PE20170131A1 - Composiciones novedosas usos y metodos para hacerlas - Google Patents
Composiciones novedosas usos y metodos para hacerlasInfo
- Publication number
- PE20170131A1 PE20170131A1 PE2016002189A PE2016002189A PE20170131A1 PE 20170131 A1 PE20170131 A1 PE 20170131A1 PE 2016002189 A PE2016002189 A PE 2016002189A PE 2016002189 A PE2016002189 A PE 2016002189A PE 20170131 A1 PE20170131 A1 PE 20170131A1
- Authority
- PE
- Peru
- Prior art keywords
- methods
- make
- iii
- novel compositions
- halogen
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Abstract
Se refiere a compuestos de formulas III (A), III(B) o III(C) o sales farmaceuticamente aceptables de los mismos, donde: L es un enlace, ligador alquileno C1-C10, entre otros opcionalmente sustituido; A es heterocicloalquilo, heteroarilo, entre otros; X es NR6, O o S; R6 es H, alquilo C1-C8, entre otros; X1 es alquilo C1-C8, heteroalquilo C2-C8, entre otros, opcionalmente sustituido o X1 es H, CN, entre otros; X2 es H, halogeno, entre otros; (U)n y (U)m son H, halogeno, entre otros. Tambien se refiere a un metodo de tratamiento. Dichos compuestos inhiben la proliferacion celular y/o inducen la apoptosis celular siendo utiles en el tratamiento de enfermedades tales como cancer de pecho, pulmon, entre otros
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461991282P | 2014-05-09 | 2014-05-09 | |
| US201462050202P | 2014-09-15 | 2014-09-15 | |
| US201462054054P | 2014-09-23 | 2014-09-23 | |
| US201562128208P | 2015-03-04 | 2015-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20170131A1 true PE20170131A1 (es) | 2017-03-19 |
Family
ID=54393079
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016002189A PE20170131A1 (es) | 2014-05-09 | 2015-05-09 | Composiciones novedosas usos y metodos para hacerlas |
| PE2017000488A PE20170678A1 (es) | 2014-05-09 | 2015-05-09 | Composiciones novedosas, usos y metodos para hacerlas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2017000488A PE20170678A1 (es) | 2014-05-09 | 2015-05-09 | Composiciones novedosas, usos y metodos para hacerlas |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9512123B2 (es) |
| EP (2) | EP3219716A1 (es) |
| JP (2) | JP6188179B2 (es) |
| KR (3) | KR20170042821A (es) |
| CN (2) | CN106995443B (es) |
| AU (3) | AU2015255738C1 (es) |
| BR (1) | BR112016026150B1 (es) |
| CA (2) | CA2948173C (es) |
| CL (2) | CL2016002798A1 (es) |
| CY (1) | CY1120935T1 (es) |
| DK (1) | DK3140305T3 (es) |
| EA (1) | EA034235B1 (es) |
| EC (3) | ECSP16088687A (es) |
| ES (1) | ES2679628T3 (es) |
| HR (1) | HRP20181105T1 (es) |
| HU (1) | HUE039733T2 (es) |
| IL (2) | IL248638B (es) |
| LT (1) | LT3140305T (es) |
| MX (1) | MX2016014555A (es) |
| NI (1) | NI201600168A (es) |
| NZ (1) | NZ725917A (es) |
| PE (2) | PE20170131A1 (es) |
| PH (2) | PH12016502213A1 (es) |
| PL (1) | PL3140305T3 (es) |
| PT (1) | PT3140305T (es) |
| RS (1) | RS57493B1 (es) |
| SG (2) | SG11201609171XA (es) |
| SI (1) | SI3140305T1 (es) |
| TR (1) | TR201809990T4 (es) |
| UA (1) | UA117182C2 (es) |
| WO (1) | WO2015172123A1 (es) |
| ZA (1) | ZA201607573B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9758518B2 (en) | 2015-03-04 | 2017-09-12 | Pimera, Inc. | Compositions, uses and methods for making them |
| JP2020512975A (ja) * | 2017-03-28 | 2020-04-30 | ピメラ，インク． | Ｐｏｌ１阻害剤の新規な結晶形態 |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| CN112300173B (zh) * | 2019-07-30 | 2021-10-01 | 上海凌达生物医药有限公司 | 一类含氮多环类化合物、制备方法和用途 |
| MX2022001940A (es) | 2019-08-14 | 2022-05-10 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2. |
| CN110606850A (zh) * | 2019-09-11 | 2019-12-24 | 中山大学 | 一种3-苯并[4,5]咪唑[1,2-a]吡嗪-1-胺类化合物及其制备方法和应用 |
| PE20221905A1 (es) | 2019-10-11 | 2022-12-23 | Incyte Corp | Aminas biciclicas como inhibidoras de la cdk2 |
| CN114685487B (zh) * | 2020-12-27 | 2024-04-19 | 上海凌达生物医药有限公司 | 一类嘧啶并杂环类化合物、制备方法和用途 |
| CN113416197B (zh) * | 2021-08-25 | 2021-12-28 | 北京鑫开元医药科技有限公司 | 甲酰胺类衍生物、制备方法、药物组合物及应用 |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| CN114276354B (zh) * | 2022-01-07 | 2023-06-02 | 中山大学 | 1-氨基苯并[4,5]咪唑并[1,2-a]吡嗪-3-甲酰胺类化合物及其制备和应用 |
| CN114539265B (zh) * | 2022-03-02 | 2023-07-21 | 中山大学 | 靶向a2a的苯并咪唑并吡嗪-3-甲酰胺及其肿瘤免疫功能 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| NL7709746A (nl) * | 1976-09-09 | 1978-03-13 | Hoechst Ag | Werkwijze ter bereiding van benzimidazo-(1,2-a)-chi- nolinen. |
