MX2023003316A - Composiciones y metodos para produccion mejorada de enduracidina en una cepa geneticamente modificada de streptomyces fungicidicus. - Google Patents
Composiciones y metodos para produccion mejorada de enduracidina en una cepa geneticamente modificada de streptomyces fungicidicus.Info
- Publication number
- MX2023003316A MX2023003316A MX2023003316A MX2023003316A MX2023003316A MX 2023003316 A MX2023003316 A MX 2023003316A MX 2023003316 A MX2023003316 A MX 2023003316A MX 2023003316 A MX2023003316 A MX 2023003316A MX 2023003316 A MX2023003316 A MX 2023003316A
- Authority
- MX
- Mexico
- Prior art keywords
- enduracidin
- methods
- genetically engineered
- compositions
- enhanced production
- Prior art date
Links
- 241000971005 Streptomyces fungicidicus Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 108700005075 Regulator Genes Proteins 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- NJCUSQKMYNTYOW-MWUYRYRWSA-N enramicina Chemical compound O.N1C(=O)NC(=O)C(C=2C=C(Cl)C(O)=C(Cl)C=2)NC(=O)C(CO)NC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(CC2N=C(N)NC2)NC(=O)C(CCCNC(N)=O)NC(=O)C(C(C)O)NC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(C(C)O)NC(=O)N(CCCCN)C(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)/C=C/C=C/CCCCC(C)CC)C(C)OC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(C)NC(=O)C1CC1CNC(N)=N1 NJCUSQKMYNTYOW-MWUYRYRWSA-N 0.000 abstract 1
- 229950003984 enramycin Drugs 0.000 abstract 1
- 108700041171 enramycin Proteins 0.000 abstract 1
- 108091008053 gene clusters Proteins 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a composiciones y métodos para mejorar la producción de enduracidina en cepas manipuladas por ingeniería genética de Streptomyces fungicidicus. En particular, la presente invención describe la manipulación genética de los genes reguladores orf 24 y orf18 asociados con el cúmulo de genes de biosíntesis de enduracidina (enramicina) de Streptomyces fungicidicus, para generar constructos de vectores y cepas recombinantes productoras de mayores rendimientos de enduracidina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662430838P | 2016-12-06 | 2016-12-06 | |
| US201762479087P | 2017-03-30 | 2017-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023003316A true MX2023003316A (es) | 2023-03-27 |
Family
ID=60788701
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019006522A MX2019006522A (es) | 2016-12-06 | 2017-12-01 | Composiciones y metodos para produccion mejorada de enduracidina en una cepa geneticamente modificada de streptomyces fungicidicus. |
| MX2023003316A MX2023003316A (es) | 2016-12-06 | 2019-06-04 | Composiciones y metodos para produccion mejorada de enduracidina en una cepa geneticamente modificada de streptomyces fungicidicus. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019006522A MX2019006522A (es) | 2016-12-06 | 2017-12-01 | Composiciones y metodos para produccion mejorada de enduracidina en una cepa geneticamente modificada de streptomyces fungicidicus. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11447530B2 (es) |
| JP (1) | JP7086984B2 (es) |
| CN (1) | CN110997700A (es) |
| BR (1) | BR112019011378A2 (es) |
| CO (1) | CO2019005761A2 (es) |
| MX (2) | MX2019006522A (es) |
| MY (1) | MY200048A (es) |
| PE (1) | PE20191767A1 (es) |
| PH (1) | PH12019501228A1 (es) |
| TW (2) | TWI828613B (es) |
| UA (1) | UA127452C2 (es) |
| WO (1) | WO2018106545A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113980881B (zh) * | 2021-11-11 | 2023-09-19 | 枣庄市杰诺生物酶有限公司 | 一种高产恩拉霉素的杀真菌素链霉菌工程菌 |
