MX350009B - Derivados de 2-metoxi-piridin-4-ilo. - Google Patents

Derivados de 2-metoxi-piridin-4-ilo.

Info

Publication number
MX350009B
MX350009B MX2013007726A MX2013007726A MX350009B MX 350009 B MX350009 B MX 350009B MX 2013007726 A MX2013007726 A MX 2013007726A MX 2013007726 A MX2013007726 A MX 2013007726A MX 350009 B MX350009 B MX 350009B
Authority
MX
Mexico
Prior art keywords
derivatives
metoxi
piridin
ilo
formula
Prior art date
Application number
MX2013007726A
Other languages
English (en)
Other versions
MX2013007726A (es
Inventor
Bolli Martin
Lescop Cyrille
Mathys Boris
Morrison Keith
Mueller Claus
Nayler Oliver
Steiner Beat
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45607310&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX350009(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MX2013007726A publication Critical patent/MX2013007726A/es
Publication of MX350009B publication Critical patent/MX350009B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invención se refiere a derivados de la piridina de la Fórmula (I) (Ver Formula) Fórmula (I) donde A, R1, R2, R3 y R4 son tal como se describen en la descripción, su preparación y su empleo como compuestos farmacéuticamente activos. Dichos compuestos actúan particularmente como agentes inmunomoduladores.
MX2013007726A 2011-01-19 2012-01-18 Derivados de 2-metoxi-piridin-4-ilo. MX350009B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2011050241 2011-01-19
PCT/IB2012/050241 WO2012098505A1 (en) 2011-01-19 2012-01-18 2-methoxy-pyridin-4-yl derivatives

Publications (2)

Publication Number Publication Date
MX2013007726A MX2013007726A (es) 2013-08-09
MX350009B true MX350009B (es) 2017-08-23

Family

ID=45607310

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007726A MX350009B (es) 2011-01-19 2012-01-18 Derivados de 2-metoxi-piridin-4-ilo.

Country Status (28)

Country Link
US (1) US9133179B2 (es)
EP (1) EP2665720B1 (es)
JP (1) JP5859570B2 (es)
KR (1) KR101869120B1 (es)
CN (1) CN103313981B (es)
AR (1) AR084883A1 (es)
AU (1) AU2012208325B2 (es)
BR (1) BR112013017923B1 (es)
CA (1) CA2818470C (es)
CL (1) CL2013002056A1 (es)
CY (1) CY1116657T1 (es)
DK (1) DK2665720T3 (es)
ES (1) ES2544086T3 (es)
HR (1) HRP20150919T1 (es)
HU (1) HUE026012T2 (es)
IL (1) IL227509A0 (es)
MA (1) MA34910B1 (es)
MX (1) MX350009B (es)
MY (1) MY163185A (es)
PH (1) PH12013501487A1 (es)
PL (1) PL2665720T3 (es)
PT (1) PT2665720E (es)
SG (1) SG191742A1 (es)
SI (1) SI2665720T1 (es)
TW (1) TWI546300B (es)
UA (1) UA109804C2 (es)
WO (1) WO2012098505A1 (es)
ZA (1) ZA201306193B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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MX363545B (es) 2013-03-15 2019-03-27 Idorsia Pharmaceuticals Ltd Derivados piridin-4-ilo.
EP2990055B1 (en) 2013-04-26 2019-06-05 Kyoto University Composition comprising a sphingosine-1-phosphate receptor 1 agonist for inhibiting formation and/or enlargement of cerebral aneurysm or for shrinking it
CN105760707B (zh) * 2014-12-18 2018-07-31 中国科学院大连化学物理研究所 细胞基因翻译过程建模方法
ES2770348T3 (es) * 2015-05-20 2020-07-01 Idorsia Pharmaceuticals Ltd Forma cristalina del compuesto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi}-propano-1,2-diol
CN107382965A (zh) * 2017-08-14 2017-11-24 河南科技大学第附属医院 具有抗肿瘤活性的新型s1p‑1受体激动剂药物分子的合成方法

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Also Published As

Publication number Publication date
ES2544086T3 (es) 2015-08-27
CN103313981A (zh) 2013-09-18
IL227509A0 (en) 2013-09-30
AR084883A1 (es) 2013-07-10
UA109804C2 (xx) 2015-10-12
NZ614367A (en) 2015-02-27
SI2665720T1 (sl) 2015-08-31
MA34910B1 (fr) 2014-02-01
WO2012098505A1 (en) 2012-07-26
US9133179B2 (en) 2015-09-15
KR101869120B1 (ko) 2018-06-19
AU2012208325A1 (en) 2013-09-05
JP5859570B2 (ja) 2016-02-10
US20130303514A1 (en) 2013-11-14
PT2665720E (pt) 2015-09-16
ZA201306193B (en) 2016-07-27
EP2665720A1 (en) 2013-11-27
SG191742A1 (en) 2013-08-30
HRP20150919T1 (hr) 2015-09-25
CA2818470C (en) 2019-03-05
RU2013138285A (ru) 2015-02-27
MY163185A (en) 2017-08-15
BR112013017923A2 (pt) 2017-03-21
HK1191645A1 (en) 2014-08-01
CN103313981B (zh) 2016-05-11
MX2013007726A (es) 2013-08-09
BR112013017923A8 (pt) 2017-12-26
KR20140014128A (ko) 2014-02-05
CY1116657T1 (el) 2018-04-04
PL2665720T3 (pl) 2015-11-30
DK2665720T3 (en) 2015-07-13
TW201309681A (zh) 2013-03-01
EP2665720B1 (en) 2015-06-10
BR112013017923B1 (pt) 2021-08-10
HUE026012T2 (en) 2016-05-30
AU2012208325B2 (en) 2016-12-22
TWI546300B (zh) 2016-08-21
CA2818470A1 (en) 2012-07-26
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PH12013501487A1 (en) 2019-10-11
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