MX339074B - Piperacinil y diacepanil benzamidas y benztioamidas. - Google Patents
Piperacinil y diacepanil benzamidas y benztioamidas.Info
- Publication number
- MX339074B MX339074B MX2009006222A MX2009006222A MX339074B MX 339074 B MX339074 B MX 339074B MX 2009006222 A MX2009006222 A MX 2009006222A MX 2009006222 A MX2009006222 A MX 2009006222A MX 339074 B MX339074 B MX 339074B
- Authority
- MX
- Mexico
- Prior art keywords
- benzthioamides
- piperazinyl
- benzamides
- diazapanyl
- diazapanyl benzamides
- Prior art date
Links
- QIOZLISABUUKJY-UHFFFAOYSA-N Thiobenzamide Chemical class NC(=S)C1=CC=CC=C1 QIOZLISABUUKJY-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004193 piperazinyl group Chemical group 0.000 title abstract 2
- 229940054066 benzamide antipsychotics Drugs 0.000 title 1
- 150000003936 benzamides Chemical class 0.000 title 1
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 229960001340 histamine Drugs 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- MCBOTNKJOSKNFJ-UHFFFAOYSA-N n-(diazepan-1-yl)benzamide Chemical class C=1C=CC=CC=1C(=O)NN1CCCCCN1 MCBOTNKJOSKNFJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0468—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K51/047—Benzodiazepines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/24—Antidepressants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42049502P | 2002-10-23 | 2002-10-23 | |
| PCT/US2003/033343 WO2004037801A1 (en) | 2002-10-23 | 2003-10-21 | Piperazinyl and diazapanyl benzamides and benzthioamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX339074B true MX339074B (es) | 2016-05-09 |
Family
ID=32176579
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009006222A MX339074B (es) | 2002-10-23 | 2003-10-21 | Piperacinil y diacepanil benzamidas y benztioamidas. |
| MXPA05004384A MXPA05004384A (es) | 2002-10-23 | 2003-10-21 | Piperacinil y diacepanil benzamidas y benztioamidas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05004384A MXPA05004384A (es) | 2002-10-23 | 2003-10-21 | Piperacinil y diacepanil benzamidas y benztioamidas. |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US7414047B2 (enExample) |
| EP (1) | EP1558595B1 (enExample) |
| JP (1) | JP4596918B2 (enExample) |
| KR (1) | KR101067732B1 (enExample) |
| CN (1) | CN100558718C (enExample) |
| AR (1) | AR041697A1 (enExample) |
| AT (1) | ATE449766T1 (enExample) |
| AU (1) | AU2003301552B2 (enExample) |
| BR (1) | BRPI0315644B8 (enExample) |
| CA (1) | CA2504269C (enExample) |
| CR (1) | CR7807A (enExample) |
| CY (1) | CY1109924T1 (enExample) |
| DE (1) | DE60330269D1 (enExample) |
| DK (1) | DK1558595T3 (enExample) |
| EA (1) | EA009860B1 (enExample) |
| EG (1) | EG25097A (enExample) |
| ES (1) | ES2335584T3 (enExample) |
| HR (1) | HRP20050352B1 (enExample) |
| IL (1) | IL168207A (enExample) |
| ME (1) | ME00334B (enExample) |
| MX (2) | MX339074B (enExample) |
| MY (1) | MY140886A (enExample) |
| NO (1) | NO330741B1 (enExample) |
| NZ (2) | NZ539595A (enExample) |
| PL (1) | PL215454B1 (enExample) |
| PT (1) | PT1558595E (enExample) |
| RS (1) | RS51681B (enExample) |
| SI (1) | SI1558595T1 (enExample) |
| TW (1) | TWI352594B (enExample) |
| UA (1) | UA80573C2 (enExample) |
| WO (1) | WO2004037801A1 (enExample) |
| ZA (1) | ZA200504067B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA009860B1 (ru) | 2002-10-23 | 2008-04-28 | Янссен Фармацевтика, Н.В. | Пиперазинил- и диазапанилбензамиды и бензтиоамиды |
| GB0324159D0 (en) | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
| CA2561945A1 (en) * | 2004-03-31 | 2005-10-20 | Janssen Pharmaceutica, N.V. | Non-imidazole heterocyclic compounds as histamine h3 receptor modulators |
| CA2561791A1 (en) * | 2004-03-31 | 2005-10-20 | Janssen Pharmaceutica, N.V. | Non-imidazole heterocyclic compounds |
| CA2622760C (en) * | 2005-09-16 | 2012-12-04 | Janssen Pharmaceutica N.V. | Cyclopropyl amines as modulators of the histamine h3 receptor |
| US7795426B2 (en) | 2005-10-31 | 2010-09-14 | Janssen Pharmaceutica Nv | Processes for the preparation of cyclopropyl-amide derivatives |
| WO2007053427A2 (en) | 2005-10-31 | 2007-05-10 | Janssen Pharmaceutica N.V. | Novel processes for the preparation of piperazinyl and diazapanyl benzamide derivatives |
