SE0102298D0 - Crystal structure of enzyme and uses thereof - Google Patents

Crystal structure of enzyme and uses thereof

Info

Publication number
SE0102298D0
SE0102298D0 SE0102298A SE0102298A SE0102298D0 SE 0102298 D0 SE0102298 D0 SE 0102298D0 SE 0102298 A SE0102298 A SE 0102298A SE 0102298 A SE0102298 A SE 0102298A SE 0102298 D0 SE0102298 D0 SE 0102298D0
Authority
SE
Sweden
Prior art keywords
mmp9
protein
modulators
enzyme
crystal structure
Prior art date
Application number
SE0102298A
Other languages
English (en)
Inventor
Holly Jepson
Claire A Minshull
Richard A Pauptit
Sian Rowsell
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0102298A priority Critical patent/SE0102298D0/sv
Publication of SE0102298D0 publication Critical patent/SE0102298D0/sv
Priority to PCT/SE2002/001266 priority patent/WO2003002729A1/en
Priority to EP02739055A priority patent/EP1404828A1/en
Priority to US10/480,621 priority patent/US20040175817A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
SE0102298A 2001-06-27 2001-06-27 Crystal structure of enzyme and uses thereof SE0102298D0 (sv)

Priority Applications (4)

Application Number Priority Date Filing Date Title
SE0102298A SE0102298D0 (sv) 2001-06-27 2001-06-27 Crystal structure of enzyme and uses thereof
PCT/SE2002/001266 WO2003002729A1 (en) 2001-06-27 2002-06-24 A crystallised catalytic domain of matrix metalloproteinase 9 (mmp9) and the use of its three dimensional structure to design mmp9 modulators
EP02739055A EP1404828A1 (en) 2001-06-27 2002-06-24 A crystallised catalytic domain of matrix metalloproteinase 9 (mmp9) and the use of its three dimensional structure to design mmp9 modulators
US10/480,621 US20040175817A1 (en) 2001-06-27 2002-06-24 Crystallised catalytic domain of matrix metalloproteinase 9 (mmp9) and the use of its three dimensional structure to design mmp9 modulators

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0102298A SE0102298D0 (sv) 2001-06-27 2001-06-27 Crystal structure of enzyme and uses thereof

Publications (1)

Publication Number Publication Date
SE0102298D0 true SE0102298D0 (sv) 2001-06-27

Family

ID=20284650

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0102298A SE0102298D0 (sv) 2001-06-27 2001-06-27 Crystal structure of enzyme and uses thereof

Country Status (4)

Country Link
US (1) US20040175817A1 (sv)
EP (1) EP1404828A1 (sv)
SE (1) SE0102298D0 (sv)
WO (1) WO2003002729A1 (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG160194A1 (en) * 2002-02-05 2010-04-29 Wyeth Corp Truncated aggrecanase molecules
JP2005534308A (ja) * 2002-07-29 2005-11-17 ワイス 修飾ａｄａｍｔｓ４分子およびその使用法
WO2009022328A2 (en) 2007-08-15 2009-02-19 Yeda Research And Development Co. Ltd. Regulators of mmp-9 and uses therof
PT2608809T (pt) 2010-08-27 2019-08-26 Gilead Biologics Inc Anticorpos para a metaloproteinase 9 da matriz
NZ629178A (en) 2012-02-29 2016-09-30 Gilead Biologics Inc Antibodies to matrix metalloproteinase 9
CN107337709B (zh) * 2017-06-29 2021-03-02 安徽省农业科学院农产品加工研究所 一种高锌螯合活性锌螯合肽及其应用

Also Published As

Publication number Publication date
EP1404828A1 (en) 2004-04-07
WO2003002729A1 (en) 2003-01-09
US20040175817A1 (en) 2004-09-09

Similar Documents

Publication Publication Date Title
WO2003031606A3 (en) Crystal structure of an aurora kinase catalytic domain, and use thereof
Troeberg et al. E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A)
TR201905393T4 (tr) Terapötik protein temelli moleküllerin yeni bir sınıfı.
ATE376559T1 (de) Methoden der verhinderung und behandlung der alzheimer'schen krankheit
NO20051107L (no) Substituerte tienylhydroksaminsyrer og deres anvendelse til behandling av sykdommer forbundet med enzymatisk histondeacetylueaktivitet
ATE465748T1 (de) Vernetzte, nicht von pilzen kommende lipase enthaltende zusammensetzung und methoden zu deren verwendung
ATE361316T1 (de) Kristallstruktur einer deacetylase und deren inhibitoren
Hata et al. Domain II of m-calpain is a Ca2+-dependent cysteine protease
DE60203692D1 (de) Latency associated peptide von tgf-beta um pharmazeutisch aktive proteine latent zu machen
ATE292801T1 (de) Verfahren zum screening von inhibitoren von asp2
ATE424894T1 (de) Zusammensetzung zur förderung des haarwachstums
WO2003095475A8 (en) Peptide compounds and their use as protease substrates
BR9910151A (pt) Composições detergentes de lavanderia e/ou para o cuidado de tecidos compreendendo uma enzima modificada
SE0102298D0 (sv) Crystal structure of enzyme and uses thereof
DE60019117D1 (de) Substituierte benzamide als inhibitoren von rhinovirus 3c protease
DE60101559D1 (de) Benutzung von comt-inhibitoren als analgetika
Steer et al. Inhibitors of metalloendopeptidase EC 3.4. 24.15 and EC 3.4. 24.16 stabilized against proteolysis by the incorporation of β-amino acids
ATE435657T1 (de) Therapeutische zubereitung von hochreinem fviia und verfahren zu dessen gewinnung
ATE340257T1 (de) Histonedeacetylase 9
DE60015098D1 (de) 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5-dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose
CY1111004T1 (el) Χρησιμες συνθεσεις για τη ρυθμιση της δρασης του γονιδιου της παρκινης
ATE446765T1 (de) Methode zur zelladhäsion und wundheilung
ATE378411T1 (de) Ratten-spezifische cathepsin, dipeptidyl peptidase i (dppi): kristallstruktur, hemmstoffe und deren anwendungen
DK0833848T3 (da) Faktor IX-bindende peptider afledt af faktor VIII og anvendelse heraf som inhibitorer af blodkoagulation
ATE295724T1 (de) Der duale inhibitor der cholesterylester und wachsester synthese avasimibe zur behandlung von erkrankungen des talgdrüse