| DE2929414A1 (de) * | 1979-07-20 | 1981-02-05 | Hoechst Ag | Pyrimido- eckige klammer auf 5',4' zu 5,6 eckige klammer zu -pyrido- eckige klammer auf 1,2-a eckige klammer zu -benzimidazole, verfahren zu ihrer herstellung und deren verwendung |
| DE3502689A1 (de) | 1985-01-26 | 1986-07-31 | Hoechst Ag, 6230 Frankfurt | Elektrophotographisches aufzeichnungsmaterial |
| EP0647226B1 (de) * | 1992-06-22 | 1997-09-03 | Boehringer Ingelheim Kg | 9-AMINO-PYRIDAZINO 4',5' : 3,4]PYRROLO- 2,1-a]ISOCHINOLINE UND DEREN VERWENDUNG FÜR DIE HERSTELLUNG VON PHARMAZEUTISCHEN ZUBEREITUNGEN |
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| DE102006051796A1 (de) | 2006-11-03 | 2008-05-08 | Merck Patent Gmbh | Triaza-benzo[e]azulenderivate |
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| PT3092901T (pt) | 2007-10-05 | 2020-05-21 | Senhwa Biosciences Inc | Análogos de quinolona e respetivos métodos relacionados |
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2015
- 2015-05-09 LT LTEP15790016.8T patent/LT3140305T/lt unknown
- 2015-05-09 SG SG11201609171XA patent/SG11201609171XA/en unknown
- 2015-05-09 US US14/708,230 patent/US9512123B2/en active Active
- 2015-05-09 PE PE2016002189A patent/PE20170131A1/es unknown
- 2015-05-09 PL PL15790016T patent/PL3140305T3/pl unknown
- 2015-05-09 KR KR1020177009732A patent/KR20170042821A/ko active Application Filing
- 2015-05-09 JP JP2016575683A patent/JP6188179B2/ja active Active
- 2015-05-09 EP EP17166200.0A patent/EP3219716A1/en active Pending
- 2015-05-09 KR KR1020187030648A patent/KR102044648B1/ko active IP Right Grant
- 2015-05-09 NZ NZ725917A patent/NZ725917A/en unknown
- 2015-05-09 PE PE2017000488A patent/PE20170678A1/es unknown
- 2015-05-09 WO PCT/US2015/030046 patent/WO2015172123A1/en active Application Filing
- 2015-05-09 RS RS20180827A patent/RS57493B1/sr unknown
- 2015-05-09 MX MX2016014555A patent/MX2016014555A/es unknown
- 2015-05-09 EA EA201692269A patent/EA034235B1/ru unknown
- 2015-05-09 CA CA2948173A patent/CA2948173C/en active Active
- 2015-05-09 TR TR2018/09990T patent/TR201809990T4/en unknown
- 2015-05-09 EP EP15790016.8A patent/EP3140305B1/en active Active
- 2015-05-09 AU AU2015255738A patent/AU2015255738C1/en active Active
- 2015-05-09 UA UAA201612474A patent/UA117182C2/uk unknown
- 2015-05-09 KR KR1020167033915A patent/KR101890505B1/ko active IP Right Grant
- 2015-05-09 CN CN201710268769.5A patent/CN106995443B/zh active Active
- 2015-05-09 CN CN201580031811.0A patent/CN106459068B/zh active Active
- 2015-05-09 PT PT157900168T patent/PT3140305T/pt unknown
- 2015-05-09 SG SG10201703658SA patent/SG10201703658SA/en unknown
- 2015-05-09 BR BR112016026150-0A patent/BR112016026150B1/pt active IP Right Grant
- 2015-05-09 ES ES15790016.8T patent/ES2679628T3/es active Active
- 2015-05-09 SI SI201530315T patent/SI3140305T1/sl unknown
- 2015-05-09 CA CA2974960A patent/CA2974960A1/en not_active Abandoned
- 2015-05-09 HU HUE15790016A patent/HUE039733T2/hu unknown
- 2015-05-09 DK DK15790016.8T patent/DK3140305T3/en active
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2016
- 2016-10-31 IL IL248638A patent/IL248638B/en active IP Right Grant
- 2016-11-02 ZA ZA2016/07573A patent/ZA201607573B/en unknown
- 2016-11-04 CL CL2016002798A patent/CL2016002798A1/es unknown
- 2016-11-07 NI NI201600168A patent/NI201600168A/es unknown
- 2016-11-08 PH PH12016502213A patent/PH12016502213A1/en unknown
- 2016-11-17 EC ECIEPI201688687A patent/ECSP16088687A/es unknown
- 2016-12-26 JP JP2016251010A patent/JP2017101038A/ja not_active Withdrawn
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2017
- 2017-02-13 CL CL2017000372A patent/CL2017000372A1/es unknown
- 2017-03-31 AU AU2017202145A patent/AU2017202145B2/en active Active
- 2017-04-07 PH PH12017500660A patent/PH12017500660A1/en unknown
- 2017-05-23 EC ECIEPI201731525A patent/ECSP17031525A/es unknown
- 2017-06-13 AU AU2017203955A patent/AU2017203955A1/en not_active Abandoned
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2018
- 2018-06-29 EC ECSENADI201849420A patent/ECSP18049420A/es unknown
- 2018-07-12 HR HRP20181105TT patent/HRP20181105T1/hr unknown
- 2018-07-18 CY CY181100752T patent/CY1120935T1/el unknown
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2019
- 2019-01-24 IL IL264454A patent/IL264454A/en unknown
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