| ES2395049T3 (es) * | 2005-10-31 | 2013-02-07 | Janssen Pharmaceutica Nv | Procedimiento para la preparación de derivados de ciclopropilamida |
| ES2381205T3 (es) | 2005-11-10 | 2012-05-24 | Msd K.K. | Derivado espiro aza-sustituido |
| KR101372941B1 (ko) | 2006-05-30 | 2014-03-14 | 얀센 파마슈티카 엔.브이. | 히스타민 ｈ３ 수용체 조절제로서의 치환된 피리딜 아미드 화합물 |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| JP5203360B2 (ja) | 2006-06-23 | 2013-06-05 | アボット・ラボラトリーズ | ヒスタミンｈ３受容体調節剤としてのシクロプロピルアミン誘導体 |
| CA2656072A1 (en) * | 2006-06-29 | 2008-01-03 | Janssen Pharmaceutica N.V. | Substituted benzamide modulators of the histamine h3 receptor |
| PT2121636T (pt) * | 2006-12-14 | 2017-04-26 | Janssen Pharmaceutica Nv | Processo para a preparação de derivados de piperazinil e diazepanil benzamida |
| CA2697941A1 (en) * | 2007-09-06 | 2009-03-12 | Glaxo Group Limited | Piperazine derivative having affinity for the histamine h3 receptor |
| AR068509A1 (es) * | 2007-09-19 | 2009-11-18 | Jerini Ag | Antagosnistas del receptor de bradiquinina b1 |
| MX2010005488A (es) | 2007-11-20 | 2010-06-01 | Janssen Pharmaceutica Nv | Compuestos de cicloalquiloxi y heterocicloalquiloxipiridina como moduladores del receptor h3 de histamina. |
| US20100130477A1 (en) * | 2008-11-25 | 2010-05-27 | Astrazeneca Ab | Spirocyclobutyl Piperidine Derivatives |
| TR201902858T4 (tr) * | 2009-03-18 | 2019-03-21 | Janssen Pharmaceutica Nv | Histamin H3 reseptörü modülatörlerinin preparasyonu için işlem. |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| RU2700595C1 (ru) * | 2019-07-30 | 2019-09-18 | Общество с ограниченной ответственностью "Кью Эм Фарма" | Производное 3,6,9-триазатрициклотетрадекана и его применение для лечения депрессии |
| WO2022113008A1 (en) | 2020-11-27 | 2022-06-02 | Richter Gedeon Nyrt. | Histamine h3 receptor antagonists/inverse agonists for the treatment of autism spectrum disorder |
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|---|---|---|---|---|
| US3714179A (en) | 1970-09-08 | 1973-01-30 | Searle & Co | 1-alkyl-2-furfurylthioimidazoles and congeners |
| US3886160A (en) | 1972-09-28 | 1975-05-27 | Searle & Co | 2-(2-Methyl-5-nitro-1-imidazolyl) ethyl-2-thiopseudoureas |
| CA1265798A (en) * | 1984-12-10 | 1990-02-13 | Motoo Mutsukado | 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it |
| JP2813747B2 (ja) | 1989-05-22 | 1998-10-22 | 富士写真フイルム株式会社 | 画像形成法 |
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| US5492891A (en) | 1991-09-05 | 1996-02-20 | Novo Nordisk A/S | Method for treatment of patients with chronic liver disease |
| US5569659A (en) | 1991-09-11 | 1996-10-29 | Mcneilab, Inc. | 4-arylpiperazines and 4-arylpiperidines |
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| US5217986A (en) | 1992-03-26 | 1993-06-08 | Harbor Branch Oceanographic Institution, Inc. | Anti-allergy agent |
| US5681954A (en) | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
| RU2124511C1 (ru) | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| US5464788A (en) | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5900422A (en) | 1994-12-22 | 1999-05-04 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
| US5889006A (en) | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| IL117149A0 (en) | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
| JPH09294056A (ja) * | 1996-04-25 | 1997-11-11 | Mitsubishi Electric Corp | 半導体集積回路 |
| JPH1059954A (ja) | 1996-08-14 | 1998-03-03 | Takeda Chem Ind Ltd | 環状アミン誘導体およびそれを含んでなる医薬 |
| US5869479A (en) | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
| AU9650398A (en) | 1997-11-07 | 1999-05-31 | Daiichi Pharmaceutical Co., Ltd. | Piperazine-cyclodextrin complexes |
| GB9803536D0 (en) | 1998-02-19 | 1998-04-15 | Black James Foundation | Histamine H,receptor ligands |
| EP0978512A1 (en) | 1998-07-29 | 2000-02-09 | Societe Civile Bioprojet | Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications |
| DE60117814T2 (de) | 2000-08-08 | 2006-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Nicht-imidazol aryloxyalkylamine als h3 rezeptor liganden |
| HUP0302893A3 (en) | 2000-08-08 | 2006-04-28 | Ortho Mcneil Pharm Inc | Non-imidazole aryloxypiperidines and pharmaceutical compositions containing them and their use |
