DE60019117D1 - Substituierte benzamide als inhibitoren von rhinovirus 3c protease - Google Patents

Substituierte benzamide als inhibitoren von rhinovirus 3c protease

Info

Publication number
DE60019117D1
DE60019117D1 DE60019117T DE60019117T DE60019117D1 DE 60019117 D1 DE60019117 D1 DE 60019117D1 DE 60019117 T DE60019117 T DE 60019117T DE 60019117 T DE60019117 T DE 60019117T DE 60019117 D1 DE60019117 D1 DE 60019117D1
Authority
DE
Germany
Prior art keywords
protease
inhibitors
rhinovirus
substituted benzamides
benzamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60019117T
Other languages
English (en)
Other versions
DE60019117T2 (de
Inventor
Siegfried Heinz Reich
Susan Elizabeth Kephart
Michael Brennan Wallace
Johnson, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agouron Pharmaceuticals LLC
Original Assignee
Agouron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals LLC filed Critical Agouron Pharmaceuticals LLC
Application granted granted Critical
Publication of DE60019117D1 publication Critical patent/DE60019117D1/de
Publication of DE60019117T2 publication Critical patent/DE60019117T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60019117T 1999-06-21 2000-06-21 Substituierte benzamide als inhibitoren von rhinovirus 3c protease Expired - Fee Related DE60019117T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14046999P 1999-06-21 1999-06-21
US140469P 1999-06-21
PCT/US2000/017026 WO2000078708A1 (en) 1999-06-21 2000-06-21 Substituted benzamide inhibitors of rhinovirus 3c protease

Publications (2)

Publication Number Publication Date
DE60019117D1 true DE60019117D1 (de) 2005-05-04
DE60019117T2 DE60019117T2 (de) 2006-05-04

Family

ID=22491366

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60019117T Expired - Fee Related DE60019117T2 (de) 1999-06-21 2000-06-21 Substituierte benzamide als inhibitoren von rhinovirus 3c protease

Country Status (11)

Country Link
US (1) US6369226B1 (de)
EP (1) EP1192127B1 (de)
JP (1) JP2003509337A (de)
AT (1) ATE292109T1 (de)
AU (1) AU5628800A (de)
BR (1) BR0011801A (de)
CA (1) CA2375356A1 (de)
DE (1) DE60019117T2 (de)
ES (1) ES2239603T3 (de)
MX (1) MXPA01013463A (de)
WO (1) WO2000078708A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE248186T1 (de) 1998-04-30 2003-09-15 Agouron Pharma Antipicornavirale verbindungen, deren herstellung und verwendung
PA8507801A1 (es) 1999-12-03 2002-08-26 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
PE20011277A1 (es) 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
EP1355878A2 (de) 2000-06-14 2003-10-29 Agouron Pharmaceuticals, Inc. Antipicornavirale verbindungen und zusammensetzungen, ihre pharmazeutischen verwendungen und stoffe für ihre synthese
JP5260818B2 (ja) * 2000-09-29 2013-08-14 ノバルティス・インターナショナル・ファーマシューティカル・リミテッド 高親和性低分子Ｃ５ａ受容体調節物質
WO2004093860A1 (en) * 2003-04-21 2004-11-04 Pfizer Inc. Inhibitors of sars related coronavirus proteinase
US20040235952A1 (en) * 2003-05-05 2004-11-25 Agouron Pharmaceuticals, Inc. Inhibitors of severe acute respiratory syndrome (SARS) 3C-like proteinase
BRPI0413595B8 (pt) * 2003-08-18 2021-05-25 H Lundbeck As sal de malonato, composição farmacêutica, uso de um sal de malonato, e, método de fabricação de um composto
GB0403864D0 (en) * 2004-02-20 2004-03-24 Ucl Ventures Modulator
AU2006210537A1 (en) * 2005-02-02 2006-08-10 Fox Chase Cencer Center Amine derivative containing compositions and methods for the treatment of viral infections related to the etiology of cancer
TWI453198B (zh) 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
TWI376373B (en) 2005-02-16 2012-11-11 Lundbeck & Co As H Crystalline base of a pharmaceutical compound
US20100075993A1 (en) * 2005-06-30 2010-03-25 Drexel University Small molecule inhibitors against west nile virus replication
MX2020007403A (es) 2018-01-10 2020-11-11 Allinky Biopharma Compuestos de tetrahidroisoquinolina.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
US5856530A (en) 1996-05-14 1999-01-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
US6020371A (en) 1997-03-28 2000-02-01 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds compositions containing them and methods for their use
NZ501315A (en) * 1997-03-28 2001-08-31 Agouron Pharma Carbonyl-ethyl-carboxamidyl-alkane and carbonyl-ethyl-thiocarboxamidyl-alkane derivatives useful as antipicornaviral agents
US5962487A (en) 1997-12-16 1999-10-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation

