MX342413B - Anticuerpos para metaloproteinasa-9 de matriz. - Google Patents
Anticuerpos para metaloproteinasa-9 de matriz.Info
- Publication number
- MX342413B MX342413B MX2013002323A MX2013002323A MX342413B MX 342413 B MX342413 B MX 342413B MX 2013002323 A MX2013002323 A MX 2013002323A MX 2013002323 A MX2013002323 A MX 2013002323A MX 342413 B MX342413 B MX 342413B
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- matrix metalloproteinase
- mmp9
- functional fragment
- binding proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a una proteína de unión a metaloproteinasa 9 de matriz (MMP9) aislada, que comprende: un polipéptido de la cadena pesada de inmunoglobulina o fragmento de unión a antígeno del mismo, y un polipéptido de la cadena ligera de inmunoglobulina o fragmento de unión a antígeno del mismo, en donde la proteína de unión a MMP9 se une específicamente a un epítope de MMP9 de humano que comprende los residuos de aminoácido R162, E111, D113 e l198, y en donde la proteína de unión a MMP9 compite por la unión a MMP9 de humano con un anticuerpo que comprende una cadena pesada que comprende una secuencia de aminoácido que se selecciona a partir del grupo que consiste de SEQ ID NOS: 3 y 5-8.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37788610P | 2010-08-27 | 2010-08-27 | |
PCT/US2011/049448 WO2012027721A2 (en) | 2010-08-27 | 2011-08-26 | Antibodies to matrix metalloproteinase 9 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013002323A MX2013002323A (es) | 2013-07-29 |
MX342413B true MX342413B (es) | 2016-09-28 |
Family
ID=45724100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013002323A MX342413B (es) | 2010-08-27 | 2011-08-26 | Anticuerpos para metaloproteinasa-9 de matriz. |
Country Status (30)
Country | Link |
---|---|
US (7) | US8377443B2 (es) |
EP (1) | EP2608809B1 (es) |
JP (3) | JP5878538B2 (es) |
KR (4) | KR101518144B1 (es) |
CN (2) | CN104530238B (es) |
AP (2) | AP2016009448A0 (es) |
AU (1) | AU2011293125B2 (es) |
BR (1) | BR112013004579B1 (es) |
CA (1) | CA2808418C (es) |
CL (1) | CL2013000535A1 (es) |
CO (1) | CO6680656A2 (es) |
CR (1) | CR20130132A (es) |
EA (1) | EA031729B1 (es) |
EC (1) | ECSP13012525A (es) |
ES (1) | ES2739505T3 (es) |
HK (1) | HK1208688A1 (es) |
IL (2) | IL224614A (es) |
MA (1) | MA34527B1 (es) |
MX (1) | MX342413B (es) |
NZ (2) | NZ606880A (es) |
PE (1) | PE20131376A1 (es) |
PH (1) | PH12016501691A1 (es) |
PL (1) | PL2608809T3 (es) |
PT (1) | PT2608809T (es) |
SG (2) | SG10201506703VA (es) |
SI (1) | SI2608809T1 (es) |
TR (1) | TR201910348T4 (es) |
UA (1) | UA109908C2 (es) |
WO (1) | WO2012027721A2 (es) |
ZA (2) | ZA201301338B (es) |
Families Citing this family (79)
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ES2865068T3 (es) | 2011-01-14 | 2021-10-14 | Univ California | Anticuerpos terapéuticos contra la proteína ROR-1 y métodos para usarlos |
EA201491599A1 (ru) * | 2012-02-29 | 2015-05-29 | Джилид Байолоджикс, Инк. | Антитела к матриксной металлопротеиназе 9 |
ES2731441T3 (es) | 2012-02-29 | 2019-11-15 | Gilead Biologics Inc | Anticuerpos dirigidos contra metaloproteinasa 9 de matriz |
EP2981276A4 (en) * | 2013-04-05 | 2017-03-22 | Claudia Zylberberg | Matrix metalloproteinases and uses thereof |
WO2015081127A2 (en) | 2013-11-26 | 2015-06-04 | Gilead Sciences, Inc. | Therapies for treating myeloproliferative disorders |
EP3102238A1 (en) | 2014-01-20 | 2016-12-14 | Gilead Sciences, Inc. | Therapies for treating cancers |
EP2985295A1 (en) * | 2014-08-13 | 2016-02-17 | Calypso Biotech SA | Antibodies specific for MMP9 |
EP2985296A1 (en) * | 2014-08-13 | 2016-02-17 | Calypso Biotech SA | Antibodies specific for MMP9 |
TW201639573A (zh) | 2015-02-03 | 2016-11-16 | 吉李德科學股份有限公司 | 有關治療癌症之合併治療 |
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