2017-05-30
MX388752B true MX388752B (es) 2025-03-20

Family

ID=54393079

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016014555A MX388752B (es) 2014-05-09 2015-05-09 Composiciones novedosas, usos y métodos para hacerlas.

Country Status (33)

Country Link
US (1) US9512123B2 (es)
EP (2) EP3140305B1 (es)
JP (2) JP6188179B2 (es)
KR (3) KR101890505B1 (es)
CN (2) CN106459068B (es)
AU (3) AU2015255738C1 (es)
BR (1) BR112016026150B1 (es)
CA (2) CA2948173C (es)
CL (2) CL2016002798A1 (es)
CY (1) CY1120935T1 (es)
DK (1) DK3140305T3 (es)
EA (1) EA034235B1 (es)
EC (3) ECSP16088687A (es)
ES (1) ES2679628T3 (es)
HR (1) HRP20181105T1 (es)
HU (1) HUE039733T2 (es)
IL (2) IL248638B (es)
LT (1) LT3140305T (es)
MX (1) MX388752B (es)
NI (1) NI201600168A (es)
NZ (1) NZ725917A (es)
PE (2) PE20170131A1 (es)
PH (2) PH12016502213B1 (es)
PL (1) PL3140305T3 (es)
PT (1) PT3140305T (es)
RS (1) RS57493B1 (es)
SG (2) SG10201703658SA (es)
SI (1) SI3140305T1 (es)
SM (1) SMT201800418T1 (es)
TR (1) TR201809990T4 (es)
UA (1) UA117182C2 (es)
WO (1) WO2015172123A1 (es)
ZA (1) ZA201607573B (es)

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CL2016002798A1 (es) 2017-03-10
EP3140305B1 (en) 2018-04-18
IL248638B (en) 2019-02-28
AU2017202145B2 (en) 2019-02-21
UA117182C2 (uk) 2018-06-25
AU2017202145A1 (en) 2017-04-20
PT3140305T (pt) 2018-07-24
PE20170678A1 (es) 2017-06-03
IL264454A (en) 2019-02-28
CA2974960A1 (en) 2015-11-12
WO2015172123A1 (en) 2015-11-12
CN106995443B (zh) 2022-01-11
KR102044648B1 (ko) 2019-11-13
NI201600168A (es) 2017-01-26
LT3140305T (lt) 2018-09-10
PH12016502213B1 (en) 2018-09-12
SG10201703658SA (en) 2017-06-29
EP3140305A1 (en) 2017-03-15
US20160326176A1 (en) 2016-11-10
JP6188179B2 (ja) 2017-08-30
ECSP18049420A (es) 2018-07-31
CA2948173A1 (en) 2015-11-12
PL3140305T3 (pl) 2018-10-31
DK3140305T3 (en) 2018-07-30
SG11201609171XA (en) 2016-12-29
AU2015255738A1 (en) 2016-11-24
EA201692269A1 (ru) 2017-04-28
HRP20181105T1 (hr) 2018-09-21
KR101890505B1 (ko) 2018-09-28
CN106459068B (zh) 2019-01-22
EP3219716A1 (en) 2017-09-20
AU2015255738C1 (en) 2017-09-28
PE20170131A1 (es) 2017-03-19
ES2679628T3 (es) 2018-08-29
CY1120935T1 (el) 2019-12-11
CL2017000372A1 (es) 2017-09-08
KR20170042821A (ko) 2017-04-19
SMT201800418T1 (it) 2018-09-13
RS57493B1 (sr) 2018-10-31
ZA201607573B (en) 2018-08-30
EA034235B1 (ru) 2020-01-20
PH12016502213A1 (en) 2017-01-16
KR20160144509A (ko) 2016-12-16
CN106995443A (zh) 2017-08-01
AU2015255738B2 (en) 2017-04-27
MX2016014555A (es) 2017-05-30
CN106459068A (zh) 2017-02-22
ECSP17031525A (es) 2017-06-30
BR112016026150B1 (pt) 2019-11-05
JP2017101038A (ja) 2017-06-08
PH12017500660A1 (en) 2019-03-04
US9512123B2 (en) 2016-12-06
SI3140305T1 (sl) 2018-09-28
AU2017203955A1 (en) 2017-07-06
ECSP16088687A (es) 2017-01-31
EP3219716B1 (en) 2024-12-25
KR20180118806A (ko) 2018-10-31
CA2948173C (en) 2018-06-19
TR201809990T4 (en) 2018-08-27
EP3140305A4 (en) 2017-03-15
NZ725917A (en) 2017-07-28
JP2017514889A (ja) 2017-06-08
HUE039733T2 (hu) 2019-01-28

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