MX366900B - Métodos y materiales para diferenciación hematoendotelial de células germinales pluripotentes humanas bajo condiciones definidas. - Google Patents
Métodos y materiales para diferenciación hematoendotelial de células germinales pluripotentes humanas bajo condiciones definidas.Info
- Publication number
- MX366900B MX366900B MX2015012202A MX2015012202A MX366900B MX 366900 B MX366900 B MX 366900B MX 2015012202 A MX2015012202 A MX 2015012202A MX 2015012202 A MX2015012202 A MX 2015012202A MX 366900 B MX366900 B MX 366900B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- stem cells
- pluripotent stem
- materials
- cells under
- Prior art date
Links
- 210000001778 pluripotent stem cell Anatomy 0.000 title abstract 2
- 230000004069 differentiation Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0056—Xeno-free medium
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0695—Stem cells; Progenitor cells; Precursor cells
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1394—Bone marrow stromal cells; whole marrow
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
Abstract
La presente invención se refiere a métodos y composiciones para diferenciar células germinales pluripotentes en células de linajes endoteliales y hematopoyéticas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361779564P | 2013-03-13 | 2013-03-13 | |
PCT/US2014/024518 WO2014165131A1 (en) | 2013-03-13 | 2014-03-12 | Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015012202A MX2015012202A (es) | 2015-11-30 |
MX366900B true MX366900B (es) | 2019-07-30 |
Family
ID=50678273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015012202A MX366900B (es) | 2013-03-13 | 2014-03-12 | Métodos y materiales para diferenciación hematoendotelial de células germinales pluripotentes humanas bajo condiciones definidas. |
Country Status (19)
Country | Link |
---|---|
US (3) | US9938499B2 (es) |
EP (1) | EP2970912B1 (es) |
JP (1) | JP6677631B2 (es) |
KR (1) | KR102151210B1 (es) |
CN (1) | CN105209609B (es) |
AU (1) | AU2014248651B2 (es) |
BR (1) | BR112015022770B1 (es) |
CA (2) | CA3141731A1 (es) |
DK (1) | DK2970912T3 (es) |
ES (1) | ES2720196T3 (es) |
HK (1) | HK1218927A1 (es) |
HU (1) | HUE043785T2 (es) |
IL (1) | IL241286B (es) |
MX (1) | MX366900B (es) |
PL (1) | PL2970912T3 (es) |
PT (1) | PT2970912T (es) |
SG (1) | SG11201507275TA (es) |
TR (1) | TR201904270T4 (es) |
WO (1) | WO2014165131A1 (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101528915A (zh) | 2006-04-14 | 2009-09-09 | 先进细胞技术公司 | 血管瘤集落形成细胞 |
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
US9868939B2 (en) | 2013-06-12 | 2018-01-16 | Wisconsin Alumni Research Foundation | Generating vasculogenic cell populations |
SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法 |
US11220672B2 (en) * | 2014-12-31 | 2022-01-11 | Wisconsin Alumni Research Foundation | Human pluripotent stem cell-based system for generating endothelial cells |
AU2016211671B2 (en) * | 2015-01-26 | 2022-05-26 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
US11674123B2 (en) | 2015-02-20 | 2023-06-13 | Wisconsin Alumni Research Foundation | Generating arterial endothelial cell populations |
WO2016141084A1 (en) * | 2015-03-03 | 2016-09-09 | The Board Of Trustees Of The Leland Stanford Junior University | Producing mesodermal cell types and methods of using the same |
