MX2020007403A - Compuestos de tetrahidroisoquinolina. - Google Patents

Compuestos de tetrahidroisoquinolina.

Info

Publication number
MX2020007403A
MX2020007403A MX2020007403A MX2020007403A MX2020007403A MX 2020007403 A MX2020007403 A MX 2020007403A MX 2020007403 A MX2020007403 A MX 2020007403A MX 2020007403 A MX2020007403 A MX 2020007403A MX 2020007403 A MX2020007403 A MX 2020007403A
Authority
MX
Mexico
Prior art keywords
tetrahydroisoquinoline compounds
compounds
tetrahydroisoquinoline
compositions
present
Prior art date
Application number
MX2020007403A
Other languages
English (en)
Inventor
García Miguel Vega
Muelas Pedro Campos
Romero Esther Carrasco
Pérez Asunción Burguete
Gutiérrez Patricia Gómez
González Juan Jesús Pérez
Peypoch Ángel Messeguer
Sánchez Balbino José Alarcón
Rojo Irene Azahara Arellano
Original Assignee
Allinky Biopharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allinky Biopharma filed Critical Allinky Biopharma
Publication of MX2020007403A publication Critical patent/MX2020007403A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se relaciona con una clase novedosa de compuestos de tetrahidroisoquinolina de la fórmula I y con las composiciones que comprenden los mismos. Los compuestos y las composiciones de la presente invención se pueden utilizar como medicamentos en el tratamiento del cáncer.
MX2020007403A 2018-01-10 2019-01-10 Compuestos de tetrahidroisoquinolina. MX2020007403A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18382010 2018-01-10
PCT/EP2019/050518 WO2019137985A1 (en) 2018-01-10 2019-01-10 Tetrahydroisoquinoline compounds

Publications (1)

Publication Number Publication Date
MX2020007403A true MX2020007403A (es) 2020-11-11

Family

ID=62104212

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020007403A MX2020007403A (es) 2018-01-10 2019-01-10 Compuestos de tetrahidroisoquinolina.

Country Status (10)

Country Link
US (1) US11466012B2 (es)
EP (1) EP3737677B1 (es)
JP (1) JP2021510699A (es)
CN (1) CN112262137A (es)
CA (1) CA3087888A1 (es)
DK (1) DK3737677T3 (es)
ES (1) ES2905568T3 (es)
MX (1) MX2020007403A (es)
RU (1) RU2020126188A (es)
WO (1) WO2019137985A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3763711A1 (en) * 2019-07-09 2021-01-13 Allinky Biopharma Tetrahydroisoquinoline compounds
IL299131A (en) 2020-06-18 2023-02-01 Revolution Medicines Inc Methods for delaying, preventing and treating acquired resistance to RAS inhibitors
WO2022060583A1 (en) 2020-09-03 2022-03-24 Revolution Medicines, Inc. Use of sos1 inhibitors to treat malignancies with shp2 mutations
WO2023169481A1 (zh) * 2022-03-09 2023-09-14 思路迪生物医药(上海)有限公司 一类作为泛-kras抑制剂的四氢异喹啉类衍生物及其制备方法和应用
CN114874201B (zh) * 2022-04-08 2023-01-20 思路迪生物医药(上海)有限公司 一类泛-kras抑制剂及其制备和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369226B1 (en) 1999-06-21 2002-04-09 Agouron Pharmaceuticals, Inc. Substituted benzamide inhibitors of rhinovirus 3C protease
NZ527276A (en) * 2001-03-27 2004-11-26 Actelion Pharmaceuticals Ltd 1,2,3,4-tetrahydroisoquinoline derivatives as urotensin II receptor antagonists
SE0303542D0 (sv) * 2003-12-22 2003-12-22 Astrazeneca Ab 1,2,3,4-Tetrahydroisoquinoline derivaties, preparations thereof and uses thereof
GEP20094640B (en) * 2004-07-15 2009-03-10 Bristol Myers Squibb Co Aryl-and heteroaryl-substituted tetrahydro isoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2008024398A2 (en) 2006-08-23 2008-02-28 Valeant Pharmaceuticals International Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
DK2074120T3 (da) 2007-10-25 2010-06-14 Exelixis Inc Tropan-forbindelser
US8343961B2 (en) * 2009-03-31 2013-01-01 Arqule, Inc. Substituted heterocyclic compounds
EP2458995A1 (en) 2009-07-28 2012-06-06 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
TWI744672B (zh) 2013-12-11 2021-11-01 美商百健Ｍａ公司 布魯頓氏(bruton's)酪胺酸激酶之聯芳基抑制劑
CN107072970B (zh) * 2014-08-29 2021-05-25 得克萨斯州大学系统董事会 用于治疗癌症和其他增殖性疾病的新的辣椒平类似物
CN106117182B (zh) * 2016-06-20 2019-08-30 中国药科大学 喹唑啉-n-苯乙基四氢异喹啉类化合物及其制备方法和应用
EP3880668B1 (en) 2018-11-14 2023-12-20 Allinky Biopharma Pyridin-sulfonamide compounds for the treatment of conditions related to interleukin 1 beta

Also Published As

Publication number Publication date
CN112262137A (zh) 2021-01-22
US20200369671A1 (en) 2020-11-26
ES2905568T3 (es) 2022-04-11
DK3737677T3 (da) 2022-01-10
JP2021510699A (ja) 2021-04-30
US11466012B2 (en) 2022-10-11
WO2019137985A1 (en) 2019-07-18
CA3087888A1 (en) 2019-07-18
EP3737677B1 (en) 2021-11-03
RU2020126188A (ru) 2022-02-10
EP3737677A1 (en) 2020-11-18

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