Also Published As

Publication number Publication date
CA2375356A1 (en) 2000-12-28
BR0011801A (pt) 2002-03-12
AU5628800A (en) 2001-01-09
DE60019117T2 (de) 2006-05-04
WO2000078708A1 (en) 2000-12-28
ES2239603T3 (es) 2005-10-01
EP1192127B1 (de) 2005-03-30
MXPA01013463A (es) 2002-07-22
US6369226B1 (en) 2002-04-09
EP1192127A1 (de) 2002-04-03
ATE292109T1 (de) 2005-04-15
JP2003509337A (ja) 2003-03-11

Similar Documents

Publication Publication Date Title
ATE348816T1 (de) 2,5-dioxoimidazolidin-4-ylacetamide und analoga als inhibitoren von metalloproteinase mmp12
EA200101166A1 (ru) Ингибиторы металлопротеаз
ATE292109T1 (de) Substituierte benzamide als inhibitoren von rhinovirus 3c protease
TR200100605T2 (tr) Arilpiperazinler ve bunların metaloproteinaz inhibe edici maddeler (MMP) olarak kullanımı
DE60135087D1 (de) Dipeptidnitrile als inhibitoren von cathepsin k
BR0317715A (pt) Composições e processos de uso de collajolie
DE60315146D1 (de) Heteroarylsubstituierte biphenylderivate als inhibitoren von p38-kinase
PT966465E (pt) Inibidores do enzima imfdh
ATE259782T1 (de) N-cyanomethylamide als protease-inhibitoren
EA200100992A1 (ru) Ингибиторы фермента impdh
DE69717268D1 (de) M-amidinophenyl-analoga als faktor-xa-inhibitoren
PT1144368E (pt) Sulfonamidas acetilenicas de acidos hidroxamicos baseados em alfa-aminoacidos como inibidores de tace
EA200300017A1 (ru) Ингибиторы серинпротеазы
DK1030836T3 (da) Hydroxam- og carboxylsyrederivater der har MMP- og TNF-inhiberende aktivitet
UY26677A1 (es) Heterociclos que son inhibidores de la enzima impdh
DK1668001T3 (da) Substituerede heteroarylbenzofuransyrer
UY25712A1 (es) Benzamidas sustituidas y su aplicación en medicamentos
DK1097173T3 (da) Anvendelse af peptider af IL-2 og derivater deraf som terapeutiske midler
DE69835532D1 (de) Quinolin-enthaltende alpha-ketoamid-basierte inhibitoren von cystein- und serin protease
SE9901077D0 (sv) Novel use
DE60033809D1 (de) Inhibitoren von metalloproteinasen
ES2120506T3 (es) Nuevas amidas, sulfonamidas y sulfonamidas de piperidilo utilizadas como inhibidores de la biosintesis del colesterol.
DE60228134D1 (de) Substituierte hydrazone als hemmer von cyclooxygenase-2
ATE295724T1 (de) Der duale inhibitor der cholesterylester und wachsester synthese avasimibe zur behandlung von erkrankungen des talgdrüse
TR200402322T4 (tr) Triptaz inhibitörler

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee