MX2023002973A - Uso de variantes de peptido natriuretico de tipo c para tratar displasia esqueletica. - Google Patents

Uso de variantes de peptido natriuretico de tipo c para tratar displasia esqueletica.

Info

Publication number
MX2023002973A
MX2023002973A MX2023002973A MX2023002973A MX2023002973A MX 2023002973 A MX2023002973 A MX 2023002973A MX 2023002973 A MX2023002973 A MX 2023002973A MX 2023002973 A MX2023002973 A MX 2023002973A MX 2023002973 A MX2023002973 A MX 2023002973A
Authority
MX
Mexico
Prior art keywords
natriuretic peptide
type natriuretic
skeletal dysplasia
peptide variants
cnp
Prior art date
Application number
MX2023002973A
Other languages
English (en)
Inventor
Daniel J Wendt
Augustus O Okhamafe
Sherry Bullens
Stuart Bunting
Tianwei Chou
Christopher P Price
Clarence Yap
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of MX2023002973A publication Critical patent/MX2023002973A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Abstract

La presente descripción se refiere al uso de variantes del péptido natriurético de tipo C (CNP), así como a formulaciones y composiciones farmacéuticas novedosas que comprenden las variantes de los péptidos CNP para el tratamiento de displasias esqueléticas, uno o más síntomas de las displasias esqueléticas, tales como crecimiento de hueso largo o velocidad de crecimiento, y otros trastornos que tienen una displasia esquelética y/o un componente o síntoma asociado con un CNP.
MX2023002973A 2015-07-30 2018-01-30 Uso de variantes de peptido natriuretico de tipo c para tratar displasia esqueletica. MX2023002973A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562199081P 2015-07-30 2015-07-30
US201662320704P 2016-04-11 2016-04-11

Publications (1)

Publication Number Publication Date
MX2023002973A true MX2023002973A (es) 2023-04-05

Family

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Family Applications (2)

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MX2018001314A MX2018001314A (es) 2015-07-30 2016-08-01 Uso de variantes de peptido natriuretico de tipo c para tratar displasia esqueletica.
MX2023002973A MX2023002973A (es) 2015-07-30 2018-01-30 Uso de variantes de peptido natriuretico de tipo c para tratar displasia esqueletica.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018001314A MX2018001314A (es) 2015-07-30 2016-08-01 Uso de variantes de peptido natriuretico de tipo c para tratar displasia esqueletica.

Country Status (19)

Country Link
US (5) US9907834B2 (es)
EP (1) EP3328416B1 (es)
JP (3) JP6882256B2 (es)
KR (1) KR20180030414A (es)
CN (2) CN108472336B (es)
AU (2) AU2016298425B2 (es)
BR (1) BR112018001761A2 (es)
CA (1) CA2994280C (es)
CL (1) CL2018000215A1 (es)
CO (1) CO2018002328A2 (es)
DK (1) DK3328416T3 (es)
FI (1) FI3328416T3 (es)
HK (1) HK1255864A1 (es)
IL (2) IL257125B (es)
MX (2) MX2018001314A (es)
PT (1) PT3328416T (es)
RU (1) RU2728567C2 (es)
TW (2) TWI773649B (es)
WO (1) WO2017020034A1 (es)

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US9907834B2 (en) 2015-07-30 2018-03-06 Biomarin Pharmaceutical Inc. Use of C-type natriuretic peptide variants to treat skeletal dysplasia
EP3574913A4 (en) * 2017-01-24 2020-07-22 Daiichi Sankyo Company, Limited SMALL SIZE THERAPEUTIC AGENT
KR102649069B1 (ko) 2018-05-31 2024-03-19 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 안면 홍조 개선용 조성물
KR102058961B1 (ko) 2018-07-28 2019-12-24 주식회사 엑소코바이오 엑소좀의 동결건조 방법
KR102163806B1 (ko) 2018-07-30 2020-10-07 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물
JP7197310B2 (ja) * 2018-08-31 2022-12-27 株式会社小松製作所 積込機械の制御装置および制御方法
WO2021030411A1 (en) * 2019-08-12 2021-02-18 Biomarin Pharmaceutical Inc. Hydrophobic peptide salts for extended release compositions
CN110514619B (zh) * 2019-08-29 2021-01-29 山东科技大学 基于有偏估计的近红外定量分析模型构建方法
KR20220063220A (ko) * 2019-09-16 2022-05-17 바이오마린 파머수티컬 인크. Cnp 변이체 및 이의 접합체
TW202313663A (zh) 2021-07-09 2023-04-01 美商拜奧馬林製藥公司 Ｃ型利鈉肽變異體治療兒童骨骼發育不良
TW202334188A (zh) 2021-12-07 2023-09-01 美商拜奧馬林製藥公司 Ｃｎｐ療法

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Publication number Publication date
AU2016298425B2 (en) 2022-11-10
HK1255864A1 (zh) 2019-08-30
TWI820795B (zh) 2023-11-01
CO2018002328A2 (es) 2018-05-10
RU2018106890A (ru) 2019-08-28
EP3328416B1 (en) 2024-03-13
CA2994280C (en) 2024-01-23
AU2023200669A1 (en) 2023-04-27
JP2021107458A (ja) 2021-07-29
US11590204B2 (en) 2023-02-28
US11911446B2 (en) 2024-02-27
US20230293637A1 (en) 2023-09-21
JP2018522022A (ja) 2018-08-09
RU2728567C2 (ru) 2020-07-30
RU2020123892A3 (es) 2021-12-03
RU2018106890A3 (es) 2019-12-27
US9907834B2 (en) 2018-03-06
FI3328416T3 (fi) 2024-03-26
US20180207239A1 (en) 2018-07-26
IL278488B2 (en) 2023-02-01
US10646550B2 (en) 2020-05-12
CN108472336A (zh) 2018-08-31
JP7336482B2 (ja) 2023-08-31
AU2016298425A1 (en) 2018-02-08
US20200246433A1 (en) 2020-08-06
CL2018000215A1 (es) 2018-06-22
CN108472336B (zh) 2022-05-31
US20170028023A1 (en) 2017-02-02
KR20180030414A (ko) 2018-03-22
CA2994280A1 (en) 2017-02-02
TW201717995A (zh) 2017-06-01
BR112018001761A2 (pt) 2018-09-18
WO2017020034A8 (en) 2018-03-15
US20200246434A1 (en) 2020-08-06
EP3328416A1 (en) 2018-06-06
DK3328416T3 (da) 2024-04-08
TW202322847A (zh) 2023-06-16
JP6882256B2 (ja) 2021-06-02
IL278488B (en) 2022-10-01
TWI773649B (zh) 2022-08-11
RU2020123892A (ru) 2020-09-18
PT3328416T (pt) 2024-04-10
CN114796460A (zh) 2022-07-29
IL257125A (en) 2018-03-29
WO2017020034A1 (en) 2017-02-02
MX2018001314A (es) 2018-05-28
IL278488A (es) 2020-12-31
IL257125B (en) 2020-11-30
JP2023144124A (ja) 2023-10-06

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