CN104660703B (zh) * | 2015-03-05 | 2017-12-15 | 国家电网公司 | 多网络融合用电信息采集系统及最优通信网络的选择方法 |
US10836997B2 (en) * | 2015-03-09 | 2020-11-17 | Keio University | Method for differentiating pluripotent stem cells into desired cell type |
WO2017004169A1 (en) * | 2015-06-29 | 2017-01-05 | Northeastern University | Dendritic cell generator |
JP6646311B2 (ja) * | 2015-07-17 | 2020-02-14 | 国立大学法人京都大学 | 多能性幹細胞から中胚葉前駆細胞および血液血管前駆細胞への分化誘導法 |
AU2016342179B2 (en) * | 2015-10-20 | 2022-08-18 | FUJIFILM Cellular Dynamics, Inc. | Multi-lineage hematopoietic precursor cell production by genetic programming |
WO2017079673A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Genomic engineering of pluripotent cells |
SG11201803145RA (en) | 2015-11-04 | 2018-05-30 | Fate Therapeutics Inc | Methods and compositions for inducing hematopoietic cell differentiation |
US11174461B2 (en) * | 2016-03-16 | 2021-11-16 | Cynata Therapeutics Limited | Colony forming medium and use thereof |
JP7080184B2 (ja) * | 2016-04-15 | 2022-06-03 | アンジオクライン・バイオサイエンス・インコーポレイテッド | 遺伝子送達の増強方法 |
US11066650B2 (en) | 2016-05-05 | 2021-07-20 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
US20190300851A1 (en) * | 2016-05-17 | 2019-10-03 | Agency For Science, Technology And Research | Human stem cell derived endothelial cells, endothelial-hepatocyte co-culture system and uses thereof |
WO2018037091A1 (en) * | 2016-08-24 | 2018-03-01 | Hi-Stem Ggmbh | Methods for the identification and isolation of hematopoietic stem and progenitor cells |
CA3035660A1 (en) | 2016-09-06 | 2018-03-15 | The Children's Medical Center Corporation | Immune cells derived from induced pluripotent stem cell |
JP7248571B2 (ja) | 2016-10-05 | 2023-03-29 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | MeCP2が破壊された誘導多能性幹細胞からの成熟系列の生成 |
BR112019006910A2 (pt) * | 2016-10-05 | 2019-07-02 | Fujifilm Cellular Dynamics Inc | métodos para diferenciação dirigida de células-tronco pluripotentes para células imunes homozigóticas de hla |
CA3045145A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
CA3056709A1 (en) * | 2017-03-21 | 2018-09-27 | Etablissement Francais Du Sang | Methods of improving hematopoietic grafts |
CN106867961A (zh) * | 2017-03-27 | 2017-06-20 | 广州润虹医药科技有限公司 | 一种诱导多能干细胞形成中胚层细胞的诱导培养基及诱导方法 |
BR112019020848A2 (pt) * | 2017-04-07 | 2020-06-02 | Cynata Therapeutics Limited | Método para tratar um efeito colateral da terapia com célula t receptor de antígeno quimérico (car) |
WO2018229251A1 (en) * | 2017-06-16 | 2018-12-20 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Blood vessel organoid, methods of producing and using said organoids |
CA3066799A1 (en) * | 2017-06-16 | 2018-12-20 | Cynata Therapeutics Limited | Method for treating a side effect of immunotherapy |
WO2019051281A1 (en) * | 2017-09-07 | 2019-03-14 | StemoniX Inc. | EFFECTIVE DIFFERENTIATION OF HUMAN STEM CELLS IN DEFINITIVE ENDODERM |
US11471493B2 (en) | 2017-09-15 | 2022-10-18 | Cynata Therapeutics Limited | Method for treating allergic airways disease (AAD)/asthma |
CA3084575A1 (en) | 2017-11-22 | 2019-05-31 | Mesoblast International Sarl | Cellular compositions and methods of treatment i |
WO2019126146A1 (en) | 2017-12-19 | 2019-06-27 | Xcell Biosciences, Inc. | Methods of modulating cell phenotype by way of regulating the gaseous environment |
AU2019205942A1 (en) * | 2018-01-05 | 2020-08-13 | Platelet Biogenesis, Inc. | Compositions and methods for producing megakaryocytes |
