MX2023009324A - Composiciones de arni de superóxido dismutasa 1 (sod1), y métodos de uso de este para el tratamiento o prevención de enfermedades neurodegenerativas relacionadas con superóxido dismutasa 1 (sod1). - Google Patents

Composiciones de arni de superóxido dismutasa 1 (sod1), y métodos de uso de este para el tratamiento o prevención de enfermedades neurodegenerativas relacionadas con superóxido dismutasa 1 (sod1).

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Publication number
MX2023009324A
MX2023009324A MX2023009324A MX2023009324A MX2023009324A MX 2023009324 A MX2023009324 A MX 2023009324A MX 2023009324 A MX2023009324 A MX 2023009324A MX 2023009324 A MX2023009324 A MX 2023009324A MX 2023009324 A MX2023009324 A MX 2023009324A
Authority
MX
Mexico
Prior art keywords
sod1
superoxide dismutase
methods
treating
neurodegenerative diseases
Prior art date
Application number
MX2023009324A
Other languages
English (en)
Spanish (es)
Inventor
Stuart Milstein
Mark K Schlegel
James D Mcininch
Adam Castoreno
Charalambos Kaittanis
Jason Gilbert
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2023009324A publication Critical patent/MX2023009324A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
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    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)
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  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
MX2023009324A 2021-02-12 2022-02-11 Composiciones de arni de superóxido dismutasa 1 (sod1), y métodos de uso de este para el tratamiento o prevención de enfermedades neurodegenerativas relacionadas con superóxido dismutasa 1 (sod1). MX2023009324A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163148991P 2021-02-12 2021-02-12
US202163270176P 2021-10-21 2021-10-21
PCT/US2022/016046 WO2022174000A2 (en) 2021-02-12 2022-02-11 Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases

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MX2023009324A true MX2023009324A (es) 2023-10-13

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MX2023009324A MX2023009324A (es) 2021-02-12 2022-02-11 Composiciones de arni de superóxido dismutasa 1 (sod1), y métodos de uso de este para el tratamiento o prevención de enfermedades neurodegenerativas relacionadas con superóxido dismutasa 1 (sod1).

Country Status (11)

Country Link
US (2) US11649459B2 (https=)
EP (1) EP4291654A2 (https=)
JP (1) JP2024508714A (https=)
KR (1) KR20230146048A (https=)
AU (1) AU2022220704A1 (https=)
BR (1) BR112023015761A2 (https=)
CA (1) CA3210763A1 (https=)
IL (1) IL304880A (https=)
MX (1) MX2023009324A (https=)
TW (1) TW202305131A (https=)
WO (1) WO2022174000A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4540390A2 (en) 2022-06-15 2025-04-23 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of superoxide dismutase 1 (sod1), compositions thereof, and methods of use
TW202446402A (zh) * 2023-04-12 2024-12-01 美商艾拉倫製藥公司 用於寡核苷酸遞送之調配物
IL324720A (en) * 2023-05-26 2026-01-01 Adarx Pharmaceuticals Inc SOD1 modulators and methods of using them

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