| EP1326863A2 (en) | 2000-09-22 | 2003-07-16 | Ortho-McNeil Pharmaceutical, Inc. | Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines |
| WO2002076925A2 (en) | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| DE60234453D1 (de) | 2001-07-02 | 2009-12-31 | High Point Pharmaceuticals Llc | Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren |
| EP1434765B1 (en) | 2001-09-14 | 2009-12-02 | High Point Pharmaceuticals, LLC | Substituted piperidines with selective binding to histamine h3-receptor |
| JP4619655B2 (ja) | 2001-09-14 | 2011-01-26 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規アミノアゼチジン、−ピロリジンおよび−ピペリジン誘導体 |
| JP4563675B2 (ja) | 2001-10-12 | 2010-10-13 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 置換ピペリジン類、およびヒスタミンｈ３受容体関連疾患の治療のためのその使用 |
| CA2469893A1 (en) | 2001-12-10 | 2003-06-19 | Ortho-Mcneil Pharmaceutical, Inc. | Phenylalkynes |
| AU2002361846A1 (en) * | 2001-12-21 | 2003-07-15 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| DE10201240A1 (de) * | 2002-01-15 | 2003-07-24 | Bayer Ag | Substituierte Alkyluracile und ihre Verwendung |
| BR0306980A (pt) | 2002-02-01 | 2004-11-09 | Novo Nordisk As | Composto, uso de um composto, composição farmacêutica, e, método para o tratamento de distúrbios ou doenças relacionadas com o receptor de histamina h3 |
| EA009860B1 (ru) | 2002-10-23 | 2008-04-28 | Янссен Фармацевтика, Н.В. | Пиперазинил- и диазапанилбензамиды и бензтиоамиды |
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| GB0324159D0 (en) | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
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2003
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- 2003-10-21 SI SI200331757T patent/SI1558595T1/sl unknown
- 2003-10-21 KR KR1020057006864A patent/KR101067732B1/ko not_active Expired - Fee Related
- 2003-10-21 MX MX2009006222A patent/MX339074B/es unknown
- 2003-10-21 NZ NZ539595A patent/NZ539595A/en not_active IP Right Cessation
- 2003-10-21 PL PL376324A patent/PL215454B1/pl unknown
- 2003-10-21 UA UAA200504801A patent/UA80573C2/uk unknown
- 2003-10-21 WO PCT/US2003/033343 patent/WO2004037801A1/en not_active Ceased
- 2003-10-21 US US10/690,115 patent/US7414047B2/en not_active Expired - Lifetime
- 2003-10-21 NZ NZ576432A patent/NZ576432A/en not_active IP Right Cessation
- 2003-10-21 AT AT03809596T patent/ATE449766T1/de active
- 2003-10-21 CN CNB2003801070529A patent/CN100558718C/zh not_active Expired - Fee Related
- 2003-10-21 PT PT03809596T patent/PT1558595E/pt unknown
- 2003-10-21 CA CA2504269A patent/CA2504269C/en not_active Expired - Lifetime
- 2003-10-21 MX MXPA05004384A patent/MXPA05004384A/es active IP Right Grant
- 2003-10-21 RS YU20050317A patent/RS51681B/sr unknown
- 2003-10-21 ES ES03809596T patent/ES2335584T3/es not_active Expired - Lifetime
- 2003-10-21 JP JP2004546967A patent/JP4596918B2/ja not_active Expired - Fee Related
- 2003-10-21 EP EP03809596A patent/EP1558595B1/en not_active Expired - Lifetime
- 2003-10-21 DE DE60330269T patent/DE60330269D1/de not_active Expired - Lifetime
- 2003-10-21 ME MEP-2008-495A patent/ME00334B/me unknown
- 2003-10-21 DK DK03809596.4T patent/DK1558595T3/da active
- 2003-10-21 BR BRPI0315644A patent/BRPI0315644B8/pt not_active IP Right Cessation
- 2003-10-21 HR HRP20050352AA patent/HRP20050352B1/hr not_active IP Right Cessation
- 2003-10-22 MY MYPI20034029A patent/MY140886A/en unknown
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- 2003-10-23 TW TW092129372A patent/TWI352594B/zh not_active IP Right Cessation
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2005
- 2005-04-20 EG EGNA2005000151 patent/EG25097A/xx active
- 2005-04-21 IL IL168207A patent/IL168207A/en active IP Right Grant
- 2005-04-22 CR CR7807A patent/CR7807A/es not_active Application Discontinuation
- 2005-05-10 NO NO20052278A patent/NO330741B1/no not_active IP Right Cessation
- 2005-05-19 ZA ZA200504067A patent/ZA200504067B/en unknown
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2007
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2010
- 2010-01-15 CY CY20101100040T patent/CY1109924T1/el unknown
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