ATE378411T1 - Ratten-spezifische cathepsin, dipeptidyl peptidase i (dppi): kristallstruktur, hemmstoffe und deren anwendungen - Google Patents

Ratten-spezifische cathepsin, dipeptidyl peptidase i (dppi): kristallstruktur, hemmstoffe und deren anwendungen

Info

Publication number
ATE378411T1
ATE378411T1 AT01984605T AT01984605T ATE378411T1 AT E378411 T1 ATE378411 T1 AT E378411T1 AT 01984605 T AT01984605 T AT 01984605T AT 01984605 T AT01984605 T AT 01984605T AT E378411 T1 ATE378411 T1 AT E378411T1
Authority
AT
Austria
Prior art keywords
dppi
dipeptidyl peptidase
rat
inhibitors
applications
Prior art date
Application number
AT01984605T
Other languages
English (en)
Inventor
Johan Olsen
Anders Kadziola
Soeren Dahl
Connie Lauritzen
Sine Larsen
John Pedersen
Dusan Turk
Marjetka Podobnik
Igor Stern
Original Assignee
Prozymex As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prozymex As filed Critical Prozymex As
Application granted granted Critical
Publication of ATE378411T1 publication Critical patent/ATE378411T1/de

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
AT01984605T 2000-09-08 2001-09-06 Ratten-spezifische cathepsin, dipeptidyl peptidase i (dppi): kristallstruktur, hemmstoffe und deren anwendungen ATE378411T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001343 2000-09-08
US24758400P 2000-11-09 2000-11-09

Publications (1)

Publication Number Publication Date
ATE378411T1 true ATE378411T1 (de) 2007-11-15

Family

ID=26068872

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01984605T ATE378411T1 (de) 2000-09-08 2001-09-06 Ratten-spezifische cathepsin, dipeptidyl peptidase i (dppi): kristallstruktur, hemmstoffe und deren anwendungen

Country Status (7)

Country Link
EP (1) EP1317555B1 (de)
AT (1) ATE378411T1 (de)
AU (1) AU3815102A (de)
CA (1) CA2422057C (de)
DE (1) DE60131423T2 (de)
DK (1) DK1317555T3 (de)
WO (1) WO2002020804A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1975153A3 (de) * 2003-05-30 2010-03-31 Prozymex A/S Proteasehemmer
US20070286854A1 (en) * 2004-04-28 2007-12-13 Bayer Healthcare Ag Diagnostics And Therapeutics For Diseases Associated With Dipeptidyl-Peptidase 1 (Dpp1)
NZ566799A (en) 2005-09-14 2011-04-29 Takeda Pharmaceutical Dipeptidyl peptidase inhibitors for treating diabetes
CN101360723A (zh) 2005-09-16 2009-02-04 武田药品工业株式会社 制备嘧啶二酮衍生物的方法
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
NO2699580T3 (de) 2014-01-24 2018-02-24

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486623A (en) * 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
US5637462A (en) * 1995-04-19 1997-06-10 Incyte Pharmaceuticals, Inc. Cathepsin C homolog
AU1115797A (en) * 1995-10-26 1997-05-15 Alessandra D'azzo Protective protein/cathepsin a and precursor: crystallization, x-ray diffraction, three-dimensional structure determination and rational drug design
GB9522558D0 (en) * 1995-11-03 1996-01-03 Smithkline Beecham Plc Novel product and process
GB9606062D0 (en) * 1996-03-22 1996-05-22 Zeneca Ltd Promoters
GB9807293D0 (en) * 1998-04-03 1998-06-03 Univ Glasgow Leishmania cysteine proteinases
WO2001007663A1 (en) * 1999-07-27 2001-02-01 Wake Forest University Methods and compositions for diagnosing palmoplantar keratodermas and dysplasias and other periodontal diseases

Also Published As

Publication number Publication date
DE60131423D1 (de) 2007-12-27
WO2002020804A8 (en) 2004-04-29
EP1317555B1 (de) 2007-11-14
DE60131423T2 (de) 2009-03-19
CA2422057C (en) 2012-11-27
WO2002020804B1 (en) 2002-07-25
AU3815102A (en) 2002-03-22
WO2002020804A1 (en) 2002-03-14
EP1317555A1 (de) 2003-06-11
CA2422057A1 (en) 2002-03-14
DK1317555T3 (da) 2008-03-25

Similar Documents

Publication Publication Date Title
ATE380175T1 (de) Pyrrolidine als dipeptidyl peptidase inhibitoren
EA200300293A1 (ru) Противовоспалительные конденсированные пирролокарбазолы
ATE370943T1 (de) Fluoropyrrolidine als dipeptidyl-peptidase inhibitoren
EA200100992A1 (ru) Ингибиторы фермента impdh
BR9813658A (pt) Cristais de peptìdeo-1 semelhantes a glucagÈnio
ATE490253T1 (de) Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen
ATE350374T1 (de) Phenylalaninderivate als hemmer der dipeptidyl peptidase zur behandlung oder prävention von diabetes
BG66085B1 (bg) Фенилаланинови производни
EA200501805A1 (ru) Фармацевтическая композиция, содержащая ингибитор фермента дипептидилпептидазы
BR0314814A (pt) Variantes otimizadas de fc e métodos para sua geração
ATE354568T1 (de) Nicht-imidazol aryloxypiperidine als h3 rezeptor liganden
PT966465E (pt) Inibidores do enzima imfdh
ATE451369T1 (de) Piperidinopyrimidindipeptidylpeptidaseinhibitor n zur behandlung von diabetes
ATE396993T1 (de) Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität
DE602005023887D1 (de) Als b-sekretase (bace)-hemmer nützliche 2-amino-chinazolinderivate
ATE319696T1 (de) Nicht-imidazol aryloxyalkylamine als h3 rezeptor liganden
ATE527261T1 (de) 7-aryl-3,9-diazabicycloä3.3.1ünon-6-en-derivate und ihre verwendung als renin-inhibitoren zur behandlung von bluthochdruck, herz-kreislauf- erkrankungen und nierenkrankheiten
DK1206484T3 (da) Antipicornavirale forbindelser og sammensætninger, deres farmaceutiske anvendelser og materialer til deres syntese
EA200200625A1 (ru) Антипикорнавирусные соединения и композиции, их фармацевтическое применение и вещества для их синтеза
ATE378411T1 (de) Ratten-spezifische cathepsin, dipeptidyl peptidase i (dppi): kristallstruktur, hemmstoffe und deren anwendungen
EA200200949A1 (ru) Метаболиты агониста/антагониста эстрогена
DE60033809D1 (de) Inhibitoren von metalloproteinasen
BRPI0410840A (pt) derivados substituìdos de pirrol, composição farmacêutica contendo os mesmos e processo para sua preparação
ATE247130T1 (de) Inhibitoren für den urokinaserezeptor
DE60015098D1 (de) 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5-dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1317555

Country of ref document: EP