AR069409A1 - Variantes de peptidos natriureticos de tipo c - Google Patents

Variantes de peptidos natriureticos de tipo c

Info

Publication number
AR069409A1
AR069409A1 ARP080105079A ARP080105079A AR069409A1 AR 069409 A1 AR069409 A1 AR 069409A1 AR P080105079 A ARP080105079 A AR P080105079A AR P080105079 A ARP080105079 A AR P080105079A AR 069409 A1 AR069409 A1 AR 069409A1
Authority
AR
Argentina
Prior art keywords
variants
cnp
type
amino acids
natural peptides
Prior art date
Application number
ARP080105079A
Other languages
English (en)
Inventor
Emil D Kakkis
Dong Wei
Dan J Wendt
Joshua R Bliesath
Sean Bell
Mika Aoyagi-Scharber
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40364250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR069409(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of AR069409A1 publication Critical patent/AR069409A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Variantes del péptido natriurético de tipo C (CNP) que comprende una o más supresiones; adiciones y/o sustituciones con aminoácidos naturales, aminoácidos no naturales y/o peptidomiméticos (incluyendo isosteros de enlaces péptidos); extensiones de aminoácidos; y/u otros grupos químicos tales como, por ejemplo, poli(etilenglicol) y ácidos hidrofobicos. Las variantes de CNP son de utilidad como agentes terapéuticos para el tratamiento de enfermedades que responden a CNP, incluyendo en un sentido no limitativo trastornos relacionados con los huesos tales como, por ejemplo, displasias del esqueleto y acondroplasia, y trastornos de la musculatura lisa vascular tales como, por ejemplo, restenosis y arteriosclerosis.
ARP080105079A 2007-11-21 2008-11-21 Variantes de peptidos natriureticos de tipo c AR069409A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98949707P 2007-11-21 2007-11-21
US6148808P 2008-06-13 2008-06-13

Publications (1)

Publication Number Publication Date
AR069409A1 true AR069409A1 (es) 2010-01-20

Family

ID=40364250

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080105079A AR069409A1 (es) 2007-11-21 2008-11-21 Variantes de peptidos natriureticos de tipo c

Country Status (10)