AU2019336221A1 (en) * | 2018-09-07 | 2021-03-04 | Wisconsin Alumni Research Foundation | Generation of hematopoietic progenitor cells from human pluripotent stem cells |
CN109334379B (zh) * | 2018-09-19 | 2021-11-23 | 江苏大学 | 重型车用液电式惯容器非线性惯性力辨识方法 |
US10647954B1 (en) | 2018-11-15 | 2020-05-12 | Flaskworks, Llc | Dendritic cell generating apparatus and method |
WO2020154412A1 (en) * | 2019-01-22 | 2020-07-30 | Washington University | Compositions and methods for generating hematopoietic stem cells (hscs) |
CN111154719B (zh) * | 2019-02-28 | 2024-03-01 | 西湖生物医药科技(杭州)有限公司 | 利用外周血体外制备成熟红细胞的方法及制剂 |
CN114423860A (zh) | 2019-08-05 | 2022-04-29 | 迈索布拉斯特国际有限公司 | 包含病毒载体的细胞组合物及治疗方法 |
US11566217B2 (en) | 2019-08-13 | 2023-01-31 | Flaskworks, Llc | Duty cycle for cell culture systems |
US20220275335A1 (en) * | 2019-08-20 | 2022-09-01 | Adaptimmune Limited | Culture medium for haematopoietic induction |
GB201911953D0 (en) * | 2019-08-20 | 2019-10-02 | Adaptimmune Ltd | T cell production fram RAG inacivated iPSCs |
GB201911957D0 (en) * | 2019-08-20 | 2019-10-02 | Adaptimmune Ltd | Methods of producing haemogenic progenitor cells from pluripotent stem cells |
AU2020369940A1 (en) | 2019-10-21 | 2022-05-26 | Flaskworks, Llc | Systems and methods for cell culturing |
WO2021085462A1 (ja) * | 2019-10-29 | 2021-05-06 | 国立大学法人京都大学 | 多能性幹細胞から造血性内皮細胞および/または造血前駆細胞を製造する方法 |
WO2021126841A1 (en) * | 2019-12-16 | 2021-06-24 | The Board Of Trustees Of The Leland Stanford Junior University | Use of polyvinyl alcohol for cell culture of immune cells |
JP7072756B2 (ja) * | 2019-12-27 | 2022-05-23 | 国立大学法人京都大学 | 多能性幹細胞から中胚葉前駆細胞および血液血管前駆細胞への分化誘導法 |
US20230293590A1 (en) | 2020-08-10 | 2023-09-21 | Mesoblast International Sárl | Cellular compositions and methods of treatment |
US20230374458A1 (en) * | 2020-08-25 | 2023-11-23 | University Health Network | Compositions and methods for generating human yolk sac-like hematopoietic cells |
US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
CN112680410B (zh) * | 2021-01-19 | 2022-08-02 | 上海爱萨尔生物科技有限公司 | 诱导多能干细胞分化培养心脏成纤维细胞的方法及其培养液 |
KR20220113586A (ko) * | 2021-02-05 | 2022-08-16 | 의료법인 성광의료재단 | 다능성 줄기세포 유래 조혈 내피세포를 이용한 유전자 편집된 세포의 제조방법 |
EP4293107A1 (en) * | 2021-02-05 | 2023-12-20 | Sungkwang Medical Foundation | Method for differentiating pluripotent stem cell-derived hemogenic endothelial cells into lymphoid lineage cells |
GB202102297D0 (en) * | 2021-02-18 | 2021-04-07 | Adaptimmune Ltd | Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells |
CN113046318B (zh) * | 2021-04-13 | 2023-04-18 | 中国科学院深圳先进技术研究院 | 一种诱导多能干细胞向造血前体细胞分化的培养基以及方法 |
CN117836405A (zh) * | 2021-08-13 | 2024-04-05 | 先声创新公司 | 三维培养多能干细胞产生造血干细胞 |
US20230377685A1 (en) | 2022-04-15 | 2023-11-23 | Aspen Neuroscience, Inc. | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ553241A (en) | 2004-09-08 | 2009-11-27 | Wisconsin Alumni Res Found | Medium and culture of pluripotent stem cells |
US8034613B2 (en) | 2005-06-01 | 2011-10-11 | Wisconsin Alumni Research Foundation | Multipotent lymphohematopoietic progenitor cells |
US7811821B2 (en) | 2005-06-01 | 2010-10-12 | Wisconsin Alumni Research Foundation | Method of forming dendritic cells from embryonic stem cells |
GB2449042B (en) | 2006-02-09 | 2010-07-07 | Wisconsin Alumni Res Found | Erythroid cells producing adult-type b-hemoglobin generated from human embryonic stem cells |
