MX385287B - Anticuerpos anti-puntos de control inmunitarios para usarse en el tratamiento de la enfermedad de alzheimer. - Google Patents

Anticuerpos anti-puntos de control inmunitarios para usarse en el tratamiento de la enfermedad de alzheimer.

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Publication number
MX385287B
MX385287B MX2016011832A MX2016011832A MX385287B MX 385287 B MX385287 B MX 385287B MX 2016011832 A MX2016011832 A MX 2016011832A MX 2016011832 A MX2016011832 A MX 2016011832A MX 385287 B MX385287 B MX 385287B
Authority
MX
Mexico
Prior art keywords
disease
treatment
alzheimer
immune checkpoint
therapy
Prior art date
Application number
MX2016011832A
Other languages
English (en)
Other versions
MX2016011832A (es
Inventor
Michal Eisenbach-Schwartz
Kuti Baruch
Neta Rosenzweig
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of MX2016011832A publication Critical patent/MX2016011832A/es
Publication of MX385287B publication Critical patent/MX385287B/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La presente invención se refiere a una composición farmacéutica para usarse en el tratamiento de la enfermedad de Alzheimer en un individuo, en donde la composición farmacéutica comprende un agente activo que causa reducción del nivel de inmunosupresión sistémica en un individuo, en donde el agente activo se selecciona de un anticuerpo anti-PD-1,anticuerpo anti-PD-L1, anticuerpo anti-TIM-3, o una combinación de los mismos, y en donde la composición farmacéutica está adaptada para ser administrable mediante un régimen de dosificación que causa reducción transitoria del nivel de la inmunosupresión sistématica que comprende por lo menos dos cursos de terapia, cada curso de terapia comprende en secuencia una sesión de tratamiento que comprende la administración de la composición farmacéutica al individuo, seguido de una sesión de no tratamiento en la que la composición farmacéutica no es administrable al individuo, en donde la sesión de tratamiento es de entre 3 días y cuatro semanas y seis meses de duración, entre dos semanas y seis meses de duración, o entre tres semanas y seis meses de duración.
MX2016011832A 2014-03-12 2015-03-12 Anticuerpos anti-puntos de control inmunitarios para usarse en el tratamiento de la enfermedad de alzheimer. MX385287B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461951783P 2014-03-12 2014-03-12
US201462030164P 2014-07-29 2014-07-29
PCT/IL2015/050265 WO2015136541A2 (en) 2014-03-12 2015-03-12 Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns

Publications (2)

Publication Number Publication Date
MX2016011832A MX2016011832A (es) 2017-05-12
MX385287B true MX385287B (es) 2025-03-18

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
MX2016011832A MX385287B (es) 2014-03-12 2015-03-12 Anticuerpos anti-puntos de control inmunitarios para usarse en el tratamiento de la enfermedad de alzheimer.
MX2018000466A MX2018000466A (es) 2014-03-12 2016-07-13 Reducción de niveles o de actividad de células t regulatorias sistémicas para el tratamiento de enfermedad y lesión del sistema nervioso central (snc).
MX2021009611A MX2021009611A (es) 2014-03-12 2016-09-12 Reduccion de los niveles o la actividad de las celulas t reguladoras sistemicas para el tratamiento de enfermedad y lesion del sistema nervioso central (snc).

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2018000466A MX2018000466A (es) 2014-03-12 2016-07-13 Reducción de niveles o de actividad de células t regulatorias sistémicas para el tratamiento de enfermedad y lesión del sistema nervioso central (snc).
MX2021009611A MX2021009611A (es) 2014-03-12 2016-09-12 Reduccion de los niveles o la actividad de las celulas t reguladoras sistemicas para el tratamiento de enfermedad y lesion del sistema nervioso central (snc).

Country Status (14)

Country Link
US (16) US10144778B2 (es)
EP (3) EP3116542B1 (es)
JP (7) JP6903432B2 (es)
KR (4) KR20230097209A (es)
CN (2) CN114081946A (es)
AU (5) AU2015228372B2 (es)
BR (2) BR112016020919A2 (es)
CA (2) CA3129892C (es)
ES (1) ES3040431T3 (es)
IL (2) IL256792B2 (es)
MX (3) MX385287B (es)
NZ (2) NZ725006A (es)
RU (2) RU2690670C2 (es)
WO (2) WO2015136541A2 (es)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE065752T2 (hu) 2008-12-09 2024-06-28 Hoffmann La Roche Anti-PD-L1 antitestek és felhasználásuk T-sejt funkció elõsegítésére
ES2746805T3 (es) 2013-12-12 2020-03-06 Shanghai hengrui pharmaceutical co ltd Anticuerpo de PD-1, fragmento de unión a antígeno del mismo y aplicación médica del mismo
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
WO2017042633A2 (en) * 2015-09-10 2017-03-16 Yeda Research And Development Co. Ltd Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns
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