Country Link
US (1) US8377884B2 (es)
EP (1) EP2217620A2 (es)
JP (1) JP2011504506A (es)
AR (1) AR069409A1 (es)
AU (1) AU2008326327A1 (es)
CA (1) CA2705603A1 (es)
CL (1) CL2008003476A1 (es)
PE (1) PE20091067A1 (es)
TW (1) TWI367213B (es)
WO (1) WO2009067639A2 (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2365023T3 (es) 2004-04-21 2011-09-20 Enobia Pharma Inc. Conjugados de administración ósea y método de uso de los mismos para dirigir proteínas a hueso.
PT2432489T (pt) 2009-05-20 2016-12-07 Biomarin Pharm Inc Variantes do péptido natriurético de tipo c
JP2011026294A (ja) * 2009-06-26 2011-02-10 Canon Inc 化合物
EP2457581B1 (en) * 2009-07-23 2014-01-08 Igisu Co., Ltd. Composition comprising cnp or bnp for external preparation for skin for the treatment of dermatitis
MX2012002175A (es) 2009-08-27 2012-06-27 Igisu Co Ltd Preparacion terapeutica para la rinitis.
US8546523B2 (en) 2009-09-25 2013-10-01 Alcon Research, Ltd. NPR-B agonists
WO2011075471A2 (en) * 2009-12-18 2011-06-23 Alcon Research, Ltd. Novel npr-b agonists and methods of use for the treatment of c-type natriuretic peptide-mediated disorders
TW201121995A (en) 2009-12-18 2011-07-01 Alcon Res Ltd Novel NPR-B agonists
US20110300071A1 (en) * 2010-06-04 2011-12-08 Washington University Targeting npr-c in angiogenesis and atherosclerosis with a c-type atrial natriuretic factor (canf)-comb nanocomplex
JP6055779B2 (ja) 2010-12-27 2016-12-27 アレクシオン ファーマシューティカルズ， インコーポレイテッド ナトリウム利尿ペプチドを含む組成物およびその使用方法
HUE035584T2 (en) 2011-01-21 2018-05-28 Igisu Co Ltd A therapeutic agent for the treatment of allopathy
JP5948683B2 (ja) 2011-02-28 2016-07-06 国立研究開発法人国立循環器病研究センター 悪性腫瘍転移抑制用医薬
EP2745846A4 (en) 2011-08-19 2015-03-18 Nat Cerebral & Cardiovascular Ct MEDICAMENT FOR PREVENTING THE ABSORPTION OF SPICY TUMORS WITH A COMBINATION OF NATRIURETIC PEPTIDE RECEPTOR GC-A AGONISTS AND GC-B AGONISTS
SG11201401605QA (en) * 2011-10-19 2014-09-26 Alexion Pharma Holding Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
US20150293119A1 (en) * 2011-12-23 2015-10-15 Mayo Foundation For Medical Education And Research Assessing renal structural alterations and outcomes
TWI578995B (zh) * 2012-04-25 2017-04-21 第一三共股份有限公司 利尿鈉肽受體npr-b促效劑之用途
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
JP6232630B2 (ja) 2013-03-10 2017-11-22 国立大学法人名古屋大学 骨系統疾患治療薬及びその用途
KR20160118264A (ko) * 2014-02-27 2016-10-11 다이이찌 산쿄 가부시키가이샤 스테로이드제 투여로 유발되는 성장 장해에 대한 의약
US10822596B2 (en) 2014-07-11 2020-11-03 Alexion Pharmaceuticals, Inc. Compositions and methods for treating craniosynostosis
CN107405390A (zh) 2014-12-05 2017-11-28 阿雷克森制药公司 用重组碱性磷酸酶治疗癫痫
AU2016205968A1 (en) * 2015-01-09 2017-07-13 Ascendis Pharma Growth Disorders A/S CNP prodrugs
US10603361B2 (en) 2015-01-28 2020-03-31 Alexion Pharmaceuticals, Inc. Methods of treating a subject with an alkaline phosphatase deficiency
US9907834B2 (en) * 2015-07-30 2018-03-06 Biomarin Pharmaceutical Inc. Use of C-type natriuretic peptide variants to treat skeletal dysplasia
EP3330280A4 (en) * 2015-07-31 2019-06-12 Igisu Co., Ltd. CYCLIC PEPTIDE CNP AND MEDICINE, PREPARATION FOR EXTERNAL USE AND COSMETIC PRODUCT, CONTAINING ALL OF SAID CYCLIC PEPTIDE
WO2017031114A1 (en) 2015-08-17 2017-02-23 Alexion Pharmaceuticals, Inc. Manufacturing of alkaline phosphatases
US11229686B2 (en) 2015-09-28 2022-01-25 Alexion Pharmaceuticals, Inc. Reduced frequency dosage regimens for tissue non-specific alkaline phosphatase (TNSALP)-enzyme replacement therapy of hypophosphatasia
JP2018533571A (ja) 2015-10-30 2018-11-15 アレクシオン ファーマシューティカルズ， インコーポレイテッド 患者の頭蓋縫合早期癒合症を治療するための方法
HUE057083T2 (hu) 2015-12-08 2022-04-28 Biomarin Pharm Inc C-típusú nátriuretikus peptid változatainak alkalmazása oszteoartritisz kezelésére
WO2017118703A1 (en) * 2016-01-08 2017-07-13 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with low initial npr-b activity
IL293979B1 (en) * 2016-01-08 2024-04-01 Ascendis Pharma Growth Disorders As Controlled-release CNP agonists with increased NEP stability
EP3400065A1 (en) * 2016-01-08 2018-11-14 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with reduced side-effects
CA3007979C (en) * 2016-01-08 2023-12-19 Ascendis Pharma Growth Disorders A/S Cnp prodrugs with carrier attachment at the ring moiety
AU2017205268B2 (en) 2016-01-08 2022-02-17 Ascendis Pharma Growth Disorders A/S CNP prodrugs with large carrier moieties
CN108472383B (zh) * 2016-01-08 2022-07-01 阿森迪斯药物生长障碍股份有限公司 具有低npr-c结合的控制释放cnp激动剂
WO2017155569A1 (en) 2016-03-08 2017-09-14 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
WO2017173395A1 (en) 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in adolescents and adults
RU2754558C2 (ru) 2016-04-01 2021-09-03 Алексион Фармасьютикалз, Инк. Лечение мышечной слабости с помощью щелочных фосфатаз
CN118078956A (zh) * 2016-05-06 2024-05-28 免疫新炉有限公司 用于受控和持续释放的elp融合蛋白
US10988744B2 (en) 2016-06-06 2021-04-27 Alexion Pharmaceuticals, Inc. Method of producing alkaline phosphatase
WO2018035420A1 (en) 2016-08-18 2018-02-22 Alexion Pharmaceuticals, Inc. Methods for treating tracheobronchomalacia
IL290054B2 (en) 2016-09-29 2024-03-01 Ascendis Pharma Growth Disorders As Combined treatment with CNP agonists with controlled release
WO2018139464A1 (ja) 2017-01-24 2018-08-02 第一三共株式会社 低身長症治療剤
AU2018239352A1 (en) * 2017-03-22 2019-10-10 Pharmain Corporation NPRA agonists, compositions, and uses thereof
EP3600383A4 (en) 2017-03-31 2020-10-28 Alexion Pharmaceuticals, Inc. METHODS FOR TREATMENT OF HYPOPHOSPHATASIA (HPP) IN ADULTS AND ADOLESCENTS
WO2019190752A1 (en) 2018-03-30 2019-10-03 Alexion Pharmaceuticals, Inc. Manufacturing of glycoproteins
EP3553079A1 (en) * 2018-04-12 2019-10-16 Bayer Aktiengesellschaft C-type natriuretic peptide engrafted antibodies
SG11202107446QA (en) 2019-02-11 2021-08-30 Ascendis Pharma Growth Disorders As Dry pharmaceutical formulations of cnp conjugates
CN111848776B (zh) * 2020-08-31 2022-03-18 江苏璟泽生物医药有限公司 聚乙二醇修饰的rhBNP及其制备方法
WO2023283657A1 (en) 2021-07-09 2023-01-12 Biomarin Pharmaceutical Inc. C-type natriuretic peptide variants to treat skeletal dysplasia in children
WO2023108005A1 (en) * 2021-12-07 2023-06-15 Biomarin Pharmaceutical Inc. C-type natriuretic peptide therapy of bone-related disorders
CA3236278A1 (en) * 2021-12-13 2023-06-22 Kennett Sprogoe Effective doses of cnp conjugates
WO2023227505A1 (en) 2022-05-23 2023-11-30 Ascendis Pharma Growth Disorders A/S Liquid pharmaceutical formulations of cnp compounds
WO2024094747A1 (en) * 2022-11-02 2024-05-10 Novo Nordisk A/S Cnp compounds
WO2024104922A1 (en) 2022-11-14 2024-05-23 Ascendis Pharma Growth Disorders A/S Method of improving skeletal muscle function