EP2137296A2 (en) | 2007-03-23 | 2009-12-30 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
US20110236971A2 (en) * | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
US7615374B2 (en) | 2007-09-25 | 2009-11-10 | Wisconsin Alumni Research Foundation | Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions |
EP2229435B1 (en) | 2007-12-06 | 2016-03-02 | Agency for Science, Technology And Research | Method for extracellular matrix mediated differentiation and proliferation of stem cells |
KR20170102048A (ko) * | 2008-05-06 | 2017-09-06 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 다능성 줄기세포로부터 유도된 탈핵 적혈구계 세포를 생산하는 방법 |
CA2753679C (en) * | 2009-02-27 | 2021-03-02 | Cellular Dynamics International, Inc. | Differentiation of pluripotent cells |
WO2010143529A1 (ja) * | 2009-06-09 | 2010-12-16 | 国立大学法人名古屋大学 | 多能性幹細胞を胸腺上皮へ分化誘導する方法 |
CN103068970A (zh) * | 2010-04-25 | 2013-04-24 | 西奈山医学院 | 来自多能细胞的前部前肠内胚层的形成 |
US9279107B2 (en) | 2010-08-05 | 2016-03-08 | Wisconsin Alumni Research Foundation | Simplified basic media for human pluripotent cell culture |
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2014
- 2014-03-12 CA CA3141731A patent/CA3141731A1/en active Pending
- 2014-03-12 JP JP2016501563A patent/JP6677631B2/ja active Active
- 2014-03-12 CN CN201480027786.4A patent/CN105209609B/zh active Active
- 2014-03-12 DK DK14722013.1T patent/DK2970912T3/en active
- 2014-03-12 SG SG11201507275TA patent/SG11201507275TA/en unknown
- 2014-03-12 HU HUE14722013A patent/HUE043785T2/hu unknown
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- 2014-03-12 BR BR112015022770-8A patent/BR112015022770B1/pt active IP Right Grant
- 2014-03-12 KR KR1020157028556A patent/KR102151210B1/ko active IP Right Grant
- 2014-03-12 WO PCT/US2014/024518 patent/WO2014165131A1/en active Application Filing
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- 2014-03-12 CA CA2905786A patent/CA2905786C/en active Active
- 2014-03-12 EP EP14722013.1A patent/EP2970912B1/en active Active
- 2014-03-12 ES ES14722013T patent/ES2720196T3/es active Active
- 2014-03-12 US US14/206,778 patent/US9938499B2/en active Active
- 2014-03-12 AU AU2014248651A patent/AU2014248651B2/en active Active
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JP6677631B2 (ja) | 2020-04-08 |
BR112015022770A8 (pt) | 2019-11-26 |
US20140273211A1 (en) | 2014-09-18 |
JP2016512031A (ja) | 2016-04-25 |
IL241286A0 (en) | 2015-11-30 |
US9938499B2 (en) | 2018-04-10 |
BR112015022770A2 (pt) | 2017-07-18 |
IL241286B (en) | 2020-03-31 |
CA3141731A1 (en) | 2014-10-09 |
HUE043785T2 (hu) | 2019-09-30 |
DK2970912T3 (en) | 2019-04-23 |
US20180258398A1 (en) | 2018-09-13 |
ES2720196T3 (es) | 2019-07-18 |
CN105209609B (zh) | 2020-08-21 |
WO2014165131A1 (en) | 2014-10-09 |
AU2014248651A1 (en) | 2015-10-01 |
SG11201507275TA (en) | 2015-10-29 |
HK1218927A1 (zh) | 2017-03-17 |
MX2015012202A (es) | 2015-11-30 |
US20220228118A1 (en) | 2022-07-21 |
EP2970912A1 (en) | 2016-01-20 |
CA2905786A1 (en) | 2014-10-09 |
PT2970912T (pt) | 2019-05-31 |
CN105209609A (zh) | 2015-12-30 |
PL2970912T3 (pl) | 2019-08-30 |
BR112015022770B1 (pt) | 2022-11-16 |
KR102151210B1 (ko) | 2020-09-02 |
TR201904270T4 (tr) | 2019-05-21 |
AU2014248651B2 (en) | 2019-01-17 |
EP2970912B1 (en) | 2019-03-06 |
CA2905786C (en) | 2022-01-25 |
KR20150126943A (ko) | 2015-11-13 |
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