| CN115261258A (zh) * | 2022-06-07 | 2022-11-01 | 四川汇邦环保科技有限公司 | 一种降解持久霉素的微生物菌剂 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1617881C2 (de) | 1965-10-13 | 1984-07-05 | Takeda Chemical Industries, Ltd., Osaka | Antibiotikum Enduracidin und seine Herstellung |
| JPS6038120B2 (ja) | 1980-10-31 | 1985-08-30 | 武田薬品工業株式会社 | 抗生物質エンジユラサイジンの製造法 |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| EP0425563B1 (en) | 1988-07-20 | 1996-05-15 | David Segev | Process for amplifying and detecting nucleic acid sequences |
| US5427930A (en) | 1990-01-26 | 1995-06-27 | Abbott Laboratories | Amplification of target nucleic acids using gap filling ligase chain reaction |
| US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| KR100392551B1 (ko) | 1994-07-15 | 2003-10-30 | 아크조 노벨 엔브이 | 핵산 증폭방법을 개선시키기 위한 rna폴리머라제의 용도 |
| AT402203B (de) | 1995-06-13 | 1997-03-25 | Himmler Gottfried Dipl Ing Dr | Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren |
| CA2255774C (en) | 1996-05-29 | 2008-03-18 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US8188245B2 (en) | 2006-09-29 | 2012-05-29 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Enduracidin biosynthetic gene cluster from streptomyces fungicidicus |
| CN103374537B (zh) | 2012-04-25 | 2015-01-07 | 牡丹江佰佳信生物科技有限公司 | 一种制备恩拉霉素的方法及其生产菌株 |
| CN104131054B (zh) | 2014-06-17 | 2017-02-01 | 安徽丰原发酵技术工程研究有限公司 | 一种用于提高恩拉霉素产量的发酵培养基及发酵方法 |
| CN104561048A (zh) | 2015-01-23 | 2015-04-29 | 天津科技大学 | 杀真菌素链霉菌恩拉霉素抗性好且产量高的基因和菌株 |
| MX2019006586A (es) | 2016-12-06 | 2019-08-22 | Intervet Int Bv | Aislamientos de streptomyces fungicidicus modificados y su uso. |
-
2017
- 2017-12-01 WO PCT/US2017/064328 patent/WO2018106545A1/en active Application Filing
- 2017-12-01 MY MYPI2019003083A patent/MY200048A/en unknown
- 2017-12-01 UA UAA201907509A patent/UA127452C2/uk unknown
- 2017-12-01 JP JP2019550553A patent/JP7086984B2/ja active Active
- 2017-12-01 CN CN201780085829.8A patent/CN110997700A/zh active Pending
- 2017-12-01 US US16/465,444 patent/US11447530B2/en active Active
- 2017-12-01 BR BR112019011378A patent/BR112019011378A2/pt unknown
- 2017-12-01 MX MX2019006522A patent/MX2019006522A/es unknown
- 2017-12-01 PE PE2019002115A patent/PE20191767A1/es unknown
- 2017-12-06 TW TW106142750A patent/TWI828613B/zh active
- 2017-12-06 TW TW112149554A patent/TW202417610A/zh unknown
-
2019
- 2019-05-31 PH PH12019501228A patent/PH12019501228A1/en unknown
- 2019-05-31 CO CONC2019/0005761A patent/CO2019005761A2/es unknown
- 2019-06-04 MX MX2023003316A patent/MX2023003316A/es unknown
-
2022
- 2022-08-04 US US17/817,413 patent/US11858967B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PH12019501228A1 (en) | 2019-10-07 |
| RU2019120981A (ru) | 2021-01-12 |
| JP7086984B2 (ja) | 2022-06-20 |
| TWI828613B (zh) | 2024-01-11 |
| MY200048A (en) | 2023-12-06 |
| US20230120672A1 (en) | 2023-04-20 |
| CN110997700A (zh) | 2020-04-10 |
| PE20191767A1 (es) | 2019-12-17 |
| US20190359659A1 (en) | 2019-11-28 |
| MX2019006522A (es) | 2020-02-20 |
| RU2019120981A3 (es) | 2021-08-23 |
| BR112019011378A2 (pt) | 2019-10-15 |
| UA127452C2 (uk) | 2023-08-30 |
| US11858967B2 (en) | 2024-01-02 |
| TW201827591A (zh) | 2018-08-01 |
| TW202417610A (zh) | 2024-05-01 |
| JP2020500561A (ja) | 2020-01-16 |
| WO2018106545A1 (en) | 2018-06-14 |
| CO2019005761A2 (es) | 2019-08-30 |
| US11447530B2 (en) | 2022-09-20 |
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