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2636500B2 (ja) * 1990-04-20 1997-07-30 壽之 松尾 ブタ由来新規生理活性ペプチド
JP2930380B2 (ja) 1990-07-13 1999-08-03 壽之 松尾 ブタ由来新規生理活性ペプチド（ｃｎｐ―５３）
JP3026351B2 (ja) 1990-07-13 2000-03-27 壽之 松尾 ブタｃｎｐ遺伝子及び前駆体蛋白
JP3026354B2 (ja) * 1990-09-27 2000-03-27 壽之 松尾 ヒトｃｎｐ遺伝子及び前駆体蛋白
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
JP2809533B2 (ja) 1991-01-31 1998-10-08 壽之 松尾 Ｃｎｐ類似体ペプチド
WO1994020534A1 (en) * 1993-03-03 1994-09-15 Mayo Foundation For Medical Education And Research Vasonatrin peptide and analogs thereof
US5665704A (en) * 1993-11-12 1997-09-09 Genentech, Inc. Receptor specific atrial natriuretic peptides
US5846932A (en) 1993-11-12 1998-12-08 Genentech, Inc. Receptor specific atrial natriuretic peptides
US5917019A (en) * 1997-02-13 1999-06-29 The Rockefeller University Altered telomere repeat binding factor 2
US6136040A (en) 1998-03-05 2000-10-24 Washington University Animal model with disrupted FGF-9 gene
IL125958A0 (en) * 1998-08-27 1999-04-11 Yeda Res & Dev Animal model for fibroblast growth factor receptor associated chondrodysplasia
WO2000061631A1 (en) 1999-04-12 2000-10-19 Astrazeneca Ab Modified pentapeptide antagonists of the atrial natriuretic peptide clearance receptor
US6887470B1 (en) * 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6407211B1 (en) * 1999-12-17 2002-06-18 Mayo Foundation For Medical Education And Research Chimeric natriuretic peptides
IL142118A0 (en) * 2001-03-20 2002-03-10 Prochon Biotech Ltd Method and composition for treatment of skeletal dysplasias
BRPI0203172B8 (pt) * 2001-09-28 2021-05-25 Nakao Kazuwa composição farmacêutica para acondroplasia
PL377813A1 (pl) 2002-11-26 2006-02-20 Biocon Limited Modyfikowane związki natriuretyczne, ich koniugaty oraz zastosowania
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US8815803B2 (en) * 2004-03-31 2014-08-26 Kazuwa Nakao Method for increasing body height comprising systemic administration of CNP-53
WO2010078325A2 (en) * 2008-12-29 2010-07-08 Mayo Foundation For Medical Education And Research Natriuretic polypeptides for reducing or preventing restenosis
JP6055779B2 (ja) * 2010-12-27 2016-12-27 アレクシオン ファーマシューティカルズ， インコーポレイテッド ナトリウム利尿ペプチドを含む組成物およびその使用方法

