MX374263B - Proceso y aparato para la producción de micropartículas. - Google Patents

Proceso y aparato para la producción de micropartículas.

Info

Publication number
MX374263B
MX374263B MX2018007466A MX2018007466A MX374263B MX 374263 B MX374263 B MX 374263B MX 2018007466 A MX2018007466 A MX 2018007466A MX 2018007466 A MX2018007466 A MX 2018007466A MX 374263 B MX374263 B MX 374263B
Authority
MX
Mexico
Prior art keywords
liquid
solvent
droplets
droplet generators
jet
Prior art date
Application number
MX2018007466A
Other languages
English (en)
Other versions
MX2018007466A (es
Inventor
Huw Jones
Liam Mcaleer
Paul Seaman
Original Assignee
Midatech Pharma Wales Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Midatech Pharma Wales Ltd filed Critical Midatech Pharma Wales Ltd
Publication of MX2018007466A publication Critical patent/MX2018007466A/es
Publication of MX374263B publication Critical patent/MX374263B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • B01J2/08—Gelation of a colloidal solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/10—Making granules by moulding the material, i.e. treating it in the molten state
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/12—Making granules characterised by structure or composition
    • B29B2009/125—Micropellets, microgranules, microparticles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Mechanical Engineering (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Particle Formation And Scattering Control In Inkjet Printers (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glanulating (AREA)

Abstract

Se proporciona un aparato para producir microparticulas polimericas solidas, el aparato comprende multiples generadores de gotas liquidas para formar gotas liquidas de un primer liquido y una boquilla para formar un chorro de un segundo liquido, donde los multiples generadores de gotas liquidas y la boquilla estan dispuestos en relacion uno con otro de manera que, cuando se usan, las gotas liquidas de los multiples generadores de gotas liquidas pasan a traves de un gas a dicho chorro del segundo liquido. Tambien se proporciona un proceso para producir microparticulas solidas, el proceso comprende: proporcionar un primer liquido que comprende un soluto y un solvente, el soluto comprende un polimero biocompatible, la concentracion de polímero en el primer liquido es de al menos 10 % p/v, donde "p" es el peso del polimero y "v" es el volumen del solvente, proporcionando multiples generadores de gotas liquidas que se pueden operar para generar gotas liquidas, proporcionando un chorro de un segundo liquido, haciendo que los multiples generadores de gotas liquidas formen gotas liquidas del primer liquido, pasando las gotas liquidas a traves de un gas para poner en contacto el chorro del segundo liquido para hacer que el solvente salga de las gotas, formando de esa manera microparticulas solidas, la solubilidad del solvente en el segundo liquido es de al menos 5 g de solvente cada 100 ml del segundo liquido, el solvente es sustancialmente mezclable con el segundo liquido.
MX2018007466A 2015-12-18 2016-12-16 Proceso y aparato para la producción de micropartículas. MX374263B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1522423.1A GB2551944B (en) 2015-12-18 2015-12-18 Microparticle production process and apparatus
PCT/EP2016/081436 WO2017103113A2 (en) 2015-12-18 2016-12-16 Microparticle production process and apparatus

Publications (2)

Publication Number Publication Date
MX2018007466A MX2018007466A (es) 2018-11-14
MX374263B true MX374263B (es) 2025-03-06

Family

ID=55311254

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018007466A MX374263B (es) 2015-12-18 2016-12-16 Proceso y aparato para la producción de micropartículas.

Country Status (13)

Country Link
US (2) US10981131B2 (es)
EP (1) EP3389840B1 (es)
JP (1) JP7112325B2 (es)
KR (1) KR102681302B1 (es)
CN (1) CN108602035B (es)
AU (1) AU2016369412B2 (es)
BR (1) BR112018012340B1 (es)
CA (1) CA3008554A1 (es)
ES (1) ES2749949T3 (es)
GB (1) GB2551944B (es)
MX (1) MX374263B (es)
PL (1) PL3389840T3 (es)
WO (1) WO2017103113A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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GB201522441D0 (en) 2015-12-18 2016-02-03 Midatech Pharma Wales Ltd Sustained release cyclosporine-loaded microparticles
DK3436188T3 (da) * 2016-03-30 2020-12-21 Iamfluidics Holding B V Fremgangsmåde og indretning til fremstilling af enkelt-dråber i bevægelse, sammensatte dråber og formstyrede (sammensatte) partikler eller fibre
US20180085314A1 (en) 2016-09-27 2018-03-29 Tadahiko MORINAGA Particulate poly(lactic-co-glycolic) acid, method for manufacturing particulate poly(lactic-co-glycolic) acid, and particulate poly(lactic-co-glycolic) acid manufacturing apparatus
EP4397343A3 (en) * 2018-10-01 2024-09-04 Pneuma Respiratory, Inc. Delivery of low surface tension compositions to the pulmonary system via electronic breath actuated droplet delivery device
KR102230329B1 (ko) * 2019-05-15 2021-03-22 경희대학교 산학협력단 마이크로 입자의 대량 생산 방법 및 이를 통해 제조된 마이크로 입자
JP2021028305A (ja) 2019-08-09 2021-02-25 株式会社リコー 粒子、医薬組成物、及び粒子の製造方法
GB202002727D0 (en) * 2020-02-26 2020-04-08 Midatech Pharma Wales Ltd Microparticle production platform, method of producing microparticles and a pharmaceutical composition
JP2021147330A (ja) * 2020-03-16 2021-09-27 株式会社リコー 徐放性粒子及びその製造方法

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Also Published As

Publication number Publication date
CA3008554A1 (en) 2017-06-22
WO2017103113A2 (en) 2017-06-22
AU2016369412A1 (en) 2018-06-14
US20190193037A1 (en) 2019-06-27
JP2019507003A (ja) 2019-03-14
MX2018007466A (es) 2018-11-14
GB201522423D0 (en) 2016-02-03
US20210268461A1 (en) 2021-09-02
KR102681302B1 (ko) 2024-07-03
US10981131B2 (en) 2021-04-20
EP3389840A2 (en) 2018-10-24
GB2551944B (en) 2021-09-01
BR112018012340A2 (en) 2018-12-04
WO2017103113A3 (en) 2017-08-24
AU2016369412B2 (en) 2021-04-01
BR112018012340B1 (pt) 2021-03-09
EP3389840B1 (en) 2019-08-21
CN108602035A (zh) 2018-09-28
GB2551944A (en) 2018-01-10
ES2749949T3 (es) 2020-03-24
JP7112325B2 (ja) 2022-08-03
PL3389840T3 (pl) 2020-01-31
KR20180111800A (ko) 2018-10-11
US11794158B2 (en) 2023-10-24
CN108602035B (zh) 2021-10-15

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