Also Published As

Publication number Publication date
CA2705603A1 (en) 2009-05-28
US20100331256A1 (en) 2010-12-30
TWI367213B (en) 2012-07-01
WO2009067639A3 (en) 2009-07-09
US8377884B2 (en) 2013-02-19
CL2008003476A1 (es) 2009-08-14
WO2009067639A2 (en) 2009-05-28
EP2217620A2 (en) 2010-08-18
JP2011504506A (ja) 2011-02-10
WO2009067639A4 (en) 2009-09-11
TW200927758A (en) 2009-07-01
PE20091067A1 (es) 2009-08-12
AU2008326327A1 (en) 2009-05-28

Similar Documents

Publication Publication Date Title
AR069409A1 (es) Variantes de peptidos natriureticos de tipo c
AR078044A1 (es) Variantes de peptidos natriureticos de tipo c
CO2019009587A2 (es) Polipéptidos de relaxina modificada que comprenden un mejorador farmacocinético y sus usos
ECSP14016014A (es) Miméticos de apelina sintéticos para el tratamiento de insuficiencia cardíaca
AR086998A1 (es) Coagonistas del receptor de glucagon/glp-1
PE20121393A1 (es) Analogo peptidico de oxintomodulina
PE20090108A1 (es) Coagonistas del receptor de glucagon/glp-1
IN2012DN00248A (es)
CO6231039A2 (es) Composiciones que comprenden anticuerpo que se fija al dominio ii de her2 y sus variantes acidas
GT200800273A (es) Polipeptidos de factor de crecimiento de tipo insulina estabilizada
CL2018003319A1 (es) Compuestos de mic-1 y usos de estos.
ATE544461T1 (de) Rekonstituierte tenside mit verbesserten eigenschaften
AR049014A1 (es) Mimeticuerpos de glp-1 humanos , composiciones y usos
AR093626A1 (es) Proteinas de fusion de enzima lisosomal y usos de las mismas
AR096162A1 (es) Péptidos terapéuticos
PE20180128A1 (es) Compuestos antisenescentes y usos de los mismos
BR112012029975A2 (pt) peptídeo como medicamento, em particular para o tratamento do câncer.
UA100127C2 (ru) Пептид cdh3 и лекарственное средство, содержащее его
PE20121643A1 (es) Polipeptidos del factor ix modificados y usos de los mismos
PE20140160A1 (es) Polipeptidos de relaxina modificados y sus usos
AR078445A1 (es) Agonistas del peptido natriuretico tipo b (npr -b)
CL2019003441A1 (es) Puestos de mic-1 y usos de estos.
ECSP10010729A (es) Péptidos dirigidos a crkl
MX2021005346A (es) Constructos de suministro para transcitosis y metodos relacionados.
EP4306123A3 (en) Saposin-a derived peptides and uses thereof

Legal Events

Date Code Title Description
FB Suspension of granting procedure